Objective: There are numerous studies suggesting that genetic polymor-phisms of inflammation factors Toll-like receptors 2 and 4 (TLR2, TLR4) might play a role in the pathophysiological process of hypertension. In thi...Objective: There are numerous studies suggesting that genetic polymor-phisms of inflammation factors Toll-like receptors 2 and 4 (TLR2, TLR4) might play a role in the pathophysiological process of hypertension. In this study, we evaluated the association in a sample of members of the Chinese Han population. Method: We selected four single nucleotide polymor-phisms (SNP) of TLR2 (rs3804099, rs3804100, rs7656411) and TLR4 (rs1927906) genes, and measured the distributions of genotypic and allelic frequencies in 1063 participants, including 391 essential hypertension pa-tients and 672 controls. Result: No significant differences in the genotypic and allelic frequencies of the four SNPs were detected between cases and controls. However, three haplotypes, CCG, TTG and TTT of TLR2, were significantly associated with a decrease in the risk of essential hyperten-sion (OR: 0.512, 95% CI: 0.397 - 0.660, P P = 0.0038;OR: 0.797, 95% CI: 0.667 - 0.952, P = 0.0122, respectively). Inversely, the risk of essential hypertension increased sig-nificantly in patients with the CTG, TCG or TCT haplotypes (OR: 2.924, 95% CI: 2.157 - 3.963, P P P Conclusion: Our study suggested that haplotypes (CCG, TTG, TTT, CTG, TCG and TCT) of TLR2 might have profound effects on the development of essential hypertension in the Chinese Han population.展开更多
目的:评价miRNA-146a rs2910164 G/C基因多态性与大肠癌易感性的相关性.方法:全面检索Pubmed、Excerpta Medica Database(Embase)、Chinese Biomedical Literature Database(CBM)and the Cochrane L i b r a r y、维普、万方数据库,收...目的:评价miRNA-146a rs2910164 G/C基因多态性与大肠癌易感性的相关性.方法:全面检索Pubmed、Excerpta Medica Database(Embase)、Chinese Biomedical Literature Database(CBM)and the Cochrane L i b r a r y、维普、万方数据库,收集研究miRNA-146a rs2910164 G/C基因多态性与大肠癌易感性相关性的文献.对miRNA-146a rs2910164 G/C各基因型的比较模型(G vs C、GG vs CC、GG vs GC、GC vs CC、GG+GC vs CC、GG vs GC+CC)进行定量综合分析.结果:共纳入7篇文献,共有大肠癌患者2978例,健康对照3576例.Meta分析尚未发现miRNA-146a rs2910164 G/C基因多态性与大肠癌易感性具有相关性(G vs C:OR=0.82,95%CI:0.52-1.30,P=0.41;GG vs CC:OR=1.10,95%CI:0.72-1.40,P=0.97;GG vs GC:OR=1.10,95%CI:0.81-1.28,P=0.91;GC vs CC:OR=0.99,95%CI:0.70-1.41,P=0.96;GG+GC vs CC:OR=1.00,95%CI:0.72-1.39,P=0.99;GG vs GC+CC:OR=1.00,95%CI:0.81-1.24,P=0.98).结论:本研究尚未发现miRNA-146a rs2910164G/C基因多态性与大肠癌易感性之间具有相关性.展开更多
文摘Objective: There are numerous studies suggesting that genetic polymor-phisms of inflammation factors Toll-like receptors 2 and 4 (TLR2, TLR4) might play a role in the pathophysiological process of hypertension. In this study, we evaluated the association in a sample of members of the Chinese Han population. Method: We selected four single nucleotide polymor-phisms (SNP) of TLR2 (rs3804099, rs3804100, rs7656411) and TLR4 (rs1927906) genes, and measured the distributions of genotypic and allelic frequencies in 1063 participants, including 391 essential hypertension pa-tients and 672 controls. Result: No significant differences in the genotypic and allelic frequencies of the four SNPs were detected between cases and controls. However, three haplotypes, CCG, TTG and TTT of TLR2, were significantly associated with a decrease in the risk of essential hyperten-sion (OR: 0.512, 95% CI: 0.397 - 0.660, P P = 0.0038;OR: 0.797, 95% CI: 0.667 - 0.952, P = 0.0122, respectively). Inversely, the risk of essential hypertension increased sig-nificantly in patients with the CTG, TCG or TCT haplotypes (OR: 2.924, 95% CI: 2.157 - 3.963, P P P Conclusion: Our study suggested that haplotypes (CCG, TTG, TTT, CTG, TCG and TCT) of TLR2 might have profound effects on the development of essential hypertension in the Chinese Han population.
文摘目的:评价miRNA-146a rs2910164 G/C基因多态性与大肠癌易感性的相关性.方法:全面检索Pubmed、Excerpta Medica Database(Embase)、Chinese Biomedical Literature Database(CBM)and the Cochrane L i b r a r y、维普、万方数据库,收集研究miRNA-146a rs2910164 G/C基因多态性与大肠癌易感性相关性的文献.对miRNA-146a rs2910164 G/C各基因型的比较模型(G vs C、GG vs CC、GG vs GC、GC vs CC、GG+GC vs CC、GG vs GC+CC)进行定量综合分析.结果:共纳入7篇文献,共有大肠癌患者2978例,健康对照3576例.Meta分析尚未发现miRNA-146a rs2910164 G/C基因多态性与大肠癌易感性具有相关性(G vs C:OR=0.82,95%CI:0.52-1.30,P=0.41;GG vs CC:OR=1.10,95%CI:0.72-1.40,P=0.97;GG vs GC:OR=1.10,95%CI:0.81-1.28,P=0.91;GC vs CC:OR=0.99,95%CI:0.70-1.41,P=0.96;GG+GC vs CC:OR=1.00,95%CI:0.72-1.39,P=0.99;GG vs GC+CC:OR=1.00,95%CI:0.81-1.24,P=0.98).结论:本研究尚未发现miRNA-146a rs2910164G/C基因多态性与大肠癌易感性之间具有相关性.
文摘目的:本Meta分析旨在探讨基质金属蛋白酶-2(matrix metalloproteinase-2,MMP-2)基因启动子区单核苷酸(C-1306T,rs243865)多态性与胃癌(gastric cancer,GC)易感性的关联.方法:参照Cochrance协作网制定的检索策略进行检索,计算机检索MEDLINE(1966-2013)、the Cochrane Library Database(Issue 12,2013)、EMBASE(1980-2013)、CINAHL(1982-2013)、Web of Science(1945-2013)、中国生物医学文献数据库(CBM)(1982-2013)、万方(1998-2013)和中国知网(CNKI)(1915-2013)等.使用STATA12.0统计软件进行M e t a分析,分别计算危险比(risk ratio,RR)及其95%可信区间(95%confidence intervals,95%CI).结果:本Meta分析共计纳入7项病例对照研究,1687例GC患者和2253名健康对照者.Meta分析结果表明:MMP-2基因C-1306T多态性可能与GC发生风险显著相关等位基因模型:RR=1.05,95%CI:1.03-1.08,P<0.001;显性基因模型:RR=1.01,95%CI:1.00-1.02,P=0.046.根据种族不同进行亚组分析发现:在亚洲人群中,MMP-2基因C-1306T多态性可能增加患GC的风险RR=1.06,95%CI:1.04-1.08,P<0.001,但在欧美人群中见明显关联性(P>0.05).进一步根据检测方法、基因型、样本量大小进行亚组分析发现,在多数亚组中发现他们之间均存在显著相关性(均P<0.05).结论:MMP-2基因C-1306T多态性可能与亚洲人群GC易感性的增加有关.
