BACKGROUND Transhepatic arterial chemoembolization(TACE),as a local treatment,has been widely used in the treatment of unresectable liver cancer.The introduction of drug carrier microspheres has brought new hope for t...BACKGROUND Transhepatic arterial chemoembolization(TACE),as a local treatment,has been widely used in the treatment of unresectable liver cancer.The introduction of drug carrier microspheres has brought new hope for the therapeutic effect of TACE.Microspheres can realize the slow release and directional delivery of drugs,reduce systemic toxicity and improve local curative effect.AIM To compare the effectiveness of traditional transcatheter arterial chemoembolization against microsphere-assisted transcatheter arterial chemoembolization in the treatment of hepatocellular carcinoma that is incurable.METHODS We searched the PubMed,Embase,Cochrane Library,and CNKI databases for clinical trials of drug-luting beads TACE(DEB-TACE)vs conventional TACE(cTACE)for the treatment of unresectable liver cancer.We screened references based on inclusion and exclusion criteria and then selected valid data for meta-analysis using RevMan 53 software.The complete response(CR)rate,partial response(PR)rate,postoperative stable disease(SD)rate,and 6-month and 12-month survival rates were compared.RESULTS A total of 12 articles were included,including 1177 patients,519 of whom received DEB-TACE and 658 of whom received cTACE.The CR rate in the DEB-TACE group was much greater than that in the cTACE group[relative risk(RR)=1.42,95%CI:1.18-1.72,P=0.0002].The 12-month survival rate significantly increased(RR=1.09;95%CI:1.01-1.17,P=0.03);the PR rate(RR=1.13;95%CI:0.97-1.30,P=0.12);the SD rate(RR=0.82;95%CI:0.64-1.05,P=0.12);and the 6-month survival rate(RR=1.05;95%CI:1.00-1.10,P=0.07).There was no significant difference(P<0.05).CONCLUSION Compared with those of iodized oil TACE,the drug-loaded microspheres tended to have therapeutic advantages.展开更多
Background:In facial plastic surgery,patients with nasal deformity are often treated by rib cartilage transplantation.In recent years,cartilage tissue engineering has developed as an alternative to complex surgery for...Background:In facial plastic surgery,patients with nasal deformity are often treated by rib cartilage transplantation.In recent years,cartilage tissue engineering has developed as an alternative to complex surgery for patients with minor nasal defects via injection of nasal filler material.In this study,we prepared an injectable nasal filler material containing poly-L-l actic acid(PLLA)porous microspheres(PMs),hyaluronic acid(HA)and adipose-derived mesenchymal stem cells(ADMSCs).Methods:We seeded ADMSCs into as-prepared PLLA PMs using our newly invented centrifugation perfusion technique.Then,HA was mixed with ADMSC-i ncorporated PLLA PMs to form a hydrophilic and injectable cell delivery system(ADMSCincorporated PMH).Results:We evaluated the biocompatibility of PMH in vitro and in vivo.PMH has good injectability and provides a favorable environment for the proliferation and chondrogenic differentiation of ADMSCs.In vivo experiments,we observed that PMH has good biocompatibility and cartilage regeneration ability.Conclusion:In this study,a injectable cell delivery system was successfully constructed.We believe that PMH has potential application in cartilage tissue engineering,especially in nasal cartilage regeneration.展开更多
BACKGROUND Liver cancer is a malignant tumor with high morbidity and mortality.Transcatheter arterial chemoembolization(TACE)is the main method for surgically unresectable liver cancer.In recent years,drug-loaded micr...BACKGROUND Liver cancer is a malignant tumor with high morbidity and mortality.Transcatheter arterial chemoembolization(TACE)is the main method for surgically unresectable liver cancer.In recent years,drug-loaded microspheres have been gradually applied in TACE technology.There are some controversies about the therapeutic effects of drug-loaded microspheres TACE(D-TACE)and traditional TACE.AIM To explore the short-term efficacy of D-TACE and traditional TACE in the treatment of advanced liver cancer.METHODS The clinical data of 73 patients with advanced liver cancer admitted to the First and Sixth Medical Centers of Chinese PLA General Hospital from January 2017 to October 2019 were retrospectively analyzed.Among them,15 patients were treated with D-TACE,and 58 patients were treated with traditional TACE.Clinical baseline characteristics,perioperative laboratory indices,postoperative adverse reactions and postoperative complications were compared between the two groups.RESULTS There was no statistical difference between the two groups for the postoperative response:The highest postoperative body temperature of the drug-loaded microsphere group was 38.0±0.9℃and the postoperative highest body temperature of the traditional TACE group was 38.3±0.7℃(t=-1.414,P=0.162).For the 24 h postoperative nausea and vomiting after surgery in terms of scoring and postoperative pain scores,the traditional TACE group was higher than the drugloaded microsphere group(χ2=14.33,P=0.014;χ2=32.967,P=0.000)and the two groups had significant statistical differences.The disease control rate at 3 mo after treatment in the drugloaded microsphere group was 60%and the disease control rate at 3 mo after treatment in the traditional TACE group was 75.9%(χ2=4.091,P=0.252).There was no statistical difference between the two groups of data.During the follow-up period,the number of interventional treatments received was once in the drug-loaded microsphere group and the traditional TACE group received an average of 1.48 treatments(χ2=10.444 P=0.005).There was a statistical difference between the two groups.CONCLUSION Compared with traditional TACE,D-TACE may have some advantages in the treatment of advanced hepatocellular carcinoma with a large tumor load in the short term,but the long-term clinical efficacy needs additional follow-up studies.In addition,compared with the traditional group,the patients in the drug-loaded microsphere group had better subjective tolerance and could reduce the number of interventional treatments.Therefore,D-TACE is worthy of clinical promotion.展开更多
A molten salt method was developed to prepare porous La1‐xSrxMn0.8Fe0.2O3 (0≤ x ≤ 0.6) micro‐spheres using hierarchical porous δ‐MnO2 microspheres as a template in eutectic NaNO3‐KNO3. X‐ray diffraction patt...A molten salt method was developed to prepare porous La1‐xSrxMn0.8Fe0.2O3 (0≤ x ≤ 0.6) micro‐spheres using hierarchical porous δ‐MnO2 microspheres as a template in eutectic NaNO3‐KNO3. X‐ray diffraction patterns showed that single phase LaMn0.8Fe0.2O3 with good crystallinity was syn‐thesized at 450℃ after 4 h. Transmission electron microscope images exhibited that the LaMn0.8Fe0.2O3 sample obtained at 450?? after 4 h possessed a porous spherical morphology com‐posed of aggregated nanocrystallites. Field emission scanning electron microscope images indicated that the growth of the porous LaMn0.8Fe0.2O3 microspheres has two stages. SEM pictures showed that a higher calcination temperature than 450?? had an adverse effect on the formation of a po‐rous spherical structure. The LaMn0.8Fe0.2O3 sample obtained at 450?? after 4 h displayed a high BET surface area of 55.73 m2/g with a pore size of 9.38 nm. Fourier transform infrared spectra suggested that Sr2+ions entered the A sites and induced a decrease of the binding energy between Mn and O. The CO conversion with the La1‐xSrxMn0.8Fe0.2O3 (0≤x≤0.6) samples indicated that the La0.4Sr0.6Mn0.8Fe0.2O3 sample had the best catalytic activity and stability. Further analysis by X‐ray photoelectron spectroscopy demonstrated that Sr2+doping altered the content of Mn4+ions, oxygen vacancies and adsorbed oxygen species on the surface, which affected the catalytic performance for CO oxidation.展开更多
