期刊文献+
共找到416,010篇文章
< 1 2 250 >
每页显示 20 50 100
A Review on the Application of Deep Learning Methods in Detection and Identification of Rice Diseases and Pests
1
作者 Xiaozhong Yu Jinhua Zheng 《Computers, Materials & Continua》 SCIE EI 2024年第1期197-225,共29页
In rice production,the prevention and management of pests and diseases have always received special attention.Traditional methods require human experts,which is costly and time-consuming.Due to the complexity of the s... In rice production,the prevention and management of pests and diseases have always received special attention.Traditional methods require human experts,which is costly and time-consuming.Due to the complexity of the structure of rice diseases and pests,quickly and reliably recognizing and locating them is difficult.Recently,deep learning technology has been employed to detect and identify rice diseases and pests.This paper introduces common publicly available datasets;summarizes the applications on rice diseases and pests from the aspects of image recognition,object detection,image segmentation,attention mechanism,and few-shot learning methods according to the network structure differences;and compares the performances of existing studies.Finally,the current issues and challenges are explored fromthe perspective of data acquisition,data processing,and application,providing possible solutions and suggestions.This study aims to review various DL models and provide improved insight into DL techniques and their cutting-edge progress in the prevention and management of rice diseases and pests. 展开更多
关键词 Deep learning rice diseases and pests image recognition object detection
下载PDF
Social Cost Analysis of Biological Control Technology for Crop Diseases and Insect Pests
2
作者 Jie XIE Lingling XIAO +4 位作者 Jinyu ZHAO Shoumei WAN Jian TANG Xiaolei JI Jing PENG 《Asian Agricultural Research》 2024年第8期14-16,共3页
With the rapid development of modern agriculture,the prevention and control of crop diseases and insect pests has become an important part to ensure the safety of agricultural production,the quality of agricultural pr... With the rapid development of modern agriculture,the prevention and control of crop diseases and insect pests has become an important part to ensure the safety of agricultural production,the quality of agricultural products and the safety of agricultural ecological environment.Although the effect of traditional chemical prevention and control technology is remarkable,the health risks and environmental problems brought by it should not be ignored.As a green and environmentally friendly means of prevention and control,biological prevention and control technology has gradually become a hot research topic and a trend of agricultural production.This paper is intended to comprehensively evaluate the social costs of biological control technologies for crop diseases and pests,including the health risks reduced,environmental improvements,economic benefits,and barriers to promotion,and put forward corresponding policy recommendations. 展开更多
关键词 CROPS diseases and INSECT pests BIOLOGICAL control SOCIAL cost
下载PDF
Technical Points of Green Prevention and Control Technology of Major Diseases and Pests in Lixian Rhubarb(Rheum palmatum L.)
3
作者 Shuizhan PAN Lianhu SUN +2 位作者 Minyan LIU Zhenkun WANG Yicun WANG 《Plant Diseases and Pests》 2024年第1期22-25,共4页
Based on different types of diseases,pests and weeds in the whole growth period of rhubarb(sowing period-harvesting period),the corresponding green prevention and control technology is proposed,aiming to further reduc... Based on different types of diseases,pests and weeds in the whole growth period of rhubarb(sowing period-harvesting period),the corresponding green prevention and control technology is proposed,aiming to further reduce the application amount of pesticides and fertilizers in the production of medicinal sources of Lixian rhubarb during the"14 th Five-Year Plan"period.The results will provide a theoretical basis for increasing the promotion and application of agricultural prevention and control(including disease-resistant varieties,ecological regulation),physical prevention and control,biological prevention and control measures,thus ensuring effective protection of the ecological environment,green,healthy and sustainable development of traditional Chinese medicine agriculture in Longnan,and source quality of authentic medicinal materials. 展开更多
