Data point selection for weighted least square fitting of cavity decay time constant

For the accurate extraction of cavity decay time, a selection of data points is supplemented to the weighted least square method. We derive the expected precision, accuracy and computation cost of this improved method, and examine these performances by simulation. By comparing this method with the nonlinear least square fitting （NLSF） method and the linear regression of the sum （LRS） method in derivations and simulations, we find that this method can achieve the same or even better precision, comparable accuracy, and lower computation cost. We test this method by experimental decay signals. The results are in agreement with the ones obtained from the nonlinear least square fitting method.

Comparison of clinical efficacy of neddle knife at acupoints selected from recent regions along meridians and according to anatomical structures in treating early and middle stage knee osteoarthritis

Objective:To stimulate tenderness points around knee joint in two metholds-corresponding acupoints selected from recent regions along meridians and anatomical structures,to compare the clinical efficacy of neddle knife of to cure early and middle stage knee osteoarthritis.Method:70 patients were randomly(Random Number Tables)divided into test group(acupoints selected from recent regions along meridians,n=35)and control group(anatomical structures,n=35),who were diagnosed as knee osteoarthritis.Observe the VAS(visual analogue scale),Lysholm,WOMAC(the Western Ontario and McMaster Unive rsities Osteoarthritis Index)and ROM(rang of motion)between two groups in first week,first month,third month after treatment.Recording the degree of improvement of knee joint’s pain,dysfunction and symptoms of osteoarthritis and rang of motion.Results:Within groups,the VAS,Lysholm,WOMAC and ROM were obviously different from pre-therapy scores in the third,sixth and twelfth week post-therapy(P<0.05).Between groups no significant difference were observed in the third week post-therapy about VAS,Lysholm,WOMAC scores(P>0.05).However,there were differences in the sixth,twelfth weeks post-therapy(P<0.05);compared with control group,the ROM of test group were difference in the third,sixth,twelfth weeks post-therapy(P<0.05).Conclusion:The clinical efficacy of stimulating corresponding acupoints tenderness points selected from recent regions along meridians to treat early and middle stage knee osteoarthritis was superior to anatomical structures,which can effectively relieve pain,dysfunction,symptoms of osteoarthritis of knee joint and rang of motion.

Study on the Rule of Acupoint Selection in Acupuncture and Moxibustion Treatment of Stomachache

A systematic collection of relevant literature on acupuncture and moxibustion treatment of stomach pain,and a summary of the rule of acupoints selection for acupuncture treatment of stomach pain.In conclusion,Zusanli,Zhongwan,Neiguan,and Liang Qiu are selected as the main acupoints.At the same time,according to the different syndrome types,dyspepsia hurt a stomach syndrome is compatible with Burong,Chengman,Tianshu and Shangjuxu acupoints.Cold evil invading the stomach syndrome is compatible with Shenque and Qihai acupoints.Liver-Qi attacking stomach syndrome is compatible with Danzhong,Zhangmen,and Qimen acupoints;for blood stasis to stop the stomach,it is compatible with Xuehai,Geshu,and Pishu acupoints.Adopting this rule of acupoints selection has a significant effect on acupuncture treatment of stomach pain,and it also provides a reference for other doctors to treat stomach pain.

RESEARCH INTO THE LOW RESISTANCE OF MERIDIAN POINTS AND CLINICAL EXPERIMENTAL OBSERVATION

This thesis has further studied the low resistance of meridian points with a new in-strument called Model TZ-03 of resistance detector for Acupoints. Through experiments and clinicalobservation, the author found that the changes of skin resistances of points are closely related to thechanges of human physiology and pathology. The experiments also show that the factors which influ-ence the results are complicated and changeable in many ways. Therefore, the absolute values of theresistances of points are not precise and stahle f and the ratio of the resistance of bilateral point of thesame name is more re1iable. In healthy people, the resistances of the sarne points on two sides of thebody are similar, and there is much difference of these resistances among people with diseases.

Similarities and differences between the trigger point of myofascial pain and the traditional meridian points

In recent years,the treatment of myofascial pain trigger point is a relatively popular technology,many people regard it as"Ashi point"in meridian theory,but compared with the traditional meridian theory,the description of myofascial pain trigger point is more intuitive and easier to master.This paper expounds the similarities and differences between myofascial pain trigger point and traditional meridian theory from the aspects of theory,basic research and clinical application,in order to provide a specific idea for the scientific interpretation of meridian phenomenon in traditional Chinese medicine.

Forty-five Cases of Apoplexy Treated by Electroacupuncture at the Points of Yin Meridians

Forty-five cases of apoplexy were treated by electroacupuncture only at the points of Yin Meridians (i.e. the Hand- and Foot-Taiyin Meridians), and the other 30 cases as the controls were treated only at the points of Yang Meridians (i.e. the Hand- and Foot-Yangming Meridians). The total effective rate was 91.1% in the former and 86.7% in the latter, with no statistically significant difference between the two groups, indicating that acupuncture only at the points of Yin-Meridians is also an effective therapy for apoplexy.

