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Existence of Monotone Positive Solution for a Fourth-Order Three-Point BVP with Sign-Changing Green’s Function
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作者 Junrui Yue Yun Zhang Qingyue Bai 《Open Journal of Applied Sciences》 2024年第1期63-69,共7页
This paper is concerned with the following fourth-order three-point boundary value problem , where , we discuss the existence of positive solutions to the above problem by applying to the fixed point theory in cones a... This paper is concerned with the following fourth-order three-point boundary value problem , where , we discuss the existence of positive solutions to the above problem by applying to the fixed point theory in cones and iterative technique. 展开更多
关键词 Fourth-Order Three-Point Boundary Value Problem Sign-Changing Green’s Function Fixed Point Index Iterative Technique Monotone positive solution EXISTENCE
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POSITIVE SOLUTIONS WITH HIGH ENERGY FOR FRACTIONAL SCHRODINGER EQUATIONS
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作者 郭青 赵雷嘎 《Acta Mathematica Scientia》 SCIE CSCD 2023年第3期1116-1130,共15页
In this paper, we study the Schrodinger equations (-△)^(s)u + V(x)u = a(x)|u|^(p-2)u + b(x)|u|^(q-2)u, x∈R^(N),where 0 < s < 1, 2 < q < p < 2_(s)^(*), 2_(s)^(*) is the fractional Sobolev critical expo... In this paper, we study the Schrodinger equations (-△)^(s)u + V(x)u = a(x)|u|^(p-2)u + b(x)|u|^(q-2)u, x∈R^(N),where 0 < s < 1, 2 < q < p < 2_(s)^(*), 2_(s)^(*) is the fractional Sobolev critical exponent. Under suitable assumptions on V, a and b for which there may be no ground state solution, the existence of positive solutions are obtained via variational methods. 展开更多
关键词 fractional Schr?dinger equations positive solution concentration compactness principle
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Hermite Positive Definite Solution of the Quaternion Matrix Equation Xm + B*XB = C
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作者 Yiwen Yao Guangmei Liu +1 位作者 Yanting Zhang Jingpin Huang 《Journal of Applied Mathematics and Physics》 2023年第11期3760-3772,共13页
This paper discusses the necessary and sufficient conditions for the existence of Hermite positive definite solutions of the quaternion matrix equation X<sup>m</sup>+ B*XB = C (m > 0) and its iterative ... This paper discusses the necessary and sufficient conditions for the existence of Hermite positive definite solutions of the quaternion matrix equation X<sup>m</sup>+ B*XB = C (m > 0) and its iterative solution method. According to the characteristics of the coefficient matrix, a corresponding algebraic equation system is ingeniously constructed, and by discussing the equation system’s solvability, the matrix equation’s existence interval is obtained. Based on the characteristics of the coefficient matrix, some necessary and sufficient conditions for the existence of Hermitian positive definite solutions of the matrix equation are derived. Then, the upper and lower bounds of the positive actual solutions are estimated by using matrix inequalities. Four iteration formats are constructed according to the given conditions and existence intervals, and their convergence is proven. The selection method for the initial matrix is also provided. Finally, using the complexification operator of quaternion matrices, an equivalent iteration on the complex field is established to solve the equation in the Matlab environment. Two numerical examples are used to test the effectiveness and feasibility of the given method. . 展开更多
关键词 QUATERNION Matrix Equation Hermite positive Definite solution Matrix Inequality ITERATIVE CONVERGENCE
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The Existence of Solutions for Kirchhoff-Type Equations with General Singular Terms
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作者 WANG Ji-nan SUN Da-wei 《Chinese Quarterly Journal of Mathematics》 2024年第3期315-323,共9页
We study the existence of solutions for Kirchhoff-type equations.Firstly,we use the Sobolev inequality and the weakly lower semi-continuity of the norm to prove that the corresponding function can reach the global min... We study the existence of solutions for Kirchhoff-type equations.Firstly,we use the Sobolev inequality and the weakly lower semi-continuity of the norm to prove that the corresponding function can reach the global minimum.Then,we use the variational method and some analytical techniques to obtain the existence of the positive solution of the equation whenλis small enough. 展开更多
关键词 Kirchhoff-type equation The existence positive solution Variational method
