Research progress on chemical constituents and pharmacological activities of Amomum longiligulare T.L.Wu

In order to develop and utilize the tropical medicinal resource Amomum(A.)longiligulare T.L.Wu more reasonably and effectively,this paper summarizes the research progress in chemical constituents and pharmacological activities of A.longiligulare by consulting the literatures,so as to provide a certain theoretical basis for exploring its material basis.The chemical constituents of A.longiligulare mainly include volatile oil,diphenylheptane and flavonoids,which have good efficacy in anti-peptic ulcer,as well as antioxidant,analgesic and other pharmacological activities.This paper briefly discusses the reasons for the differences in the composition of volatile oil studied by different scholars.By summarizing its pharmacological activities,it is found that its various pharmacological activities may be the basis of its anti-peptic ulcer.

Study on the pharmacological activities and chemical structures of Viburnum dilatatum

Viburnum dilatatum(jiami in Chinese),belonging to the Caprifollaceae family,is widely distributed in Japan and China.Phytochemical investigations of Viburnum dilatatum(V.dilatatum)have resulted in the isolation of triterpenoids,phenolic glycosides essential oil,norisoprenoids,etc.Research results have shown that the chemical constituents of V.dilatatum possess various pharmacological activities,including antihyperglycemic,antioxidant activity and antiulcer effects.This study reviewed the chemical constituents and pharmacological activities of V.dilatatum to provide practical and useful information for further research and development of this plant.

Advances in Research of Pharmacological Activities of Resveratrol

Resveratrol is a non-ketone polyphenolic compound containing a stilbene structure.It exists in many common medicinal plants.It has many pharmacological activities such as anti-tumor,antioxidant,antibacterial and cardiovascular protection.In this paper,the advances in research of pharmacological activities of resveratrol in recent years were reviewed,to provide a reference for its further development and utilization.

Research progress on chemical constituents in Sigesbeckiae Herba and their pharmacological activities

Sigesbeckiae Herba,a dry whole plant of Sigesbeckia glabrescens Makino,Sigesbeckia pubescens Makino and Sigesbeckia orientalis L.,is a traditional Chinese medicine used to dispel dampness,dredge meridians and collaterals,clear heat and detoxicate.Its chemical components are complex and abundant,including mainly diterpenoids,sesquiterpenoids and flavonoids.Among them,diterpenoids are the main active components.Modern pharmacological studies have found that the compounds isolated from Sigesbeckiae Herba have anti-inflammatory,anti-tumor,antithrombus and other pharmacological activities.This review systematically summarized the chemical components identified from Sigesbeckiae Herba and their pharmacological activities by searching Chinese and English databases,in order to provide references for the further development of Sigesbeckiae Herba and the improvement of its quality standards.

Research review on the main chemical constituents and pharmacological activities of Viburnum awabuki

Viburnum awabuki(V.awabuki),belonging to the Viburnum genus,is an ideal tree species for landscaping.Phytochemical investigations of the V.awabuki have resulted in the isolation and identification of coumarins,lignans,sesquiterpenes,diterpenes and triterpenes.It has been reported that the extracts of V.awabuki have multiple pharmacological activities,including anti-tumor,anti-oxidant,plant growth inhibitory and neurite outgrowth-promoting activities.The research progress on the chemical constituents of V.awabuki and pharmacological activities were summarized in this review.

Research progress on chemical constituents in Periploca forrestii and their pharmacological activities

Periploca forrestii Schltr.belonging to the family of Apocynaceae,is one of the“three treasures of Miao medicine”,which was utilized by the Miao people in China for the treatment of rheumatoid arthritis,fractures and wound.Phytochemical investigations have discovered that the main constituents of Periploca forrestii were steroids,terpenoids,flavonoids and their glycosides,flavanols,quinones and phenylpropanoids.Modern pharmacological studies have shown that it possesses a wide range of biological activities,such as anti-inflammatory,anti-rheumatoid arthritis,anticancer,immunosuppressive,neuroprotective and other properties.This paper summarized the primary chemical constituents and pharmacological effects of Periploca forrestii,hoping to provide a reference for its further development and utilization.

A review:Chemical constituents and pharmacological activities of Solanum lyratum Thunb.

Solanum lyratum Thunb.belonging to the family Solanaceae,is a common Chinese herbal medicine in folk.It has been used for the treatment of colds,fever,jaundice hepatitis,cholecystitis,cholelithiasis,nephritis,edema and cancer.Previous phytochemical studies on S.lyratum have led to the identification of many chemical constituents,including steroidal saponins,alkaloids,terpenoids,flavonoids,quinonoids,phenylpropanoids,organic acids and several other kinds of compounds,which showed diverse bioactivities,such as anticancer,anti-inflammatory and antioxidant activities.This paper summarized the primary chemical constituents and pharmacological effects of S.lyratum to provide reference for its further development and utilization.

