Background: Coronavirus disease (Covid-19) becomes a pandemic worldwide in 2020. Different dermatological manifestations associated with Covid-19 infection like maculopapular, morbilliform, urticarial, vesicular, chil...Background: Coronavirus disease (Covid-19) becomes a pandemic worldwide in 2020. Different dermatological manifestations associated with Covid-19 infection like maculopapular, morbilliform, urticarial, vesicular, chilblain-like, petechiae, purpura, and livedoid rashes. Pityriasis rosea (PR) and PR-like eruptions were recently reported to increase in coronavirus cases. Aim: To evaluate and review the literature on PR and PR-like eruption associated with Covid-19 disease. Case Report: A 24-year-old female patient presented with a history of asymptomatic PR-like eruption that started during infection with the Covid-19 virus and resolved spontaneously over 14 weeks without therapy. Conclusion: PR and PR-like eruptions are not uncommon with Covid-19 disease and could be the early manifestation of SARS-CoV-2 virus infection.展开更多
Pityriasis rosea(PR) is a common erythemato-squamous dermatosis which almost always, is easily diagnosed. Mostly the disease presents in its classical form. However, clinical dermatology is all about variations and PR...Pityriasis rosea(PR) is a common erythemato-squamous dermatosis which almost always, is easily diagnosed. Mostly the disease presents in its classical form. However, clinical dermatology is all about variations and PR is not an exception. Variants of the disease in some cases may be troublesome to diagnose and confuse clinicians. Prompt diagnosis and treatment of the condition becomes necessary to avoid unnecessary investigations. We hereby review and illustrate atypical presentations of the disease, including diverse forms of location and morphology of the lesions, the course of the eruption, and its differential diagnoses.展开更多
Background: Most recently there was a well established study showed that pityriasis alba of ten progresses into vitiligo (Sharquie et al.). These findings were considered a new thought that might support a new hypothe...Background: Most recently there was a well established study showed that pityriasis alba of ten progresses into vitiligo (Sharquie et al.). These findings were considered a new thought that might support a new hypothesis regarding the pathogenesis of vitiligo. Objective: In order to do further work on hypothesis which is in favor that pityriasis alba might progress into vitiligo, so the present research including clinical and histopathological study to confirm that pityriasis alba might progress to vitiligo. Patients and method: This is a descriptive clinical and histopathological comparative study carried out in Department of Dermatology, Baghdad Teaching Hospital during the period from January 2015 to August 2016. Thirty eight patients with pityriasis alba (group A) and twenty eight patients with vitiligo stage I (group B) and twelve patients with both pityriasis alba and vitiligo (group C) were included in this study. All patients were fully interviewed and full history was taken from all the patients. Also careful asking about personal and family history of vitiligo was taken. Blunt trauma was done to induce Koebner’s phenomenon. Punch biopsies were taken from skin lesion of all patients and ten biopsies from 10 persons were taken from normal skin. Each biopsy specimen was processed and stained with Hematoxylin-eosin (H & E) and Fontana-Masson (FM) for histological evaluations. Results: Clinical study-Group A: Pityriasis alba patients: The mean of age of patients in pityriasis alba ± SD was 8.68 ± 5.94 years including 33 (86.84%) males and 5 (13.16%) females. Koebner’s phenomenon was positive in 2 (5.26%) patients and family history of vitiligo was positive in 17 (44.74%) patients. Group B: stage I vitiligo patients: The mean of age ± SD was 15.46 ± 12.50 years with 15 (57.14%) male patients and 12 (42.86%) female patients. A Koebner’s phenomenon was positive in 11 (39.28%) patients and family history of vitiligo was found in 11 (39.29%) patients. Group C: pityriasis alba and vitiligo patients: The mean of age ± SD was 8.33 ± 2.78 years including 9 (75%) male patients and 3 (25%) female patients. Koebner’s phenomenon was positive in 6 (50%) patients and family history of vitiligo was positive in 7 (58.33%) patients. Histopathological study: Group A: pityriasisalba: </展开更多