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GLOBAL SOLUTIONS TO 1D COMPRESSIBLE NAVIER-STOKES/ALLEN-CAHN SYSTEM WITH DENSITY-DEPENDENT VISCOSITY AND FREE-BOUNDARY 被引量:1
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作者 丁时进 李颖花 王喻 《Acta Mathematica Scientia》 SCIE CSCD 2024年第1期195-214,共20页
This paper is concerned with the Navier-Stokes/Allen-Cahn system,which is used to model the dynamics of immiscible two-phase flows.We consider a 1D free boundary problem and assume that the viscosity coefficient depen... This paper is concerned with the Navier-Stokes/Allen-Cahn system,which is used to model the dynamics of immiscible two-phase flows.We consider a 1D free boundary problem and assume that the viscosity coefficient depends on the density in the form ofη(ρ)=ρ^(α).The existence of unique global H^(2m)-solutions(m∈N)to the free boundary problem is proven for when 0<α<1/4.Furthermore,we obtain the global C^(∞)-solutions if the initial data is smooth. 展开更多
关键词 Navier-Stokes/Allen-Cahn system density-dependent viscosity free boundary global solutions
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POSITIVE CLASSICAL SOLUTIONS OF DIRICHLET PROBLEM FOR THE STEADY RELATIVISTIC HEAT EQUATION
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作者 杨田洁 袁光伟 《Acta Mathematica Scientia》 SCIE CSCD 2023年第5期2279-2290,共12页
In this paper,for a bounded C2 domain,we prove the existence and uniqueness of positive classical solutions to the Dirichlet problem for the steady relativistic heat equation with a class of restricted positive C2 bou... In this paper,for a bounded C2 domain,we prove the existence and uniqueness of positive classical solutions to the Dirichlet problem for the steady relativistic heat equation with a class of restricted positive C2 boundary data.We have a non-existence result,which is the justification for taking into account the restricted boundary data.There is a smooth positive boundary datum that precludes the existence of the positive classical solution. 展开更多
关键词 Dirichlet problem steady relativistic heat equation classical solution
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The Existence of Ground State Solutions for Schrödinger-Kirchhoff Equations Involving the Potential without a Positive Lower Bound
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作者 Yuqi Wang Die Wang Shaoxiong Chen 《Journal of Applied Mathematics and Physics》 2023年第3期790-803,共14页
In this paper, we study the following Schrödinger-Kirchhoff equation where V(x) ≥ 0 and vanishes on an open set of R<sup>2</sup> and f has critical exponential growth. By using a version of Trudinger... In this paper, we study the following Schrödinger-Kirchhoff equation where V(x) ≥ 0 and vanishes on an open set of R<sup>2</sup> and f has critical exponential growth. By using a version of Trudinger-Moser inequality and variational methods, we obtain the existence of ground state solutions for this problem. 展开更多
关键词 Schrödinger-Kirchhoff Equations Critical Exponential Growth Ground State solution Degenerate Potential
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Semi-analytical solution for mechanical analysis of tunnels crossing strike-slip fault zone considering nonuniform fault displacement and uncertain fault plane position
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作者 YANG Heng-hong WANG Ming-nian +1 位作者 YU Li ZHANG Xiao 《Journal of Central South University》 SCIE EI CAS CSCD 2024年第6期2116-2136,共21页
The tunnel subjected to strike-slip fault dislocation exhibits severe and catastrophic damage.The existing analysis models frequently assume uniform fault displacement and fixed fault plane position.In contrast,post-e... The tunnel subjected to strike-slip fault dislocation exhibits severe and catastrophic damage.The existing analysis models frequently assume uniform fault displacement and fixed fault plane position.In contrast,post-earthquake observations indicate that the displacement near the fault zone is typically nonuniform,and the fault plane position is uncertain.In this study,we first established a series of improved governing equations to analyze the mechanical response of tunnels under strike-slip fault dislocation.The proposed methodology incorporated key factors such as nonuniform fault displacement and uncertain fault plane position into the governing equations,thereby significantly enhancing the applicability range and accuracy of the model.In contrast to previous analytical models,the maximum computational error has decreased from 57.1%to 1.1%.Subsequently,we conducted a rigorous validation of the proposed methodology by undertaking a comparative analysis with a 3D finite element numerical model,and