Research progress on chemical constituents and pharmacological activities of Viburnum tinus L.

Viburnum tinus L.is a shrub native to the Mediterranean basin.Because of its sedative and antispasmodic activities,it is often used as a folk medicine in Europe.Phytochemical researches have shown that numerous chemical components,including iridoid glycosides,diterpenes,triterpenes,coumarin,flavonoids and anthocyanidins have been isolated from Viburnum tinus L..This study reviewed the chemical constituents and pharmacological activities of Viburnum tinus L.to provide a reference for further researches.

Research progress on chemical constituents in Sophora alopecuroides L.and their pharmacological activities

Sophora alopecuroides L.,a perennial plant belonging to Leguminosae family,is used as medicinal materials to treat a variety of skin diseases.Its chemical components are complex and diverse,mainly including alkaloids and flavonoids.Modern pharmacological studies have found that the isolated compounds from S.alopecuroides have a variety of pharmacological activities.In particular,alkaloids represented by matrine,aloperine and oxymatrine have significant anti-inflammatory,anti-viral,anti-tumor,anti-bacterial and immunomodulatory activities.This paper summarized the chemical constituents and pharmacological activities of S.alopecuroides,aiming to provide the basis for further research.

The Genus Bletilla:A review of chemical constituents and pharmacological activities

Bletilla striata is the traditional medicine widely used to treat a series of diseases such as bleeding,burns and tumor.The congeners have similar effect.This study reviewed the recent research progress on the chemical components and pharmacological activities of the genus Bletilla.The review summarized over 160 compounds isolated from the plants of genus Bletilla,including phenanthrenes,diphenanthrenes,bibenzyls,flavonoids and quinones.The plants of genus Bletilla have potent bioactivities,such as hemostatic activity,effect of promoting wound healing,antitumor activity and anti-inflammatory activity.Although a lot of compounds have been isolated from the genus Bletilla,pharmacological studies have been limited to anti-inflammatory and antibacterial activities.

Chemical composition and pharmacological activities of Polygonum cuspidatum

Polygonum cuspidatum is a traditional Chinese medicine,and its medicinal part is dry rhizome.It is mainly used to treat damp heat jaundice,burns,carbuncle,ulcer poisoning,amenorrhea,and snake bite.Recent studies have found that P.cuspidatum also contains active ingredients against coronaviruses.This paper reviews the chemical constituents and pharmacological activities of P.cuspidatum,so as to provide a scientific basis for the development and utilization of P.cuspidatum resources in the future.

A review:The chemical components and pharmacological activities of Piper auritum Kunth

Piper auritum Kunth,a member of the Piperacea family,is a small shrub native to the Central American tropics.This plant was traditionally used in Latin American countries for the treatment of various medical conditions.Increase in the recent studies of P.auritum’s chemical components leads to the isolation of monoterpenoids,sesquiterpenoids,phenylpropanoids and several other compounds.Previous research has revealed that these secondary metabolites have diverse pharmacological activities including antidiabetic,antioxidant,anti-inflammatory,anti-pathogeny microorganism and repellent activity.This review summarizes relevant findings on P.auritum,and hopes to contribute to the exploration of its potentials for further development as an alternative medicine.

Effects of bioactive compounds and pharmacological activities in medicinal fruits and vegetables by thermal processing

With the advancement of living standards,the role of healthy diets in maintaining well-being has gained prominence.The concept of“medicinal fruits and vegetables”has attracted much research attention recently.Medicinal fruits and vegetables are rich in nutrients and high in edible value,and are also necessary for people's daily diet.In order to better exert the effect of medicinal fruits and vegetables and prolong their shelf life,this paper reviews the effects of common thermal processing methods(boiling,steaming,microwaving,hot air drying,and pasteurization)on the bioactive compounds and pharmacological activities of medicinal fruits and vegetables.It is found that different heat treatment methods have their own advantages and disadvantages,and microwave drying has greater advantages in comparison.Through the summary of the thermal processing methods of medicinal fruits and vegetables,it is expected to provide a theoretical reference for its rational utilization in the field of fruits and vegetables and the improvement of thermal processing methods.

Chemical constituents and pharmacological effects of Croton crassifolius

Croton crassifolius(CC)is a kind of traditional Chinese medicine rich in terpenoids,with among which diterpene species are the most.CC had biological activities in the treatment of cancer,inflammation,ulcerative colitis,osteoporosis and Alzheimer’s disease.This study reviews the chemical compositions and pharmacological activities of CC to provide reference for further research.

Chemical constituents and pharmacological effects of Lonicerae japonicae

Lonicera japonica,also known as honeysuckle,is an evergreen shrub in the family of Syzygium.By consulting Sciencedirect databases and Web of Science databases,79 related articles were found,of which 22 were related to chemical composition and pharmacological activity.These articles show that L.japonica has a wide range of pharmacological activities,including antiviral,anti-tumor,and antioxidant effects.These activities have important applications in the pharmaceutical,food,and fragrance industries.This review focuses on the chemical composition and pharmacological effects of L.japonicae,which is of great significance to the development of new drugs and therapeutic methods.

