Acknowledgments to reviewers of World Journal of Gastrointestinal Pharmacology and Therapeutics

We acknowledge our sincere thanks to our reviewers. Many reviewers have contributed their expertise and time to the peer review, a critical process to ensure the quality of our World Series Journals. Both the editors of the journals and authors of the manuscripts submitted to the journals are grateful to the following reviewers

Acknowledgments to reviewers of World Journal of Gastrointestinal Pharmacology and Therapeutics

Many reviewers have contributed their expertise and time to the peer review, a critical process to ensure the quality of World Journal of Gastrointestinal

Acknowledgments to reviewers of World Journal of Gastrointestinal Pharmacology and Therapeutics

Many reviewers have contributed their expertise and time to the peer review,a critical process to ensure the quality of World Journal of Gastrointestinal

Acknowledgments to reviewers of World Journal of Gastrointestinal Pharmacology and Therapeutics

We acknowledge our sincere thanks to our reviewers.Many reviewers have contributed their expertise and time to the peer review,a critical process to ensure the quality of our World Series Journals.Both the editors of the journals and authors of the manuscripts submitted to the journals are grateful to the following reviewers for reviewing the articles(either published or rejected) over the past period of time.

Acknowledgments to reviewers of World Journal of Gastrointestinal Pharmacology and Therapeutics

Many reviewers have contributed their expertise and time to the peer review, a critical process to ensure the quality of World Journal of Gastrointestinal Pharmacology and Therapeutics. The editors

Acknowledgments to reviewers of World Journal of Gastrointestinal Pharmacology and Therapeutics

Many reviewers have contributed their expertise and time to the peer review,a critical process to ensure the quality of World Journal of Gastrointestinal Pharmacology and Therapeutics.The editors and authors of the articles submitted to the journal are grateful to the

痰热清注射液治疗慢性阻塞性肺病急性加重期作用机制探讨

目的:研究痰热清注射液治疗慢性阻塞性肺病急性加重期作用机制。方法:在线查询TCMSP数据库、既往文献获取黄芩、熊胆粉、山羊角、金银花、连翘等中药的主要活性成分,利用swisstargetprediction数据库获取其活性成分对应靶点;利用GeneCards、OMMI、Drug Bank等数据库获取慢性阻塞性肺病急性加重期靶点。利用Venny平台在线获取药物与疾病靶点交集,通过DAVID数据库对相交靶点进行基因本体分析和通路富集分析,使用STRING数据库构建蛋白相互作用网络,借助Cytoscapr软件行可视化处理并筛选主要活性成分、关键靶点。最后通过AutoDock vina软件将核心靶点与核心成分进行分子对接验证,并利用pymol可视化处理。结果:痰热清注射液中含主要活性成分90个,对应靶点557个;连翘、黄芩、金银花为痰热清注射液的关键作用药物;baicalein、Norwogonin、5,7,4’-Trihydroxy-8-methoxyflavone、5,2’,6’-Trihydroxy-7,8-dimethoxyflavone、(2R)-7-hydroxy-5-methoxy-2-phenylchroman-4-one、Panicolin、Skullcapflavone II、Moslosooflavone、5,7,2,5-tetrahydroxy-8,6-dimethoxyflavone、quercetin等为核心活性成分;STAT3、HSP90AA1、ESR1、SRC、EP300、AKT1、JUN、PIK3R1、RELA等靶点为蛋白互作网络中的核心靶点。结论:痰热清注射液治疗主要通过黄酮类物质调节细胞炎症反应、细胞增殖、凋亡等对慢性阻塞性肺病急性加重期发挥潜在作用。

基于网络药理学及分子对接探讨二至丸治疗早发性卵巢功能不全的作用机制

目的基于网络药理学方法探讨二至丸治疗早发性卵巢功能不全(POI)的可能分子作用机制。方法使用网络药理学平台(TCMSP)采集二至丸的有效成分和相关的基因;通过基因组注释数据平台(GeneCards)、人类孟德尔遗传数据库(OMIM)数据库获取POI疾病靶点;用蛋白互作网络数据库(STRING)构建蛋白质相互作用网络(PPI),通过CytoHubba筛选核心靶点。使用生物学信息注释数据库(DAVID)平台进行富集分析,采用Cytoscape 3.10.0软件进行拓扑学分析,利用AutoDockTools进行分子对接。结果二至丸内最主要的有效成分为槲皮素、木犀草素、山柰酚、刺槐素等,其中的AKT1、TP53等是关键靶点,包含的通路主要为PI3K-Akt信号通路、流体剪切应力和动脉粥样硬化信号通路等。分子对接验证大部分靶点与成分能进行有效结合。结论揭示二至丸能够经多种成分、靶点及多条信号通路对POI发挥协同治疗作用。