关键词 Lixian rhubarb disease pest WEED Green prevention and control
下载PDF
Major Diseases and Pests of Blueberry in Guizhou Province and Progress in Their Prevention and Control
4
作者 Yanling REN Shoumei WAN +10 位作者 Tao WANG Min ZHANG Lidan MA Zhi LI Youwen TIAN Haibin FU Xingning WANG Jing PENG Lingling XIAO Dandan LU Jinyu ZHAO 《Plant Diseases and Pests》 2024年第3期1-4,7,共5页
As the blueberry industry continues to evolve,the effective control of its diseases and pests has become an essential component of local agricultural development.This paper provides a comprehensive overview of the pri... As the blueberry industry continues to evolve,the effective control of its diseases and pests has become an essential component of local agricultural development.This paper provides a comprehensive overview of the principal types of blueberry diseases and pests in Guizhou Province,along with the corresponding control measures,in order to serve as a valuable reference for blueberry growers. 展开更多
关键词 BLUEBERRIES diseases and pests Prevention and control Guizhou Province
下载PDF
Comprehensive Prevention and Control Technology of Vegetable Diseases and Pests in Shandong Province
5
作者 Dongwen SUN Hui YU +7 位作者 Yang QIN Yujie LIN Xiaomeng QI Yuxuan CHEN Yuxin HE Xinying YAN Jia'er XU Shumei GUO 《Plant Diseases and Pests》 2024年第1期26-27,32,共3页
An in-depth research and practice has been conducted on vegetable diseases and pests in Shandong Province,and the principles of comprehensive and ecological control of diseases and pests are put forward,including agri... An in-depth research and practice has been conducted on vegetable diseases and pests in Shandong Province,and the principles of comprehensive and ecological control of diseases and pests are put forward,including agricultural control measures such as crop rotation,field cleaning,fertilizer and water management,physical control measures such as catching and killing,trapping,blocking,photoelectric energy treatment,biological control measures such as the use of natural enemies,pathogenic microorganisms,other beneficial organisms and metabolites,and scientific and rational chemical control measures.Comprehensive prevention and control not only controls vegetable diseases and pests effectively,but also protects the ecological environment. 展开更多
关键词 VEGETABLE diseases and pests Comprehensive prevention and control
下载PDF
The Yield and Diseases-Pest Performance of Breeding Materials for Tomatoes (Lycopersicon esculentum) Sourced from Different Exotic Sources
6
作者 Akm Quamruzzaman Limu Akter 《American Journal of Plant Sciences》 CAS 2024年第9期766-776,共11页
A study was conducted with 36 tomato germplasm [PGRC (19), The Netherlands (7), Japan (2), and Bangladesh (9)] with 3 check varieties in the research field of the Olericulture Division of Horticulture Research Centre ... A study was conducted with 36 tomato germplasm [PGRC (19), The Netherlands (7), Japan (2), and Bangladesh (9)] with 3 check varieties in the research field of the Olericulture Division of Horticulture Research Centre (HRC), Bangladesh Agricultural Research Institute (BARI), Gazipur during the winter season of 2022-23 to identify promising tomato breeding germplasm. All the germplasm showed differences in most of the parameters studied. Considerable variation was observed for fruit yield per hectare varied from 39 to 144 tons, while the highest fruit yield per hectare was harvested from the germplasm viz., BD 7759B, BD 7757, BD 7751, BD 7301, QM, BD 7759A, BD 7762, QF, BD 7753, BD 8886, BD 10351, NL-1A, SLA-19. The number of locules, total soluble solids (TSS) and plant height at last harvest varied from 2 to 6.6, 2.6 to 5.9%, and 66 to 154cm, respectively. The TYLCV infection (%) and leaf-sucking pest infestation (%) were observed with a 1 to 20% range in the field condition in both cases. So, we can select that germplasm has zero per cent infestation. Considering the plant growth habit, earliness, different yield contributing horticultural traits, virus and pest infestation thirteen germplasm viz., BD 7759B, BD 7757, BD 7751, BD 7301, QM, BD 7759A, BD 7762, QF, BD 7753, BD 8886, BD 10351, NL-1A, SLA-19 were selected as breeding materials for further tomato improvement program. 展开更多
