Oral lichen planus(OLPS),a common oral mucosa disease,not only affects the patients’daily life,but also has a certain risk of cancerization.In traditional Chinese medicine,“phlegm”and“heat”can cause many various ...Oral lichen planus(OLPS),a common oral mucosa disease,not only affects the patients’daily life,but also has a certain risk of cancerization.In traditional Chinese medicine,“phlegm”and“heat”can cause many various illnesses.Professor Bo Zhang holds the point that the pathogenesis of OLPS is related to phlegm-heat amassment.He treated the patient in the case report with traditional Chinese medicine which was based on the principle of clearing phlegm and heat,and got a good curative effect.He treats OLPS with his own unique experience,which is taking clearing phlegm-heat and coordinating spleen-stomach as the main method,taking strengthening vital Qi to eliminate pathogenic factor as the supplement,and applying Wendan Decoction flexiblly.In order to provide a reference and guidance for clinicians,we report the typical case of OLPS.展开更多
目的:采用Meta分析的方法对热毒宁注射液不良反应进行统计分析,评价其临床安全性。方法:检索国家知识基础设施数据库(CNKI)、中国学术期刊数据库(CSPD)、中文科技期刊数据库(CCD),以及PubMed、Cochrane Library、Web of Science,检索公...目的:采用Meta分析的方法对热毒宁注射液不良反应进行统计分析,评价其临床安全性。方法:检索国家知识基础设施数据库(CNKI)、中国学术期刊数据库(CSPD)、中文科技期刊数据库(CCD),以及PubMed、Cochrane Library、Web of Science,检索公开发表的有关热毒宁注射液的临床随机对照试验,时间从建库至2020年4月。由2名研究人员分别独立检索并根据纳入及排除标准筛选文献、提取信息、进行质量评价,采用RevMan 5.3统计软件进行数据分析。同时对不同对照药品、不同用药天数、不同年龄人群的不良反应发生率进行分析。结果:最终符合纳入标准的文献共36篇(37项对照研究),总样本量3917例。Meta分析显示,热毒宁注射液不良反应发生率(3.50%)低于对照组(11.84%),差异有统计学意义(RR=0.31,95%CI为0.24~0.40,Z=9.07,P<0.00001)。亚组分析显示,在利巴韦林亚组(P<0.00001)、用药天数≤5 d亚组(P<0.0001)和>5 d亚组(P=0.0005)以及儿童亚组(P<0.00001)中,热毒宁注射液不良反应发生率均显著低于对照组。与利巴韦林(P<0.00001)、炎琥宁(P=0.01)、痰热清(P=0.02)、双黄连(P=0.001)、头孢曲松(P=0.01)比较,热毒宁注射液有效率均显著高于对照组。结论:热毒宁注射液与利巴韦林比较,不良反应发生率低,疗效好;与炎琥宁、痰热清比较,有较好的临床疗效,但安全性方面没有显著优势。展开更多
文摘Oral lichen planus(OLPS),a common oral mucosa disease,not only affects the patients’daily life,but also has a certain risk of cancerization.In traditional Chinese medicine,“phlegm”and“heat”can cause many various illnesses.Professor Bo Zhang holds the point that the pathogenesis of OLPS is related to phlegm-heat amassment.He treated the patient in the case report with traditional Chinese medicine which was based on the principle of clearing phlegm and heat,and got a good curative effect.He treats OLPS with his own unique experience,which is taking clearing phlegm-heat and coordinating spleen-stomach as the main method,taking strengthening vital Qi to eliminate pathogenic factor as the supplement,and applying Wendan Decoction flexiblly.In order to provide a reference and guidance for clinicians,we report the typical case of OLPS.
