BACKGROUND Postherpetic neuralgia(PHN)is a typical neuropathic pain condition that appears in the lesioned skin regions following the healing of shingles.The pain condition tends to persist,which is often accompanied ...BACKGROUND Postherpetic neuralgia(PHN)is a typical neuropathic pain condition that appears in the lesioned skin regions following the healing of shingles.The pain condition tends to persist,which is often accompanied by negative emotions(e.g.,anxiety and depression)and substantially reduces the quality of life.In addition to analgesia(e.g.,pregabalin and gabapentin),nerve radiofrequency technology is an effective treatment for intractable PHN.However,there is still a significant portion of patients who do not benefit from this treatment.As a non-invasive form of brain stimulation,repetitive transcranial magnetic stimulation(rTMS)targeting the motor cortex is able to reduce neuropathic pain with grade A evidence.CASE SUMMARY Here we report two cases in which motor cortex rTMS was used to treat intractable PHN that did not respond to initial drug and radiofrequency therapies.Moreover,we specifically investigated rTMS efficacy at 3 mo following treatment.CONCLUSION Motor cortex rTMS can treat intractable PHN that did not respond to initial drug and radiofrequency therapies.展开更多
Post herpetic neuralgia (PHN) is a chronic neuropathic pain syndrome in the area of the herpes zoster (HZ) rash, persisting after the cutaneous lesions have subsided. Despite numerous treatment advances, many patients...Post herpetic neuralgia (PHN) is a chronic neuropathic pain syndrome in the area of the herpes zoster (HZ) rash, persisting after the cutaneous lesions have subsided. Despite numerous treatment advances, many patients remain refractory to the current therapies and continue to have pain, physical, economical and psychological distress. In this review, we will focus on the current treatment and prevention of PHN.展开更多
目的探讨干扰素联合更昔洛韦治疗带状疱疹的临床疗效及对后遗神经痛和IL-6、IL-10的影响。方法选取2014年1月~2015年2月于黑龙江省电力医院治疗的106例带状疱疹患者作为研究对象,随机数字表法分为对照组52例和观察组54例。2组患者均给...目的探讨干扰素联合更昔洛韦治疗带状疱疹的临床疗效及对后遗神经痛和IL-6、IL-10的影响。方法选取2014年1月~2015年2月于黑龙江省电力医院治疗的106例带状疱疹患者作为研究对象,随机数字表法分为对照组52例和观察组54例。2组患者均给予止痛等对症治疗。在此基础上,对照组给予更昔洛韦治疗,观察组在对照组基础上联合应用干扰素治疗。观察比较组间带状疱疹临床疗效、后遗神经痛发生率、后遗神经痛患者疼痛评分及炎性因子IL-6、IL-10水平,并于治疗期间观察不良反应发生情况。结果观察组带状疱疹治疗总有效率显著高于对照组（92.6%vs 78.8%,P〈0.05）。治疗后,观察组和对照组后遗神经痛发生率分别为44.4%和50.0%,组间比较差异无统计学意义,而观察组后遗神经痛患者VAS评分低于对照组[（3.5±0.7）分vs（5.8±0.9）分,P〈0.05]。炎性因子方面,与对照相比,观察组治疗后IL-6水平降低[（137.6±32.4）pg/m L vs（340.5±30.6）pg/m L,P〈0.05],IL-10水平升高[（179.3±22.5）μg/m L vs（150.6±24.1）μg/m L,P〈0.05]。治疗期间,2组患者均无严重不良反应。结论干扰素联合更昔洛韦治疗带状疱疹能够显著提高临床疗效,减轻后遗神经痛疼痛程度,且不良反应轻微。展开更多
Plasma nitrocarburizing and plasma oxidizing treatments were performed to improve the wear and corrosion resistance of SKD 61 steel.Plasma nitrocarburizing was conducted for 12 h at 540℃in the nitrogen, hydrogen and ...Plasma nitrocarburizing and plasma oxidizing treatments were performed to improve the wear and corrosion resistance of SKD 61 steel.Plasma nitrocarburizing was conducted for 12 h at 540℃in the nitrogen, hydrogen and methane atmosphere to produce theε-Fe-（2-3）（N,C） phase.The compound layer produced by plasma nitrocarburising was predominantly composed ofε-phase,with a small proportion ofγ′-Fe-4 （N,C） phase. The thickness of the compound layer and the diffusion layer are about 10μm and about 200μm,respectively. Plasma post oxidation was performed on the nitrocarburized samples with various oxygen/hydrogen ratio at constant temperature of 500℃for 1 h.The very thin magnetite （Fe-3O-4） layer of 1-2μm in thickness on top of the compound layer was obtained.Anodic polarization test revealed that plasma nitrocarburizing process contributed a significant improvement of corrosion resistance of SKD 61 steel.However,the corrosion characteristics of the nitrocarburized compound layer was deteriorated by oxidation treatment.展开更多
Plasma nitrocarburizing and plasma oxidizing treatments were performed to improve the wear and corrosion resistance of AISI 4140 steel. Plasma nitrocarburizing was conducted for 3 h at 570 ℃ in the nitrogen, hydrogen...Plasma nitrocarburizing and plasma oxidizing treatments were performed to improve the wear and corrosion resistance of AISI 4140 steel. Plasma nitrocarburizing was conducted for 3 h at 570 ℃ in the nitrogen, hydrogen and methane atmosphere to produce the ε-Fe2-3(N,C) phase. It was found that the compound layer produced by plasma nitrocarburising was predominantly composed of ε-phase, with a small proportion of γ′-Fe4(N,C) phase. The thickness of the compound layer was about 10 μm and the diffusion layer was about 300 μm in thickness, respectively. Plasma post oxidation was performed on the nitrocarburized samples with various oxygen/hydrogen ratio at a constant temperature of 500 ℃ for 1 h. The very thin magnetite (Fe3O4) layer 1-2 μm in thickness on top of the compound layer was obtained by plasma post oxidation. It was confirmed that the corrosion characteristics of the nitrocarburized compound layer can be further improved by the application of the superficial magnetite layer.展开更多
文摘BACKGROUND Postherpetic neuralgia(PHN)is a typical neuropathic pain condition that appears in the lesioned skin regions following the healing of shingles.The pain condition tends to persist,which is often accompanied by negative emotions(e.g.,anxiety and depression)and substantially reduces the quality of life.In addition to analgesia(e.g.,pregabalin and gabapentin),nerve radiofrequency technology is an effective treatment for intractable PHN.However,there is still a significant portion of patients who do not benefit from this treatment.As a non-invasive form of brain stimulation,repetitive transcranial magnetic stimulation(rTMS)targeting the motor cortex is able to reduce neuropathic pain with grade A evidence.CASE SUMMARY Here we report two cases in which motor cortex rTMS was used to treat intractable PHN that did not respond to initial drug and radiofrequency therapies.Moreover,we specifically investigated rTMS efficacy at 3 mo following treatment.CONCLUSION Motor cortex rTMS can treat intractable PHN that did not respond to initial drug and radiofrequency therapies.
