Pathogenic bacterial infection is severely threatening public health globally.The multi-modal antibacterial nanoplatforms could significantly improve the antibacterial efficiency.Here,we report a metal(Ti)-organic fra...Pathogenic bacterial infection is severely threatening public health globally.The multi-modal antibacterial nanoplatforms could significantly improve the antibacterial efficiency.Here,we report a metal(Ti)-organic framework(MOF)derived nanocarbon(C-Ti-MOF)as a biosafety material for synergistic sterilization of pathogenic bacteria via efficient photodynamic catalysis and robust photothermal effects.The C-Ti-MOF consists of abundant TiO_(2) nanodots embedded in graphitic carbon frameworks.Under visible light irradiation,TiO_(2) nanodots can catalyze H_(2)O_(2) and O_(2) to produce superoxide anion(•O_(2)^(–))and singlet oxygen(1O2),respectively.Meanwhile,under near-infrared irradiation(NIR),C-Ti-MOF can generate massive heat to destroy bacterial membranes.Systematic antibacterial experiments reveal that the C-Ti-MOF nanoagents have a long-lasting and nearly 100%bactericidal ratio at an extremely low dose(0.16 mg/mL),which is much better than the state-of-the-art TiO_(2)(Commercial TiO_(2)(P25),0.64 mg/mL).Furthermore,the C-Ti-MOF can be electrospun into an antibacterial nanofiber membrane via mixing with polymeric matrix for treating bacteriacontaminated wastewater,and the membranes possess integrated antibacterial activity and excellent biocompatibility.Our study demonstrates a promising Ti-MOF-based biosafety material for efficient and long-life disinfection,which may stimulate new research in MOF-related biological applications in various disciplines ranging from water decontaminations to nanotherapeutics.展开更多
目的比较无针输液接头两种消毒方式的效果。方法选取2019年1—3月中南大学湘雅医学院附属海口医院的26例护士为研究对象,26例护士均参加对照组和观察组。对照组护士使用2%安尔碘棉签消毒无针输液接头150次,观察组护士使用独立包装4 cm&#...目的比较无针输液接头两种消毒方式的效果。方法选取2019年1—3月中南大学湘雅医学院附属海口医院的26例护士为研究对象,26例护士均参加对照组和观察组。对照组护士使用2%安尔碘棉签消毒无针输液接头150次,观察组护士使用独立包装4 cm×4 cm 75%酒精棉片消毒无针接头150次。比较两组的无针输液接头消毒操作时间及使用时间、耗材成本、消毒后再污染情况、临床护士的满意度及意愿度。结果对照组和观察组消毒后不被污染和消毒后再污染的占比分别为(88.0%、12.0%,94.0%、6.0%),观察组的消毒后不被污染比例高于对照组,差异有统计学意义(P<0.05)。对照组和观察组的耗材成本和消毒操作时间分别为(61.6±1.62)元、(36±3)s,(37.8±0.82)元、(16±1)s,观察组的耗材成本低于对照组,消毒操作时间短于对照组,差异均有统计学意义(P<0.05)。对照组和观察组的护士满意度和意愿度分别为(46.0%、46.0%,92.0%、92.0%),观察组护士满意度和意愿度高于对照组,差异有统计学意义(P<0.05)。结论使用独立包装4 cm×4 cm 75%酒精棉片,对无针输液接头进行维护,方便护士使用揉搓法消毒接头凹槽处,有效清除接头凹槽处残留微生物。缩短消毒操作时间,节约耗材成本,有效降低无针输液接头消毒后再污染,提高临床护士使用的满意度和意愿度,值得临床推广应用。展开更多
基金supported by the National Key R&D Program of China(2021YFE0205000)National Natural Science Foundation of China(Nos.52161145402,52173133,82102064,82102065,82001020,and 82001829)+6 种基金the Science and Technology Project of Sichuan Province(Nos.2021YFH0135,2021YFS0050,2021YJ0434,2021YFH0180,2021YFH0087,and 2021YFG0238)the 1·3·5 Project for Disciplines of Excellence,West China Hospital,Sichuan University(Grant No.ZYJC21047)the innovation project of Med-X Center for Materials,Sichuan University(Grant No.MCM202102)the China Postdoctoral Science Foundation(Grant Nos.2021 M702334,2021 M692291,2021 M692288,and 2021 M692303)the Post-Doctor Research Project,West China Hospital,Sichuan University(Grant Nos.2021SCU12034,2021SCU12013,and 2020HXBH071)Prof.Cheng acknowledges the financial support of the State Key Laboratory of Polymer Materials Engineering(Grant No.sklpme2021-4-02)Fundamental Research Funds for the Central Universities.