关键词 Lycopersicon esculentum TOMATO TYLCV Leaf-Sucking pest Fruit Yield
下载PDF
Advanced biosensing technologies for monitoring of agriculture pests and diseases:A review
7
作者 Jiayao He Ke Chen +2 位作者 Xubin Pan Junfeng Zhai Xiangmei Lin 《Journal of Semiconductors》 EI CAS CSCD 2023年第2期57-65,共9页
The threat posed to crop production by pests and diseases is one of the key factors that could reduce global food security.Early detection is of critical importance to make accurate predictions,optimize control strate... The threat posed to crop production by pests and diseases is one of the key factors that could reduce global food security.Early detection is of critical importance to make accurate predictions,optimize control strategies and prevent crop losses.Recent technological advancements highlight the opportunity to revolutionize monitoring of pests and diseases.Biosensing methodologies offer potential solutions for real-time and automated monitoring,which allow advancements in early and accurate detection and thus support sustainable crop protection.Herein,advanced biosensing technologies for pests and diseases monitoring,including image-based technologies,electronic noses,and wearable sensing methods are presented.Besides,challenges and future perspectives for widespread adoption of these technologies are discussed.Moreover,we believe it is necessary to integrate technologies through interdisciplinary cooperation for further exploration,which may provide unlimited possibilities for innovations and applications of agriculture monitoring. 展开更多
关键词 precision agriculture biosensors CROPS disease and pest management
下载PDF
Differentiation of Wheat Diseases and Pests Based on Hyperspectral Imaging Technology with a Few Specific Bands
8
作者 Lin Yuan Jingcheng Zhang +3 位作者 Quan Deng Yingying Dong Haolin Wang Xiankun Du 《Phyton-International Journal of Experimental Botany》 SCIE 2023年第2期611-628,共18页
Hyperspectral imaging technique is known as a promising non-destructive way for detecting plants diseases and pests.In most previous studies,the utilization of the whole spectrum or a large number of bands as well as ... Hyperspectral imaging technique is known as a promising non-destructive way for detecting plants diseases and pests.In most previous studies,the utilization of the whole spectrum or a large number of bands as well as the complexity of model structure severely hampers the application of the technique in practice.If a detection system can be established with a few bands and a relatively simple logic,it would be of great significance for application.This study established a method for identifying and discriminating three commonly occurring diseases and pests of wheat,i.e.,powdery mildew,yellow rust and aphid with a few specific bands.Through a comprehensive spectral analysis,only three bands at 570,680 and 750 nm were selected.A novel vegetation index namely Ratio Triangular Vegetation Index(RTVI)was developed for detecting anomalous areas on leaves.Then,the Support Vector Machine(SVM)method was applied to construct the discrimination model based on the spectral ratio analysis.The validating results suggested that the proposed method with only three spectral bands achieved a promising accuracy with the Overall Accuracy(OA)of 83%.With three bands from the hyperspectral imaging data,the three wheat diseases and pests were successfully detected and discriminated.A stepwise strategy including background removal,damage lesions recognition and stresses discrimination was proposed.The present work can provide a basis for the design of low cost and smart instruments for disease and pest detection. 展开更多
关键词 Winter wheat diseases pests hyperspectral imaging discriminant analysis
下载PDF
Main Pests and Diseases of Zingiberaceae and Their Control
9
作者 Jun’ai Hui Nian Liu 《American Journal of Plant Sciences》 2023年第9期988-993,共6页
