Objective China began providing antiretroviral therapy to people living with HIV/AIDS （PLWHA） in 2003. This study was to investigate the living conditions, including quality of life and happiness, and need for palli...Objective China began providing antiretroviral therapy to people living with HIV/AIDS （PLWHA） in 2003. This study was to investigate the living conditions, including quality of life and happiness, and need for palliative care of end-of-life PLWHA in rural Henan. Methods One hundred end-of-life AIDS patients were selected from Weishi, Zhenping and Tanghe counties in Henan, using convenience sampling. The World Health Organization Quality of Life for HIV （WHOQOL-HIV） BREF Chinese Version was used to measure the quality of life and the Memorial University of Newfoundland Scale of Happiness （MUNSH） was employed to measure subjective welfare. Qualitative interviews and focus group discussions were undertaken to learn about the palliative care provided and the specific needs of the end-of-life patients. Results Patients’ overall quality of life was moderate （12.62±1.97）. Highest scores were in the spirituality/religion/personal beliefs, higher than the average scores in the Chinese population （P0.01）, while psychological （13.58±2.06） and environment （12.50±3.28） domain scores were similar to the latter （P0.05）. Both independence （12.15±2.15） and physiological （14.04±3.16） domain scores were lower than the average of the people living with HIV/AIDS in other studies （P0.01）; however, all were in the moderate range. The average MUNSH score was 21.00±6.20, which was also moderate. The in-depth interviews indicated that the Henan Provincial Government’s policy of treatment and care had a beneficial impact on end-of-life AIDS patients, although the care components could be improved. Conclusions Living conditions of the end-of-life AIDS patients were moderate, and the HIV/AIDS palliative care model used was beneficial to them. Care could be improved by assisting the family unit as a whole.展开更多
Patients infected through commercial bloodselling practices(former plasma donors,FPDs)in China represent a unique patient population compared to individuals infected through sexual contact or intravenous drug use.FPDs...Patients infected through commercial bloodselling practices(former plasma donors,FPDs)in China represent a unique patient population compared to individuals infected through sexual contact or intravenous drug use.FPDs all have an approximate time of human immunodeficiency virus(HIV)infection during the mid-1990s.Few studies about the natural history of HIV infection in these patients were performed.The current study focuses on characterizing the duration of asymptomatic infection as well as the time to disease and mortality of infected FPDs in China.A retrospective cohort study was conducted based on data collected from 5484 HIV-1 infected FPDs in Shangcai county,Henan province.Kaplan-Meier analysis was applied to estimate the asymptomatic duration from the time of infection to the onset of AIDS as well as the survival period from the onset of AIDS to the time of death.The estimated median asymptomatic phase was about 9.21 years,which is similar to that reported in other developing countries in Africa.The estimated median life span after the onset of symptoms was about 9.91 months,which is notably shorter than life spans reported elsewhere.This is the first large-scale retrospective study on the natural history of HIV infection in FPDs in rural China.The findings not only provide valuable insight into an understudied population,but should also serve as an important reference for patient management and care.展开更多
基金supported by the China Global Fund Round 3 and the China Multidisciplinary AIDS Prevention Training Program with NIH Research Grant #U2R TW06918-01funded by the Fogarty International Centre,the National Institute on Drug Abuse and the National Institute of Mental Health (China ICOHRTA, with Principal Investigator being Zun-You WU)
文摘Objective China began providing antiretroviral therapy to people living with HIV/AIDS （PLWHA） in 2003. This study was to investigate the living conditions, including quality of life and happiness, and need for palliative care of end-of-life PLWHA in rural Henan. Methods One hundred end-of-life AIDS patients were selected from Weishi, Zhenping and Tanghe counties in Henan, using convenience sampling. The World Health Organization Quality of Life for HIV （WHOQOL-HIV） BREF Chinese Version was used to measure the quality of life and the Memorial University of Newfoundland Scale of Happiness （MUNSH） was employed to measure subjective welfare. Qualitative interviews and focus group discussions were undertaken to learn about the palliative care provided and the specific needs of the end-of-life patients. Results Patients’ overall quality of life was moderate （12.62±1.97）. Highest scores were in the spirituality/religion/personal beliefs, higher than the average scores in the Chinese population （P0.01）, while psychological （13.58±2.06） and environment （12.50±3.28） domain scores were similar to the latter （P0.05）. Both independence （12.15±2.15） and physiological （14.04±3.16） domain scores were lower than the average of the people living with HIV/AIDS in other studies （P0.01）; however, all were in the moderate range. The average MUNSH score was 21.00±6.20, which was also moderate. The in-depth interviews indicated that the Henan Provincial Government’s policy of treatment and care had a beneficial impact on end-of-life AIDS patients, although the care components could be improved. Conclusions Living conditions of the end-of-life AIDS patients were moderate, and the HIV/AIDS palliative care model used was beneficial to them. Care could be improved by assisting the family unit as a whole.
基金supported by the eleventh Five-Year Project on Tackling Key Problems of National Science and Technology(No.2008ZX10001-001 and 2008ZX10001-004)the Special Funds for State Key Development Program for Basic Research of China(973 Program)(No.2006CB504200).
文摘Patients infected through commercial bloodselling practices(former plasma donors,FPDs)in China represent a unique patient population compared to individuals infected through sexual contact or intravenous drug use.FPDs all have an approximate time of human immunodeficiency virus(HIV)infection during the mid-1990s.Few studies about the natural history of HIV infection in these patients were performed.The current study focuses on characterizing the duration of asymptomatic infection as well as the time to disease and mortality of infected FPDs in China.A retrospective cohort study was conducted based on data collected from 5484 HIV-1 infected FPDs in Shangcai county,Henan province.Kaplan-Meier analysis was applied to estimate the asymptomatic duration from the time of infection to the onset of AIDS as well as the survival period from the onset of AIDS to the time of death.The estimated median asymptomatic phase was about 9.21 years,which is similar to that reported in other developing countries in Africa.The estimated median life span after the onset of symptoms was about 9.91 months,which is notably shorter than life spans reported elsewhere.This is the first large-scale retrospective study on the natural history of HIV infection in FPDs in rural China.The findings not only provide valuable insight into an understudied population,but should also serve as an important reference for patient management and care.
文摘目的评价献血者HBsAg阳性血液标本在-20°C冻存8年后ELISA法HBsAg检测的结果,评估血站目前留样保存方式的有效性。方法收集本站2014年5月—2015年3月100份经HBsAg ELISA检测阳性的献血者血浆标本,冻存在-20°C冰箱,于2023年解冻标本并通过同种方法再次检测。结果100份血浆标本的HBsAg再检定性结果均为阳性,再检符合率100%,冻存后S/CO值降低明显(27.52 vs 19.03,P<0.05)。结论长期冻存会使HBsAg ELISA检测S/CO值下降,但不影响阳性定性结果。