Porous titanium with porosity of 60% was prepared by metal injection molding(MIM),and coated with gelatin sustained-release microspheres which were made by improved emulsified cold condensation method.The effects of...Porous titanium with porosity of 60% was prepared by metal injection molding(MIM),and coated with gelatin sustained-release microspheres which were made by improved emulsified cold condensation method.The effects of porous titanium coated with insulin-like growth factor-1(IGF-1) and transforming growth factor-β1(TGF-β1) gelatin microspheres on the function of MG63 cells were evaluated in vitro.The results show that porous titanium coated with gelatin sustained-release microspheres has no cytotoxicity.The IGF-1 and TGF-β1 loading concentrations are positively correlative with the proliferation and differentiation of MG63 after co-culturing with the concentrations of IGF-1 and TGF-β1 gelatin microspheres in the range of 0.1-10 ng/mg and 0.25-2.5 ng/mg,respectively.The MG63 cells exhibit the best proliferation and differentiation with the IGF-1 and TGF-β1 loading concentrations of 10 ng/mg and 2.5 ng/mg,respectively.The joint application of IGF-1 and TGF-β1 group,which promote adhesion,proliferation and differentiation of MG63 cells,is superior to a single application group.展开更多
Water contamination caused by hazardous organic dyes has drawn considerable attention, among all of the techniques released, adsorption has been widely used, which however to a large degree is dependent on the develop...Water contamination caused by hazardous organic dyes has drawn considerable attention, among all of the techniques released, adsorption has been widely used, which however to a large degree is dependent on the development of high efficiency adsorbents. Waste biomass based porous carbon is becoming the new star class of adsorbents, and thus contribute more to the sustainable development of the society. In this work, for the first time to the best of our knowledge, abundant waste fallen Platanus orientalis leaves are employed as the raw material for hierarchical activated porous carbon(APC) microspheres via a mild hydrothermal carbonization(210 ℃,12.0 h) followed by one-step calcination(750 ℃, 1.0 h). The APC microspheres exhibit a specific surface area of 1355.53 m^2·g^-1 and abundant functional groups such as O—H and C=O. Furthermore, the APC microspheres are used as the adsorbents for removal of Rh B and MO, with the maximum adsorption capabilities of 557.06 mg·g^-1 and 327.49 mg·g^-1, respectively, higher than those of the most porous carbon originated from biomass. The adsorption rates rapidly approach to 98.2%(RhB) and 95.4%(MO) within 10 min. The adsorption data can be well fitted by Langmuir isotherm model and the pseudo-second-order kinetic model, meanwhile the intra-particle diffusion and Boyd models simultaneously indicate that the diffusion within the pores is the main rate-limiting step. Besides, the APC microspheres also demonstrate good recyclability, and may also be applied to other areas such as heterogeneous catalysis and energy storage.展开更多
Functional porous microspheres used for the slow release carrier of actives in cosmetics or pharmaceuticals were prepared by modified suspension polymerization of styrene (ST) with divinylbenzene (DVB) in the pres...Functional porous microspheres used for the slow release carrier of actives in cosmetics or pharmaceuticals were prepared by modified suspension polymerization of styrene (ST) with divinylbenzene (DVB) in the presence of toluene, cyclohexanol and heptane as porogenic diluents. The use of ultrasonic dispersion decreases the beads' size and improves the uniformity. The effects of the porogen mixture, DVB content and solvent extraction on the surface performance of the synthesized beads were studied. The microspheres were characterized by scanning electron microscopy (SEM) and BET surface area determination. It was found that a great proportion of the non-solvating porogen increases the pore diameter and the specific surface area. High DVB concentration also results in the great specific surface area and porosity. When the ratio of toluene/cyclohexanol is 1:2, DVB content is at the range of 40%-60% and methylene chloride was used as extractant, the beads with good spherical shape and pore size were obtained. The prepared porous microspheres were applied as active carriers and showed satisfactory slow release effect. Over 10h constantly sustained release was observed in vitro releasing test for hydroquinone-loaded microspheres. Great surface area promoted high concentration of released hydroquinone.展开更多
Metal–organic framework-templated nitrogen-doped graphitic carbon(NGC)and polydopaminederived carbon(PDA-derived C)-double coated one-dimensional CoSe_(2) nanorods supported highly porous threedimensional microsphere...Metal–organic framework-templated nitrogen-doped graphitic carbon(NGC)and polydopaminederived carbon(PDA-derived C)-double coated one-dimensional CoSe_(2) nanorods supported highly porous threedimensional microspheres are introduced as anodes for excellent Na-ion batteries,particularly with long-lived cycle under carbonate-based electrolyte system.The microspheres uniformly composed of ZIF-67 polyhedrons and polystyrene nanobeads(φ=40 nm)are synthesized using the facile spray pyrolysis technique,followed by the selenization process(P-CoSe_(2)@NGC NR).Further,the PDA-derived C-coated microspheres are obtained using a solution-based coating approach and the subsequent carbonization process(P-CoSe_(2)@PDA-C NR).The rational synthesis approach benefited from the synergistic effects of dual carbon coating,resulting in a highly conductive and porous nanostructure that could facilitate rapid diffusion of charge species along with efficient electrolyte infiltration and effectively channelize the volume stress.Consequently,the prepared nanostructure exhibits extraordinary electrochemical performance,particularly the ultra-long cycle life stability.For instance,the advanced anode has a discharge capacity of 291(1000th cycle,average capacity decay of 0.017%)and 142 mAh g^(-1)(5000th cycle,average capacity decay of 0.011%)at a current density of 0.5 and 2.0 A g^(-1),respectively.展开更多
Used as high-performance electrodes,both structural and compositional alterations of carbon materials play very important roles in energy conversion/storage devices.Especially in supercapacitors,hierarchical pores and...Used as high-performance electrodes,both structural and compositional alterations of carbon materials play very important roles in energy conversion/storage devices.Especially in supercapacitors,hierarchical pores and heteroatom doping in carbon materials are indispensable.Here the rambutan-like hierarchically porous carbon microspheres(PCMs)have been constructed via a hydrothermal treatment,followed by carbonization/activation.The hierarchically porous microstructure is composed of three-dimensional porous carbon networks,which give rise to a large surface area.Moreover,N and O functional groups are introduced in the as-prepared samples,which could generate the extra pseudocapacitance.Benefitting from the interconnected hierarchical and open structure,PCM exhibits outstanding capacitive performance,for example,superior specific capacitance and rate capability(397 and 288 F g^(−1) at 0.5 and 20A g^(−1),respectively),as well as long cycling stability(about 95%capacitance retention after 10,000 cycles).These encouraging results may pave an efficient way to fabricate advanced supercapacitors in the future.展开更多
It is hoped to develop a simple and low cost route for preparing the CaO with a novel morphology which can present high catalytic activity in catalyzing transesterification reaction for biodiesel. The porous CaO micro...It is hoped to develop a simple and low cost route for preparing the CaO with a novel morphology which can present high catalytic activity in catalyzing transesterification reaction for biodiesel. The porous CaO microsphere was synthesized by calcining spherical CaCO3 precursor which was prepared easily by mixing CaCl2 with Na2CO3. The as-prepared CaO microsphere was characterized by scanning electronic microscopy(SEM), powder X-ray diffractometry(XRD) and N2 adsorption experiment. The results reveal that the synthesized CaO is regular microsphere with many pores in its exterior and interior. The CaO microsphere is applied in catalyzing the transesterification reaction of soybean oil for biodiesel and presents excellent catalytic ability with a transesterification yield of 98.72%. This catalyst could have potential applications in other fields in view of its well-defined morphology, simply synthetic route and low cost.展开更多