The primary diseases affecting Zingiberaceae plants include ginger plague, spot blotch, anthracnose, leaf spot, leaf blight, and soft rot. Insect pests that pose a threat to these plants encompass root-knot nematode d... The primary diseases affecting Zingiberaceae plants include ginger plague, spot blotch, anthracnose, leaf spot, leaf blight, and soft rot. Insect pests that pose a threat to these plants encompass root-knot nematode disease, drilling bugs, beet nightshade moths, mesquite, thrips, and aphids. This article aims to summarize the defining features of the principal pests and diseases as well as their control methods. The intention is to offer theoretical support for the preservation of ginger plants. 展开更多
关键词 Zingiberaceae Plants diseases pests
下载PDF
Effects of Diseases and Pests on Quality, Industry and International Trade of Tea
10
作者 Yanling REN Jinyu ZHAO +4 位作者 Yao LIU Mei LI Jian TANG Xiaolei JI Jing PENG 《Plant Diseases and Pests》 CAS 2023年第3期30-32,共3页
Starting from the effects of diseases and pests on tea quality,tea industry and export trade,the status quo and control of tea diseases and pests,assurance and traceability of tea quality safety,tea industry and expor... Starting from the effects of diseases and pests on tea quality,tea industry and export trade,the status quo and control of tea diseases and pests,assurance and traceability of tea quality safety,tea industry and export trade development are analyzed in detail,and green prevention and control measures against tea diseases and pests are put forward combined with the status quo of tea in China. 展开更多
关键词 TEA Quality safety diseases and pests International trade
下载PDF
Species and Control Techniques of Main Diseases and Insect Pests of Camellia oleifera in Anhui Province
11
作者 Juanjuan HU Hao SONG +5 位作者 Zhihua CAO Yulu CHEN Jie WANG Wangsheng ZHU Dewu YAO Bangxing HAN 《Plant Diseases and Pests》 CAS 2023年第3期1-4,13,共5页
[Objectives]The paper was to master the species,incidence regularity and control techniques of main diseases and insect pests of Camellia oleifera in Anhui Province.[Methods]The species of main diseases and insect pes... [Objectives]The paper was to master the species,incidence regularity and control techniques of main diseases and insect pests of Camellia oleifera in Anhui Province.[Methods]The species of main diseases and insect pests of C.oleifera in major C.oleifera afforestation bases and seedling bases in Anhui Province were investigated through field survey and literature search.Afterwards,the symptom characteristics,occurrence regularity and harms of diseases and insect pests were analyzed,and scientific and reasonable control techniques were put forward.[Results]The main diseases of C.oleifera in Anhui Province were soft rot disease,blister blight,anthracnose,sooty blotch,etc.,and the main insect pests were Euproctis pseudoconspersa,Biston marginata,Hypomeces squamosus,Curculio chinensts,Chrenoma atritarsis,etc.The control techniques mainly included ecological regulation,physical prevention and control,chemical prevention and control,and biological prevention and control.[Conclusions]The results will promote the high-quality development of C.oleifera industry in Anhui Province,and contribute to the improvement of China s edible vegetable oil supply and national grain and oil security. 展开更多
关键词 Anhui Province Camellia oleifera diseases Insect pests Prevention and control technique
下载PDF
Law of Occurrence and the Damage of Main Diseases and Pests in Ligusticum chuanxiong Hort Field 被引量:3
12
作者 曾华兰 叶鹏盛 +2 位作者 何炼 韦树谷 刘朝辉 《Agricultural Science & Technology》 CAS 2010年第1期135-137,170,共4页
[Objective]The aim was to provide scientific basis for the prevention and treatment of the main diseases and pests. [Method]The systematic investigation was carried out in the process of seedling and field cultivation... [Objective]The aim was to provide scientific basis for the prevention and treatment of the main diseases and pests. [Method]The systematic investigation was carried out in the process of seedling and field cultivation of Ligusticum chuanxiong. [Result]The main diseases were root rot,Powdery mildew and Spot blight,while the main pests were Epinotia leucantha Meyrick,Prodenia litura Fabr.,Scarabaeoidea,Tetranychus cinnabarinus Boisduval and Delia platura Meigen. [Conclusion]The law of occurrence of main diseases and pests were confirmed. 展开更多
