The"4+4"Medical Doctor(MD)Pilot Program at PUMC:Implementation,Performance,and Prospects

Peking Union Medical College(PUMC)launched the"4+4"Medical Doctor(MD)pilot program in 2018,admitting students with non-medical backgrounds from top universities,aligning with national medical talent training policies to foster diverse and eager learners in medicine.On the occasion of the graduation of the first class of the"4+4"MD pilot class at PUMC in 2023,we reviewed the teaching reform in the pilot program and carried out a systematic survey and interviews with students,faculties,and management staff of the pilot class.This article reports on the measures taken by the pilot class at PUMC in enrollment and curriculum setting,and demonstrates the achievements of the pilot class in terms of student academic background structure,knowledge acquisition and skill learning,scientific research ability,and course evaluation.The results indicated that the pilot class had met the national demand for the"Medicine+X"talent training model.More specifically,with a diverse academic backgrounds,the pilot class graduates had academic levels comparable to the eight-year medical education graduates,and their scientific research abilities were satisfactory.The pilot program at PUMC will optimize the curriculum setting,strengthen the construction of faculty,learning resources,and teaching facilities,and reform the academic evaluation methods,thus deepening the reform of medical education and improving the"4+4"MD program as a novel medical education model.

Exploration of Operation and Maintenance Management Mode and Innovation Mechanism of Pilot Base of Chemical Park

Based on the current situation of the operation and maintenance management of the pilot base in many chemical parks in China,this paper conducts an in-depth exploration of the operation and maintenance management and innovation mode of the pilot base from the aspects of the evaluation of the pilot project entering the park,safety and environmental protection supervision,pilot mode,and industrialization mode of the pilot test results,so as to provide solutions for accelerating the process and industrialization of the pilot project and realizing the innovation value of the pilot base.

Optimization of Enzymatic Extraction Process of Polysaccharides from Pseudostellaria heterophylla Fibrous Roots by Response Surface Methodology and Its Pilot Application

[Objectives]To study and optimize the process conditions of enzymatic hydrolysis technology for extracting polysaccharides from Pseudostellaria heterophylla fibrous roots and its application in workshop pilot tests.[Methods]P.heterophylla fibrous roots were taken as the matrix material,and Box Behnken design was used to analyze the extraction time,composite enzyme addition amount,and liquid-solid ratio for response surface optimization experiments,and then applied to the pilot extraction of P.heterophylla fibrous roots.[Results]Response surface analysis showed that all factors had a significant impact on the experimental indicators.The optimal extraction process conditions for polysaccharides from P.heterophylla fibrous roots were extraction time of 2.7 h,compound enzyme addition of 2.5%,and liquid-solid ratio of 32.The yield of polysaccharides from P.heterophylla fibrous roots was 4.83%.The water extraction process of P.heterophylla fibrous roots extraction pilot was used as the control group for response surface optimization of the pilot experiment.The optimization results showed that the extraction time was 3 h,the amount of composite enzyme added was 2.5%,and the liquid-solid ratio was 28.The polysaccharide yield was 4.75%,an increase of 4.63%compared to the control group.[Conclusions]This paper could provide feasibility for the innovation of enzy-matic hydrolysis technology for P.heterophylla fibrous roots and its workshop pilot practice application,as well as a reference for the industrial application of its medicinal resources.

Adverse Pregnancy Outcomes Following Cryotherapy, Thermal Ablation and Loop Electrosurgical Excision Procedure for Cervical Intraepithelial Neoplasia Treatment: A Pilot Study among Zambian Women