Analysis of environmental selection pressure of superoxide dismutase in deep-sea sea cucumber

Manganese superoxide dismutase(MnSOD)is an antioxidant that exists in mitochondria and can effectively remove superoxide anions in mitochondria.In a dark,high-pressure,and low-temperature deep-sea environment,MnSOD is essential for the survival of sea cucumbers.Six MnSODs were identified from the transcriptomes of deep and shallow-sea sea cucumbers.To explore their environmental adaptation mechanism,we conducted environmental selection pressure analysis through the branching site model of PAML software.We obtained night positive selection sites,and two of them were significant(97F→H,134K→V):97F→H located in a highly conservative characteristic sequence,and its polarity c hange might have a great impact on the function of MnSOD;134K→V had a change in piezophilic a bility,which might help MnSOD adapt to the environment of high hydrostatic pressure in the deepsea.To further study the effect of these two positive selection sites on MnSOD,we predicted the point mutations of F97H and K134V on shallow-sea sea cucumber by using MAESTROweb and PyMOL.Results show that 97F→H,134K→V might improve MnSOD’s efficiency of scavenging superoxide a nion and its ability to resist high hydrostatic pressure by moderately reducing its stability.The above results indicated that MnSODs of deep-sea sea cucumber adapted to deep-sea environments through their amino acid changes in polarity,piezophilic behavior,and local stability.This study revealed the correlation between MnSOD and extreme environment,and will help improve our understanding of the organism’s adaptation mechanisms in deep sea.

Physical and numerical investigations of target stratum selection for ground hydraulic fracturing of multiple hard roofs

Ground hydraulic fracturing plays a crucial role in controlling the far-field hard roof,making it imperative to identify the most suitable target stratum for effective control.Physical experiments are conducted based on engineering properties to simulate the gradual collapse of the roof during longwall top coal caving(LTCC).A numerical model is established using the material point method(MPM)and the strain-softening damage constitutive model according to the structure of the physical model.Numerical simulations are conducted to analyze the LTCC process under different hard roofs for ground hydraulic fracturing.The results show that ground hydraulic fracturing releases the energy and stress of the target stratum,resulting in a substantial lag in the fracturing of the overburden before collapse occurs in the hydraulic fracturing stratum.Ground hydraulic fracturing of a low hard roof reduces the lag effect of hydraulic fractures,dissipates the energy consumed by the fracture of the hard roof,and reduces the abutment stress.Therefore,it is advisable to prioritize the selection of the lower hard roof as the target stratum.

Disease Location Identification as A Major Guide to Acupoint Selection

Selecting acupoints according to channel pathway is the major point selection principle in acupuncture treatment for which there is a consensus. However, defining the disease location remains the premise of acupoint selection based on channel pathway. What is the substance of disease location identification in clinical acupuncture？ Besides indicating acupoint selection according to channel pathway, what guidance can it provide for acupuncture treatment？ This is the main topic discussed in this article.

Mechanism of the acupoints of the governor vessel in treatment of post-stroke depression on the base of the specificity of meridian points

Focusing on the effect specificity of meridian points along the running course of meridian,by taking the treatment of post-stroke depression(PSD)with the acupoints of the governor vessel as an example,the correlation between meridian points and disease was explored.The specific regulatory effect of governor vessel,Baihui(百会GV20)and Shenting(神庭GV24)in physiology and pathology in PSD and the material basis of the specificity effect were analyzed.Finally,the specific relationship between the acupoints of the governor vessel and PSD was explained.

Genes for the high life： New genetic variants point to positive selection for high altitude hypoxia in Tibetans

People living on the high plateaus of the world have long fascinated biological anthropologists and geneticists because they live in ＂thin air＂ and epitomize an extreme of human biological adaptation.

Application of Rollout Strategy to Test Points Selection for Integer-Coded Fault Wise Table

Test points selection for integer-coded fault wise table is a discrete optimization problem. The global minimum set of test points can only be guaranteed by an exhaustive search which is eompurationally expensive. In this paper, this problem is formulated as a heuristic depth-first graph search problem at first. The graph node expanding method and rules are given. Then, rollout strategies are applied, which can be combined with the heuristic graph search algorithms, in a computationally more efficient manner than the optimal strategies, to obtain solutions superior to those using the greedy heuristic algorithms. The proposed rollout-based test points selection algorithm is illustrated and tested using an analog circuit and a set of simulated integer-coded fault wise tables. Computa- tional results are shown, which suggest that the rollout strategy policies are significantly better than other strategies.

