Objective: To explore the clinical efficacy of the principle of activating blood circulation to break stasis (ABCBS) and its influence on platelet membranous protein particle (GMP-140) and D 2 dimer (D-dimer) before...Objective: To explore the clinical efficacy of the principle of activating blood circulation to break stasis (ABCBS) and its influence on platelet membranous protein particle (GMP-140) and D 2 dimer (D-dimer) before and after treatment. Methods: Eighty-eight patients with blood stasis syndrome (BSS) of acute cerebral infarction (ACI) were randomly divided into two groups, both of which were treated with conventional treatment, i.e. with western medicine (WM), with Salvia injection added through intravenously dripping.One of the two groups was used as the control and the other group as the treated group who had ABCBS herbs orally taken in addition. The duration of treatment course for both groups was 3 weeks. Results: There were changes in both groups over clinical symptoms, nerve function deficit scoring and GMP-140, D-dimer, but the treated group showed significantly better than that of the control group, ( P <0.05). Conclusion: ABCBS principle could serve as an important auxiliary treating method for BSS of ACI, as it can effectively alter the blood of ACI patients which was viscous, condense, coagulant and aggregating.展开更多
Objective To investigate the dynamic changes and the clinic significance of coagulation and fibrinolysis markers in patients with severe craniocerebral trauma.Methods Thirty three consecutive patients [Glasgow coma sc...Objective To investigate the dynamic changes and the clinic significance of coagulation and fibrinolysis markers in patients with severe craniocerebral trauma.Methods Thirty three consecutive patients [Glasgow coma scale (GCS) ≤8 and APACHE Ⅱ≥10] including 10 women and 23 men with age of (46.3±16.3) years old and with severe craniocerebral trauma were enrolled in this study.Endothelin(ET),alpha-granular membrane protein-140(GMP-140) and D-dimer(DD) were measured at 1st day,3rd day and 7th day of admission,head computerized tomography(CT) was performed on each patient.Twenty healthy people with similar age were as control.ET was determined by the reagent kit which from Shanghai Shenjia company and GC-1200 γ radiatory counter.GMP-140 was determined by the reagent kit which from Suzhou university and PEKINEINMER WIZARD-1470 γ radiatory counter.DD was determined by the reagent kit Shanghai sung biological product company limited and measured by latex agglutination.Results ET,GMP-140 and DD levels were significantly increased at the time of admission[(75.24±26.44)pg/ml,(26.43±13.94)ng/ml,(3.20±0.97)μg/ml,respectively],then gradually decreased.ET and DD levels were significantly higher than control group even after 7 days[(44.66±15.25)pg/ml,(1.35±0.55) μg/ml,respectively],but not for GMP-140.All of the coagulation and fibrinolysis abnormalities markers were negatively correlated with GCS,P<0.05.There were 18 survivors including 8 vegetables and 15 dead including 1 case suffered from disseminated intravascular coagulation(DIC) in this investigation.Conclusions Coagulation and fibrinolysis abnormalities markers were occurred at the very early stage in the patients with severe craniocerebral trauma.The levels of ET,GMP-140 and DD levels were negatively correlated with GCS.展开更多
文摘Objective: To explore the clinical efficacy of the principle of activating blood circulation to break stasis (ABCBS) and its influence on platelet membranous protein particle (GMP-140) and D 2 dimer (D-dimer) before and after treatment. Methods: Eighty-eight patients with blood stasis syndrome (BSS) of acute cerebral infarction (ACI) were randomly divided into two groups, both of which were treated with conventional treatment, i.e. with western medicine (WM), with Salvia injection added through intravenously dripping.One of the two groups was used as the control and the other group as the treated group who had ABCBS herbs orally taken in addition. The duration of treatment course for both groups was 3 weeks. Results: There were changes in both groups over clinical symptoms, nerve function deficit scoring and GMP-140, D-dimer, but the treated group showed significantly better than that of the control group, ( P <0.05). Conclusion: ABCBS principle could serve as an important auxiliary treating method for BSS of ACI, as it can effectively alter the blood of ACI patients which was viscous, condense, coagulant and aggregating.
文摘Objective To investigate the dynamic changes and the clinic significance of coagulation and fibrinolysis markers in patients with severe craniocerebral trauma.Methods Thirty three consecutive patients [Glasgow coma scale (GCS) ≤8 and APACHE Ⅱ≥10] including 10 women and 23 men with age of (46.3±16.3) years old and with severe craniocerebral trauma were enrolled in this study.Endothelin(ET),alpha-granular membrane protein-140(GMP-140) and D-dimer(DD) were measured at 1st day,3rd day and 7th day of admission,head computerized tomography(CT) was performed on each patient.Twenty healthy people with similar age were as control.ET was determined by the reagent kit which from Shanghai Shenjia company and GC-1200 γ radiatory counter.GMP-140 was determined by the reagent kit which from Suzhou university and PEKINEINMER WIZARD-1470 γ radiatory counter.DD was determined by the reagent kit Shanghai sung biological product company limited and measured by latex agglutination.Results ET,GMP-140 and DD levels were significantly increased at the time of admission[(75.24±26.44)pg/ml,(26.43±13.94)ng/ml,(3.20±0.97)μg/ml,respectively],then gradually decreased.ET and DD levels were significantly higher than control group even after 7 days[(44.66±15.25)pg/ml,(1.35±0.55) μg/ml,respectively],but not for GMP-140.All of the coagulation and fibrinolysis abnormalities markers were negatively correlated with GCS,P<0.05.There were 18 survivors including 8 vegetables and 15 dead including 1 case suffered from disseminated intravascular coagulation(DIC) in this investigation.Conclusions Coagulation and fibrinolysis abnormalities markers were occurred at the very early stage in the patients with severe craniocerebral trauma.The levels of ET,GMP-140 and DD levels were negatively correlated with GCS.
