BACKGROUND Liver cirrhosis is the end stage of progressive liver fibrosis as a consequence of chronic liver inflammation,wherein the standard hepatic architecture is replaced by regenerative hepatic nodules,which even...BACKGROUND Liver cirrhosis is the end stage of progressive liver fibrosis as a consequence of chronic liver inflammation,wherein the standard hepatic architecture is replaced by regenerative hepatic nodules,which eventually lead to liver failure.Cirrhosis without any symptoms is referred to as compensated cirrhosis.Complications such as ascites,variceal bleeding,and hepatic encephalopathy indicate the onset of decompensated cirrhosis.Gastroesophageal varices are the hallmark of clini-cally significant portal hypertension.AIM To determine the accuracy of the platelet count-to-spleen diameter(PC/SD)ratio to evaluate esophageal varices(EV)in patients with cirrhosis.METHODS This retrospective observational study was conducted at Tikur Anbessa Specia-lized Hospital and Adera Medical Center from January 1,2019,to December 30,2023.Data were collected via chart review and direct patient interviews using structured questionnaires.The data were exported to the SPSS software version 26 for analysis and clearance.A receiver operating characteristic curve was plotted for splenic diameter,platelet count,and PC/SD ratio to obtain sensitivity,speci-ficity,positive predictive value,negative predictive value,positive likelihood ratio,and negative likelihood ratio.RESULTS Of the 140 participants,67%were men.Hepatitis B(38%)was the most common cause of cirrhosis,followed by cryptogenic cirrhosis(28%)and hepatitis C(16%).Approximately 83.6%of the participants had endoscopic evidence of EV,whereas 51.1%had gastric varices.Decompensated cirrhosis and PC were associated with the presence of EV with adjusted odds ratios of 12.63(95%CI:3.16-67.58,P=0.001)and 0.14(95%CI:0.037-0.52,P=0.004),respectively.A PC/SD ratio<1119 had a sensitivity of 86.32%and specificity of 70%with area under the curve of 0.835(95%CI:0.736-0.934,P<0.001).CONCLUSION A PC/SD ratio<1119 predicts EV in patients with cirrhosis.It is a valuable,noninvasive tool for EV risk assess-ment in resource-limited settings.展开更多
目的探讨原发性高血压患者平均血小板体积/血小板计数比值(MPV/PLC)与左心室肥厚的关系。方法回顾性分析新发的原发性高血压患者111例资料,根据MPV/PLC比值,采用二等分法分为两组:低MPV/PLC组(MPV/PLC≤44.35 f L·10^(-12)·L^...目的探讨原发性高血压患者平均血小板体积/血小板计数比值(MPV/PLC)与左心室肥厚的关系。方法回顾性分析新发的原发性高血压患者111例资料,根据MPV/PLC比值,采用二等分法分为两组:低MPV/PLC组(MPV/PLC≤44.35 f L·10^(-12)·L^(-1))和高MPV/PLC组(MPV/PLC>44.35 f L·10^(-12)·L^(-1)),比较两组的基线情况、血压水平、超声心动图参数等指标;采用相关性分析MPV/PLC与左心室心肌质量指数(LVMI)的关系;采用多元线性回归分析LVMI的影响因素。结果与高MPV/PLC组比较,低MPV/PLC组的LVMI较高[(115.29±23.18)g/m^2比(107.37±16.83)g/m^2,P<0.05];相关性分析显示,LVMI与MPV/PLC呈负相关(r=-0.196,P<0.05);多元线性相关分析显示,MPV/PLC是原发性高血压患者LVMI的影响因素(B=-0.347,P<0.05)。结论原发性高血压患者的MPV/PLC与左心室肥厚相关。展开更多
目的 分析血小板计数/脾脏直径比值、心排血量在预测肝硬化食管静脉曲张存在及出血的价值.方法 收集2007年5月至2012年5月福建医科大学附属漳州市医院肝硬化住院患者63例,其中男41例、女22例,年龄40 ～63岁.按胃镜检查结果分为曲张组（4...目的 分析血小板计数/脾脏直径比值、心排血量在预测肝硬化食管静脉曲张存在及出血的价值.方法 收集2007年5月至2012年5月福建医科大学附属漳州市医院肝硬化住院患者63例,其中男41例、女22例,年龄40 ～63岁.按胃镜检查结果分为曲张组（44例）与非曲张组（19例）,出血组（36例）与非出血组（27例）,分析组间血小板计数/脾脏直径比值、心排血量.结果 曲张组与非曲张组之间血小板计数/脾脏直径比值（0.46±0.33 vs 0.50±0.31）、心排血量差异（4973.73±1315.04 vs 4673.08±1907.95）均无统计学意义（P〉0.05）,出血组与非出血组之间血小板计数/脾脏直径比值（0.37±0.24 vs 0.42±0.39）差异有统计学意义（P〈0.05）、心排血量（5397.99±1107.03 vs 4730.73±1763.28）差异无统计学意义（P〉0.05）.结论 血小板计数/脾脏直径比值在预测食管静脉曲张破裂出血上有一定价值.展开更多