the results from both approaches exhibited a high degree of qualitative and quantitative agreement with a maximum error of 9.9%.Finally,the proposed methodology was utilized to perform a parametric analysis to explore the effects of various parameters,such as fault displacement,fault zone width,fault zone strength,the ratio of maximum fault displacement of the hanging wall to the footwall,and fault plane position,on the response of tunnels subjected to strike-slip fault dislocation.The findings indicate a progressive increase in the peak internal forces of the tunnel with the rise in fault displacement and fault zone strength.Conversely,an augmentation in fault zone width is found to contribute to a decrease in the peak internal forces.For example,for a fault zone width of 10 m,the peak values of bending moment,shear force,and axial force are approximately 46.9%,102.4%,and 28.7% higher,respectively,compared to those observed for a fault zone width of 50 m.Furthermore,the position of the peak internal forces is influenced by variations in the ratio of maximum fault displacement of the hanging wall to footwall and the fault plane location,while the peak values of shear force and axial force always align with the fault plane.The maximum peak internal forces are observed when the footwall exclusively bears the entirety of the fault displacement,corresponding to a ratio of 0:1.The peak values of bending moment,shear force,and axial force for the ratio of 0:1 amount to approximately 123.8%,148.6%,and 111.1% of those for the ratio of 0.5:0.5,respectively. 展开更多
关键词 strike-slip fault tunnel engineering semi-analytical solution fault zone width nonuniform fault displacement uncertain fault plane position
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Localized wave solutions and interactions of the (2+1)-dimensional Hirota-Satsuma-Ito equation
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作者 巩乾坤 王惠 王云虎 《Chinese Physics B》 SCIE EI CAS CSCD 2024年第4期409-416,共8页
This paper studies the(2+1)-dimensional Hirota-Satsuma-Ito equation.Based on an associated Hirota bilinear form,lump-type solution,two types of interaction solutions,and breather wave solution of the(2+1)-dimensional ... This paper studies the(2+1)-dimensional Hirota-Satsuma-Ito equation.Based on an associated Hirota bilinear form,lump-type solution,two types of interaction solutions,and breather wave solution of the(2+1)-dimensional Hirota-Satsuma-Ito equation are obtained,which are all related to the seed solution of the equation.It is interesting that the rogue wave is aroused by the interaction between one-lump soliton and a pair of resonance stripe solitons,and the fusion and fission phenomena are also found in the interaction between lump solitons and one-stripe soliton.Furthermore,the breather wave solution is also obtained by reducing the two-soliton solutions.The trajectory and period of the one-order breather wave are analyzed.The corresponding dynamical characteristics are demonstrated by the graphs. 展开更多
关键词 lump solution rogue wave solution breather wave solution (2+1)-dimensional Hirota-Satsuma-Ito equation
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PDE Standardization Analysis and Solution of TypicalMechanics Problems
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作者 Ningjie Wang Yihao Wang +1 位作者 Yongle Pei Luxian Li 《Computer Modeling in Engineering & Sciences》 SCIE EI 2024年第10期171-186,共16页
A numerical approach is an effective means of solving boundary value problems(BVPs).This study focuses on physical problems with general partial differential equations(PDEs).It investigates the solution approach throu... A numerical approach is an effective means of solving boundary value problems(BVPs).This study focuses on physical problems with general partial differential equations(PDEs).It investigates the solution approach through the standard forms of the PDE module in COMSOL.Two typical mechanics problems are exemplified:The deflection of a thin plate,which can be addressed with the dedicated finite element module,and the stress of a pure bending beamthat cannot be tackled.The procedure for the two problems regarding the three standard forms required by the PDE module is detailed.The results were in good agreement with the literature,indicating that the PDE module provides a promising means to solve complex PDEs,especially for those a dedicated finite element module has yet to be developed. 展开更多
关键词 Three standard forms expression input PDE module deflection solution stress solution
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THE LIMITING PROFILE OF SOLUTIONS FOR SEMILINEAR ELLIPTIC SYSTEMS WITH A SHRINKING SELF-FOCUSING CORE
