生长激素(PST)脂质体的制备

用冰冻熔融法制备脂质体 ,包封率可达 2 9% ,当n(卵磷脂 )∶n(胆固醇 ) =5∶2 (摩尔比 ) ,超声时间 3min ,中性环境 ,冰冻 2 4h或 4℃贮藏 3d ,其稳定性良好 ,包封率 (2 9.1± 0 .4) % ,变化不显著。

Studies on Pharmacokinetics of Porcine Somatotropin Liposomes

This paper focuses on the pharmacokinetics in fattening pigs as well as the change of serum resulting from the use of porcine somatotropin(PST) and its liposomes. A slow-release model was determined to be relevant to following an examination of all dynamic parameters. The results indicate that the slow-release effect of PST liposomes was significant, with an extended release time of over 7 d.

生长激素脂质体的研制

用冰冻熔融法制备脂质体 ,包封率可达 2 9% ,当n(卵磷脂 )∶n(胆固醇 ) =5∶2 ,超声时间 3min ,中性环境 ,冰冻 2 4h或 4℃贮藏 3d ,其稳定性良好 ,包封率 ( 2 9.1± 0 .4 ) % 。

猪用生长激素脂质体对小鼠的促生长作用

[目的]研究猪用生长激素(porcine somatotropin,PST)脂质体对小鼠的促生长作用与缓释效果。[方法]将试验小鼠随机分组,试验组小鼠分别腹腔注射PST纯品和PST脂质体,对照组腹腔注射生理盐水。分别于7、14和28 d后称重,计算小鼠增重率。[结果]试验组小鼠增重与对照组差异显著(P<0.05),表明PST和PST脂质体对小鼠有促生长作用,且PST脂质体具有明显的缓释效果。[结论]PST脂质体缓释期长达7 d以上,具有显著的促生长效果。