Monomethoxy poly(ethylene glycol)-block-poly(D,L-lactic acid)(PEG-PLA)is a typical amphiphilic di-block copolymer widely used as a nanoparticle carrier(nanocarrier)in drug delivery.Understanding the in vivo fate of PE...Monomethoxy poly(ethylene glycol)-block-poly(D,L-lactic acid)(PEG-PLA)is a typical amphiphilic di-block copolymer widely used as a nanoparticle carrier(nanocarrier)in drug delivery.Understanding the in vivo fate of PEG-PLA is required to evaluate its overall safety and promote the development of PEG-PLA-based nanocarrier drug delivery systems.However,acquiring such understanding is limited by the lack of a suitable analytical method for the bioassay of PEG-PLA.In this study,the pharmacokinetics,biodistribution,metabolism and excretion of PEG-PLA were investigated in rat after intravenous administration.The results show that unchanged PEG-PLA is mainly distributed to spleen,liver,and kidney before being eliminated in urine over 48 h mainly(>80%)in the form of its PEG metabolite.Our study provides a clear and comprehensive picture of the in vivo fate of PEG-PLA which we anticipate will facilitate the scientifc design and safety evaluation of PEG-PLA-based nanocarrier drug delivery systems and thereby enhance their clinical development.展开更多
The goal of this study is to design and synthesize a linear segmented shape memory poly（urethane-urea） （SMPUU） that possesses near-body-temperature shape memory temperature （Ttran） and enhanced mechanical proper...The goal of this study is to design and synthesize a linear segmented shape memory poly（urethane-urea） （SMPUU） that possesses near-body-temperature shape memory temperature （Ttran） and enhanced mechanical properties by incorporating flexible poly（ethylene glycol） 400 （PEG400） to form poly（D,L-lactic acid）-based macro- diols （PDLLA-PEG400-PDLLA） and then rigid piperazine （PPZ） as a chain extender to form the desired SMPUUs （PEG400-PUU-PPZ）. PEG400 increased Mn while maintaining a lower Tg of PDLLA-PEG400-PDLLA, which together with PPZ improved the mechanical properties of PEG400-PUU-PPZ. The obtained optimum SMPUU with enhanced mechanical properties （O＇y = 24.28 MPa; zf = 698%; Uf = 181.5 MJIm3） and a Tg of 40.62~C exhibited sound shape memory properties as well, suggesting a promising SMPUU for in vivo biomedical applications.展开更多
基金supported by the National Natural Science Foundation of China(Grant Nos.81872831 and 82030107)the National Science and Technology Major Projects for signifcant new drugs creation of the 13th fve-year plan(2017ZX09101001 and 2018ZX09721002007,China)。
文摘Monomethoxy poly(ethylene glycol)-block-poly(D,L-lactic acid)(PEG-PLA)is a typical amphiphilic di-block copolymer widely used as a nanoparticle carrier(nanocarrier)in drug delivery.Understanding the in vivo fate of PEG-PLA is required to evaluate its overall safety and promote the development of PEG-PLA-based nanocarrier drug delivery systems.However,acquiring such understanding is limited by the lack of a suitable analytical method for the bioassay of PEG-PLA.In this study,the pharmacokinetics,biodistribution,metabolism and excretion of PEG-PLA were investigated in rat after intravenous administration.The results show that unchanged PEG-PLA is mainly distributed to spleen,liver,and kidney before being eliminated in urine over 48 h mainly(>80%)in the form of its PEG metabolite.Our study provides a clear and comprehensive picture of the in vivo fate of PEG-PLA which we anticipate will facilitate the scientifc design and safety evaluation of PEG-PLA-based nanocarrier drug delivery systems and thereby enhance their clinical development.
文摘The goal of this study is to design and synthesize a linear segmented shape memory poly（urethane-urea） （SMPUU） that possesses near-body-temperature shape memory temperature （Ttran） and enhanced mechanical properties by incorporating flexible poly（ethylene glycol） 400 （PEG400） to form poly（D,L-lactic acid）-based macro- diols （PDLLA-PEG400-PDLLA） and then rigid piperazine （PPZ） as a chain extender to form the desired SMPUUs （PEG400-PUU-PPZ）. PEG400 increased Mn while maintaining a lower Tg of PDLLA-PEG400-PDLLA, which together with PPZ improved the mechanical properties of PEG400-PUU-PPZ. The obtained optimum SMPUU with enhanced mechanical properties （O＇y = 24.28 MPa; zf = 698%; Uf = 181.5 MJIm3） and a Tg of 40.62~C exhibited sound shape memory properties as well, suggesting a promising SMPUU for in vivo biomedical applications.