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作者 金可 石影 谢华飞 《Acta Mathematica Scientia》 SCIE CSCD 2024年第2期583-608,共26页
In this paper,we consider the semilinear elliptic equation systems{△u+u=αQ_(n)(x)|u|^(α-2)|v|^(β)u in R^(N),-△v+v=βQ(x)|u|^(α)|v|^(β-2)v in R^(N),where N≥3,α,β>1,α+β<2^(*),2^(*)=2N/N-2 and Q_(n) are... In this paper,we consider the semilinear elliptic equation systems{△u+u=αQ_(n)(x)|u|^(α-2)|v|^(β)u in R^(N),-△v+v=βQ(x)|u|^(α)|v|^(β-2)v in R^(N),where N≥3,α,β>1,α+β<2^(*),2^(*)=2N/N-2 and Q_(n) are bounded given functions whose self-focusing cores{x∈R^(N)|Q_(n)(x)>0} shrink to a set with finitely many points as n→∞.Motivated by the work of Fang and Wang[13],we use variational methods to study the limiting profile of ground state solutions which are concentrated at one point of the set with finitely many points,and we build the localized concentrated bound state solutions for the above equation systems. 展开更多
关键词 Schrödinger system ground states solutions bound state solutions
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Solution approximations for a mathematical model of relativistic electrons with beta derivative
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作者 Ibrahim Yalcinkaya Orkun Tasbozan +1 位作者 Ali Kurt Hijaz Ahmad 《Applied Mathematics(A Journal of Chinese Universities)》 SCIE CSCD 2024年第3期469-485,共17页
The main aim of this paper is to obtain the exact and semi-analytical solutions of the nonlinear Klein-Fock-Gordon(KFG)equation which is a model of relativistic electrons arising in the laser thermonuclear fusion with... The main aim of this paper is to obtain the exact and semi-analytical solutions of the nonlinear Klein-Fock-Gordon(KFG)equation which is a model of relativistic electrons arising in the laser thermonuclear fusion with beta derivative.For this purpose,both the modified extended tanh-function(mETF)method and the homotopy analysis method(HAM)are used.While applying the mETF the chain rule for beta derivative and complex wave transform are used for obtaining the exact solution.The advantage of this procedure is that discretization or normalization is not required.By applying the mETF,the exact solutions are obtained.Also,by applying the HAM semi-analytical results for the considered equation are acquired.In HAM?curve gives us a chance to find the suitable value of the for the convergence of the solution series.Also,comparative graphical representations are given to show the effectiveness,reliability of the methods.The results show that the m ETF and HAM are reliable and applicable tools for obtaining the solutions of non-linear fractional partial differential equations that involve beta derivative.This study can bring a new perspective for studies on fractional differential equations.On the other hand,it can be said that scientists can apply the considered methods for different mathematical models arising in physics,chemistry,engineering,social sciences and etc.which involves fractional differentiation.Briefly the results may cause a new insight who studies on relativistic electron modelling. 展开更多
关键词 Klein-Fock-Gordon(KFG)equation beta derivative semi-analytical solution exact solution
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Bifurcations, Analytical and Non-Analytical Traveling Wave Solutions of (2 + 1)-Dimensional Nonlinear Dispersive Boussinesq Equation
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作者 Dahe Feng Jibin Li Airen Zhou 《Applied Mathematics》 2024年第8期543-567,共25页
For the (2 + 1)-dimensional nonlinear dispersive Boussinesq equation, by using the bifurcation theory of planar dynamical systems to study its corresponding traveling wave system, the bifurcations and phase portraits ... For the (2 + 1)-dimensional nonlinear dispersive Boussinesq equation, by using the bifurcation theory of planar dynamical systems to study its corresponding traveling wave system, the bifurcations and phase portraits of the regular system are obtained. Under different parametric conditions, various sufficient conditions to guarantee the existence of analytical and non-analytical solutions of the singular system are given by using singular traveling wave theory. For certain special cases, some explicit and exact parametric representations of traveling wave solutions are derived such as analytical periodic waves and non-analytical periodic cusp waves. Further, two-dimensional wave plots of analytical periodic solutions and non-analytical periodic cusp wave solutions are drawn to visualize the dynamics of the equation. 展开更多
关键词 (2 + 1)-Dimensional Nonlinear Dispersive Boussinesq Equation BIFURCATIONS Phase Portrait Analytical Periodic Wave solution Periodic Cusp Wave solution