Objective:Pityriasis versicolor(PV)is usually a clinical diagnosis.In uncertain cases,PV is confirmed by microscopic examination with 10%potassium hydroxide(KOH).However,the KOH test is not 100%sensitive in diagnosing...Objective:Pityriasis versicolor(PV)is usually a clinical diagnosis.In uncertain cases,PV is confirmed by microscopic examination with 10%potassium hydroxide(KOH).However,the KOH test is not 100%sensitive in diagnosing PV.Dermoscopy of PV is still an unexplored area with very little data reported.This study was planned to study the various dermoscopic features and their utility in the diagnosis of PV.Methods:This cross-sectional observational study was carried out over a 1-year period(September 2020-September 2021)among 57 patients with KOH-confirmed PV.All patients underwent dermoscopy using a handheld dermoscope(DermLite DL4;DermLite LLC).The chi-square test or Fisher’s exact test was used to analyze the data.Results:Of the 57 patients,43(75.44%)had the hypopigmented type,followed by the hyperpigmented type(n=12,21.05%)and the perifollicular type(n=2,3.51%).Nonuniform pigmentation was the most common dermoscopic finding observed in both patients with hypopigmented PV(n=42,97.67%)and hyperpigmented PV(n=12,100%)(P=0.001).Scaling was the second most commonly observed finding;patchy scaling(n=25,58.13%)and perifollicular scaling(n=13,30.23%)were commonly seen in hypopigmented PV,while hyperpigmented PV showed more diffuse scaling(n=6,50.00%)(P=0.04)followed by patchy scaling(n=5,41.66%).Dermoscopy showed unique“double-edged scales”in all lesions with furrow scaling(n=11,19.30%)after eliciting a positive evoked scale sign.Other interesting features seen in hypopigmented PV were hypopigmentation around the hair follicle(n=24,55.48%)(P=0.001)and perilesional hyperpigmentation(the halo sign)(n=15,34.88%)(P=0.04).Conclusion:We observed several dermoscopic findings in PV that can serve as useful clues for differentiating PV from other similar disorders.展开更多
Objective:This study was performed to analyze the correlation between pityriasis alba(PA)and the serum 25-hydroxyvitamin D status in children.Methods:The study population comprised 460 patients with PA and 254 age-and...Objective:This study was performed to analyze the correlation between pityriasis alba(PA)and the serum 25-hydroxyvitamin D status in children.Methods:The study population comprised 460 patients with PA and 254 age-and sex-matched healthy controls.The serum level of 25-hydroxyvitamin D was compared between the two groups by studentt test.Results:The serum level of 25-hydroxyvitamin D was significantly lower in patients with PA than in healthy controls(P<0.001).There were statistically significant differences in the serum vitamin D status between the PA group and control group(P<0.001);specifically,patients with PA had a significantly higher frequency of vitamin D deficiency(52.83%vs.24.35%,P=0.001)and lower frequency of vitamin D sufficiency(22.83%vs.37.01%,P<0.001)than controls.PA patients showed significantly lower serum level of vitamin D than controls in deficient and sufficient groups(P=0.005 and 0.027,respectively),and in insufficient group,serum vitamin D level was lower in PA patients than in controls,but it showed no statistical difference(P=0.061).Conclusion:Vitamin D may play a role in the pathogenesis of PA.Further investigations are required to establish the relationship between the severity of PA and the vitamin D status and to evaluate the potential for use of vitamin D in the treatment of PA.展开更多
Introduction:Pityriasis rubra pilaris(PRP)is a rare chronic papulosquamous disease and is often difficult to treat,especially in children.Here we reported a PRP infant successfully treated by cyclosporine A.Case prese...Introduction:Pityriasis rubra pilaris(PRP)is a rare chronic papulosquamous disease and is often difficult to treat,especially in children.Here we reported a PRP infant successfully treated by cyclosporine A.Case presentation:An 18-month-old infant with severe PRP presented with reddish follicular papules and inflammatory,infiltrated erythema over the whole body.The condition rapidly and completely responded to oral cyclosporine A.Complete clearance of the lesions was achieved within 16 weeks,and no recurrence developed during 6 months of follow-up.During both treatment and follow-up,routine blood parameters,serum creatinine,serum urea nitrogen,liver function,and blood pressure were regularly monitored once a month and remained within the reference ranges.Moreover,the child grew and developed normally and the body weight increased by 3 kg.Discussion:To date,there are not well established protocols for treatment of PRP in children.Cyclosporine A has been demonstrated to be effective treatment in psoriasis in adults and children which do not respond to some other treatments.The rapid onset of action and good efficacy of cyclosporine A were observed in our case,who achieved complete response after 16 weeks of treatment without any side effects.Conclusion:Cyclosporine A might be a safe and effective option for treating severe PRP in children.展开更多