关键词 Ligusticum chuanxiong diseasE pest Occurrence law
下载PDF
Microglial response to aging and neuroinflammation in the development of neurodegenerative diseases 被引量:3
13
作者 Tingting Han Yuxiang Xu +2 位作者 Lin Sun Makoto Hashimoto Jianshe Wei 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第6期1241-1248,共8页
Cellular senescence and chronic inflammation in response to aging are considered to be indicators of brain aging;they have a great impact on the aging process and are the main risk factors for neurodegeneration.Review... Cellular senescence and chronic inflammation in response to aging are considered to be indicators of brain aging;they have a great impact on the aging process and are the main risk factors for neurodegeneration.Reviewing the microglial response to aging and neuroinflammation in neurodegenerative diseases will help understand the importance of microglia in neurodegenerative diseases.This review describes the origin and function of microglia and focuses on the role of different states of the microglial response to aging and chronic inflammation on the occurrence and development of neurodegenerative diseases,including Alzheimer's disease,Huntington's chorea,and Parkinson's disease.This review also describes the potential benefits of treating neurodegenerative diseases by modulating changes in microglial states.Therefore,inducing a shift from the neurotoxic to neuroprotective microglial state in neurodegenerative diseases induced by aging and chronic inflammation holds promise for the treatment of neurodegenerative diseases in the future. 展开更多
关键词 AGING Alzheimer's disease cytokines Huntington's disease MICROGLIA neurodegenerative diseases NEUROINFLAMMATION NEUROPROTECTION NEUROTOXICITY Parkinson's disease
下载PDF
Effects of Six Cultivation Patterns on Occurrence of Major Diseases and Pests and Yield of Rice 被引量:1
14
作者 张舒 吕亮 +3 位作者 常向前 程建平 余永志 钟爱荣 《Agricultural Science & Technology》 CAS 2016年第3期700-707,共8页
The occurrence rules of major diseases and pests in rice were investigated under six cultivation patterns, i.e., mechanical plowing-artificial transplanting, mechanical plowing-mechanical transplanting, mechanical plo... The occurrence rules of major diseases and pests in rice were investigated under six cultivation patterns, i.e., mechanical plowing-artificial transplanting, mechanical plowing-mechanical transplanting, mechanical plowing-scattered transplanting,cattle plowing-artificial transplanting, cattle plowing-mechanical transplanting and cattle plowing-scattered transplanting. The results showed that the six cultivation patterns showed small effects on the occurrence of rice sheath blight, second-generation rice planthopper, rice stem borer and rice false smut, but showed great effects on the occurrence of rice leaf folder, third-and fourth-generation rice planthopper and weeds; there were certain differences in the rice yield among different cultivation patterns, and the rice yield under the pattern of mechanical plowing-mechanical transplanting ranked first, while that under the pattern of cattle plowing-scattered transplanting ranked last. 展开更多
关键词 Cultivation pattern RICE disease pest WEED Effect
下载PDF
Construction of Early-warning Model for Plant Diseases and Pests Based on Improved Neural Network 被引量:2
15
作者 曹志勇 邱靖 +1 位作者 曹志娟 杨毅 《Agricultural Science & Technology》 CAS 2009年第6期135-137,154,共4页
By studying principles and methods related to early-warning model of plant diseases and using PSO method, parameter optimization was conducted to backward propagation neural network, and a pre-warning model for plant ... By studying principles and methods related to early-warning model of plant diseases and using PSO method, parameter optimization was conducted to backward propagation neural network, and a pre-warning model for plant diseases based on particle swarm and neural network algorithm was established. The test results showed that the construction of early-warning model is effective and feasible, which will provide a via- ble model structure to establish the effective early-warning platform. 展开更多
关键词 Backward propagation neural network Particle swarm algorithm Plant diseases and pests Early-warning model
