Microwave-Assisted Au and Ag Nanoparticle Synthesis: An Energy Phase-Space Projection Analysis

Microwave-assisted synthesis of gold and silver nanoparticles, as a function of Green Chemistry, non Green Chemistry, and four applicator types are reported. The applicator types are Domestic microwave ovens, commercial temperature controlled microwave chemistry ovens (TCMC), digesters, and axial field helical antennae. For each of these microwave applicators the process energy budget where estimated (Watts multiplied by process time = kJ) and energy density (applied energy divided by suspension volume = kJ·ml-1) range between 180 ± 176.8 kJ, and 79.5 ± 79 kJ·ml-1, respectively. The axial field helical field an-tenna applicator is found to be the most energy efficient (0.253 kJ·m-1 per kJ, at 36 W). Followed by microwave ovens (4.47 ± 3.9 kJ·ml-1 per 76.83 ± 39 kJ), and TCMC ovens (2.86 ± 2.3 kJ·m-1 per 343 ± 321.5 kJ). The digester applicators have the least energy efficiency (36.2 ± 50.7 kJ·m-1 per 1010 ± 620 kJ). A comparison with reconstructed ‘non-thermal’ microwave oven inactivation microorganism experiments yields a power-law signature of n = 0.846 (R2 = 0.7923) four orders of magnitude. The paper provides a discussion on the Au and Ag nanoparticle chemistry and bio-chemistry synthesis aspects of the microwave applicator energy datasets and variation within each dataset. The visual and analytical approach within the energy phase-space projection enables a nanoparticle synthesis route to be systematically characterized, and where changes to the synthesis are to be mapped and compared directly with historical datasets. In order to help identify lower cost nanoparticle synthesis, in addition to potentially reduce synthesis energy to routes informed changes to potentially reduce synthesis energy budget, along with nanoparticle morphology and yield.

强组合PhaseⅠ－PhaseⅡ次可行方向法

本文对Ｐｏｌａｋ等人的组合ＮａｓｅⅠ－Ⅱ可行方向法进行改进，使之不仅能自动地将初始化阶段（Ｐｈａｓｅｌ）和最优化阶段（ＰｈａｓｅⅡ）统一起来，而且保证了满足不等式约束的函数个数不断叠累递增，故称改进后的算法为强组合ＰｈａｓｅⅠ－ⅡＰｈａｓｅⅡ次可行方向法．本文算法包含了一种新的目标局数非单词的非精确线搜索，它保证了算法产生的点列的任何聚点都是问题的Ｋ－Ｔ的点．

Safety and Tolerance of Adefovir Dipivoxil in Chinese Healthy Volunteers: A PhaseⅠRandomized and Open-Label Trial

Aim To assess the safety and tolerance of adefovir dipivoxil （ADV） in Chinese healthy volunteers. Methods A total of 52 healthy volunteers, 26 males and 26 females, aged from 19 to 26 were enrolled in the study. Forty-two subjects were randomized into 5, 10, 20, 40, and 60 mg dose groups （6 - 10 subjects in each） matched by sex and weight for single-dose trial. Ten subjects were orally given 10 mg of ADV tablets once daily for 7 d for multiple-dose trial. Physical examination, vital signs examination, electrocardiography, type-B ultrasonography, chest fluoroscopy, routine blood test, routine urine test, coagulation tests, and blood biochemical test were conducted on schedule and statistically evaluated. Results Asthenia frequently occurred in multiple-dose trial, nausea, abdominal pain, and diarrhea occurred in both single- and multiple-dose trials. ALT, bilirubin, CK, and LDH were slightly elevated. All adverse reactions and laboratory abnormalities were mild, and the frequency and severity were not related to doses. Conclusion ADV is safe and well tolerated in Chinese healthy volunteers at dose of 5 - 60 mg oncedaily or 10 nag once daily for 7 d. The recommended oral dosage regimen is 10 mg once daily. Attention should be paid to renal and liver functions, CK, AMY and LDH, if we take ADV for a long period of time.