Background: Cervical Intraepithelial neoplasia treatments have become essential interventions to manage cervical lesions. Majority of the recipients of these treatments are women within the reproductive age group, who according to literature may be at risk of adverse pregnancy outcomes. This pilot study is part of a study investigating adverse pregnancy outcomes among women who received Cryotherapy, Thermal ablation and Loop Electrosurgical Excision Procedure compared to the untreated women in Zambia. Materials and Methods: This descriptive study analyzed records of 886 (n = 443 treated and n = 443 untreated) women aged 15 - 49 years. The women were either screened with Visual Inspection with Acetic Acid or treated for Cervical Intraepithelial neoplasia at the Adult Infectious Disease Centre between January 2010 and December 2020. Women meeting the criteria were identified using the Visual Inspection with Acetic Acid screening records and telephone interviews to obtain the adverse pregnancy outcome experienced. Data were analysed using STATA version 16 to determine the prevalence and obtain frequency distribution of outcomes of interest. Univariate and multivariable binary logistic regression estimated odds of adverse pregnancy outcomes across the three treatments. Results: The respondents were aged 15 to 49 years. Adverse pregnancy outcomes were observed to be more prevalent in the treatment group (18.5%) compared to the untreated group (5.4%). Normal pregnancy outcomes were lower in the treated (46.3%;n = 443) than the untreated (53.7%;n = 443). The treated group accounted for the majority of abortions (85.2%), prolonged labour (85.7%) and low birth weight (80%), whereas, the untreated accounted for the majority of still births (72.7%). Women treated with cryotherapy (aOR = 2.43, 95% CI = 1.32 - 4.49, p = 0.004), thermal ablation (aOR = 6.37, 95% CI = 0.99 - 41.2, p = 0.052) and Loop Electrosurgical Excision Procedure (aOR = 9.67, 95% CI = 2.17 - 43.1, p = 0.003) had two-, six- and ten-times higher odds of adverse pregnancy outcomes respectively, relative to women who required no treatment. Conclusion: Adverse pregnancy outcomes are prevalent among women who have received treatment in Zambia. The findings indicate that treating Cervical Intraepithelial Neoplasia has been linked to higher chances of experiencing abortion, delivering low birth weight babies and enduring prolonged labor that may result in a caesarean section delivery. Cervical neoplasia treatments, particularly Loop Electrosurgical Excision Procedure, are associated with significantly increased odds of adverse pregnancy outcomes. It is essential to include information about prior Cervical Intraepithelial neoplasia treatment outcomes in obstetric care.

The Tenth Anniversary of Free Trade Pilot Zones in China:Fundamental Experiences and Enhancement Strategies

Since the 18th National Congress of the Communist Party of China,the country has established 21 Free Trade Pilot Zones(FTZs),achieving significant pioneering results in reform and opening up and creating a strong demonstrative effect nationwide.The basic experience from a decade of FTZs includes:adhering to the centralized and unified leadership of the CPC Central Committee;combining top-level design with encouragement of grassroots innovation;leveraging the distinct characteristics and strengths of FTZs to form a differentiated development pattern;maintaining the integration of opening up with domestic reforms;using openness to drive reforms;and organically combining openness with national security assurance.Under the current and future new circumstances,China’s FTZs face new challenges and tasks.In accordance with the directives of the 20th National Congress of the Communist Party of China,an enhancement strategy for the FTZs needs to be implemented.This involves the following:First,accurately understanding and responding to the changing situation to create strategic opportunities.Second,shifting paradigms to implement innovation-driven strategies,using the new development pattern concept to guide the reform experiments and construction of the FTZs.Third,granting more autonomy to FTZs for reforms,pursuing progress while maintaining stability,and solidly advancing the reform experiments in the FTZs.Fourth,orderly expanding the opening up of the service sector and cautiously advancing the internationalization of the renminbi.Fifth,promoting innovative development in trade to build a strong trade nation.Sixth,establishing synergy with bilateral FTZs,Belt and Road cooperation,and national diplomatic strategies to enhance the linkage effect.