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Analytic Solutions for Hindered Rotation Quantum Problem
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作者 Mirco Ragni 《Applied Mathematics》 2024年第10期709-718,共10页
Normalizable analytic solutions of the quantum rotor problem with divergent potential are presented here as solution of the Schrödinger equation. These solutions, unknown to the literature, represent a mathematic... Normalizable analytic solutions of the quantum rotor problem with divergent potential are presented here as solution of the Schrödinger equation. These solutions, unknown to the literature, represent a mathematical advance in the description of physical phenomena described by the second derivative operator associated with a divergent interaction potential and, being analytical, guarantee the optimal interpretation of such phenomena. 展开更多
关键词 Analytics solutions Schrodinger Equation Interaction Potential
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Assessment of Liver Fibrosis in HBsAg-Negative and Anti HBc Positive Patients
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作者 Kounpiélimé Sosthène Somda Aboubacar Coulibaly +4 位作者 Oyétoundé Taofick Amanda Sandrine Marie Odile Soudre Lawagoulé Joseph Emile Ky Christiane Bere Arsène Roger Sombie 《Open Journal of Gastroenterology》 CAS 2024年第10期331-339,共9页
Background: Surface antigen (HBsAg) is the mean marker of hepatitis B virus infection. During the course of the infection, some patients lose the HBsAg and only the presence of anti-HBc antibody indicates previous con... Background: Surface antigen (HBsAg) is the mean marker of hepatitis B virus infection. During the course of the infection, some patients lose the HBsAg and only the presence of anti-HBc antibody indicates previous contact with the virus. Among these patients, some have detectable viral load (occult infection) but most without viral replication. There is no guideline regarding these patients. The aim of this study was to assess hepatic fibrosis in patients with only the hepatitis B virus contact marker “total anti-HBc”. Patients and methods: it was a descriptive and analytical cross-sectional study, conducted in three private hospitals from January to August 2022. Were included HBsAg-negative and HBc-positive patients, consulting in Gastroenterology departments. Noninvasive methods (APRI, FIB-4 and FIBROSCAN) were used to evaluate liver stiffness because of their easy accessibility and low-cost. The hepatic fibrosis was considered significant when the score determined by APRI, FIB-4 and FIBROSCAN® tests was respectively greater than 1.5;2.67 and 8 kPa corresponding to fibrosis level 2 (F2). Results: A total of 63 HBsAg-negative/total HBcAg-positive patients were included. The mean age was 49.9 ± 13.4 years. The male/female sex ratio was 1.78. Of the 63 patients, 19 had significant liver fibrosis (30.1%) among which 9 patients had HCC. The FIB-4 score outperformed the APRI score in assessing liver fibrosis, with a sensitivity of 84.2%, a specificity of 100% and a negative predictive value of 93.6%. In univariate analysis, there was a significant association between the occurrence of significant liver fibrosis and age over 40 years, dyslipidaemia, obesity, alcohol consumption, smoking, herbal medicine, negative anti-HBs immunological status and detectable viral load. Conclusion: Our study revealed a high prevalence of significant to severe hepatic fibrosis in anti-HBc positive patients. In most of the cases, the fibrosis was severe. Progression to HCC has also been possible. There is no consensus on the follow-up strategy for those patients. However, screening for hepatic fibrosis using noninvasive methods should be recommended for patients aged over 40 years, alcohol or herbal medicine users, patients with metabolic syndrome or occult hepatitis B. In HBsAg-negative/anti-HBc-positive patients, liver stiffness should be evaluated and if it is greater than F2, HCC screening should be started. 展开更多
关键词 Anti HBc positives Liver Fibrosis Sub-Saharan Hepatitis B Virus
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Existence of Entropy Solution for Degenerate Parabolic-Hyperbolic Problem Involving p(x)-Laplacian with Neumann Boundary Condition
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作者 Mohamed Karimou Gazibo Duni Yegbonoma Frédéric Zongo 《Applied Mathematics》 2024年第7期455-463,共9页
We consider a strongly non-linear degenerate parabolic-hyperbolic problem with p(x)-Laplacian diffusion flux function. We propose an entropy formulation and prove the existence of an entropy solution.