Low side lobe pattern synthesis using projection method with genetic algorithm for truncated cone conformal phased arrays

A hybrid method for synthesizing antenna＇s three dimensional （3D） pattern is proposed to obtain the low sidelobe feature of truncated cone conformal phased arrays. In this method, the elements of truncated cone conformal phased arrays are projected to the tangent plane in one generatrix of the truncated cone. Then two dimensional （2D） Chebyshev amplitude distribution optimization is respectively used in two mutual vertical directions of the tangent plane. According to the location of the elements, the excitation current amplitude distribution of each element on the conformal structure is derived reversely, then the excitation current amplitude is further optimized by using the genetic algorithm （GA）. A truncated cone problem with 8x8 elements on it, and a 3D pattern desired side lobe level （SLL） up to 35 dB, is studied. By using the hybrid method, the optimal goal is accomplished with acceptable CPU time, which indicates that this hybrid method for the low sidelobe synthesis is feasible.

DEFORMATION MEASUREMENT USING DUAL-FREQUENCY PROJECTION GRATING PHASE-SHIFT PROFILOMETRY

2π phase ambiguity problem is very important in phase measurement when a deformed object has a large out of plane displacement. The dual-frequency projection grating phaseshifting profilometry （PSP） can be used to solve such an issue. In the measurement, two properchosen frequency gratings are utilized to synthesize an equivalent wavelength grating which ensures the computed phase in a principal phase range. Thus, the error caused by the phase unwrapping process with the conventional phase reconstruct algorithm can be eliminated. Finally, experimental result of a specimen with large plastic deformation is given to prove that the proposed method is effective to handle the phase discontinuity.

PhaseⅠdose-escalation and expansion study of PARP inhibitor,fluzoparib(SHR3162),in patients with advanced solid tumors

Objective:Fluzoparib(SHR3162)is a novel,potent poly(ADP-ribose)polymerases(PARP)1,2 inhibitor that showed anti-tumor activity in xenograft models.We conducted a phaseⅠ,first-in-human,dose-escalation and expansion(D-Esc and D-Ex)trial in patients with advanced solid cancer.Methods:This was a 3+3 phaseⅠD-Esc trial with a 3-level D-Ex at 5 hospitals in China.Eligible patients for DEsc had advanced solid tumors refractory to standard therapies,and D-Ex enrolled patients with ovarian cancer(OC).Fluzoparib was administered orally once or twice daily(bid)at 11 dose levels from 10 to 400 mg/d.Endpoints included dose-finding,safety,pharmacokinetics,and antitumor activity.Results:Seventy-nine patients were enrolled from March,2015 to January,2018[OC(47,59.5%);breast cancer(BC)(16,20.3%);colorectal cancer(8,10.1%),other tumors(8,10.1%)];48 patients were treated in the D-Esc arm and 31 in the D-Ex arm.The maximum tolerated dose(MTD)was 150 mg bid,with a half-life of 9.14 h.Grade 3/4 adverse events included anemia(7.6%)and neutropenia(5.1%).The objective response rate(ORR)was 30%(3/10)in patients with platinum-sensitive OC and 7.7%(1/13)in patients with BC.Among patients treated with fluzoparib≥120 mg/d,median progression-free survival(m PFS)was 7.2[95%confidence interval(95%CI),1.8-9.3]months in OC,9.3(95%CI,7.2-9.3)months in platinum-sensitive OC,and 3.5(range,2.0-28.0)months in BC.In patients with germline BC susceptibility gene mutation(g BRCAMut)(11/43 OC;2/16 BC),m PFS was 8.9 months for OC(range,1.0-23.2;95%CI,1.0-16.8)and 14 and 28 months for BC(those two patients both also had somatic BRCAMut).Conclusions:The MTD of fluzoparib was 150 mg bid in advanced solid malignancies.Fluzoparib demonstrated single-agent antitumor activity in BC and OC,particularly in BRCAMut and platinum-sensitive OC.

Profilometry with Grating Projection Based on One-step Phase Shift

An optical technique for 3 D shape measurement is presented. This technique, based on a deformed projected grating pattern which carries 3 D information of the measured object, can automatically and accurately obtain the phase map of a measured object by using one step phase shift algorithm.In comparison with traditional phase shift technique, the technique is much faster, with the equivalent accuracy. Only one frame image is sufficient for measuring. Experimental result of typical object is presented.