文摘Post herpetic neuralgia (PHN) is a chronic neuropathic pain syndrome in the area of the herpes zoster (HZ) rash, persisting after the cutaneous lesions have subsided. Despite numerous treatment advances, many patients remain refractory to the current therapies and continue to have pain, physical, economical and psychological distress. In this review, we will focus on the current treatment and prevention of PHN.
文摘目的探讨干扰素联合更昔洛韦治疗带状疱疹的临床疗效及对后遗神经痛和IL-6、IL-10的影响。方法选取2014年1月~2015年2月于黑龙江省电力医院治疗的106例带状疱疹患者作为研究对象,随机数字表法分为对照组52例和观察组54例。2组患者均给予止痛等对症治疗。在此基础上,对照组给予更昔洛韦治疗,观察组在对照组基础上联合应用干扰素治疗。观察比较组间带状疱疹临床疗效、后遗神经痛发生率、后遗神经痛患者疼痛评分及炎性因子IL-6、IL-10水平,并于治疗期间观察不良反应发生情况。结果观察组带状疱疹治疗总有效率显著高于对照组（92.6%vs 78.8%,P〈0.05）。治疗后,观察组和对照组后遗神经痛发生率分别为44.4%和50.0%,组间比较差异无统计学意义,而观察组后遗神经痛患者VAS评分低于对照组[（3.5±0.7）分vs（5.8±0.9）分,P〈0.05]。炎性因子方面,与对照相比,观察组治疗后IL-6水平降低[（137.6±32.4）pg/m L vs（340.5±30.6）pg/m L,P〈0.05],IL-10水平升高[（179.3±22.5）μg/m L vs（150.6±24.1）μg/m L,P〈0.05]。治疗期间,2组患者均无严重不良反应。结论干扰素联合更昔洛韦治疗带状疱疹能够显著提高临床疗效,减轻后遗神经痛疼痛程度,且不良反应轻微。
文摘Plasma nitrocarburizing and plasma oxidizing treatments were performed to improve the wear and corrosion resistance of SKD 61 steel.Plasma nitrocarburizing was conducted for 12 h at 540℃in the nitrogen, hydrogen and methane atmosphere to produce theε-Fe-（2-3）（N,C） phase.The compound layer produced by plasma nitrocarburising was predominantly composed ofε-phase,with a small proportion ofγ′-Fe-4 （N,C） phase. The thickness of the compound layer and the diffusion layer are about 10μm and about 200μm,respectively. Plasma post oxidation was performed on the nitrocarburized samples with various oxygen/hydrogen ratio at constant temperature of 500℃for 1 h.The very thin magnetite （Fe-3O-4） layer of 1-2μm in thickness on top of the compound layer was obtained.Anodic polarization test revealed that plasma nitrocarburizing process contributed a significant improvement of corrosion resistance of SKD 61 steel.However,the corrosion characteristics of the nitrocarburized compound layer was deteriorated by oxidation treatment.
文摘Plasma nitrocarburizing and plasma oxidizing treatments were performed to improve the wear and corrosion resistance of AISI 4140 steel. Plasma nitrocarburizing was conducted for 3 h at 570 ℃ in the nitrogen, hydrogen and methane atmosphere to produce the ε-Fe2-3(N,C) phase. It was found that the compound layer produced by plasma nitrocarburising was predominantly composed of ε-phase, with a small proportion of γ′-Fe4(N,C) phase. The thickness of the compound layer was about 10 μm and the diffusion layer was about 300 μm in thickness, respectively. Plasma post oxidation was performed on the nitrocarburized samples with various oxygen/hydrogen ratio at a constant temperature of 500 ℃ for 1 h. The very thin magnetite (Fe3O4) layer 1-2 μm in thickness on top of the compound layer was obtained by plasma post oxidation. It was confirmed that the corrosion characteristics of the nitrocarburized compound layer can be further improved by the application of the superficial magnetite layer.