关键词 Lebesgue and Sobolev Spaces with Variable Exponent Weak solution Entropy solution Degenerate Parabolic-Hyperbolic Equation Conservation Law Leray Lions Type Operator Neumann Boundary Condition Existence Result
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Malargüe Site Remediation:A Successful Solution for Uranium Mill Tailings
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作者 BARARI E DíAZ J G +1 位作者 GIOMIA KEMPF R A 《原子能科学技术》 EI CAS CSCD 北大核心 2024年第10期2088-2094,共7页
Comisión Nacional de Energía Atómica (CNEA) has the responsibility for restoring uranium mining facilities once the operations have finished.CNEA,within its Environmental Program and in compliance with ... Comisión Nacional de Energía Atómica (CNEA) has the responsibility for restoring uranium mining facilities once the operations have finished.CNEA,within its Environmental Program and in compliance with its legal responsibilities,decides to implement a restoration project for all sites related to the mining and processing of uranium ores.The Malargüe Site is located within the Province of Mendoza in the city of Malargüe.It is the first site to successfully complete its remediation.The activities consist of relocation of tailings to an engineering repository.The tailings management(encapsulation) and rehabilitation of the area was finished in June 2017.The remediation alternative for the ore tailings was selected after conducting comparative studies and submitted the project to the society for consideration.The objective of the encapsulation of the mineral tails is to isolate them from the environment,also proceeding with the decontamination and rehabilitation of the area (landscaping,post-closure monitoring and 20 years monitoring period).Encapsulation consisted of the construction of a containment cell for the mine tailings,to isolate them and prevent pollutants from entering the environment through the transfer routes.To clean the impacted areas,the soil was removed,it was incorporated into the encapsulation,and the filling was carried out with natural soils from the area.Remediation prevents radon transfer to the environment,as ^(222)Ra is an alpha emitter with a half-life of four days,which produces its own radioactive progeny.Radon progeny are solids,and when a ^(222)Ra nucleus emits an alpha particle into the air,the resulting ^(218)Po nucleus,momentarily electrically charged,adheres to any dust particle.Remediation prevents the discharge into the air containing radon and also containing dust particles charged with intensely radioactive radon progeny.The tasks mentioned make it possible to decrease radon emanation,reduce radiological risks to the public and prevent the entry of rainwater into the system.In addition,the containment system prevents the discharge of contaminated liquids into the environment,avoiding contamination of the groundwater.All these activities are according to the concepts of sustainability. 展开更多
关键词 REMEDIATION radionuclide transfer TAILINGS ENCAPSULATION solution sustainable
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GLOBAL WEAK SOLUTIONS FOR AN ATTRACTION-REPULSION CHEMOTAXIS SYSTEM WITH p-LAPLACIAN DIFFUSION AND LOGISTIC SOURCE
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作者 王晓闪 王忠谦 贾哲 《Acta Mathematica Scientia》 SCIE CSCD 2024年第3期909-924,共16页
This paper is concerned with the following attraction-repulsion chemotaxis system with p-Laplacian diffusion and logistic source:■The system here is under a homogenous Neumann boundary condition in a bounded domainΩ... This paper is concerned with the following attraction-repulsion chemotaxis system with p-Laplacian diffusion and logistic source:■The system here is under a homogenous Neumann boundary condition in a bounded domainΩ ■ R^(n)(n≥2),with χ,ξ,α,β,γ,δ,k_(1),k_(2)> 0,p> 2.In addition,the function f is smooth and satisfies that f(s)≤κ-μs~l for all s≥0,with κ ∈ R,μ> 0,l> 1.It is shown that(ⅰ)if l> max{2k_(1),(2k_(1)n)/(2+n)+1/(p-1)},then system possesses a global bounded weak solution and(ⅱ)if k_(2)> max{2k_(1)-1,(2k_(1)n)/(2+n)+(2-p)/(p-1)} with l> 2,then system possesses a global bounded weak solution. 展开更多