对熊去氧胆酸不完全应答的原发性胆汁性肝硬化患者应用熊去氧胆酸联合非诺贝特可改善预后

【据《Aliment Pharmacol Ther》2016年1月报道】题：对熊去氧胆酸不完全应答的原发性胆汁性肝硬化患者应用熊去氧胆酸联合非诺贝特可改善预后（作者Cheung AC等）贝特类似乎能够改善原发性胆汁性肝硬化（PBC）患者的生化指标,但是哪些因素可以预测应答以及治疗是否可以提高无肝移植的生存率仍不清楚。来自加拿大的Cheung等在一家三级医疗中心进行了一项回顾性队列研究。

INSTRUCTIONS TO AUTHORS

GENERAL INFORMATION World Journal of Gastrointestinal Pharmacology and Therapeutics(World J Gastrointest Pharmacol Ther,WJGPT,online ISSN 2150-5349,DOI:10.4292),is a peer-reviewed open access academic journal that aims to guide clinical practice and improve diagnostic and therapeutic skills of clinicians.Aim and scope WJGPT covers topics concerning:(1)Clinical pharmacological research articles on specific drugs,concerning with pharmacodynamics,pharmacokinetics,toxicology,clinical trial,drug reactions,drug metabolism and adverse reaction monitoring,etc.;(2)Research progress of clinical pharmacology;(3)Introduction and

INSTRUCTIONS TO AUTHORS

GENERAL INFORMATION World Journal of Gastrointestinal Pharmacology and Therapeutics(World J Gastrointest Pharmacol Ther,WJGPT,online ISSN 2150-5349,DOI:10.4292),is a bimonthly,open-access(OA),peer-reviewed

INSTRUCTIONS TO AUTHORS

GENERAL INFORMATION World Journal of Gastrointestinal Pharmacology and Therapeutics (World J Gastrointest Pharmacol Ther,WJGPT,online ISSN 2150-5349,DOI: 10.4292),is a bimonthly, open-

INSTRUCTIONS TO AUTHORS

GENERAL INFORMATION World Journal of Gastrointestinal Pharmacology and Therapeutics (World J Gastrointest Pharmacol Ther, WJGPT, online ISSN 2150-5349, DOI:10.4292), is a bimonthly, open-access (OA), peer-reviewed

INSTRUCTIONS TO AUTHORS

GENERAL INFORMATION World Journal of Gastrointestinal Pharmacology and Therapeutics(World J Gastrointest Pharmacol Ther,WJGPT,online ISSN 2150-5349,DOI:10.4292),is a bimonthly,open-access(OA),peer-reviewed journal supported by an editorial board of 188 experts in gastrointestinal pharmacology and therapeutics from 36

INSTRUCTIONS TO AUTHORS

GENERAL INFORMATION World Journal of Gastrointestinal Pharmacology and Therapeutics (World J Gastrointest Pharmacol Ther,WJGPT,online ISSN 2150-5349,DOI:10.4292),is a peer-reviewed open access academic journal that aims to guide clinical practice and improve diagnostic and therapeutic skills of clinicians.Aim and scope WJGPT covers topics concerning:(1)Clinical pharmacological research articles on specific drugs,concerning with pharmacody-

INSTRUCTIONS TO AUTHORS

GENERAL INFORMATION World Journal of Gastrointestinal Pharmacology and Therapeutics(World J Gastrointest Pharmacol Ther,WJGPT,online ISSN 2150-5349,DOI: 10.4292),is a bimonthly,open-access(OA),peer-reviewed journal supported by an editorial board of 188 experts in

INSTRUCTIONS TO AUTHORS

GENERAL INFORMATION World Journal of Gastrointestinal Pharmacology and Therapeutics(World J Gastrointest Pharmacol Ther,WJGPT,online ISSN 2150-5349,DOI: 10.4292),is a bimonthly,open-

Instructions to authors

GENERAL INFORMATION World Journal of Gastrointestinal Pharmacology and Therapeutics(World J Gastrointest Pharmacol Ther,WJGPT,online ISSN 2150-5349,DOI: 10.4292),is a bimonthly,open-access(OA),peer-reviewed journal supported by an editorial board of 188 experts in gastrointestinal pharmacology and therapeutics from 36

INSTRUCTIONS TO AUTHORS

GENERAL INFORMATION World Journal of Gastrointestinal Pharmacology and Therapeutics (World J Gastrointest Pharmacol Ther, WJGPT, online ISSN 2150-5349, DOI:10.4292), is a peer-reviewed open access academic journal that aims to guide clinical practice and improve diagnostic and therapeutic skills of clinicians.

INSTRUCTIONS TO AUTHORS

GENERAL INFORMATION World Journal of Gastrointestinal Pharmacology and Therapeutics (World J Gastrointest Pharmacol Ther,WJGPT,online ISSN 2150-5349,DOI:10.4292),is a bimonthly,open-access (OA),peer-reviewed journal supported by an editorial board of 188 experts in gastrointestinal pharmacology and therapeutics from 36