Objective: To explore the specificity of Tongli(HT 5) and Xuanzhong(GB 39) paired acupionts in aspects of Deqi sensation and brain activation patterns during electroacupuncture. Methods: In this study, 15 healthy subj...Objective: To explore the specificity of Tongli(HT 5) and Xuanzhong(GB 39) paired acupionts in aspects of Deqi sensation and brain activation patterns during electroacupuncture. Methods: In this study, 15 healthy subjects were enrolled. All participants suffered two kinds of functional magnetic resonance imaging(f MRI) examinations randomly: Examination A received electro-acupuncture(EA) at the bilateral Tongli(HT5) and Xuanzhong(GB 39) acupoints(ACU), and examination B received EA at bilateral non-acupoints(NAP). The subjects reported the feeling of Deqi at each examination later respectively. A multi-voxel pattern analysis method and Statistical Program for Social Sciences were used to analyze the data. Results: The ACU group(Exam A) reported fullness, heaviness, numbness, soreness and throbbing of significantly greater intensity than the NAP group(Exam B). In addition, there was no statistical significance between two groups in aching, tingling, deep pressure, sharp pain, dull pain, warmness and cold. Meanwhile, f MRI data revealed differences between two groups in discriminating accuracy of brain somatosensory cortex and language-related cortices. Conclusion: Needling HT 5 and GB 39 may modulate language function through a complex brain network, suggesting that it may be beneficial to the recovery of language function in patients with aphasia.展开更多
Therapies that complement free radical scavenging are an important approach for treating aging in the brain. In the present study, two formulations of moxa cone moxibustion were applied at acupoints Zusanfi （ST 36） ...Therapies that complement free radical scavenging are an important approach for treating aging in the brain. In the present study, two formulations of moxa cone moxibustion were applied at acupoints Zusanfi （ST 36） and Xuanzhong （GB 39）, and at acupoints Baihui （DU 20） and Guanyuan （RN 4）, in D-galactose-induced senile mice. The results revealed that moxa cone moxibustion improved total superoxide dismutase and Cu/Zn-superoxide dismutase activity in the homogenates of the cerebral tissue, as well as ameliorating deficits in neuronal morphology and neuronal density in the cerebral cortex and hippocampal CA3. Moxa cone moxibustion also enhanced learning and memory functions of senile mice. Moxa cone moxibustion at Zusanli, Xuanzhong, Baihuiand Guanyuan acupoints can thus be used to complement free radical scavengers, with efficacy that is equal to that of electroacupuncture at Zusanliand Xuanzhong, and superior to that of nimodipine treatment.展开更多
基金Supported by the National Natural Science Foundation of China(No.81072768)the New Century Excellent Talents in University of the Ministry of Education of China(No.NCET-11-0603)Capital Featured Clinical Research of Beijing Municipal Science and Technology,China(No.Z131107002213094)
文摘Objective: To explore the specificity of Tongli(HT 5) and Xuanzhong(GB 39) paired acupionts in aspects of Deqi sensation and brain activation patterns during electroacupuncture. Methods: In this study, 15 healthy subjects were enrolled. All participants suffered two kinds of functional magnetic resonance imaging(f MRI) examinations randomly: Examination A received electro-acupuncture(EA) at the bilateral Tongli(HT5) and Xuanzhong(GB 39) acupoints(ACU), and examination B received EA at bilateral non-acupoints(NAP). The subjects reported the feeling of Deqi at each examination later respectively. A multi-voxel pattern analysis method and Statistical Program for Social Sciences were used to analyze the data. Results: The ACU group(Exam A) reported fullness, heaviness, numbness, soreness and throbbing of significantly greater intensity than the NAP group(Exam B). In addition, there was no statistical significance between two groups in aching, tingling, deep pressure, sharp pain, dull pain, warmness and cold. Meanwhile, f MRI data revealed differences between two groups in discriminating accuracy of brain somatosensory cortex and language-related cortices. Conclusion: Needling HT 5 and GB 39 may modulate language function through a complex brain network, suggesting that it may be beneficial to the recovery of language function in patients with aphasia.
基金Scientific Research Projects of Education Bureau of Guangxi Zhuang Autonomous Region,No.200710LX022the Natural Science Foundation of Guangxi Zhuang Autonomous Region,No.0832170
文摘Therapies that complement free radical scavenging are an important approach for treating aging in the brain. In the present study, two formulations of moxa cone moxibustion were applied at acupoints Zusanfi （ST 36） and Xuanzhong （GB 39）, and at acupoints Baihui （DU 20） and Guanyuan （RN 4）, in D-galactose-induced senile mice. The results revealed that moxa cone moxibustion improved total superoxide dismutase and Cu/Zn-superoxide dismutase activity in the homogenates of the cerebral tissue, as well as ameliorating deficits in neuronal morphology and neuronal density in the cerebral cortex and hippocampal CA3. Moxa cone moxibustion also enhanced learning and memory functions of senile mice. Moxa cone moxibustion at Zusanli, Xuanzhong, Baihuiand Guanyuan acupoints can thus be used to complement free radical scavengers, with efficacy that is equal to that of electroacupuncture at Zusanliand Xuanzhong, and superior to that of nimodipine treatment.