Selection of Minimal Test Points Set for Integer-Coded Fault Wise Table

Test points selection for integer-coded fault wise table is a discrete optimization problem. On one hand, traditional exhaustive search method is computationally expensive. On the other hand, the space complexity of traditional exhaustive is low. A tradeoff method between the high time complexity and low space complexity is proposed. At first, a new fault-pair table is constructed based on the integer-coded fault wise table. The fault-pair table consists of two columns： one column represents fault pair and the other represents test points set that can distinguish the corresponding faults. Then, the rows are arranged in ascending order according to the cardinality of corresponding test points set. Thirdly, test points in the top rows are selected one by one until all fault pair are isolated. During the test points selection process, the rows that contain selected test points are deleted and then the dimension of fault-pair table decreases gradually. The proposed test points selection algorithm is illustrated and tested using an integercoded fault wise table derived from a real analog circuit. Computational results suggest show policies are better than the exhaustive strategy.

Continuous Selections and Fixed Points forφ-maps with Their Applications to Section Problems

The concept of finitely continuous topological space is introduced and the basic properties of the space are given. Several continuous selection theorems and fixed point theorems for Ф-maps are established, and as applications of the above fixed point theorems, some section problems are discussed. The results generalize and improve many corresponding conclusions.

Use of Rough Sets Theory in Point Cluster and River Network Selection

In this paper, we applied the rough sets to the point cluster and river network selection. In order to meet the requirements of rough sets, first, we structuralize and quantify the spatial information of objects by convex hull, triangulated irregular network (TIN), Voronoi diagram, etc.;second, we manually assign decisional attributes to the information table according to conditional attributes. In doing so, the spatial information and attribute information are integrated together to evaluate the importance of points and rivers by rough sets theory. Finally, we select the point cluster and the river network in a progressive manner. The experimental results show that our method is valid and effective. In comparison with previous work, our method has the advantage to adaptively consider the spatial and attribute information at the same time without any a priori knowledge.

Optimal Test Points Selection Based on Multi-Objective Genetic Algorithm

A new approach to select anoptimal set of test points is proposed. The described method uses fault-wise table and multi-objective genetic algorithm to find the optimal set of test points. First, the fault-wise table is constructed whose entries are measurements associated with faults and test points. The selection of optimal test points is transformed to the selection of the columns that isolate the rows of the table. Then, four objectives are described according to practical test requirements. The multi-objective genetic algorithm is explained. Finally, the presented approach is illustrated by a practical example. The results indicate that the proposed method can efficiently and accurately find the optimal set of test points and is practical for large scale systems.

A Machine Learning-Based Distributed Denial of Service Detection Approach for Early Warning in Internet Exchange Points

The Internet service provider(ISP)is the heart of any country’s Internet infrastructure and plays an important role in connecting to theWorld WideWeb.Internet exchange point(IXP)allows the interconnection of two or more separate network infrastructures.All Internet traffic entering a country should pass through its IXP.Thus,it is an ideal location for performing malicious traffic analysis.Distributed denial of service(DDoS)attacks are becoming a more serious daily threat.Malicious actors in DDoS attacks control numerous infected machines known as botnets.Botnets are used to send numerous fake requests to overwhelm the resources of victims and make them unavailable for some periods.To date,such attacks present a major devastating security threat on the Internet.This paper proposes an effective and efficient machine learning(ML)-based DDoS detection approach for the early warning and protection of the Saudi Arabia Internet exchange point(SAIXP)platform.The effectiveness and efficiency of the proposed approach are verified by selecting an accurate ML method with a small number of input features.A chi-square method is used for feature selection because it is easier to compute than other methods,and it does not require any assumption about feature distribution values.Several ML methods are assessed using holdout and 10-fold tests on a public large-size dataset.The experiments showed that the performance of the decision tree(DT)classifier achieved a high accuracy result(99.98%)with a small number of features(10 features).The experimental results confirmthe applicability of using DT and chi-square for DDoS detection and early warning in SAIXP.