文摘Pathogenic bacterial infection is severely threatening public health globally.The multi-modal antibacterial nanoplatforms could significantly improve the antibacterial efficiency.Here,we report a metal(Ti)-organic framework(MOF)derived nanocarbon(C-Ti-MOF)as a biosafety material for synergistic sterilization of pathogenic bacteria via efficient photodynamic catalysis and robust photothermal effects.The C-Ti-MOF consists of abundant TiO_(2) nanodots embedded in graphitic carbon frameworks.Under visible light irradiation,TiO_(2) nanodots can catalyze H_(2)O_(2) and O_(2) to produce superoxide anion(•O_(2)^(–))and singlet oxygen(1O2),respectively.Meanwhile,under near-infrared irradiation(NIR),C-Ti-MOF can generate massive heat to destroy bacterial membranes.Systematic antibacterial experiments reveal that the C-Ti-MOF nanoagents have a long-lasting and nearly 100%bactericidal ratio at an extremely low dose(0.16 mg/mL),which is much better than the state-of-the-art TiO_(2)(Commercial TiO_(2)(P25),0.64 mg/mL).Furthermore,the C-Ti-MOF can be electrospun into an antibacterial nanofiber membrane via mixing with polymeric matrix for treating bacteriacontaminated wastewater,and the membranes possess integrated antibacterial activity and excellent biocompatibility.Our study demonstrates a promising Ti-MOF-based biosafety material for efficient and long-life disinfection,which may stimulate new research in MOF-related biological applications in various disciplines ranging from water decontaminations to nanotherapeutics.
文摘目的比较无针输液接头两种消毒方式的效果。方法选取2019年1—3月中南大学湘雅医学院附属海口医院的26例护士为研究对象,26例护士均参加对照组和观察组。对照组护士使用2%安尔碘棉签消毒无针输液接头150次,观察组护士使用独立包装4 cm×4 cm 75%酒精棉片消毒无针接头150次。比较两组的无针输液接头消毒操作时间及使用时间、耗材成本、消毒后再污染情况、临床护士的满意度及意愿度。结果对照组和观察组消毒后不被污染和消毒后再污染的占比分别为(88.0%、12.0%,94.0%、6.0%),观察组的消毒后不被污染比例高于对照组,差异有统计学意义(P<0.05)。对照组和观察组的耗材成本和消毒操作时间分别为(61.6±1.62)元、(36±3)s,(37.8±0.82)元、(16±1)s,观察组的耗材成本低于对照组,消毒操作时间短于对照组,差异均有统计学意义(P<0.05)。对照组和观察组的护士满意度和意愿度分别为(46.0%、46.0%,92.0%、92.0%),观察组护士满意度和意愿度高于对照组,差异有统计学意义(P<0.05)。结论使用独立包装4 cm×4 cm 75%酒精棉片,对无针输液接头进行维护,方便护士使用揉搓法消毒接头凹槽处,有效清除接头凹槽处残留微生物。缩短消毒操作时间,节约耗材成本,有效降低无针输液接头消毒后再污染,提高临床护士使用的满意度和意愿度,值得临床推广应用。