Project Construction and Important Technical Innovation for Qinshan Phase Ⅲ (PHWR) Nuclear Power Plant

Qinshan Phase Ⅲ(PHWR)Nuclear Power Plant,the first commercial heavy water reactor nuclear power plant in China,was the biggest trade project performed between the governments of China and Canada.As the owner,the Third Qinshan Nuclear Power Company(TQNPC)persisted in independent innovation management during the project construction,commissioning and self-dependent operation,efficiently realizing the three controls of the project,i.e.quality control,schedule control and investment control,and persisted in technical improvement on the basis of digestion and absorption of CANDU-6 technology to improve the unit safety and reliability.The project construction practice has helped China's nuclear power project management to becomeprogrammed,computerized,standardized and internationalized management from the existing basis.After completion of the project,with unit safe and steady operation as the prerequisite,TQNPC performed several technical modifications and innovations to continuously improve the unit performance.In the area of staff development,TQNPC paid much attention to cultivation of corporate culture,strengthed staff training and built up a good circulating mechanism with staff training and project construction promoting each other.Further to "Zero Breakthrough" and a new step forward of locolization successfully realized in Qinshan Nuclear Power Plant and Nuclear Power Qinshan Joint Venture Company,the improvement and developemnt of nuclear power project management level in Qinshan Phase Ⅲ(PHWR)Nuclear Power Plant provided reference for promotion of nuclear power development in China and standardized management of introducing large imported project.

Quality Guided Phase Unwrapping for Fringe Projection Profilometry

Fringe projection technique is a non-contact, full field 3-D shape measurement method. The object depth information is recorded in one or several deformed fringe patterns. The phase-shifting algorithm or the Fourier transform method can be used to extract the wrapped phase data. A phase unwrapping process is then applied to retrieve a continuous phase distribution, which represents the surface profile of the test object. In this paper, a quality-guided phase unwrapping approach is incorporated and two novel phase quality evaluation methods are proposed to facilitate the phase unwrapping process.

A consistent projection-based SUPG/PSPG XFEM for incompressible two-phase flows

In this paper, a consistent projection-based streamline upwind/pressure stabilizing Petrov-Galerkin （SUPG/PSPG） extended finite element method （XFEM） is presented to model incompressible immiscible two-phase flows. As the application of linear elements in SUPG/PSPG schemes gives rise to inconsistency in stabilization terms due to the inability to regenerate the diffusive term from viscous stresses, the numerical accuracy would deteriorate dramatically. To address this issue, projections of convection and pressure gradient terms are constructed and incorporated into the stabilization formulation in our method. This would substantially recover the consistency and free the practitioner from burdensome computations of most items in the residual. Moreover, the XFEM is employed to consider in a convenient way the fluid properties that have interfacial jumps leading to discontinuities in the velocity and pressure fields as well as the projections. A number of numerical examples are analyzed to demonstrate the complete recovery of consistency, the reproduction of interfacial discontinuities and the ability of the proposed projection-based SUPG/PSPG XFEM to model two-phase flows with open and closed interfaces.

Specification of phase Ⅰ of new drugs' clinical tolerance trials

Phase Ⅰ of clinical trials is the first stage of clinical pharmacology and body safety evaluation,including body tolerance test and pharmacokinetics test.The aim is providing evidence for dosage regimen and be the cornerstone of the preliminary assessment of efficacy and safety of phase Ⅱ of clinical trials.This text discussed the technique and requirement of phase Ⅰ of new drugs' clinical tolerance trials.