A facile eco-friendly hydrothermal route (180 ℃, 12.0 h) has been developed for the first time to the uniform hierarchical porous MgBO2(OH) microspheres without the aid of any organic additive, surfactant or temp...A facile eco-friendly hydrothermal route (180 ℃, 12.0 h) has been developed for the first time to the uniform hierarchical porous MgBO2(OH) microspheres without the aid of any organic additive, surfactant or template, by using the abundant MgCl2·6H2O, H3BO3 and NaOH as the raw materials. The as-obtained porous microspheres exhibit a specific surface area of 94.752 mg·g-1, pore volume of 0.814 cm3.g-1, and ca. 84.0% of which have a diameter of 2.25-3.40 μm. The thermal decomposition of the porous MgBO2(OH) microspheres (650 ℃, 2.5 ℃. min-l) leads to the porous Mg2B2O5 rnicrospheres with well-retained morphology. When utilized as the adsorbents for the removal of CR from mimic waste water, the present porous MgBO2(OH) microspheres exhibit satisfactory adsorption capacity, with the maximum adsorption capacity qm of 309.1 mg-g-1, much higher than that derived from most of the referenced adsorbents. This opens a new window for the facile green hydrothermal synthesis of the hierarchical porous MgBO2(OH) microspheres, and extends the potential application of the 3D hierarchical porous metal borates as high-efficiency adsorbents for organic dyes removal.展开更多
To prepare polymer supported ionic liquids(PSILs)as effective catalysts for esterification,the free radical suspension copolymerization of vinylbenzyl chloride(VBC,monomer),styrene(St,monomer)and divinylbenzene(DVB,cr...To prepare polymer supported ionic liquids(PSILs)as effective catalysts for esterification,the free radical suspension copolymerization of vinylbenzyl chloride(VBC,monomer),styrene(St,monomer)and divinylbenzene(DVB,crosslinker)with the addition of n-heptane(porogen)was carried out for the fabrication of the porous polymer(PVD)microsphere as support,followed by the immobilization of sulfonic acid-functionalized ionic liquids by the successive treatment of benzimidazole(BIm),1,3-propane sultone and sulfuric acid(H2SO4)or trifluoromethanesulfonic acid(CF3SO3H).The effects of the compositions of DVB and n-heptane on the internal structure of the polymer supports were investigated,and it was found that the support with 40 wt%DVB and 60 wt%n-heptane(with relative to the monomer)could endow the final PSILs with the relatively optimal catalytic performance.The preliminary experiment in the batch reactor indicated that PSILs herein exhibited higher catalytic activities than commercial Amberlyst 46 resin for the esterification of propanoic acid(PROAc)with n-propanol(PROOH).Consequently,the optimal PSILs catalyst,PVD-[Bim-SO3H]HSO4,was selected for further study in the batch reactive distillation column because of low cost and its ease of preparation.The yield of propyl ropionate(PROPRO)could reach up to 97.78%at the optimized conditions of PROOH/PROAc molar ratio(2:1)and catalyst dosage(2.0 wt%).The investigation of the reaction kinetic manifested that the calculated results of second order pseudo-homogeneous kinetic model were in good agreement with experimental values.The pre-exponential factor and activation energy were 4.12×107 L·mol-1·min-1 and 60.57 k J·mol-1,respectively.It is worth noting that the PSILs catalyst could be simply recovered and reused with relatively satisfactory decrease in the catalytic activity,which made it an environmental friendly and promising catalyst in the industrial application.展开更多
With the advantages of high energy/power density,long cycling life and low cost,dual-carbon potassium ion hybrid capacitors(PIHCs)have great potential in the field of energy storage.Here,a novel bilayer-shelled N,O-do...With the advantages of high energy/power density,long cycling life and low cost,dual-carbon potassium ion hybrid capacitors(PIHCs)have great potential in the field of energy storage.Here,a novel bilayer-shelled N,O-doped hollow porous carbon microspheres(NOHPC)anode has been prepared by a self-template method,which is consisted of a dense thin shell and a hollow porous spherical core.Excitingly,the NOHPC anode possesses a high K-storage capacity of 325.9 mA h g^(−1)at 0.1 A g^(−1)and a capacity of 201.1 mAh g^(−1)at 5 A g^(−1)after 6000 cycles.In combination with ex situ characterizations and density functional theory calculations,the high reversible capacity has been demonstrated to be attributed to the co-doping of N/O heteroatoms and porous structure improved K+adsorption and intercalation capabilities,and the stable long-cycling performance originating from the bilayer-shelled hollow porous carbon sphere structure.Meanwhile,the hollow porous activated carbon microspheres(HPAC)cathode with a high specific surface area(1472.65 m^(2)g^(−1))deriving from etching NOHPC with KOH,contributing to a high electrochemical adsorption capacity of 71.2 mAh g^(−1)at 1 A g^(−1).Notably,the NOHPC//HPAC PIHC delivers a high energy density of 90.1 Wh kg^(−1)at a power density of 939.6 W kg^(−1)after 6000 consecutive charge-discharge cycles.展开更多
Functional porous microspheres used for the slow release carrier of actives in cosmetics or pharmaceu- ticals were prepared by modified suspension polymerization of styrene (ST) with divinylbenzene (DVB) in the presen...Functional porous microspheres used for the slow release carrier of actives in cosmetics or pharmaceu- ticals were prepared by modified suspension polymerization of styrene (ST) with divinylbenzene (DVB) in the presence of toluene, cyclohexanol and heptane as porogenic diluents. The use of ultrasonic dispersion decreases the beads’ size and improves the uniformity. The effects of the porogen mixture, DVB content and solvent extraction on the surface performance of the synthesized beads were studied. The microspheres were characterized by scanning electron microscopy (SEM) and BET surface area determination. It was found that a great proportion of the non-solvating porogen increases the pore diameter and the specific surface area. High DVB concentration also re- sults in the great specific surface area and porosity. When the ratio of toluene/cyclohexanol is 1:2, DVB content is at the range of 40%—60% and methylene chloride was used as extractant, the beads with good spherical shape and pore size were obtained. The prepared porous microspheres were applied as active carriers and showed satisfactory slow release effect. Over 10h constantly sustained release was observed in vitro releasing test for hydro- quinone-loaded microspheres. Great surface area promoted high concentration of released hydroquinone.展开更多
Hydroxyapatite(HAP)is a common bio-adsorbent,which performance depends heavily upon its morphology and microporous structure.In this study,a novel synthesis strategy was proposed for hierarchical porous HAP microspher...Hydroxyapatite(HAP)is a common bio-adsorbent,which performance depends heavily upon its morphology and microporous structure.In this study,a novel synthesis strategy was proposed for hierarchical porous HAP microspheres by a simple"one-pot"hydrothermal reaction.In the strategy,L-glutamic acid serves as soft template to modulate the morphology and inner crystalline of HAP.To evaluate the application potential,doping Ni^(2+) on hierarchical porous HAP microspheres gives metal chelated affinity adsorbents.The prepared adsorbents show a perfect spherical shape,particles size of 96.6μm,relatively specific surface area of 48.5 m^(2)·g^(-1) and hierarchical pores(mesopores:4 nm and macropores:53 nm).By the adsorption evaluation,it reveals that the Ni^(2+)-HAP adsorbents have high adsorption capacities of275.11 and 97.55 m^(2)·g^(-1) for hemoglobin and bovine serum albumin,respectively,which is comparable to other similar adsorbent.Therefore,this work provides a promising method for high-efficiency hydroxyapatite microspheres for proteins purification.展开更多
