In 1950, I graduated from Tsinghua University,majoring in machine building. Three years later, Ientered the Iron & Steel College in Moscow to start studying metallurgy as a postgraduate. After obtaining my associa...In 1950, I graduated from Tsinghua University,majoring in machine building. Three years later, Ientered the Iron & Steel College in Moscow to start studying metallurgy as a postgraduate. After obtaining my associate professorship, I came back home. I devoted the succeeding 40 years to the theory and technology of solidification, because I had realized the importance of the physical process of solidification in materials science and engineering technologies as a means of upgrading the properties of traditional materials and developing new materials. My contributions in this field might be listed as follows:展开更多
In this study, a point source mathematical model is proposed to describe the diffusion of adenosine di-phosphate (ADP) from either damaged red blood cell (RBC) or activated platelet. The convective diffusion equation ...In this study, a point source mathematical model is proposed to describe the diffusion of adenosine di-phosphate (ADP) from either damaged red blood cell (RBC) or activated platelet. The convective diffusion equation is reduced to describe the suggested problem. The final differential equation is solved using Laplace transforms and ADP concentration profiles around the source are obtained. Thrombi of 5 to 20 μm<sup>3</sup> containing platelets and a range of red blood cells (RBCs) (0%, 25%, 50%, 75%, 100%) concentrations are used to apply the model. Reported ADP concentrations in the literature are used and its dynamic release from the point source is calculated. Results suggest that RBC chemical contribution to platelet aggregation in the bulk is much less than that of platelet (almost) negligible. However, the physical effect of RBCs is dominant in the bulk through augmentation of released ADP and platelets diffusivities. Moreover, the chemical contribution reported in previous studies is suggested to be as a result of interaction of RBC with the surface under the influence of shear stresses in the boundary region.展开更多
文摘In 1950, I graduated from Tsinghua University,majoring in machine building. Three years later, Ientered the Iron & Steel College in Moscow to start studying metallurgy as a postgraduate. After obtaining my associate professorship, I came back home. I devoted the succeeding 40 years to the theory and technology of solidification, because I had realized the importance of the physical process of solidification in materials science and engineering technologies as a means of upgrading the properties of traditional materials and developing new materials. My contributions in this field might be listed as follows:
文摘In this study, a point source mathematical model is proposed to describe the diffusion of adenosine di-phosphate (ADP) from either damaged red blood cell (RBC) or activated platelet. The convective diffusion equation is reduced to describe the suggested problem. The final differential equation is solved using Laplace transforms and ADP concentration profiles around the source are obtained. Thrombi of 5 to 20 μm<sup>3</sup> containing platelets and a range of red blood cells (RBCs) (0%, 25%, 50%, 75%, 100%) concentrations are used to apply the model. Reported ADP concentrations in the literature are used and its dynamic release from the point source is calculated. Results suggest that RBC chemical contribution to platelet aggregation in the bulk is much less than that of platelet (almost) negligible. However, the physical effect of RBCs is dominant in the bulk through augmentation of released ADP and platelets diffusivities. Moreover, the chemical contribution reported in previous studies is suggested to be as a result of interaction of RBC with the surface under the influence of shear stresses in the boundary region.