文摘Background: Coronavirus disease (Covid-19) becomes a pandemic worldwide in 2020. Different dermatological manifestations associated with Covid-19 infection like maculopapular, morbilliform, urticarial, vesicular, chilblain-like, petechiae, purpura, and livedoid rashes. Pityriasis rosea (PR) and PR-like eruptions were recently reported to increase in coronavirus cases. Aim: To evaluate and review the literature on PR and PR-like eruption associated with Covid-19 disease. Case Report: A 24-year-old female patient presented with a history of asymptomatic PR-like eruption that started during infection with the Covid-19 virus and resolved spontaneously over 14 weeks without therapy. Conclusion: PR and PR-like eruptions are not uncommon with Covid-19 disease and could be the early manifestation of SARS-CoV-2 virus infection.
文摘Pityriasis rosea(PR) is a common erythemato-squamous dermatosis which almost always, is easily diagnosed. Mostly the disease presents in its classical form. However, clinical dermatology is all about variations and PR is not an exception. Variants of the disease in some cases may be troublesome to diagnose and confuse clinicians. Prompt diagnosis and treatment of the condition becomes necessary to avoid unnecessary investigations. We hereby review and illustrate atypical presentations of the disease, including diverse forms of location and morphology of the lesions, the course of the eruption, and its differential diagnoses.
文摘Background: Most recently there was a well established study showed that pityriasis alba of ten progresses into vitiligo (Sharquie et al.). These findings were considered a new thought that might support a new hypothesis regarding the pathogenesis of vitiligo. Objective: In order to do further work on hypothesis which is in favor that pityriasis alba might progress into vitiligo, so the present research including clinical and histopathological study to confirm that pityriasis alba might progress to vitiligo. Patients and method: This is a descriptive clinical and histopathological comparative study carried out in Department of Dermatology, Baghdad Teaching Hospital during the period from January 2015 to August 2016. Thirty eight patients with pityriasis alba (group A) and twenty eight patients with vitiligo stage I (group B) and twelve patients with both pityriasis alba and vitiligo (group C) were included in this study. All patients were fully interviewed and full history was taken from all the patients. Also careful asking about personal and family history of vitiligo was taken. Blunt trauma was done to induce Koebner’s phenomenon. Punch biopsies were taken from skin lesion of all patients and ten biopsies from 10 persons were taken from normal skin. Each biopsy specimen was processed and stained with Hematoxylin-eosin (H & E) and Fontana-Masson (FM) for histological evaluations. Results: Clinical study-Group A: Pityriasis alba patients: The mean of age of patients in pityriasis alba ± SD was 8.68 ± 5.94 years including 33 (86.84%) males and 5 (13.16%) females. Koebner’s phenomenon was positive in 2 (5.26%) patients and family history of vitiligo was positive in 17 (44.74%) patients. Group B: stage I vitiligo patients: The mean of age ± SD was 15.46 ± 12.50 years with 15 (57.14%) male patients and 12 (42.86%) female patients. A Koebner’s phenomenon was positive in 11 (39.28%) patients and family history of vitiligo was found in 11 (39.29%) patients. Group C: pityriasis alba and vitiligo patients: The mean of age ± SD was 8.33 ± 2.78 years including 9 (75%) male patients and 3 (25%) female patients. Koebner’s phenomenon was positive in 6 (50%) patients and family history of vitiligo was positive in 7 (58.33%) patients. Histopathological study: Group A: pityriasisalba: </