下载PDF
The role of exosomes in adult neurogenesis:implications for neurodegenerative diseases 被引量:2
16
作者 Zhuoyang Yu Yan Teng +1 位作者 Jing Yang Lu Yang 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第2期282-288,共7页
Exosomes are cup-shaped extracellular vesicles with a lipid bilayer that is approximately 30 to 200 nm in thickness.Exosomes are widely distributed in a range of body fluids,including urine,blood,milk,and saliva.Exoso... Exosomes are cup-shaped extracellular vesicles with a lipid bilayer that is approximately 30 to 200 nm in thickness.Exosomes are widely distributed in a range of body fluids,including urine,blood,milk,and saliva.Exosomes exert biological function by transporting factors between different cells and by regulating biological pathways in recipient cells.As an important form of intercellular communication,exosomes are increasingly being investigated due to their ability to transfer bioactive molecules such as lipids,proteins,mRNAs,and microRNAs between cells,and because they can regulate physiological and pathological processes in the central nervous system.Adult neurogenesis is a multistage process by which new neurons are generated and migrate to be integrated into existing neuronal circuits.In the adult brain,neurogenesis is mainly localized in two specialized niches:the subventricular zone adjacent to the lateral ventricles and the subgranular zone of the dentate gyrus.An increasing body of evidence indicates that adult neurogenesis is tightly controlled by environmental conditions with the niches.In recent studies,exosomes released from different sources of cells were shown to play an active role in regulating neurogenesis both in vitro and in vivo,thereby participating in the progression of neurodegenerative disorders in patients and in various disease models.Here,we provide a state-of-the-art synopsis of existing research that aimed to identify the diverse components of exosome cargoes and elucidate the therapeutic potential of exosomal contents in the regulation of neurogenesis in several neurodegenerative diseases.We emphasize that exosomal cargoes could serve as a potential biomarker to monitor functional neurogenesis in adults.In addition,exosomes can also be considered as a novel therapeutic approach to treat various neurodegenerative disorders by improving endogenous neurogenesis to mitigate neuronal loss in the central nervous system. 展开更多
关键词 adult neurogenesis Alzheimer’s disease amyotrophic lateral sclerosis EXOSOME Huntington’s disease neurodegenerative disease neurogenic niches Parkinson’s disease
下载PDF
Lactate metabolism in neurodegenerative diseases 被引量:5
17
作者 Chaoguang Yang Rui-Yuan Pan +1 位作者 Fangxia Guan Zengqiang Yuan 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第1期69-74,共6页
Lactate,a byproduct of glycolysis,was thought to be a metabolic waste until the discovery of the Warburg effect.Lactate not only functions as a metabolic substrate to provide energy but can also function as a signalin... Lactate,a byproduct of glycolysis,was thought to be a metabolic waste until the discovery of the Warburg effect.Lactate not only functions as a metabolic substrate to provide energy but can also function as a signaling molecule to modulate cellular functions under pathophysiological conditions.The Astrocyte-Neuron Lactate Shuttle has cla rified that lactate plays a pivotal role in the central nervous system.Moreover,protein lactylation highlights the novel role of lactate in regulating transcription,cellular functions,and disease development.This review summarizes the recent advances in lactate metabolism and its role in neurodegenerative diseases,thus providing optimal pers pectives for future research. 展开更多
关键词 Alzheimer's disease Astrocyte-Neuron Lactate Shuttle brain central nervous system glucose metabolism GLYCOLYSIS NEUROINFLAMMATION Parkinson's disease protein lactylation signaling molecule
下载PDF
Short-term Prediction of Occurrence Period of Main Diseases and Pests of Flos lonicerae using Phenoecology 被引量:1
18
作者 苏桂花 谢恩倍 +7 位作者 欧善生 黄雪兰 石化玉 黄奉茂 简峰 黄艳花 覃连红 陈彩贤 《Agricultural Science & Technology》 CAS 2011年第6期858-861,共4页