文摘BACKGROUND Liver cirrhosis is the end stage of progressive liver fibrosis as a consequence of chronic liver inflammation,wherein the standard hepatic architecture is replaced by regenerative hepatic nodules,which eventually lead to liver failure.Cirrhosis without any symptoms is referred to as compensated cirrhosis.Complications such as ascites,variceal bleeding,and hepatic encephalopathy indicate the onset of decompensated cirrhosis.Gastroesophageal varices are the hallmark of clini-cally significant portal hypertension.AIM To determine the accuracy of the platelet count-to-spleen diameter(PC/SD)ratio to evaluate esophageal varices(EV)in patients with cirrhosis.METHODS This retrospective observational study was conducted at Tikur Anbessa Specia-lized Hospital and Adera Medical Center from January 1,2019,to December 30,2023.Data were collected via chart review and direct patient interviews using structured questionnaires.The data were exported to the SPSS software version 26 for analysis and clearance.A receiver operating characteristic curve was plotted for splenic diameter,platelet count,and PC/SD ratio to obtain sensitivity,speci-ficity,positive predictive value,negative predictive value,positive likelihood ratio,and negative likelihood ratio.RESULTS Of the 140 participants,67%were men.Hepatitis B(38%)was the most common cause of cirrhosis,followed by cryptogenic cirrhosis(28%)and hepatitis C(16%).Approximately 83.6%of the participants had endoscopic evidence of EV,whereas 51.1%had gastric varices.Decompensated cirrhosis and PC were associated with the presence of EV with adjusted odds ratios of 12.63(95%CI:3.16-67.58,P=0.001)and 0.14(95%CI:0.037-0.52,P=0.004),respectively.A PC/SD ratio<1119 had a sensitivity of 86.32%and specificity of 70%with area under the curve of 0.835(95%CI:0.736-0.934,P<0.001).CONCLUSION A PC/SD ratio<1119 predicts EV in patients with cirrhosis.It is a valuable,noninvasive tool for EV risk assess-ment in resource-limited settings.
文摘目的探讨原发性高血压患者平均血小板体积/血小板计数比值(MPV/PLC)与左心室肥厚的关系。方法回顾性分析新发的原发性高血压患者111例资料,根据MPV/PLC比值,采用二等分法分为两组:低MPV/PLC组(MPV/PLC≤44.35 f L·10^(-12)·L^(-1))和高MPV/PLC组(MPV/PLC>44.35 f L·10^(-12)·L^(-1)),比较两组的基线情况、血压水平、超声心动图参数等指标;采用相关性分析MPV/PLC与左心室心肌质量指数(LVMI)的关系;采用多元线性回归分析LVMI的影响因素。结果与高MPV/PLC组比较,低MPV/PLC组的LVMI较高[(115.29±23.18)g/m^2比(107.37±16.83)g/m^2,P<0.05];相关性分析显示,LVMI与MPV/PLC呈负相关(r=-0.196,P<0.05);多元线性相关分析显示,MPV/PLC是原发性高血压患者LVMI的影响因素(B=-0.347,P<0.05)。结论原发性高血压患者的MPV/PLC与左心室肥厚相关。
文摘目的 分析血小板计数/脾脏直径比值、心排血量在预测肝硬化食管静脉曲张存在及出血的价值.方法 收集2007年5月至2012年5月福建医科大学附属漳州市医院肝硬化住院患者63例,其中男41例、女22例,年龄40 ～63岁.按胃镜检查结果分为曲张组（44例）与非曲张组（19例）,出血组（36例）与非出血组（27例）,分析组间血小板计数/脾脏直径比值、心排血量.结果 曲张组与非曲张组之间血小板计数/脾脏直径比值（0.46±0.33 vs 0.50±0.31）、心排血量差异（4973.73±1315.04 vs 4673.08±1907.95）均无统计学意义（P〉0.05）,出血组与非出血组之间血小板计数/脾脏直径比值（0.37±0.24 vs 0.42±0.39）差异有统计学意义（P〈0.05）、心排血量（5397.99±1107.03 vs 4730.73±1763.28）差异无统计学意义（P〉0.05）.结论 血小板计数/脾脏直径比值在预测食管静脉曲张破裂出血上有一定价值.