Hazardous Attitude Factors Influence Risk Perception in General Aviation Pilots

This manuscript presents a research proposal to investigate how hazardous attitudes among general aviation pilots influence pilot performance in aviation accidents. General aviation pilots train to maintain safe flying conditions, but accidents still occur, and human factors figure prominently among the causes of aviation accidents. The levels of hazardous attitudes among pilots may influence the likelihood of engaging in risky flight behaviors that can lead to accidents. This quantitative study aims to determine whether dangerous attitudes impact risk perception in general aviation pilots. The study will focus on two specific hazardous attitudes, “Anti-Authority” and Macho” behaviors. Among the hazardous attitudes identified by the Federal Aviation Administration (FAA), the two attitudes often stand out in accident investigations and pilot narratives. While all hazardous attitudes have inherent dangers, these two attitudes tend to be more frequently cited in accident reports and investigations. Despite rigorous training in safe flying conditions, general aviation accidents still transpire due to human factors. This research hypothesizes that the five attitudes from the hazardous attitude model, particularly Anti-Authority and Macho, significantly shape pilots’ risk perception. The insights from this study would benefit stakeholders, like the Aircraft Owners and Pilots Association (AOPA), Air Safety Institute, and aviation training programs, in creating training modules tailored to reduce such attitudes.

The Current Situation and Future Expectationsof China's Pilot Boatsl

Pilots need to board the ship for pilotage,but there are risks or potential dangers in the transfer of pilot.The author reviewed the history of the development of pilot boats,analyzed the potential risks or dangers of transferring pilot,proposed that pilot boat shall have the function of ensuring the safety of pilot when embarking or disembarking the ships,some suggestions on the future design and manufacture of Chinese pilot boats are also given according to the advantages and disadvantages of domestic and foreign pilot boats.

连续Pilot体制CDMA高速移动台自适应信道估计器

提出了连续Ｐｉｌｏｔ 信号体制ＣＤＭＡ系统中，高速移动台自适应信道估计的方法，它包括信道变化速率的检测和信道估计积分长度的自适应调整两个部分．仿真结果显示，该信道估计器有效拓展了移动台正常工作的运动速度范围，提高了ＲＡＫＥ接收机的适应性．

iPAS:A deep Monte Carlo Tree Search-based intelligent pilot-power allocation scheme for massive MIMO system

Massive Multiple-Input-Multiple-Output(MIMO)is a promising technology to meet the demand for the connection of massive devices and high data capacity for mobile networks in the next generation communication system.However,due to the massive connectivity of mobile devices,the pilot contamination problem will severely degrade the communication quality and spectrum efficiency of the massive MIMO system.We propose a deep Monte Carlo Tree Search(MCTS)-based intelligent Pilot-power Allocation Scheme(iPAS)to address this issue.The core of iPAS is a multi-task deep reinforcement learning algorithm that can automatically learn the radio environment and make decisions on the pilot sequence and power allocation to maximize the spectrum efficiency with self-play training.To accelerate the searching convergence,we introduce a Deep Neural Network(DNN)to predict the pilot sequence and power allocation actions.The DNN is trained in a self-supervised learning manner,where the training data is generated from the searching process of the MCTS algorithm.Numerical results show that our proposed iPAS achieves a better Cumulative Distribution Function(CDF)of the ergodic spectral efficiency compared with the previous suboptimal algorithms.

Hybrid orthogonal and non-orthogonal pilot distribution based channel estimation in massive MIMO system

How to obtain accurate channel state information(CSI)at the transmitter with less pilot overhead for frequency division duplexing(FDD) massive multiple-input multiple-output(MIMO)system is a challenging issue due to the large number of antennas. To reduce the overwhelming pilot overhead, a hybrid orthogonal and non-orthogonal pilot distribution at the base station(BS),which is a generalization of the existing pilot distribution scheme,is proposed by exploiting the common sparsity of channel due to the compact antenna arrangement. Then the block sparsity for antennas with hybrid pilot distribution is derived respectively and can be used to obtain channel impulse response. By employing the theoretical analysis of block sparse recovery, the total coherence criterion is proposed to optimize the sensing matrix composed by orthogonal pilots. Due to the huge complexity of optimal pilot acquisition, a genetic algorithm based pilot allocation(GAPA) algorithm is proposed to acquire optimal pilot distribution locations with fast convergence. Furthermore, the Cramer Rao lower bound is derived for non-orthogonal pilot-based channel estimation and can be asymptotically approached by the prior support set, especially when the optimized pilot is employed.