The occurrence periods of Semiaphis heraclei Takahashi,Frankliniella sp.,Haptonchus luteolus and Microsphara linicerae Enchson wint.in Rabenh.causing damage on Flos lonicerae were investigated in F.lonicerae planting ... The occurrence periods of Semiaphis heraclei Takahashi,Frankliniella sp.,Haptonchus luteolus and Microsphara linicerae Enchson wint.in Rabenh.causing damage on Flos lonicerae were investigated in F.lonicerae planting area in XinCheng county of Guangxi Province during 2008-2010,which were coincided with the occurrence periods of related phenology of local Prunus persica Rootstock.With P.persica Rootstock as indicator plant,the occurrence periods of three species of pests and one species of disease were predicted,respectively,and the method was simple and accurate,which could be the foundation for preventing these pests and diseases in the local field. 展开更多
关键词 Flos lonicerae diseases and pests Phenological forecasting method
下载PDF
Neuroprotective effects of chaperone-mediated autophagy in neurodegenerative diseases 被引量:3
19
作者 Qi Jia Jin Li +5 位作者 Xiaofeng Guo Yi Li You Wu Yuliang Peng Zongping Fang Xijing Zhang 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第6期1291-1298,共8页
Chaperone-mediated autophagy is one of three types of autophagy and is characterized by the selective degradation of proteins.Chaperone-mediated autophagy contributes to energy balance and helps maintain cellular home... Chaperone-mediated autophagy is one of three types of autophagy and is characterized by the selective degradation of proteins.Chaperone-mediated autophagy contributes to energy balance and helps maintain cellular homeostasis,while providing nutrients and support for cell survival.Chaperone-mediated autophagy activity can be detected in almost all cells,including neurons.Owing to the extreme sensitivity of neurons to their environmental changes,maintaining neuronal homeostasis is critical for neuronal growth and survival.Chaperone-mediated autophagy dysfunction is closely related to central nervous system diseases.It has been shown that neuronal damage and cell death are accompanied by chaperone-mediated autophagy dysfunction.Under certain conditions,regulation of chaperone-mediated autophagy activity attenuates neurotoxicity.In this paper,we review the changes in chaperone-mediated autophagy in neurodegenerative diseases,brain injury,glioma,and autoimmune diseases.We also summarize the most recent research progress on chaperone-mediated autophagy regulation and discuss the potential of chaperone-mediated autophagy as a therapeutic target for central nervous system diseases. 展开更多
关键词 chaperone-mediated autophagy neurodegenerative disease neuronal homeostasis NEUROPROTECTION
下载PDF
Antisense therapy:a potential breakthrough in the treatment of neurodegenerative diseases 被引量:1
20
作者 Roberta Romano Cecilia Bucci 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第5期1027-1035,共9页
Neurodegenerative diseases are a group of disorders characterized by the progressive degeneration of neurons in the central or peripheral nervous system.Currently,there is no cure for neurodegenerative diseases and th... Neurodegenerative diseases are a group of disorders characterized by the progressive degeneration of neurons in the central or peripheral nervous system.Currently,there is no cure for neurodegenerative diseases and this means a heavy burden for patients and the health system worldwide.Therefore,it is necessary to find new therapeutic approaches,and antisense therapies offer this possibility,having the great advantage of not modifying cellular genome and potentially being safer.Many preclinical and clinical studies aim to test the safety and effectiveness of antisense therapies in the treatment of neurodegenerative diseases.The objective of this review is to summarize the recent advances in the development of these new technologies to treat the most common neurodegenerative diseases,with a focus on those antisense therapies that have already received the approval of the U.S.Food and Drug Administration. 展开更多
关键词 Alzheimer’s disease amyotrophic lateral sclerosis antisense oligonucleotide Huntington’s disease neurodegenerative disorders Parkinson’s disease SIRNA
下载PDF
上一页 1 2 250 下一页 到第
使用帮助 返回顶部