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Lim kinase,a bi-functional effector in injury-induced structural plasticity of synapses 被引量:4
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作者 Weiwei Wang Ellen Townes-Anderson 《Neural Regeneration Research》 SCIE CAS CSCD 2016年第7期1029-1032,共4页
The structural plasticity of synaptic terminals contributes to normal nervous system function but also to neural degeneration, in the form of terminal retraction, and regeneration, due to process growth. Synaptic morp... The structural plasticity of synaptic terminals contributes to normal nervous system function but also to neural degeneration, in the form of terminal retraction, and regeneration, due to process growth. Synaptic morphological change is mediated through the actin cytoskeleton, which is enriched in axonal and dendritic terminals. Whereas the three RhoGTPases, RhoA, Cdc42 and Rac, function as upstream signaling nodes sensitive to extracellular stimuli, LIMK-cofilin activity serves as a common downstream effector to up-regulate actin turnover, which is necessary for both polymerization and depolymerization. The dual effects of LIMK activity make LIMK a potential target of therapeutic intervention for iniury-induced synaptic plasticity, as LIMK inhibition can stabilize actin cytoskeleton and preserve existing structure. This therapeutic benefit of LIMK inhibition has been demonstrated in animal models of injury-induced axon retraction and neuritic sprouting by rod photoreceptors. A better understanding of the regulation of LIMK-cofilin activity and the interaction with the microtubular cytoskeleton may open new ways to promote synaptic regeneration that can benefit neuronal degenerative disease. 展开更多
关键词 LIMK COFILIN RHOGTPASES actin turnover structural plasticity synaptic degeneration andregeneration
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Ketamine enhances structural plasticity in human dopaminergic neurons:possible relevance for treatment-resistant depression 被引量:3
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作者 Ginetta Collo Emilio Merlo Pich 《Neural Regeneration Research》 SCIE CAS CSCD 2018年第4期645-646,共2页
Depression refers to a series of mental health issues characterized by loss of interest and enjoyment in everyday life,low mood and selected emotional,cognitive,physical and behavioral symptoms.Depression is a common ... Depression refers to a series of mental health issues characterized by loss of interest and enjoyment in everyday life,low mood and selected emotional,cognitive,physical and behavioral symptoms.Depression is a common disorder,affecting 5–15%of the general population.When diagnosed as major depressive disorder(MDD),patients are currentlytreated with pharmacological agents such as serotonin or noradren- aline uptake inhibitors (SSRI or SNRI) or tricyclics. 展开更多
关键词 MEK ERK Ketamine enhances structural plasticity in human dopaminergic neurons:possible relevance for treatment-resistant depression TRD MDD
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Brain structural plasticity in rats subjected to early binocular enucleation characterized by high resolution anatomical magnetic resonance imaging and diffusion tensor imaging
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作者 Xuxia Wang Fuchun Lin +1 位作者 Yan Kang Hao Lei 《Magnetic Resonance Letters》 2023年第1期14-21,I0002,共9页
Visual deprivation leads to structural neuroplasticity in the blind subjects,including gray matter(GM)and white matter(WM)atrophy and alterations in structural connectivity.The rat model of binocular enucleation(BE)is... Visual deprivation leads to structural neuroplasticity in the blind subjects,including gray matter(GM)and white matter(WM)atrophy and alterations in structural connectivity.The rat model of binocular enucleation(BE)is a frequently used animal model for studying brain plasticity induced by early blindness.Yet few neuroimaging studies have been performed on this model to investigate whether or not the BE rats have image phenotypes similar to or comparable to,those observed in the early blind subjects.The current study aimed to assess brain structural plasticity in BE rats using anatomical magnetic resonance imaging(MRI)and diffusion tensor imaging(DTI).The results demonstrated that early BE at postnatal day 4(P4)caused almost complete degeneration of optic nerve(ON)and optic chiasma(OCH),atrophy in a number of visual and non-visual structures,including optic tract(OT),dorsal lateral geniculate nucleus(DLG)and corpus callosum(CC).The BE rats also exhibited impairments of WM microstructural integrity in the OT,and reduction of structural connectivity between the normal-appearing visual cortex(VC)and somatosensory/motor cortices at 4 months of age,likely as manifestations of deafferentationinduced maldevelopment.The structural neuroplasticity in BE rats observable to structural MRI parallels largely with what has been reported in blind subjects,suggesting that longitudinal neuroimaging studies on animal models of sensory deprivation can provide insights into how the brain changes its wiring and function during development/adaption in response to the lack of sensory stimuli. 展开更多
