Objective:To perform a systematic review and meta analysis on the association of C-589T and C-590T polymorphisms of IL-4 with asthma and to estimate allele frequencies, the magnitude of the gene effect as well as the ...Objective:To perform a systematic review and meta analysis on the association of C-589T and C-590T polymorphisms of IL-4 with asthma and to estimate allele frequencies, the magnitude of the gene effect as well as the possible mode of inheritance. Methods: A genetic model-free approach was used to perform a meta analysis. Heterogeneity, sensitivity analysis and publication bias were also explored. Results: Our meta analysis summarized the evidence to date regarding the association of C-589T and C-590T polymorphisms in the promoter region of IL-4 gene with asthma. For C-590T, the results showed a significant recessive genetic model, and the CC genotype was about 24% less likely to have asthma than the genotype CT and TT. Although there was evidence suggesting a recessive genetic model for C-589T, the recessive model was not statistically significant. Conclusion: This meta analysis suggests that there may be an important effect of single nucleotide polymorphisms (SNPs) in the promoter region of IL-4 gene on the pathogenesis of asthma.展开更多
目的研究白细胞介素-23受体(IL-23R)基因多态性与汉族人银屑病易感性的关系。方法结合本课题组银屑病易感基因的全基因组关联分析数据,在1103例银屑病患者和1104例正常对照中,应用Sequenom Mass Array质谱阵列技术对IL-23R基因及其上、...目的研究白细胞介素-23受体(IL-23R)基因多态性与汉族人银屑病易感性的关系。方法结合本课题组银屑病易感基因的全基因组关联分析数据,在1103例银屑病患者和1104例正常对照中,应用Sequenom Mass Array质谱阵列技术对IL-23R基因及其上、下游各大约10kb范围内的8个标签单核苷酸多态性(TagSNP)进行基因分型,用Plink1.03软件对数据资料进行统计分析。结果8个TagSNP位点的等位基因频率在病例组和对照组之间的差异无统计学意义(P>0.05)。结论IL-23R基因多态性可能与汉族人银屑病易感性无关联。展开更多
基金Supported by a grant from the Science Foundation of Third Military Medical University (No. XG200353)
文摘Objective:To perform a systematic review and meta analysis on the association of C-589T and C-590T polymorphisms of IL-4 with asthma and to estimate allele frequencies, the magnitude of the gene effect as well as the possible mode of inheritance. Methods: A genetic model-free approach was used to perform a meta analysis. Heterogeneity, sensitivity analysis and publication bias were also explored. Results: Our meta analysis summarized the evidence to date regarding the association of C-589T and C-590T polymorphisms in the promoter region of IL-4 gene with asthma. For C-590T, the results showed a significant recessive genetic model, and the CC genotype was about 24% less likely to have asthma than the genotype CT and TT. Although there was evidence suggesting a recessive genetic model for C-589T, the recessive model was not statistically significant. Conclusion: This meta analysis suggests that there may be an important effect of single nucleotide polymorphisms (SNPs) in the promoter region of IL-4 gene on the pathogenesis of asthma.
文摘植物的DREB2转录因子具有抗旱、抗盐碱的功能。对小麦族赖草属的14个物种的DREB2基因进行了克隆、测序和比对分析。结果表明:(1)14个赖草属植物的DREB2基因序列和氨基酸序列相对保守,总相似度分别为98.05%和97.78%;(2)Leymus mollis的DREB2基因在编码区有3 bp CTT的缺失;(3)14条DREB2基因序列共发现79个SNP,SNP发生频率为1SNP/10.6 bp;(4)进化树分析显示DREB2基因能把14个赖草属物种很好的分开。
文摘目的研究白细胞介素-23受体(IL-23R)基因多态性与汉族人银屑病易感性的关系。方法结合本课题组银屑病易感基因的全基因组关联分析数据,在1103例银屑病患者和1104例正常对照中,应用Sequenom Mass Array质谱阵列技术对IL-23R基因及其上、下游各大约10kb范围内的8个标签单核苷酸多态性(TagSNP)进行基因分型,用Plink1.03软件对数据资料进行统计分析。结果8个TagSNP位点的等位基因频率在病例组和对照组之间的差异无统计学意义(P>0.05)。结论IL-23R基因多态性可能与汉族人银屑病易感性无关联。