Conceptual Architecture for Remotely Piloted Operation Mode in Commercial Aircraft

With the increasing civil aviation passengers and the rapid development of aviation logistics,the study on remotely piloted operation(RPO)mode has received extensive attention.RPO mode constructs the piloting decisionmaking mode which involves the tripartite collaboration among airborne automatic/autonomous system,remote ground-based crews and air traffic control.In this paper,we describe the organizing architecture for commercial remotely piloted aircraft(CRPA)system and its components.Compared with the current operation mode,the new air-ground collaborative decision-making mode has been established with six different situations based on the type of the flight and the condition of the remote pilot.Taking airport surface operation as an experimental example,we model the airport surface operation process and compare the advantages and disadvantages between RPO mode and the current dual-pilot mode from the perspectives of time and operation coverage,and draw conclusions that RPO mode can basically cover the flight operations of the dual-pilot,improve the accuracy of pilot operations and greatly reduce response time by 48%in pre-flight inspection.The above research would be the foundation for the RPO development of commercial aircraft in China.

运用ProtectionPilot保护医院局域网

文章详细介绍了针对当前医院使用的由为数众多的计算机构成的各种网络,以及运用ProtectionPilot来统一部署杀毒软件McAfee VirusScan Enterprise 8.5i,进而充分发挥McAfee系列产品的强大安全防护功能,保护整个医院局域网系统的安全。

A Pilot Contamination Avoidance Based on Pilot Pattern Design for Ultra-Dense Network

With the ever-growing number of base stations(BSs)and user equipments(UEs)in ultra-dense networks(UDN),reusing the same pilot sequences among the cells is inevitable.With pilot reuse scheme,the channel estimation obtained at a BS contains not only the desired channel-state information(CSI)but also interference from neighboring cells,which can severely degrade CSI estimation performance and adversely affect communication performance.In this paper we consider a pilot contamination avoidance based on pilot pattern design for UDN where the pilot reuse employed and the interfering users from neighboring cells may be not at lower power levels at the BS compared to the in-cell users.We present a novel statistical interference model of sub-carriers to describe the non-deterministic interference from neighboring cells.Then,we provide a pilot pattern design model with non-uniform pilot distribution.Based on this,a pilot contamination avoidance based on pilot pattern design is proposed where pilot reuse scheme and the non-deterministic interference from neighboring cells are taken into consideration.Unlike existing interference mitigation approaches,the proposed method eliminates interference through the method of interference avoidance and can be applied to different kinds of channel estimation algorithms.Simulation results showed that the proposed approach can effectively avoid the interference and ensure the accuracy of channel estimation.

采用color—pilot颜色校正软件校正比色片数码照片并分析其在CIEL＊a＊b＊色度空间中的位置变化

目的:采用color-pilot颜色校正软件校正比色片数码照片并分析其在色度空间中的位置变化。方法:采用Vita 3D Master比色板作为试件,在诊室内拍摄比色片数码照片,并运用color-pilot颜色校正软件进行校正,最后与暗箱内拍摄的相应比色片数码照片进行对比。结果:比较诊室内与暗箱内拍摄的比色片数码照片,发现两组照片L*值之间、a*值之间差异明显(P<0.05),b*值之间则无明显差异(P>0.05);运用color-pilot颜色校正软件校正诊室内拍摄的数码照片后,发现两组照片L*值之间的差异仍然存在(P<0.05),但差异缩小(较诊室内拍摄的数码照片,校正后的数码照片L*值更接近于暗箱内拍摄的数码照片L*值),而a*值之间无明显差异(P>0.05),b*值之间依然无明显差异(P>0.05)。二者在色度空间中的位置也较校正前更为靠近。计算暗箱内、诊室内、校正后3组照片的ΔE值发现,校正后与暗箱内数码照片此值最小。结论:color-pilot颜色校正软件校正比色片数码照片后,可以在一定程度上减小数码照片的色彩偏差。