This paper introduces the method of porous ZnO microspheres by sodium citrate assisted hydrothermal synthesis with a mild, economy: first, basic synthesis globose precursor of Zinc Carbonate Hydroxide, then followed ...This paper introduces the method of porous ZnO microspheres by sodium citrate assisted hydrothermal synthesis with a mild, economy: first, basic synthesis globose precursor of Zinc Carbonate Hydroxide, then followed by thermal decompose the precursor to obtain porous Zinc Oxide microspheres. The morphology and structure of the precursor and synthesized porous microspheres were characterize by a series of methods, and did a series of experiments by changing dosage and reaction time of the sodium citrate and urea, finally the paper discussed the formation mechanism of porous ZnO microspheres.展开更多
BACKGROUND Drug-eluting beads show good safety and promising efficacy when used as part of a transarterial chemoembolization regimen for primary liver cancer.However,data on the clinical efficacy and safety of pirarub...BACKGROUND Drug-eluting beads show good safety and promising efficacy when used as part of a transarterial chemoembolization regimen for primary liver cancer.However,data on the clinical efficacy and safety of pirarubicin-loaded beads combined with lobaplatin are lacking in China.AIM To evaluate the efficacy and safety of transcatheter arterial chemoembolization using pirarubicin-loaded beads combined with lobaplatin for primary liver cancer.METHODS Between January 2019 and March 2020,60 patients with primary liver cancer were selected at Hebei North University Affiliated First Hospital.According to different treatment methods,the participants were categorized into two groups with 30 patients treated with pirarubicin-loaded microspheres combined with lobaplatin included in an observation group and 30 patients treated with pirarubicin emulsion with lipiodol combined with lobaplatin were included in a control group.The progression-free survival,overall survival,clinical response rate,disease control rate,liver and kidney function and adverse reactions were compared between the two groups.RESULTS The progression-free survival was 14 mo in the observation group,which was significantly higher than 9 mo of the control group(P<0.05).The 6-mo,12-mo and 18-mo survival rates were 93.33%(28/30),66.67%(20/30)and 23.33%(7/30),respectively in the observation group,which were significantly higher than 83.33%(25/30),50.00%(15/30)and 13.33%(4/30),respectively,of the control group(all P<0.05).The clinical efficacy rate and disease control rate were 73.33%and 93.33%,respectively,in the observation group,which were significantly higher than those of the control group(53.55%and 80.00%,respectively,all P<0.05).There was no significant difference in alpha-fetoprotein between the two groups before the treatment(P>0.05).After the treatment,alpha-fetoprotein was 289.06±76.21 ng/m L in the observation group and 365.01±73.11 ng/m L in the control group,which were low in both groups compared with those before the treatment(all P<0.05).The incidence of nausea and vomiting was significantly lower in the observation group than in the control group(P<0.05).There was no significant difference for the adverse reactions of pain and fever between the two groups(P<0.05).CONCLUSION The combination of pirarubicin-loaded beads and lobaplatin can improve treatment efficacy resulting in mild liver function damage and postoperative complications in patients with primary liver cancer.It can be used in clinical practice.展开更多
Herein, novel plasmonic Bi metal in situ deposited in reduced Ti O2 microspheres(Bi@R-Ti O2) are fabricated via a bimetallic MOF-derived synthesized strategy by adjusting the synthesizing temperature. Different charac...Herein, novel plasmonic Bi metal in situ deposited in reduced Ti O2 microspheres(Bi@R-Ti O2) are fabricated via a bimetallic MOF-derived synthesized strategy by adjusting the synthesizing temperature. Different characterization techniques, including XRD, SEM, TEM, XPS, DRS, PL, EIS, and photocurrent generation, are performed to investigate the structural and optical properties of the as-prepared samples. The results indicate that the Bi particles are generated inside and outside of reduced Ti O2 microspheres via the reduction of Ti4+ and Bi3+ by ethylene glycol. When the annealing temperature is controlled at 300 o C, the corresponding Bi@R-Ti O2-300 sample with an appropriate amount of Bi nanoparticles exhibits the highest full solar spectrum photocatalytic oxygen evolution activity(4728.709 μmol h–1 g–1), which is 5.9 and 9.5 times higher than that of pure Ti O2 and Bi-Ti bimetal organic frameworks(Bi-Ti-MOFs). Several reasons are suggested for the above results:(1) Bi metal behaves as an "electron acceptor" to accelerate the charge carrier transfer from Ti O2 to Bi;(2) The surface plasmon resonance effect of loaded metallic Bi particles can enhance the visible and NIR light absorption capacity;(3) The generation of Ti3+ further narrows the band gap of TiO2.展开更多
The quest for lightweight and functional materials poses stringent requirements on mechanical performance of porous materials.However,the contradiction between high strength and elevated porosity of porous materials s...The quest for lightweight and functional materials poses stringent requirements on mechanical performance of porous materials.However,the contradiction between high strength and elevated porosity of porous materials severely limits their application scenarios in emerging fields.Herein,high-strength multifunctional mullite-based porous ceramic monoliths were fabricated utilizing waste fly ash hollow microspheres(FAHMs)by the protein gelling technique.Owing to their unique shell-pore structure inspired by shell-protected biomaterials,the monoliths with porosity of 54.69%–70.02% exhibited a high compressive strength(32.3–42.9 MPa)which was 2–5 times that of mullite-based porous ceramics with similar density reported elsewhere.Moreover,their pore structure and properties could be tuned by regulation of the particle size and content of the FAHMs,and the resultant monoliths demonstrated superior integrated performances for multifunctional applications,such as broadband sound insulation,efficient thermal insulation,and high-temperature fire resistance(>1300℃).On this basis,mullite-based porous ceramic lattices(porosity 68.28%–84.79%)with a hierarchical porous structure were successfully assembled by direct ink writing(DIW),which exhibited significantly higher compressive strength(3.02–10.77 MPa)than most other ceramic lattices with comparable densities.This unique shell-pore structure can be extended to other porous materials,and our strategy paves a new way for cost-effective,scalable and green production of multifunctional materials with well-defined microstructure.展开更多
Titania microspheres were synthesized using hydrothermal methods to exploit a new liquid chromatography stationary phase. The prepared titania microspheres were approximately 7 μm in diameter, and the particle size d...Titania microspheres were synthesized using hydrothermal methods to exploit a new liquid chromatography stationary phase. The prepared titania microspheres were approximately 7 μm in diameter, and the particle size distribution was relatively narrow and uniform. Furthermore, the average specific surface area was 276.0 m2·g·1, the average pore volume was approximately 0.25 mL·g·1, and the pore diameter was approximately 35.9 nm for sintering titania microspheres. These parameters indicate that the titania microspheres prepared for this study have excellent surface properties for chromatography. Additionally, columns filled with the titania microspheres were able to separate basic compounds, including benzene, nitrobenzene and o-nitroanisole. It could be proposed that the titania microspheres prepared for this study would be a promising stationary phase for liquid chromatography.展开更多
基金Supported by Scientific Research project of Hunan Provincial Health Commission,No.B202303077689Hunan Natural Science Foundation Project,No.2023JJ40397.