A systematic review of pharmacological activities, toxicological mechanisms and pharmacokinetic studies on Aconitum alkaloids

The tubers and roots of Aconitum(Ranunculaceae)are widely used as heart medicine or analgesic agents for the treatment of coronary heart disease,chronic heart failure,rheumatoid arthritis and neuropathic pain since ancient times.As a type of natural products mainly extracted from Aconitum plants,Aconitum alkaloids have complex chemical structures and exert remarkable biological activity,which are mainly responsible for significant effects of Aconitum plants.The present review is to summarize the progress of the pharmacological,toxicological,and pharmacokinetic studies of Aconitum alkaloids,so as to provide evidence for better clinical application.Research data concerning pharmacological,toxicological and pharmacokinetic studies of Aconitum alkaloids were collected from different scientific databases(PubMed,CNKI,Google Scholar,Baidu Scholar,and Web of Science)using the phrase Aconitum alkaloids,as well as generic synonyms.Aconitum alkaloids are both bioactive compounds and toxic ingredients in Aconitum plants.They produce a wide range of pharmacological activities,including protecting the cardiovascular system,nervous system,and immune system and anti-cancer effects.Notably,Aconitum alkaloids also exert strong cardiac toxicity,neurotoxicity and liver toxicity,which are supported by clinical studies.Finally,pharmacokinetic studies indicated that cytochrome P450 proteins(CYPs)and efflux transporters(ETs)are closely related to the low bioavailability of Aconitum alkaloids and play an important role in their metabolism and detoxification in vivo.

The Fruits of Xanthium sibiricum Patr: A Review on Phytochemistry, Pharmacological Activities, and Toxicity

In recent years,drug development and research have gradually shifted from chemical synthesis to biopharmaceutical and natural drugs.Natural medicines,such as traditional Chinese medicine,have been among the first studied because of their long medicinal history,simplicity,and the relatively low cost of research.Among them,Xanthii Fructus(XF)is famous for the treatment of sinusitis.In this article,the achievements of research on XF from 1953 to 2020 are systematically reviewed,focusing on the aspects of chemical constituents,pharmacological effects,clinical applications,toxicity and side effects,and processing methods.To date,there have been significant advances in both the phytochemistry and pharmacology of XF.Some traditional uses have been validated and clarified in modern pharmacological studies.However,its mechanism of action in the treatment of allergic diseases has not been satisfactorily explained.Further in vitro and in vivo studies are required to rationally develop new drugs and to elucidate the therapeutic potential of XF.A comprehensive evaluation of XF and an understanding of network pharmacology are also needed.

Advances in studying of the pharmacological activities and structure–activity relationships of natural C-glycosylflavonoids

C-glycosylflavonoids are characterized by a bond between the anomeric carbon of a sugar moiety and the C-6 or C-8 position of a flavonoid A ring.These compounds are widespread in nature and have become the subject of increasing research interest due to their high biological potential.This review focuses on the biological effects of various C-glycosylflavonoids and their structure–activity relationships(SAR)as elucidated over the last 5 years.

Chemical constituents and their pharmacological activities of plants from Cichorium genus

Plants of genus Cichorium are famous due to their therapeutic and medicinal properties.They are used as traditional medicine and edible food.To date,several scholars concentrated on compounds belonging to coumarins,flavonoids,sesquiterpenoids,triterpenoids,steroids,organic acids and other chemical constituents.Pharmacological effects such as photo-protective,hepatoprotective,anti-diabetic and lipid lowering,antioxidant,anti-inflammation,antifungal,antimalarial,increased bone mineral density,as well as vasorelaxant and antitumour activity were wildly reported.In this study,botanical resources,ethnopharmacological application,chemical constituents and bioactivities,as well as safety and toxicity of clinical applications of genus Cichorium were reviewed,which may provide a reliable basis for further development and utilization of Cichorium genetic resources.

Medicinal significance,pharmacological activities,and analytical aspects of ricinine:A concise report

Ricinine(3-cyano-4-methoxy-N-methyl-2-pyridone)is an alkaloid present in leaves and seeds of castor plant i.e.Ricinus communis.It can cause vomiting,convulsions,hypotension,liver and kidney damage and several other complications in human.Ricinine presents mainly in young plant and it is the only cyano-substituted pyridine compounds occurred naturally.Ricinine also found in some other plants such as Piper nigrum,Discocleidion rufescens,Aparisthmium cordatum and Nicotiana tabacum.Accidental and intended Ricinus communis intoxications in humans and animals have been known for centuries.In the present review,we summarize the information regarding its medicinal uses,pharmacological activities,analytical techniques and intended and unintended poisoning cases in humans and animals.This review will be beneficial for the researcher in the field of herbal medicine and other allied sciences.