联合循环前缀和Pilot的OFDM系统定时同步方法

提出了一种联合循环前缀和Pilot的定时同步方法,并将其用于高速传输的无线移动正交频分复用(OFDM)系统.算法首先利用循环前缀定时函数得到时偏的估计范围,然后在估计范围内利用导频定时函数得到时偏的精确估计.由于不需要加入训练序列,提出的定时同步方法最大限度地节省了系统开销,提高了系统的频带利用率,而且利用导频序列进行定时同步可以有效地克服符号间干扰的影响.仿真结果表明,该算法能够改进时频估计在多径信道下的精度,提高系统在多径衰落信道下的性能.

Nitrogen and phosphorus removal in pilot-scale anaerobic-anoxic oxidation ditch system

To achieve high efficiency of nitrogen and phosphorus removal and to investigate the rule of simultaneous nitrification and denitrification phosphorus removal （SNDPR）, a whole course of SNDPR damage and recovery was studied in a pilot-scale, anaerobicanoxic oxidation ditch （OD）, where the volumes of anaerobic zone, anoxic zone, and ditches zone of the OD system were 7, 21, and 280 L, respectively. The reactor was fed with municipal wastewater with a flow rate of 336 L/d. The concept of simultaneous nitrification and denitrification （SND） rate （rSND） was put forward to quantify SND. The results indicate that： （1） high nitrogen and phosphorus removal efficiencies were achieved during the stable SND phase, total nitrogen （TN） and total phosphate （TP） removal rates were 80% and 85%, respectively; （2） when the system was aerated excessively, the stability of SND was damaged, and rSND dropped from 80% to 20% or less; （3） the natural logarithm of the ratio of NOx to NH4^＋ in the effluent had a linear correlation to oxidation-reduction potential （ORP）; （4） when NO3^- was less than 6 mg/L, high phosphorus removal efficiency could be achieved; （5） denitrifying phosphorus removal （DNPR） could take place in the anaerobic-anoxic OD system. The major innovation was that the SND rate was devised and quantified.

A New Kind of Pilot Controlled Proportional Direction Valve with Internal Flow Feedback

Proportional direction valve is one of the most fundamental elements in electronic-hydraulic control technique. Its function is to control the operating speed, direction, position, and strength of output force of the hydraulic actuator continuously. Considering the different application and the cost, the existing technique mainly includes the internal feedback valve used in open loop system, and the electronic closed loop controlled valve used in closed loop system. Because of their different mechanical structure and the gre at different in performance, it brings inconvenience for customer to select, also inconvenience for enterprise to produce. Aiming at this problem, the idea of combining the above two kinds of valves into one body is proposed first, and then the new valve＇s structure to realize this target is designed. The idea intends to apply the displacement pilot flow feedback control principle in present 2-position 2-way valve system to the proportional direction valve of 3-position 4-way system. Newly designed feed forward controller can decouple the interference between the internal feedback and the electronic closed loop. Redundant conversion is designed to electronic switch mode. Experiment on dynamic and static characteristic of new proportional direction valve in internal feedback control mode and electronic closed loop control mode is discussed to prove the new theory is correct. Although the new valve is of excellent dynamic response characteristic, its steady control characteristic in open loop control mode needs to be improved further. The research results prepare one new fundamental element for electronic-hydraulic control technology.