文摘BACKGROUND Transhepatic arterial chemoembolization(TACE),as a local treatment,has been widely used in the treatment of unresectable liver cancer.The introduction of drug carrier microspheres has brought new hope for the therapeutic effect of TACE.Microspheres can realize the slow release and directional delivery of drugs,reduce systemic toxicity and improve local curative effect.AIM To compare the effectiveness of traditional transcatheter arterial chemoembolization against microsphere-assisted transcatheter arterial chemoembolization in the treatment of hepatocellular carcinoma that is incurable.METHODS We searched the PubMed,Embase,Cochrane Library,and CNKI databases for clinical trials of drug-luting beads TACE(DEB-TACE)vs conventional TACE(cTACE)for the treatment of unresectable liver cancer.We screened references based on inclusion and exclusion criteria and then selected valid data for meta-analysis using RevMan 53 software.The complete response(CR)rate,partial response(PR)rate,postoperative stable disease(SD)rate,and 6-month and 12-month survival rates were compared.RESULTS A total of 12 articles were included,including 1177 patients,519 of whom received DEB-TACE and 658 of whom received cTACE.The CR rate in the DEB-TACE group was much greater than that in the cTACE group[relative risk(RR)=1.42,95%CI:1.18-1.72,P=0.0002].The 12-month survival rate significantly increased(RR=1.09;95%CI:1.01-1.17,P=0.03);the PR rate(RR=1.13;95%CI:0.97-1.30,P=0.12);the SD rate(RR=0.82;95%CI:0.64-1.05,P=0.12);and the 6-month survival rate(RR=1.05;95%CI:1.00-1.10,P=0.07).There was no significant difference(P<0.05).CONCLUSION Compared with those of iodized oil TACE,the drug-loaded microspheres tended to have therapeutic advantages.
基金supported by grants from the CAMS Innovation Fund for Medical Sciences(2021-I2M-1-052)Tianjin Natural Science Foundation for Jingjinji Collaboration(23JCZXJC00240)+2 种基金Capital's Funds for Health Improvement and Research(CFH:2022-2-5072)Tianjin Hospital Fund for Science and Technology(Tjyy2109)the Open Fund of Tianjin Key Laboratory of Biomedical Materials(2022BMEKFKT002)。
文摘Background:In facial plastic surgery,patients with nasal deformity are often treated by rib cartilage transplantation.In recent years,cartilage tissue engineering has developed as an alternative to complex surgery for patients with minor nasal defects via injection of nasal filler material.In this study,we prepared an injectable nasal filler material containing poly-L-l actic acid(PLLA)porous microspheres(PMs),hyaluronic acid(HA)and adipose-derived mesenchymal stem cells(ADMSCs).Methods:We seeded ADMSCs into as-prepared PLLA PMs using our newly invented centrifugation perfusion technique.Then,HA was mixed with ADMSC-i ncorporated PLLA PMs to form a hydrophilic and injectable cell delivery system(ADMSCincorporated PMH).Results:We evaluated the biocompatibility of PMH in vitro and in vivo.PMH has good injectability and provides a favorable environment for the proliferation and chondrogenic differentiation of ADMSCs.In vivo experiments,we observed that PMH has good biocompatibility and cartilage regeneration ability.Conclusion:In this study,a injectable cell delivery system was successfully constructed.We believe that PMH has potential application in cartilage tissue engineering,especially in nasal cartilage regeneration.
基金National key research and development project of Ministry of Science and Technology,No.2016YFC0103908.
文摘BACKGROUND Liver cancer is a malignant tumor with high morbidity and mortality.Transcatheter arterial chemoembolization(TACE)is the main method for surgically unresectable liver cancer.In recent years,drug-loaded microspheres have been gradually applied in TACE technology.There are some controversies about the therapeutic effects of drug-loaded microspheres TACE(D-TACE)and traditional TACE.AIM To explore the short-term efficacy of D-TACE and traditional TACE in the treatment of advanced liver cancer.METHODS The clinical data of 73 patients with advanced liver cancer admitted to the First and Sixth Medical Centers of Chinese PLA General Hospital from January 2017 to October 2019 were retrospectively analyzed.Among them,15 patients were treated with D-TACE,and 58 patients were treated with traditional TACE.Clinical baseline characteristics,perioperative laboratory indices,postoperative adverse reactions and postoperative complications were compared between the two groups.RESULTS There was no statistical difference between the two groups for the postoperative response:The highest postoperative body temperature of the drug-loaded microsphere group was 38.0±0.9℃and the postoperative highest body temperature of the traditional TACE group was 38.3±0.7℃(t=-1.414,P=0.162).For the 24 h postoperative nausea and vomiting after surgery in terms of scoring and postoperative pain scores,the traditional TACE group was higher than the drugloaded microsphere group(χ2=14.33,P=0.014;χ2=32.967,P=0.000)and the two groups had significant statistical differences.The disease control rate at 3 mo after treatment in the drugloaded microsphere group was 60%and the disease control rate at 3 mo after treatment in the traditional TACE group was 75.9%(χ2=4.091,P=0.252).There was no statistical difference between the two groups of data.During the follow-up period,the number of interventional treatments received was once in the drug-loaded microsphere group and the traditional TACE group received an average of 1.48 treatments(χ2=10.444 P=0.005).There was a statistical difference between the two groups.CONCLUSION Compared with traditional TACE,D-TACE may have some advantages in the treatment of advanced hepatocellular carcinoma with a large tumor load in the short term,but the long-term clinical efficacy needs additional follow-up studies.In addition,compared with the traditional group,the patients in the drug-loaded microsphere group had better subjective tolerance and could reduce the number of interventional treatments.Therefore,D-TACE is worthy of clinical promotion.
基金supported by the National Science Foundation for Young Scientists of China (51202171)~~
文摘A molten salt method was developed to prepare porous La1‐xSrxMn0.8Fe0.2O3 (0≤ x ≤ 0.6) micro‐spheres using hierarchical porous δ‐MnO2 microspheres as a template in eutectic NaNO3‐KNO3. X‐ray diffraction patterns showed that single phase LaMn0.8Fe0.2O3 with good crystallinity was syn‐thesized at 450℃ after 4 h. Transmission electron microscope images exhibited that the LaMn0.8Fe0.2O3 sample obtained at 450?? after 4 h possessed a porous spherical morphology com‐posed of aggregated nanocrystallites. Field emission scanning electron microscope images indicated that the growth of the porous LaMn0.8Fe0.2O3 microspheres has two stages. SEM pictures showed that a higher calcination temperature than 450?? had an adverse effect on the formation of a po‐rous spherical structure. The LaMn0.8Fe0.2O3 sample obtained at 450?? after 4 h displayed a high BET surface area of 55.73 m2/g with a pore size of 9.38 nm. Fourier transform infrared spectra suggested that Sr2+ions entered the A sites and induced a decrease of the binding energy between Mn and O. The CO conversion with the La1‐xSrxMn0.8Fe0.2O3 (0≤x≤0.6) samples indicated that the La0.4Sr0.6Mn0.8Fe0.2O3 sample had the best catalytic activity and stability. Further analysis by X‐ray photoelectron spectroscopy demonstrated that Sr2+doping altered the content of Mn4+ions, oxygen vacancies and adsorbed oxygen species on the surface, which affected the catalytic performance for CO oxidation.
