目的 基于功能性磁共振成像(functional magnetic resonance imaging,fMRI)技术,观察针刺阳陵泉对右侧缺血性卒中患者百分比振幅(percent amplitude of fluctuation,PerAF)变化的影响。方法 纳入右侧缺血性卒中患者28例(观察组),并募集...目的 基于功能性磁共振成像(functional magnetic resonance imaging,fMRI)技术,观察针刺阳陵泉对右侧缺血性卒中患者百分比振幅(percent amplitude of fluctuation,PerAF)变化的影响。方法 纳入右侧缺血性卒中患者28例(观察组),并募集与患者性别和年龄相匹配的健康受试者28例(对照组)。观察组分别进行静息态及针刺阳陵泉后静息态fMRI扫描,对照组仅进行静息态fMRI扫描。计算两组全脑体素的PerAF。结果观察组静息态左侧楔前叶PerAF值高于对照组静息态(GRF校正,体素水平P<0.001,团块水平P<0.05,双尾);观察组针刺后左侧楔前叶PerAF值与对照组静息态比较有升高有降低(GRF校正,体素水平P<0.001,团块水平P<0.05,双尾),观察组针刺后左侧枕中回、右侧角回和右侧中扣带回PerAF值较对照组静息态降低(GRF校正,体素水平P<0.001,团块水平P<0.05,双尾)。观察组针刺后右侧中扣带回PerAF值较观察组静息态降低(GRF校正,体素水平P<0.001,团块水平P<0.05,双尾)。结论 右侧缺血性卒中患者静息态左侧楔前叶PerAF值高于健康者,针刺阳陵泉穴可调节右侧缺血性卒中患者多个脑区PerAF值,右侧中扣带回可能是其发挥脑效应机制潜在脑区。展开更多
Few studies have examined the effects of different stimuli at a single acupoint using functional magnetic resonance imaging.The present study applied acupuncture at the Neiguan（PC 6）,Waiguan（SJ 5）,Zhigou（SJ 6） a...Few studies have examined the effects of different stimuli at a single acupoint using functional magnetic resonance imaging.The present study applied acupuncture at the Neiguan（PC 6）,Waiguan（SJ 5）,Zhigou（SJ 6） and Yanglingquan（GB 34） acupoints in healthy volunteers.fMRI was used to examine the activation of brain areas in response to different types of acupuncture（cutaneous or routine acupuncture） at each acupoint.There were no significant differences in the distribution of activation in the regions of interest between cutaneous and routine acupuncture at the Neiguan,Waiguan,and Zhigou acupoints,but some differences were observed between the two methods of acupuncture at the Yanglingquan acupoint.There were no significant differences in the intensity of induced activation between cutaneous and routine acupuncture at the Neiguan,Zhigou and Yanglingquan acupoints,but the activation intensity in the right cerebellum induced by routine acupuncture at the Waiguan acupoint was greater than that induced by cutaneous acupuncture.Results confirmed that cutaneous and routine acupuncture at the Neiguan,Waiguan,Zhigou and Yanglingquan acupoints activated different functional brain areas,and caused activation of different intensities in some areas.展开更多
文摘目的 基于功能性磁共振成像(functional magnetic resonance imaging,fMRI)技术,观察针刺阳陵泉对右侧缺血性卒中患者百分比振幅(percent amplitude of fluctuation,PerAF)变化的影响。方法 纳入右侧缺血性卒中患者28例(观察组),并募集与患者性别和年龄相匹配的健康受试者28例(对照组)。观察组分别进行静息态及针刺阳陵泉后静息态fMRI扫描,对照组仅进行静息态fMRI扫描。计算两组全脑体素的PerAF。结果观察组静息态左侧楔前叶PerAF值高于对照组静息态(GRF校正,体素水平P<0.001,团块水平P<0.05,双尾);观察组针刺后左侧楔前叶PerAF值与对照组静息态比较有升高有降低(GRF校正,体素水平P<0.001,团块水平P<0.05,双尾),观察组针刺后左侧枕中回、右侧角回和右侧中扣带回PerAF值较对照组静息态降低(GRF校正,体素水平P<0.001,团块水平P<0.05,双尾)。观察组针刺后右侧中扣带回PerAF值较观察组静息态降低(GRF校正,体素水平P<0.001,团块水平P<0.05,双尾)。结论 右侧缺血性卒中患者静息态左侧楔前叶PerAF值高于健康者,针刺阳陵泉穴可调节右侧缺血性卒中患者多个脑区PerAF值,右侧中扣带回可能是其发挥脑效应机制潜在脑区。
基金the National Basic Research Program of China (973 Program), No. 2006CB504505the National Natural Science Foundation of China, No. 90709027
文摘Few studies have examined the effects of different stimuli at a single acupoint using functional magnetic resonance imaging.The present study applied acupuncture at the Neiguan（PC 6）,Waiguan（SJ 5）,Zhigou（SJ 6） and Yanglingquan（GB 34） acupoints in healthy volunteers.fMRI was used to examine the activation of brain areas in response to different types of acupuncture（cutaneous or routine acupuncture） at each acupoint.There were no significant differences in the distribution of activation in the regions of interest between cutaneous and routine acupuncture at the Neiguan,Waiguan,and Zhigou acupoints,but some differences were observed between the two methods of acupuncture at the Yanglingquan acupoint.There were no significant differences in the intensity of induced activation between cutaneous and routine acupuncture at the Neiguan,Zhigou and Yanglingquan acupoints,but the activation intensity in the right cerebellum induced by routine acupuncture at the Waiguan acupoint was greater than that induced by cutaneous acupuncture.Results confirmed that cutaneous and routine acupuncture at the Neiguan,Waiguan,Zhigou and Yanglingquan acupoints activated different functional brain areas,and caused activation of different intensities in some areas.
文摘目的观察恢刺联合超声引导下冲击波对卒中后痉挛(post-stroke spasticity,PSS)患者肌张力和运动功能的影响。方法将96例PSS患者随机分为观察组和对照组,每组48例。对照组给予超声引导下体外冲击波(extra-corporeal shock wave therapy,ESWT)治疗,观察组在对照组基础上采用恢刺阳陵泉穴治疗。观察两组治疗前后改良Ashworth量表(modified Ashworth scale,MAS)、Wolf运动功能测试(Wolf motor function test,WMFT)、功能综合评定(functional comprehensive assessment,FCA)量表、肌电均方根值(root mean square,RMS)和积分肌电值(integrated electromyogram,iEMG)变化。结果两组治疗后肌张力评分等级分布优于治疗前(P<0.05),且观察组等级分布优于对照组(P<0.05)。治疗后,两组WMFT评分均高于治疗前(P<0.05),且观察组高于对照组(P<0.05);两组FCA日常生活功能、认知功能及总分高于治疗前(P<0.05),且观察组高于对照组(P<0.05);两组RMS、iEMG低于治疗前(P<0.05),且观察组低于对照组(P<0.05)。结论恢刺联合超声引导下冲击波治疗PSS效果显著,可有效改善肌电生理指标、肌张力及运动功能,提高日常生活能力及认知水平。