Acceptability of an acupuncture intervention for geriatric chronic pain: an open pilot study

OBJECTIVE： This study investigated the acceptability and effectiveness of acupuncture for persistent musculoskeletat pain in the elderly and assessed the conditions for a future controlled trial. METHODS： A total of 60 patients, hospitalized in a geriatric hospital were enrolled. The intervention consisted of eight acupuncture sessions. The main outcome was the patient＇s participation rate. Regarding pain, the evaluation was based on pre- and post-treatment variations. As a high proportion of the patients had cognitive impairment, the behavioral pain scale DOLOPLUS-2 was chosen although self evaluation was used wherever possible. RESULTS： The mean age of the patients was 83 years. The acceptance rate was very high （89.6%） and 90% of the patients completed the entire course of treatment. After five weeks, the mean DOLOPLUS score had decreased significantly （P〈0.01）. The patients reported improved sleep quality and a reduction in their anxiety symptoms. Furthermore, caregivers noticed a decrease in patient aggressiveness making care easier. CONCLUSION： Our results suggest that acupuncture is highly acceptable and could be very useful in the management of chronic pain when performed in very old frail people with chronic physical and mental disability. TRIAL REGISTRATION IDENTIFIER： NCT01043692 ClinicalTrials.gov.

A comparison of Kneipp hydrotherapy with conventional physiotherapy in the treatment of osteoarthritis: a pilot trial

BACKGROUND： An increasingly aging population implies an increasing prevalence of osteoarthritis （OA） of hip or knee. It has been ascertained that unspecific hydrotherapy of OA according to Sebastian Kneipp not only improves the range of mobility but also reduces pain significantly and increases the quality of life of the patients affected. OBJECTIVE： The main aim of this pilot study was to determine the effects of hydrotherapy in comparison to conventional physiotherapy, and to analyze the feasibility of the study design under clinical circumstances. DESIGN, SETTING, PARTICIPANTS AND INTERVENTIONS： The study design is a prospective randomized controlled three-arm clinical pilot trial, carried out at a specialist clinic for integrative medicine. Thirty patients diagnosed with symptomatic OA of hip or knee and radiologic findings were randomly assigned to one of two intervention groups and a control group： hydrotherapy （group 1）, physiotherapy （group 2）, and both physiotherapy and hydrotherapy （group 3, control group） of the affected joint. MAIN OUTCOME MEASURES： Primary outcome： pain intensity of the affected joint in the course of inpatient treatment; secondary outcome： health-related quality of life, joint-specific pain and mobility in the course of the study. RESULTS： Concerning the main outcome, intervention group 1 showed most beneficial effects in the course of inpatient treatment, followed by groups 3 and 2, and also the indirect flexion ability of hip or knee together with the general patient mobility through the ＂timed up and go＂ test were mainly improved within group 1 followed by groups 3 and 2. CONCLUSION： The results of this pilot study demonstrate beneficial effects of hydrotherapy. The study design is feasible. For statistically significant evidence and a robust conclusion of efficacy of Kneipp＇s hydrotherapy, a larger sample size is necessary. TRIAL REGISTRATION NUMBER： NCT 00950326.

Dynamic Analysis of the Seafloor Pilot Miner Based on Single-Body Vehicle Model and Discretized Track-Terrain Interaction Model

In order to achieve the complex dynamic analysis of the self-propelled seafloor pilot miner moving on the seafloor of extremely cohesive soft soil and further to make it possible to integrate the miner system with some subsystems to form the complete integrated deep ocean mining pilot system and perform dynamic analysis, a new method for the dynamic modeling and analysis of the miner is proposed and developed in this paper, resulting in a simplified 3D single-body vehicle model with three translational and three rotational degrees of freedom, while the track-terrain interaction model is built by partitioning the track-terrain interface into discrete elements with parameterized force dements built on the theory of terramechanics acting on each discrete dement. To evaluate and verify the correctness and effectiveness of this new modeling and analysis method, typical comparative studies with regard to computational efficiency and solution accuracy are carried out between the traditional modeling method of building the tracked vehicle as a multi-body model and the new modeling method. In full consideration of the particMar structure design of the pilot miner, the special characteristics of the seafioor soil and the hydrodynamic force of near-seafloor currnt, the dynamic simulation analysis of the miner is performed and discussed, which can provide useful guidance and reference for the practical miner system in design and operation. This new method can not only realize the rapid dynamic simulation analysis of the miner but also make possible the integration and rapid dynamic analysis of the complete integrated deep ocean mining pilot system in further researches.