基金Project(2013zzts306)supported by the Fundamental Research Funds for the Central Universities of Central South University,ChinaProject(225)supported by the High Level Health Personnel in Hunan Province,China
文摘Porous titanium with porosity of 60% was prepared by metal injection molding(MIM),and coated with gelatin sustained-release microspheres which were made by improved emulsified cold condensation method.The effects of porous titanium coated with insulin-like growth factor-1(IGF-1) and transforming growth factor-β1(TGF-β1) gelatin microspheres on the function of MG63 cells were evaluated in vitro.The results show that porous titanium coated with gelatin sustained-release microspheres has no cytotoxicity.The IGF-1 and TGF-β1 loading concentrations are positively correlative with the proliferation and differentiation of MG63 after co-culturing with the concentrations of IGF-1 and TGF-β1 gelatin microspheres in the range of 0.1-10 ng/mg and 0.25-2.5 ng/mg,respectively.The MG63 cells exhibit the best proliferation and differentiation with the IGF-1 and TGF-β1 loading concentrations of 10 ng/mg and 2.5 ng/mg,respectively.The joint application of IGF-1 and TGF-β1 group,which promote adhesion,proliferation and differentiation of MG63 cells,is superior to a single application group.
基金Supported by the National Natural Science Foundation of China(21276141)the State Key Laboratory of Chemical Engineering,China(SKL-Ch E-17A03).
文摘Water contamination caused by hazardous organic dyes has drawn considerable attention, among all of the techniques released, adsorption has been widely used, which however to a large degree is dependent on the development of high efficiency adsorbents. Waste biomass based porous carbon is becoming the new star class of adsorbents, and thus contribute more to the sustainable development of the society. In this work, for the first time to the best of our knowledge, abundant waste fallen Platanus orientalis leaves are employed as the raw material for hierarchical activated porous carbon(APC) microspheres via a mild hydrothermal carbonization(210 ℃,12.0 h) followed by one-step calcination(750 ℃, 1.0 h). The APC microspheres exhibit a specific surface area of 1355.53 m^2·g^-1 and abundant functional groups such as O—H and C=O. Furthermore, the APC microspheres are used as the adsorbents for removal of Rh B and MO, with the maximum adsorption capabilities of 557.06 mg·g^-1 and 327.49 mg·g^-1, respectively, higher than those of the most porous carbon originated from biomass. The adsorption rates rapidly approach to 98.2%(RhB) and 95.4%(MO) within 10 min. The adsorption data can be well fitted by Langmuir isotherm model and the pseudo-second-order kinetic model, meanwhile the intra-particle diffusion and Boyd models simultaneously indicate that the diffusion within the pores is the main rate-limiting step. Besides, the APC microspheres also demonstrate good recyclability, and may also be applied to other areas such as heterogeneous catalysis and energy storage.
基金Natural Science Foundation of Guangdong Province (No.05006556).
文摘Functional porous microspheres used for the slow release carrier of actives in cosmetics or pharmaceuticals were prepared by modified suspension polymerization of styrene (ST) with divinylbenzene (DVB) in the presence of toluene, cyclohexanol and heptane as porogenic diluents. The use of ultrasonic dispersion decreases the beads' size and improves the uniformity. The effects of the porogen mixture, DVB content and solvent extraction on the surface performance of the synthesized beads were studied. The microspheres were characterized by scanning electron microscopy (SEM) and BET surface area determination. It was found that a great proportion of the non-solvating porogen increases the pore diameter and the specific surface area. High DVB concentration also results in the great specific surface area and porosity. When the ratio of toluene/cyclohexanol is 1:2, DVB content is at the range of 40%-60% and methylene chloride was used as extractant, the beads with good spherical shape and pore size were obtained. The prepared porous microspheres were applied as active carriers and showed satisfactory slow release effect. Over 10h constantly sustained release was observed in vitro releasing test for hydroquinone-loaded microspheres. Great surface area promoted high concentration of released hydroquinone.
基金supported by a National Research Foundation of Korea(NRF)grant funded by the Korean government(MSIP)(NRF-2021R1A4A2001687,and NRF-2021R1I1A3057700)。
文摘Metal–organic framework-templated nitrogen-doped graphitic carbon(NGC)and polydopaminederived carbon(PDA-derived C)-double coated one-dimensional CoSe_(2) nanorods supported highly porous threedimensional microspheres are introduced as anodes for excellent Na-ion batteries,particularly with long-lived cycle under carbonate-based electrolyte system.The microspheres uniformly composed of ZIF-67 polyhedrons and polystyrene nanobeads(φ=40 nm)are synthesized using the facile spray pyrolysis technique,followed by the selenization process(P-CoSe_(2)@NGC NR).Further,the PDA-derived C-coated microspheres are obtained using a solution-based coating approach and the subsequent carbonization process(P-CoSe_(2)@PDA-C NR).The rational synthesis approach benefited from the synergistic effects of dual carbon coating,resulting in a highly conductive and porous nanostructure that could facilitate rapid diffusion of charge species along with efficient electrolyte infiltration and effectively channelize the volume stress.Consequently,the prepared nanostructure exhibits extraordinary electrochemical performance,particularly the ultra-long cycle life stability.For instance,the advanced anode has a discharge capacity of 291(1000th cycle,average capacity decay of 0.017%)and 142 mAh g^(-1)(5000th cycle,average capacity decay of 0.011%)at a current density of 0.5 and 2.0 A g^(-1),respectively.
基金The authors gratefully acknowledge the financial support from the National Natural Science Foundation of China(Grant Nos.21965007,51671062,and 51871065)the Guangxi Natural Science Foundation(Grant No.2018GXNSFFA281005)+1 种基金the Scientific Research and Technology Development Program of Guangxi(Grant Nos.AA19182014 and AA17202030-1)Guangxi Bagui Scholar Foundation,Guangxi Advanced Functional Materials Foundation and Application Talents Small Highlands,and Chinesisch-Deutsche Kooperationsgruppe(Grant No.GZ1528).
文摘Used as high-performance electrodes,both structural and compositional alterations of carbon materials play very important roles in energy conversion/storage devices.Especially in supercapacitors,hierarchical pores and heteroatom doping in carbon materials are indispensable.Here the rambutan-like hierarchically porous carbon microspheres(PCMs)have been constructed via a hydrothermal treatment,followed by carbonization/activation.The hierarchically porous microstructure is composed of three-dimensional porous carbon networks,which give rise to a large surface area.Moreover,N and O functional groups are introduced in the as-prepared samples,which could generate the extra pseudocapacitance.Benefitting from the interconnected hierarchical and open structure,PCM exhibits outstanding capacitive performance,for example,superior specific capacitance and rate capability(397 and 288 F g^(−1) at 0.5 and 20A g^(−1),respectively),as well as long cycling stability(about 95%capacitance retention after 10,000 cycles).These encouraging results may pave an efficient way to fabricate advanced supercapacitors in the future.