文摘Objective:Pityriasis versicolor(PV)is usually a clinical diagnosis.In uncertain cases,PV is confirmed by microscopic examination with 10%potassium hydroxide(KOH).However,the KOH test is not 100%sensitive in diagnosing PV.Dermoscopy of PV is still an unexplored area with very little data reported.This study was planned to study the various dermoscopic features and their utility in the diagnosis of PV.Methods:This cross-sectional observational study was carried out over a 1-year period(September 2020-September 2021)among 57 patients with KOH-confirmed PV.All patients underwent dermoscopy using a handheld dermoscope(DermLite DL4;DermLite LLC).The chi-square test or Fisher’s exact test was used to analyze the data.Results:Of the 57 patients,43(75.44%)had the hypopigmented type,followed by the hyperpigmented type(n=12,21.05%)and the perifollicular type(n=2,3.51%).Nonuniform pigmentation was the most common dermoscopic finding observed in both patients with hypopigmented PV(n=42,97.67%)and hyperpigmented PV(n=12,100%)(P=0.001).Scaling was the second most commonly observed finding;patchy scaling(n=25,58.13%)and perifollicular scaling(n=13,30.23%)were commonly seen in hypopigmented PV,while hyperpigmented PV showed more diffuse scaling(n=6,50.00%)(P=0.04)followed by patchy scaling(n=5,41.66%).Dermoscopy showed unique“double-edged scales”in all lesions with furrow scaling(n=11,19.30%)after eliciting a positive evoked scale sign.Other interesting features seen in hypopigmented PV were hypopigmentation around the hair follicle(n=24,55.48%)(P=0.001)and perilesional hyperpigmentation(the halo sign)(n=15,34.88%)(P=0.04).Conclusion:We observed several dermoscopic findings in PV that can serve as useful clues for differentiating PV from other similar disorders.
文摘Objective:This study was performed to analyze the correlation between pityriasis alba(PA)and the serum 25-hydroxyvitamin D status in children.Methods:The study population comprised 460 patients with PA and 254 age-and sex-matched healthy controls.The serum level of 25-hydroxyvitamin D was compared between the two groups by studentt test.Results:The serum level of 25-hydroxyvitamin D was significantly lower in patients with PA than in healthy controls(P<0.001).There were statistically significant differences in the serum vitamin D status between the PA group and control group(P<0.001);specifically,patients with PA had a significantly higher frequency of vitamin D deficiency(52.83%vs.24.35%,P=0.001)and lower frequency of vitamin D sufficiency(22.83%vs.37.01%,P<0.001)than controls.PA patients showed significantly lower serum level of vitamin D than controls in deficient and sufficient groups(P=0.005 and 0.027,respectively),and in insufficient group,serum vitamin D level was lower in PA patients than in controls,but it showed no statistical difference(P=0.061).Conclusion:Vitamin D may play a role in the pathogenesis of PA.Further investigations are required to establish the relationship between the severity of PA and the vitamin D status and to evaluate the potential for use of vitamin D in the treatment of PA.
文摘Introduction:Pityriasis rubra pilaris(PRP)is a rare chronic papulosquamous disease and is often difficult to treat,especially in children.Here we reported a PRP infant successfully treated by cyclosporine A.Case presentation:An 18-month-old infant with severe PRP presented with reddish follicular papules and inflammatory,infiltrated erythema over the whole body.The condition rapidly and completely responded to oral cyclosporine A.Complete clearance of the lesions was achieved within 16 weeks,and no recurrence developed during 6 months of follow-up.During both treatment and follow-up,routine blood parameters,serum creatinine,serum urea nitrogen,liver function,and blood pressure were regularly monitored once a month and remained within the reference ranges.Moreover,the child grew and developed normally and the body weight increased by 3 kg.Discussion:To date,there are not well established protocols for treatment of PRP in children.Cyclosporine A has been demonstrated to be effective treatment in psoriasis in adults and children which do not respond to some other treatments.The rapid onset of action and good efficacy of cyclosporine A were observed in our case,who achieved complete response after 16 weeks of treatment without any side effects.Conclusion:Cyclosporine A might be a safe and effective option for treating severe PRP in children.