关键词 BLINDNESS BRAIN Structural plasticity MRI RATS
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Low dose of corticosterone treatment with exercise increases hippocampal cell proliferation, and improves cognition
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作者 Suk-Yu Yau Jada Chia-Di Lee +4 位作者 Benson Wui-Man Lau Tatia M.C. Lee Yick-Pang Ching Siu-Wa Tang Kwok-Fai So 《Neural Regeneration Research》 SCIE CAS CSCD 2011年第34期2645-2655,共11页
Intermediate level of stress is beneficial for brain functions, whereas extreme low level or high level of stress is deleterious. We have previously shown that chronic exposure to high doses of corticosterone (CORT)... Intermediate level of stress is beneficial for brain functions, whereas extreme low level or high level of stress is deleterious. We have previously shown that chronic exposure to high doses of corticosterone (CORT) suppressed hippocampal plasticity and physical exercise in terms of running counteracted the detrimental effects of CORT treatment. We aimed to study whether a mild stress, that mimicked by a treatment with low CORT dose, improved hippocampal plasticity in terms of hippocampal cell proliferation and dendritic remodeling, and to examine whether running with CORT treatment showed an additive effect on improving hippocampal plasticity. The rats were treated with 20 mg/kg CORT for 14 days with or without running, followed by Morris water maze test or forced swim test. The hippocampal proliferating cells was labeled by intraperitoneal injection of 5-bromo-2'-deoxyuridine. The dendritic morphology was analyzed using Golgi staining method. Treatment with 20 mg/kg CORT alone yielded a higher number of hippocampal cell proliferation and significantly increased dendritic branching compared to vehicle-treated non-runners, but had no behavioral effects. In contrast, CORT treatment with running showed an additive increase in hippocampal cell proliferation and dendritic remodeling that was associated with improved spatial learning and decreased depression-like behavior; however, there was no additive improvement in behavior compared to vehicle-treated runners. These findings suggest that mild stress does not always cause detrimental effect on the brain, and combining mild stress with running could promote hippocampal plasticity via inducing cell proliferation and dendritic remodeling. 展开更多
关键词 hippocampal cell proliferation physical exercise spatial learning stress structural plasticity neural plasticity
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Electric-Induced Cycloelimination for Simulating Structural Plasticity in Organic Nociceptors
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作者 Zhiheng Zhu Kai Liu +12 位作者 Haojie Huang Yangshuang Bian Mingcong Qin Chengyu Wang Wei Wen Mingliang Zhu Wenkang Shi Yanwei Liu Zhiyuan Zhao Huijuan Yan Hanlin Wang Yunqi Liu Yunlong Guo 《CCS Chemistry》 CSCD 2024年第6期1466-1476,共11页
Continuous lifelong acquisition,updating,and finetuning of knowledge and skills is of crucial significance for the survival of humans.However,current neuromorphic devices exhibit obvious catastrophic forgetting when r... Continuous lifelong acquisition,updating,and finetuning of knowledge and skills is of crucial significance for the survival of humans.However,current neuromorphic devices exhibit obvious catastrophic forgetting when restimulated by new information.This remains a challenge for neuromorphic devices and artificial intelligence to achieve continuous learning.Herein,we propose an electric-induced cycloelimination strategy to realize an organic transistor nociceptor that can simulate synaptic and structural plasticity.The system benefits from the ring-opening characteristics of cross-linked poly(vinyl cinnamate)under a strong pulse voltage,during which new energy-level trap states are formed.The prepared organic transistor nociceptors exhibit both structural and synaptic plasticity.They simulate the characteristics of human nociceptors,including threshold,relaxation,sensitization,and maladaptation behavior.For the first time,we have simulated and explored the structural plasticity behavior in organisms based on electronic devices.More remarkably,the transistor nociceptors realize the reinput of information without forgetting the initial informa tion.The strategy developed for the preparation of organic transistor nociceptors provides insights for addressing the catastrophic forgetting in the lifelong learning of intelligent neuromorphic devices. 展开更多
关键词 electric-induced cycloelimination structural plasticity organic nociceptors organic transistors METAplasticITY
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Structural plasticity-based hydrogel optical Willshaw model for one-shot on-the-fly edge learning
