Amyloid-beta peptides （Aβ） are believed to be .responsible for the mental decline in patients with Alzheimer＇s reported that pathology in vaccination disease （AD）. In 1999, Schenk et all immunization with Aβ at...Amyloid-beta peptides （Aβ） are believed to be .responsible for the mental decline in patients with Alzheimer＇s reported that pathology in vaccination disease （AD）. In 1999, Schenk et all immunization with Aβ attenuated AD-like the PDAPP mouse, and developed a new approach to AD. Such vaccines were successfully tested in mouse models of AD for the reduction of Aβ plaque burden and the improvement of cognitive performance. However, 6% of AD patients developed symptoms of brain inflammation after vaccination that resembled enceohalitis or meningitis.展开更多
基金the grants from National Natural Science Foundation of China (No. 3040052)Natural Science and Technology Foundation of Guangdong Province (No. 04300218, 2005B10401047, 2006B36004001)Foundation of Science and Technology Bureau of Guangzhou City (No. 2004Z3-E0151, 2005Z3-E4021, 2006J1-C0101)
文摘Amyloid-beta peptides （Aβ） are believed to be .responsible for the mental decline in patients with Alzheimer＇s reported that pathology in vaccination disease （AD）. In 1999, Schenk et all immunization with Aβ attenuated AD-like the PDAPP mouse, and developed a new approach to AD. Such vaccines were successfully tested in mouse models of AD for the reduction of Aβ plaque burden and the improvement of cognitive performance. However, 6% of AD patients developed symptoms of brain inflammation after vaccination that resembled enceohalitis or meningitis.
