Aim: To correlate obstetric data with the appearance of antithyroid antibodies. Methods: A 6 months follow up was performed on 135 healthy women with assessment of TSH, T3, T4 and antithyroid antibodies (anti thyroglo...Aim: To correlate obstetric data with the appearance of antithyroid antibodies. Methods: A 6 months follow up was performed on 135 healthy women with assessment of TSH, T3, T4 and antithyroid antibodies (anti thyroglobulin and anti peroxidase). Correlation of diverse obstetrical parameters with the appearance of antithyroid antibodies at 2 and 6 months postpartum was determined. Results: Only two parameters were significant during the complete follow up: the newborn weight, which correlated with both antibodies (anti-thyroglobulin and anti-peroxidase) positivity and the maternal height, which exclusively correlated with anti-thyroglobulin positivity. Conclusions: Correlation of maternal height and newborn weight with positive autoantibodies allows to consider a future clinical screening test for this disorder.展开更多
目的:对国内外妊娠期和产后甲状腺疾病诊治指南进行质量评价,并对指南推荐意见差异进行总结,旨在为今后相关指南的制定提供参考。方法:计算机检索PubMed、Embase、Web of Science、VIP、CNKI、万方数据库及国内外相关指南数据库,搜集妊...目的:对国内外妊娠期和产后甲状腺疾病诊治指南进行质量评价,并对指南推荐意见差异进行总结,旨在为今后相关指南的制定提供参考。方法:计算机检索PubMed、Embase、Web of Science、VIP、CNKI、万方数据库及国内外相关指南数据库,搜集妊娠期和产后甲状腺疾病诊治相关的临床实践指南,检索时限均从建库至2023年10月。由2名研究者独立筛选文献、提取资料,4名研究者运用AGREEⅡ工具对纳入的指南进行质量评价,并对指南推荐意见进行比较。结果:共纳入14部指南。6个领域的AGREEⅡ评分中位数依次为:范围和目的(86.11%)、参与人员(49.31%)、严谨性(45.05%)、清晰性(70.14%)、应用性(42.71%)、独立性(46.88%)。推荐级别为:A级(推荐)5部,B级(修改完善后推荐)5部,C级(不推荐)4部。指南推荐意见差异主要为妊娠期亚临床甲状腺功能减退症和甲状腺自身抗体阳性的诊断标准和药物治疗推荐意见。结论:妊娠期和产后甲状腺疾病诊治指南在严谨性、应用性、独立性方面需进一步完善。展开更多
文摘Aim: To correlate obstetric data with the appearance of antithyroid antibodies. Methods: A 6 months follow up was performed on 135 healthy women with assessment of TSH, T3, T4 and antithyroid antibodies (anti thyroglobulin and anti peroxidase). Correlation of diverse obstetrical parameters with the appearance of antithyroid antibodies at 2 and 6 months postpartum was determined. Results: Only two parameters were significant during the complete follow up: the newborn weight, which correlated with both antibodies (anti-thyroglobulin and anti-peroxidase) positivity and the maternal height, which exclusively correlated with anti-thyroglobulin positivity. Conclusions: Correlation of maternal height and newborn weight with positive autoantibodies allows to consider a future clinical screening test for this disorder.
文摘目的:对国内外妊娠期和产后甲状腺疾病诊治指南进行质量评价,并对指南推荐意见差异进行总结,旨在为今后相关指南的制定提供参考。方法:计算机检索PubMed、Embase、Web of Science、VIP、CNKI、万方数据库及国内外相关指南数据库,搜集妊娠期和产后甲状腺疾病诊治相关的临床实践指南,检索时限均从建库至2023年10月。由2名研究者独立筛选文献、提取资料,4名研究者运用AGREEⅡ工具对纳入的指南进行质量评价,并对指南推荐意见进行比较。结果:共纳入14部指南。6个领域的AGREEⅡ评分中位数依次为:范围和目的(86.11%)、参与人员(49.31%)、严谨性(45.05%)、清晰性(70.14%)、应用性(42.71%)、独立性(46.88%)。推荐级别为:A级(推荐)5部,B级(修改完善后推荐)5部,C级(不推荐)4部。指南推荐意见差异主要为妊娠期亚临床甲状腺功能减退症和甲状腺自身抗体阳性的诊断标准和药物治疗推荐意见。结论:妊娠期和产后甲状腺疾病诊治指南在严谨性、应用性、独立性方面需进一步完善。