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作者 Dingchen Wang Dingyao Liu +19 位作者 Yinan Lin Anran Yuan Woyu Zhang Yaping Zhao Shaocong Wang Xi Chen Hegan Chen Yi Zhang Yang Jiang Shuhui Shi Kam Chi Loong Jia Chen Songrui Wei Qing Wang Hongyu Yu Renjing Xu Dashan Shang Han Zhang Shiming Zhang Zhongrui Wang 《InfoMat》 SCIE CSCD 2023年第4期48-59,共12页
Autonomous one-shot on-the-fly learning copes with the high privacy,small dataset,and in-stream data at the edge.Implementing such learning on digital hardware suffers from the well-known von-Neumann and scaling bottl... Autonomous one-shot on-the-fly learning copes with the high privacy,small dataset,and in-stream data at the edge.Implementing such learning on digital hardware suffers from the well-known von-Neumann and scaling bottlenecks.The optical neural networks featuring large parallelism,low latency,and high efficiency offer a promising solution.However,ex-situ training of conventional optical networks,where optical path configuration and deep learning model optimization are separated,incurs hardware,energy and time overheads,and defeats the advantages in edge learning.Here,we introduced a bio-inspired material-algorithm co-design to construct a hydrogel-based optical Willshaw model(HOWM),manifesting Hebbian-rule-based structural plasticity for simultaneous optical path configuration and deep learning model optimization thanks to the underlying opto-chemical reactions.We first employed the HOWM as an all optical in-sensor AI processor for one-shot pattern classification,association and denoising.We then leveraged HOWM to function as a ternary content addressable memory(TCAM)of an optical memory augmented neural network(MANN)for one-shot learning the Omniglot dataset.The HOWM empowered one-shot on-the-fly edge learning leads to 1000boost of energy efficiency and 10boost of speed,which paves the way for the next-generation autonomous,efficient,and affordable smart edge systems. 展开更多
关键词 associative memory HYDROGEL one-shot learning optical neural network structural plasticity Willshaw model
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Energy Absorption and Deformation Mechanism of Lotus-type Porous Coppers in Perpendicular Direction 被引量:2
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作者 Weidong Li Kai Xu +3 位作者 Honghao Li Haoling Jia Xinhua Liu Jianxin xie 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2017年第11期1353-1361,共9页
As metallic foams used for energy absorption in the automotive and aerospace industries, recently invented lotus-type porous metals are viewed as potential energy absorbers. Yet, solid conclusion on their eligibility ... As metallic foams used for energy absorption in the automotive and aerospace industries, recently invented lotus-type porous metals are viewed as potential energy absorbers. Yet, solid conclusion on their eligibility as energy absorbers is still in question, particularly when compression is in the direction perpendicular to the axial orientation of cylindrical pores. In this work, the energy absorption of lotus-type porous coppers in the perpendicular direction is investigated at strain rates from 0.001 s^(-1) to^2400 s^(-1). The energy absorption capacity and the energy absorption efficiency are calculated to be4–16 k J/kg and 0.32–0.7, respectively, slightly inferior to metal foams and the same porous solid compressed in the parallel direction due to the shortened extent of the plateau stress region. The deformation mechanism is examined experimentally in conjunction with finite element modeling. Both suggest that gradual squeeze and collapse of pores are the mechanisms accommodating the energy absorption. The deformation is generally evenly distributed over pore ligaments and independent of strain rate. 展开更多
关键词 Lotus-type porous structure Energy absorption Plateau stress region plastic collapse Strain rate effect
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Serration and Noise Behavior in Advanced Materials
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作者 Yong ZHANG Wei-hua WANG +2 位作者 Peter K.LIAW Gang WANG Jun-wei QIAO 《Journal of Iron and Steel Research International》 SCIE EI CAS CSCD 2016年第1期1-1,共1页
The Chinese Materials Research Society(C-MRS)Conference(2015)was held in the Guizhou Park Hotel International Conference Center,Guiyang,China,from July 10-14,2015.This conference consists of 30symposia,including 4... The Chinese Materials Research Society(C-MRS)Conference(2015)was held in the Guizhou Park Hotel International Conference Center,Guiyang,China,from July 10-14,2015.This conference consists of 30symposia,including 4international symposia.As one of 4international symposia,"Serration and noise behavior in advanced materials" 展开更多
关键词 plastic deformation and serration behavior High entropy and amorphous alloys Structural flow units for plastic deformation Deformation behaviour in AlMg alloys Twinning Behavior in titanium alloy
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