基金Project(0805167) supported by China Postdoctoral Science FoundationProjects(30700349, 30700348) supported by the Scientific Research Foundation for Doctors in Henan Agricultural University, China+1 种基金Project(20735003) supported by the National Natural Science Foundation of ChinaProject(KJCX2YWH09) supported by Chinese Academy of Sciences
文摘It is hoped to develop a simple and low cost route for preparing the CaO with a novel morphology which can present high catalytic activity in catalyzing transesterification reaction for biodiesel. The porous CaO microsphere was synthesized by calcining spherical CaCO3 precursor which was prepared easily by mixing CaCl2 with Na2CO3. The as-prepared CaO microsphere was characterized by scanning electronic microscopy(SEM), powder X-ray diffractometry(XRD) and N2 adsorption experiment. The results reveal that the synthesized CaO is regular microsphere with many pores in its exterior and interior. The CaO microsphere is applied in catalyzing the transesterification reaction of soybean oil for biodiesel and presents excellent catalytic ability with a transesterification yield of 98.72%. This catalyst could have potential applications in other fields in view of its well-defined morphology, simply synthetic route and low cost.
基金Supported by the National Natural Science Foundation of China(21276141)the State Key Laboratory of Chemical Engineering,China(SKL-Ch E-17A03)
文摘A facile eco-friendly hydrothermal route (180 ℃, 12.0 h) has been developed for the first time to the uniform hierarchical porous MgBO2(OH) microspheres without the aid of any organic additive, surfactant or template, by using the abundant MgCl2·6H2O, H3BO3 and NaOH as the raw materials. The as-obtained porous microspheres exhibit a specific surface area of 94.752 mg·g-1, pore volume of 0.814 cm3.g-1, and ca. 84.0% of which have a diameter of 2.25-3.40 μm. The thermal decomposition of the porous MgBO2(OH) microspheres (650 ℃, 2.5 ℃. min-l) leads to the porous Mg2B2O5 rnicrospheres with well-retained morphology. When utilized as the adsorbents for the removal of CR from mimic waste water, the present porous MgBO2(OH) microspheres exhibit satisfactory adsorption capacity, with the maximum adsorption capacity qm of 309.1 mg-g-1, much higher than that derived from most of the referenced adsorbents. This opens a new window for the facile green hydrothermal synthesis of the hierarchical porous MgBO2(OH) microspheres, and extends the potential application of the 3D hierarchical porous metal borates as high-efficiency adsorbents for organic dyes removal.
基金The National Natural Science Foundation of China(21576053,91534106)the Natural Science Foundation of Fujian Province(2016J01689).
文摘To prepare polymer supported ionic liquids(PSILs)as effective catalysts for esterification,the free radical suspension copolymerization of vinylbenzyl chloride(VBC,monomer),styrene(St,monomer)and divinylbenzene(DVB,crosslinker)with the addition of n-heptane(porogen)was carried out for the fabrication of the porous polymer(PVD)microsphere as support,followed by the immobilization of sulfonic acid-functionalized ionic liquids by the successive treatment of benzimidazole(BIm),1,3-propane sultone and sulfuric acid(H2SO4)or trifluoromethanesulfonic acid(CF3SO3H).The effects of the compositions of DVB and n-heptane on the internal structure of the polymer supports were investigated,and it was found that the support with 40 wt%DVB and 60 wt%n-heptane(with relative to the monomer)could endow the final PSILs with the relatively optimal catalytic performance.The preliminary experiment in the batch reactor indicated that PSILs herein exhibited higher catalytic activities than commercial Amberlyst 46 resin for the esterification of propanoic acid(PROAc)with n-propanol(PROOH).Consequently,the optimal PSILs catalyst,PVD-[Bim-SO3H]HSO4,was selected for further study in the batch reactive distillation column because of low cost and its ease of preparation.The yield of propyl ropionate(PROPRO)could reach up to 97.78%at the optimized conditions of PROOH/PROAc molar ratio(2:1)and catalyst dosage(2.0 wt%).The investigation of the reaction kinetic manifested that the calculated results of second order pseudo-homogeneous kinetic model were in good agreement with experimental values.The pre-exponential factor and activation energy were 4.12×107 L·mol-1·min-1 and 60.57 k J·mol-1,respectively.It is worth noting that the PSILs catalyst could be simply recovered and reused with relatively satisfactory decrease in the catalytic activity,which made it an environmental friendly and promising catalyst in the industrial application.
基金supported by the National Natural Science Foundation of China(Nos.21701163,21671181,21831006,and 22075268)the Fundamental Research Funds for the Central Universities(No.WK5290000003)Innovation Key Fund Project of University of Science and Technology of China(YD2060002023).
文摘With the advantages of high energy/power density,long cycling life and low cost,dual-carbon potassium ion hybrid capacitors(PIHCs)have great potential in the field of energy storage.Here,a novel bilayer-shelled N,O-doped hollow porous carbon microspheres(NOHPC)anode has been prepared by a self-template method,which is consisted of a dense thin shell and a hollow porous spherical core.Excitingly,the NOHPC anode possesses a high K-storage capacity of 325.9 mA h g^(−1)at 0.1 A g^(−1)and a capacity of 201.1 mAh g^(−1)at 5 A g^(−1)after 6000 cycles.In combination with ex situ characterizations and density functional theory calculations,the high reversible capacity has been demonstrated to be attributed to the co-doping of N/O heteroatoms and porous structure improved K+adsorption and intercalation capabilities,and the stable long-cycling performance originating from the bilayer-shelled hollow porous carbon sphere structure.Meanwhile,the hollow porous activated carbon microspheres(HPAC)cathode with a high specific surface area(1472.65 m^(2)g^(−1))deriving from etching NOHPC with KOH,contributing to a high electrochemical adsorption capacity of 71.2 mAh g^(−1)at 1 A g^(−1).Notably,the NOHPC//HPAC PIHC delivers a high energy density of 90.1 Wh kg^(−1)at a power density of 939.6 W kg^(−1)after 6000 consecutive charge-discharge cycles.
基金Supported by Natural Science Foundation of Guangdong Province (No.05006556).
文摘Functional porous microspheres used for the slow release carrier of actives in cosmetics or pharmaceu- ticals were prepared by modified suspension polymerization of styrene (ST) with divinylbenzene (DVB) in the presence of toluene, cyclohexanol and heptane as porogenic diluents. The use of ultrasonic dispersion decreases the beads’ size and improves the uniformity. The effects of the porogen mixture, DVB content and solvent extraction on the surface performance of the synthesized beads were studied. The microspheres were characterized by scanning electron microscopy (SEM) and BET surface area determination. It was found that a great proportion of the non-solvating porogen increases the pore diameter and the specific surface area. High DVB concentration also re- sults in the great specific surface area and porosity. When the ratio of toluene/cyclohexanol is 1:2, DVB content is at the range of 40%—60% and methylene chloride was used as extractant, the beads with good spherical shape and pore size were obtained. The prepared porous microspheres were applied as active carriers and showed satisfactory slow release effect. Over 10h constantly sustained release was observed in vitro releasing test for hydro- quinone-loaded microspheres. Great surface area promoted high concentration of released hydroquinone.