关键词 global weak solutions attraction-repulsion P-LAPLACIAN logistic source
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Open AccessAmplifying colorectal cancer progression:impact of a PDIA4/SP1 positive feedback loop by circPDIA4 sponging miR-9-5p
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作者 Yan Zhuang Yiding Ai +6 位作者 Peng Li Xin Yue Yue Li Luling Shan Tongtong Wang Peng Zhao Xun Jin 《Cancer Biology & Medicine》 SCIE CAS CSCD 2024年第10期916-933,共18页
Objective:Colorectal cancer(CRC)is a prevalent malignant tumor with a high fatality rate.CircPDIA4 has been shown to have a vital role in cancer development by acting as a facilitator.Nevertheless,the impact of the ci... Objective:Colorectal cancer(CRC)is a prevalent malignant tumor with a high fatality rate.CircPDIA4 has been shown to have a vital role in cancer development by acting as a facilitator.Nevertheless,the impact of the circPDIA4/miR-9-5p/SP1 axis on development of CRC has not been studied.Methods:Western blot,immunohistochemistry,and reverse transcription-quantitative polymerase chain reaction assays were used to analyze gene expression.The CCK-8 assay was used to assess cell growth.The Transwell assay was used to detect invasion and migration of cells.The luciferase reporter and RNA immunoprecipitation tests were used to determine if miR-9-5p and circPDIA4(or SP1)bind to one another.An in vivo assay was used to measure tumor growth.Results:It was shown that circPDIA4 expression was greater in CRC cell lines and tissues than healthy cell lines and tissues.CircPDIA4 knockdown prevented the invasion,migration,and proliferation of cells in CRC.Additionally,the combination of circPDIA4 and miR-9-5p was confirmed,as well as miR-9-5p binding to SP1.Rescue experiments also showed that the circPDIA4/miR-9-5p/SP1 axis accelerated the development of CRC.In addition,SP1 combined with the promoter region of circPDIA4 and induced circPDIA4 transcription.CircPDIA4 was shown to facilitate tumor growth in an in vivo assay.Conclusions:The circPDIA4/miR-9-5p/SP1 feedback loop was shown to aggravate CRC progression.This finding suggests that the ceRNA axis may be a promising biomarker for CRC patient treatment. 展开更多
关键词 CircRNA positive feedback loop colorectal cancer PDIA4 SP1
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Hamiltonian system for the inhomogeneous plane elasticity of dodecagonal quasicrystal plates and its analytical solutions
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作者 孙志强 侯国林 +1 位作者 乔艳芬 刘金存 《Chinese Physics B》 SCIE EI CAS CSCD 2024年第1期581-590,共10页
A Hamiltonian system is derived for the plane elasticity problem of two-dimensional dodecagonal quasicrystals by introducing the simple state function. By using symplectic elasticity approach, the analytic solutions o... A Hamiltonian system is derived for the plane elasticity problem of two-dimensional dodecagonal quasicrystals by introducing the simple state function. By using symplectic elasticity approach, the analytic solutions of the phonon and phason displacements are obtained further for the quasicrystal plates. In addition, the effectiveness of the approach is verified by comparison with the data of the finite integral transformation method. 展开更多
关键词 Hamiltonian system symplectic elasticity QUASICRYSTALS analytic solution state function
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