经筋透刺法联合穴位注射治疗顽固性面瘫60例临床观察

目的探讨经筋透刺法联合穴位注射治疗顽固性面瘫的临床疗效。方法选取2020年5月至2021年10月在遂宁市中医院接受治疗的120例顽固性面瘫病人,采用随机数字表法随机分为单一组(60例)和联合组(60例),两组病人均给予常规西药治疗,单一组在此基础上给予穴位注射,联合组在此基础上给予经筋透刺法联合穴位注射,比较两组病人治疗前后面神经功能、神经生长因子(NGF)和胶质细胞源性神经营养因子(GDNF)水平、神经功能分级(H-B)评分、面瘫Portmann评分、Sunnybrook量表、复发率及临床疗效。结果单一组和联合组治疗后面神经功能明显改善,且联合组面神经功能改善情况明显优于单一组(P<0.05);单一组H-B评分治疗后较治疗前降低(2.63±0.54)分比(4.01±0.73)分,联合组(1.67±0.49)分比(4.03±0.71)分(P<0.05),且联合组H-B评分低于单一组(P<0.05),单一组和联合组GDNF(12.16±3.33)mg/L比(8.92±1.35)mg/L、(15.54±3.42)mg/L比(8.89±1.37)mg/L、NGF水平(12.16±3.33)mg/L比(8.92±1.35)mg/L、(15.54±3.42)mg/L比(8.89±1.37)mg/L、面瘫Portmann评分(15.31±1.03)分比(6.69±0.68)分、(17.24±1.16)分比(6.72±0.71)分、Sunnybrook量表评分(69.16±10.67)分比(36.42±10.17)分、(78.64±11.56)分比(36.17±10.13)分治疗后较治疗前升高,且联合组GDNF、NGF水平、面瘫Portmann评分、Sunnybrook量表评分高于单一组(P<0.05);联合组总复发率(3.33%)低于单一组(13.33%)(P<0.05);联合组总有效率(90.00%)明显高于单一组(75.00%)(P<0.05)。结论经筋透刺法联合穴位注射可改善顽固性面瘫病人临床症状及面神经功能,疗效较好且复发率较低。

基于“经脉所过,主治所及”理论探讨阿尔茨海默病的辨经论治

阿尔茨海默病(alzheimer’s disease,AD)是一种中枢神经系统退行性疾病,其治疗是现阶段的研究热点。中医对AD的发病机制和治疗有独到的见解,文章从五脏角度阐述了它的病因病机,从针刺作用方面解释了其治疗原则。针灸在AD的治疗上具有独特的优势和效果,针刺通过调节脏腑经脉的阴阳气血平衡,达到治疗效果,穴位的选择和针法的选取是针灸治疗中的重中之重。文章从“经脉所过,主治所及”理论出发,通过回顾针灸治疗AD的基础和临床研究,探讨了在AD的治疗中所选取的经脉、经脉中的穴位,分析了经脉及穴位的作用机制,同时讨论了在临床AD治疗中各家针法的选穴及中、西医作用原理。希冀通过文章为广大科研工作者提供研究思路,进一步揭示针刺在AD治疗中的深层作用原理,以期为临床治疗AD提供一定的参考依据,寻找可能具有真正改善疾病的治疗方法。

补肾壮骨温经汤配合针刺循经取穴治疗类风湿性膝关节炎的疗效研究

目的观察补肾壮骨温经汤配合针刺循经取穴治疗类风湿性膝关节炎(RG)的疗效。方法选取2020年6月至2022年6月宝鸡市中医医院收治的102例RG患者作为研究对象,按随机数表法分为联合组、对照1组与对照2组各34例。对照1组患者给予常规西药治疗,对照2组患者给予常规西药联合针刺循经取穴治疗,联合组患者则在对照2组基础上予以补肾壮骨温经汤联合治疗。治疗3个月后,比较三组患者的临床疗效及治疗前后的临床证候评分、骨关节炎指数(WOMAC)评分以及血清学指标[类风湿因子(RF)、红细胞沉降率(ESR)、抗环状瓜氨酸抗体(CCP)]水平;同时比较三组患者治疗期间的不良反应的发生情况。结果联合组患者的临床治疗总有效率为91.18%,明显高于对照1组的64.71%和对照2组的70.59%,差异均具有统计学意义(P<0.05),但对照1组与对照2组患者的治疗总有效率比较差异均无统计学意义(P>0.05);治疗3个月后,联合组患者的关节冷痛、屈伸不利、肿胀、头晕耳鸣以及肢体沉重各临床证候评分明显低于对照1组与对照2组,差异均具有统计学意义(P<0.05),但对照1组与对照2组患者的临床证候评分比较差异均无统计学意义(P>0.05);联合组患者的WOMAC评分为(38.45±11.48)分,明显低于对照1组的(45.58±12.71)分和对照2组的(44.34±12.06)分,且联合组患者的RF、ESR及CCP水平分别为(86.37±14.74)IU/mL、(32.27±3.38)mm/h、(187.34±19.08)IU/mL,明显低于对照1组的(103.22±16.75)IU/mL、(43.16±5.25)mm/h、(219.58±21.77)IU/mL和对照2组的(98.41±15.28)IU/mL、(41.83±5.19)mm/h、(210.66±19.48)IU/mL,差异均有统计学意义(P<0.05),但对照1组与对照2组患者的WOMAC评分、RF、ESR及CCP水平比较差异均无统计学意义(P>0.05);治疗期间三组患者的不良反应总发生率比较差异无统计学意义(P>0.05)。结论补肾壮骨温经汤配合针刺循经取穴治疗RG可有效缓解患者的相关临床症状,改善膝关节功能及血清学指标水平,临床疗效确切,具有临床应用价值。