基金funded by the National Natural Science Foundation of China(21676170)。
文摘Hydroxyapatite(HAP)is a common bio-adsorbent,which performance depends heavily upon its morphology and microporous structure.In this study,a novel synthesis strategy was proposed for hierarchical porous HAP microspheres by a simple"one-pot"hydrothermal reaction.In the strategy,L-glutamic acid serves as soft template to modulate the morphology and inner crystalline of HAP.To evaluate the application potential,doping Ni^(2+) on hierarchical porous HAP microspheres gives metal chelated affinity adsorbents.The prepared adsorbents show a perfect spherical shape,particles size of 96.6μm,relatively specific surface area of 48.5 m^(2)·g^(-1) and hierarchical pores(mesopores:4 nm and macropores:53 nm).By the adsorption evaluation,it reveals that the Ni^(2+)-HAP adsorbents have high adsorption capacities of275.11 and 97.55 m^(2)·g^(-1) for hemoglobin and bovine serum albumin,respectively,which is comparable to other similar adsorbent.Therefore,this work provides a promising method for high-efficiency hydroxyapatite microspheres for proteins purification.
文摘This paper introduces the method of porous ZnO microspheres by sodium citrate assisted hydrothermal synthesis with a mild, economy: first, basic synthesis globose precursor of Zinc Carbonate Hydroxide, then followed by thermal decompose the precursor to obtain porous Zinc Oxide microspheres. The morphology and structure of the precursor and synthesized porous microspheres were characterize by a series of methods, and did a series of experiments by changing dosage and reaction time of the sodium citrate and urea, finally the paper discussed the formation mechanism of porous ZnO microspheres.
基金Supported by Zhangjiakou Science and Technology Research and Development Program,No.1821154HZhangjiakou Technology Innovation Guidance Program,No.2021194H。
文摘BACKGROUND Drug-eluting beads show good safety and promising efficacy when used as part of a transarterial chemoembolization regimen for primary liver cancer.However,data on the clinical efficacy and safety of pirarubicin-loaded beads combined with lobaplatin are lacking in China.AIM To evaluate the efficacy and safety of transcatheter arterial chemoembolization using pirarubicin-loaded beads combined with lobaplatin for primary liver cancer.METHODS Between January 2019 and March 2020,60 patients with primary liver cancer were selected at Hebei North University Affiliated First Hospital.According to different treatment methods,the participants were categorized into two groups with 30 patients treated with pirarubicin-loaded microspheres combined with lobaplatin included in an observation group and 30 patients treated with pirarubicin emulsion with lipiodol combined with lobaplatin were included in a control group.The progression-free survival,overall survival,clinical response rate,disease control rate,liver and kidney function and adverse reactions were compared between the two groups.RESULTS The progression-free survival was 14 mo in the observation group,which was significantly higher than 9 mo of the control group(P<0.05).The 6-mo,12-mo and 18-mo survival rates were 93.33%(28/30),66.67%(20/30)and 23.33%(7/30),respectively in the observation group,which were significantly higher than 83.33%(25/30),50.00%(15/30)and 13.33%(4/30),respectively,of the control group(all P<0.05).The clinical efficacy rate and disease control rate were 73.33%and 93.33%,respectively,in the observation group,which were significantly higher than those of the control group(53.55%and 80.00%,respectively,all P<0.05).There was no significant difference in alpha-fetoprotein between the two groups before the treatment(P>0.05).After the treatment,alpha-fetoprotein was 289.06±76.21 ng/m L in the observation group and 365.01±73.11 ng/m L in the control group,which were low in both groups compared with those before the treatment(all P<0.05).The incidence of nausea and vomiting was significantly lower in the observation group than in the control group(P<0.05).There was no significant difference for the adverse reactions of pain and fever between the two groups(P<0.05).CONCLUSION The combination of pirarubicin-loaded beads and lobaplatin can improve treatment efficacy resulting in mild liver function damage and postoperative complications in patients with primary liver cancer.It can be used in clinical practice.
基金the National Natural Science Foundation of China(51872173 and 51772176)Taishan Scholarship of Young Scholars(tsqn201812068)+2 种基金Natural Science Foundation of Shandong Province(ZR2017JL020)Taishan Scholarship of Climbing Plan(tspd20161006)Key Research and Development Program of Shandong Province(2018GGX102028)~~
文摘Herein, novel plasmonic Bi metal in situ deposited in reduced Ti O2 microspheres(Bi@R-Ti O2) are fabricated via a bimetallic MOF-derived synthesized strategy by adjusting the synthesizing temperature. Different characterization techniques, including XRD, SEM, TEM, XPS, DRS, PL, EIS, and photocurrent generation, are performed to investigate the structural and optical properties of the as-prepared samples. The results indicate that the Bi particles are generated inside and outside of reduced Ti O2 microspheres via the reduction of Ti4+ and Bi3+ by ethylene glycol. When the annealing temperature is controlled at 300 o C, the corresponding Bi@R-Ti O2-300 sample with an appropriate amount of Bi nanoparticles exhibits the highest full solar spectrum photocatalytic oxygen evolution activity(4728.709 μmol h–1 g–1), which is 5.9 and 9.5 times higher than that of pure Ti O2 and Bi-Ti bimetal organic frameworks(Bi-Ti-MOFs). Several reasons are suggested for the above results:(1) Bi metal behaves as an "electron acceptor" to accelerate the charge carrier transfer from Ti O2 to Bi;(2) The surface plasmon resonance effect of loaded metallic Bi particles can enhance the visible and NIR light absorption capacity;(3) The generation of Ti3+ further narrows the band gap of TiO2.
基金financially supported by the National Natural Science Foundation of China(Grant No.51802347)the Natural Science Foundation of Hubei Province(Grant No.2022CFB939).
文摘The quest for lightweight and functional materials poses stringent requirements on mechanical performance of porous materials.However,the contradiction between high strength and elevated porosity of porous materials severely limits their application scenarios in emerging fields.Herein,high-strength multifunctional mullite-based porous ceramic monoliths were fabricated utilizing waste fly ash hollow microspheres(FAHMs)by the protein gelling technique.Owing to their unique shell-pore structure inspired by shell-protected biomaterials,the monoliths with porosity of 54.69%–70.02% exhibited a high compressive strength(32.3–42.9 MPa)which was 2–5 times that of mullite-based porous ceramics with similar density reported elsewhere.Moreover,their pore structure and properties could be tuned by regulation of the particle size and content of the FAHMs,and the resultant monoliths demonstrated superior integrated performances for multifunctional applications,such as broadband sound insulation,efficient thermal insulation,and high-temperature fire resistance(>1300℃).On this basis,mullite-based porous ceramic lattices(porosity 68.28%–84.79%)with a hierarchical porous structure were successfully assembled by direct ink writing(DIW),which exhibited significantly higher compressive strength(3.02–10.77 MPa)than most other ceramic lattices with comparable densities.This unique shell-pore structure can be extended to other porous materials,and our strategy paves a new way for cost-effective,scalable and green production of multifunctional materials with well-defined microstructure.
文摘Titania microspheres were synthesized using hydrothermal methods to exploit a new liquid chromatography stationary phase. The prepared titania microspheres were approximately 7 μm in diameter, and the particle size distribution was relatively narrow and uniform. Furthermore, the average specific surface area was 276.0 m2·g·1, the average pore volume was approximately 0.25 mL·g·1, and the pore diameter was approximately 35.9 nm for sintering titania microspheres. These parameters indicate that the titania microspheres prepared for this study have excellent surface properties for chromatography. Additionally, columns filled with the titania microspheres were able to separate basic compounds, including benzene, nitrobenzene and o-nitroanisole. It could be proposed that the titania microspheres prepared for this study would be a promising stationary phase for liquid chromatography.