Risk Assessment at the Design Phase of Construction Projects in Ghana

The study was carried out exclusively in Ghana to explore the approaches employed by consultants in risk assessment at the design phase of projects in Ghana. One hundred and fourteen (114) consultants were selected out of a population of one hundred and eighty six (186) from three main professional associations in Ghana made up of the Ghana Institute of Architects, Ghana Institution of Engineers and the Ghana Institution of Surveyors (Quantity Surveying Division) practicing in Ghana for the study. Both primary and secondary data were collected. A descriptive survey was also used to observe and describe the presence, frequency or absence of characteristics of a phenomenon as it naturally occurred, in order to gain additional information. A questionnaire was also designed to collect data from the architects, engineers and quantity surveyors. The data was analyzed using Statistical Package for the Social Scientists (SPSS) 17.0. Descriptive and inferential statistics, such as frequency tables, percentages and cross tabulations were used in the data analysis and summaries. Simple tests of associations were undertaken by using Chi square and Cramer’s V statistics to compare relationships between variables. Again, relative importance index was also used to analyze some of the data by computing to deduce their rankings. The relative importance index was used to analyze some of the data by computing to deduce their rankings. The research revealed that majority of consultants had an average knowledge of risk management. Based on the findings it was recommended that consultants undergo advanced training in risk assessment. It was therefore suggested that consultancy firms should develop a set of laid down procedures for consultants to use in risk assessment in order that the use of intuition employed by majority is lessened. The challenges observed in risk assessment and the remedial steps suggested curtailing the detrimental effects of risks would be of wide importance to many developing economies.

Velocity Projection with Upwind Scheme Based on the Discontinuous Galerkin Methods for the Two Phase Flow Problem

The upwind scheme is very important in the numerical approximation of some problems such as the convection dominated problem, the two-phase flow problem, and so on. For the fractional flow formulation of the two-phase flow problem, the Penalty Discontinuous Galerkin (PDG) methods combined with the upwind scheme are usually used to solve the phase pressure equation. In this case, unless the upwind scheme is taken into consideration in the velocity reconstruction, the local mass balance cannot hold exactly. In this paper, we present a scheme of velocity reconstruction in some H(div) spaces with considering the upwind scheme totally. Furthermore, the different ways to calculate the nonlinear coefficients may have distinct and significant effects, which have been investigated by some authors. We propose a new algorithm to obtain a more effective and stable approximation of the coefficients under the consideration of the upwind scheme.

Macro-decision-making on Phase I Construction of the Three Gorges Project (TGP)

In this paper,the dominance of the national enterprise and current situation of project management are analyzed on the basis of sum of Phase Ⅰ Construction management of the Three Gorges Project.From the start point of idea modification and inner reformation of enterprise,some of concrete suggestions enhancing the project management, are offered in the paper.

Self-reliance and Innovation of Qinshan Phase Ⅱ NPP Project

This article mainly describes the self-reliance and innovation of Qinshan nuclear power project of phase II,in-between it contains new reactor core design,as well as related experimental and calculation analysis,especially for new reactor design produced fluid-induced vibration model test,theoretical analysis and testing in-built reactor;aiming at two-loop NSSS a series improvement made for safety systems and related safety analysis to enhance their reliability and redundancy;according to specialty of two-loop NSSS an optimization made for NPP parameters and design of related equipments,for the purpose to make the output of NPP maximal;design of main reactor building and T-G building also improved according to characteristics of two-loop NSSS and site conditions.CRDM and refueling machine are researched and manufactured on base of self-reliance,their performance are better than design requirements,large portion of key equipments are localized through different way.In construction first time realized the integrated erection of containment dome.During the commissioning non-nuclear steam driving of T-G set,as well as 500 kV high voltage rising using emergent diesel generator,etc.are carried out.In period of operation still continuous innovation and improvement are made,so that to keep the good record of operation.

TITE(e)-U-Keyboard两阶段Ⅰ/Ⅱ期试验设计研究

目的针对肿瘤靶向制剂和细胞免疫疗法治疗效应延迟的问题,基于Ⅰ/Ⅱ期试验设计框架,构建创新试验设计方法TITE(e)-U-Keyboard。方法采用二项近似似然法纳入尚未观测到的有效性结局信息,构建近似分布,辅助决策,并将TITE(e)-U-Keyboard同Ⅰ/Ⅱ期试验设计方法U-BOIN、BOIN12从多个角度进行模拟比较研究。结果模拟结果显示在考虑有效性结局延迟的情况下三种方法的OBD选择准确率及最优剂量分配受试者数相当,但TITE(e)-U-Keyboard所需试验时长最短;敏感性分析表明有效性观察窗会对TITE(e)-U-Keyboard试验时长产生影响,且随着有效性观察窗的增加而增加。结论TITE(e)-U-Keyboard在保持良好试验设计性能的同时显著缩短了试验时长,可以解决Ⅰ/Ⅱ期临床试验中治疗效应延迟的问题,加速临床试验进程。