Mental disorders after myocardial infarction:potential mediator role for chemokines in heart-brain interaction?

Acute myocardial infarction(MI)remains one of the leading causes of mortality and morbidity in the global communities.A prevailing topic that has attracted increasing attentions over the past few decades is the so-called heart-brain interaction,in particular following a major traumatic event such as MI.Increased prevalence of depression and other mental disorders has been recognized in cardiac patients after MI,coronary catheterization,or cardiothoracic surgeries.In this review,we focus on the potential pathogenic mechanisms and pre-clinical transcriptomic evidence for identifying potential mediators of post-MI depression.We first summarize the conventional mechanistic understanding that leads to the current clinical management of post-MI depression with the use of selective serotonin reuptake inhibitors(SSRIs)and cognitive behavior and exercise therapies.We further envisage a possible role played by certain chemokines,e.g.,Chemokine(C-X-C motif)ligand 12(CXCL12)and Chemokine(C-C motif)ligand 2(CCL22),in serving as signaling molecules to connect the MI-induced heart damage to the pro-depressive changes in brain during the post-MI period.Future in-depth investigations into this chemokine hypothesis will be instrumental in developing new chemokine-targeted therapies for better management of the cardiac patients suffering from post-MI depression.

On the Role of Chemical Potential in Determining the Temperature Dependent Critical Magnetic Field and the Penetration Depth of Superconductors

Dealing with both elemental and high-Tc superconductors (SCs) - Sn, Nb and Pb belonging to the former category, and MgB2 and different samples of YBCO to the latter - we show that the difference in the values of their critical magnetic field Hc1,c2 and the penetration depth λL(0) is, remarkably, attributable predominantly to the difference in the values of a single parameter, viz., the chemical potential (μ) close to their critical temperatures (Tcs). Based directly on the dynamics of pairing in a magnetic field and the corresponding number equation, our approach relates Hc1,c2 of an SC with the following set of its properties: S1 = {μ, Tc, Debye temperature, effective mass of the electron, magnetic interaction parameter, Landau index}. Hence, it provides an alternative to the approach followed by Talantsev [Mod. Phys. Lett. B 33, 1950195 (2019)] who has shown by ingeniously combining the results of various well-established theories that Hc2 of an SC can be calculated via four different equations, each of which invokes two or more properties from its sample-specific set S2 = {Tc, gap, coherence length, λL(0), jump in sp. ht.}, which is radically different from S1.

New perspectives in prognostication of hepatocellular carcinoma:The role and clinical implications of transient receptor potential family genes

The study titled“Transient receptor potential-related risk model predicts prognosis of hepatocellular carcinoma patients”is a significant contribution to hepatocellular carcinoma(HCC)research,highlighting the role of transient receptor potential(TRP)family genes in the disease’s progression and prognosis.Utilizing data from The Cancer Genome Atlas database,it establishes a new risk assessment model,emphasizing the interaction of TRP genes with tumor proliferation pathways,key metabolic reactions like retinol metabolism,and the tumor immune microenvironment.Notably,the overexpression of the TRPC1 gene in HCC correlates with poorer patient survival outcomes,suggesting its potential as a prognostic biomarker and a target for personalized therapy,particularly in strategies combining immunotherapy and anti-TRP agents.

Mitochondria–cGAS–STING axis is a potential therapeutic target for senescence-dependent inflammaging-associated neurodegeneration

The word “senescence” comes from the Latin senescens, meaning “to begin to age”, and is characterized by a long-lasting but reversible block in proliferation, resulting from stress-induced cell cycle arrest of previously replication-competent cells.

Geological Conditions and Petroleum Exploration Potential of the Albertine Graben of Uganda

The Albertine Graben in western Uganda is a Mesozoic-Cenozoic rift basin with petroleum exploration potential. A fundamental evaluation of petroleum potential of the graben is given based on field research, data processing of gravity and magnetism, analysis of graben structure, geochemistry, reservoir and composition research. The basin has a double-layered framework and a large thickness of sediments. Gravity highs shown in a residual anomaly map might indicate central uplift zones. There exist at least two sets of mature or low-maturity source rocks corresponding to a certain source rock in the Cretaceous or Paleogene and Neogene strata. The graben has basement rock with potential reservoirs and Tertiary sandstone reservoirs and thus has petroleum exploration potential.

Study of Infection of Echinococcus granulosus in Yak in Spring and Its Potential Role in Transmission of Cystic Echinococcosis in Rangtang County of Sichuan,China

Dear Editor, Cystic echinococcosis （CE）, caused by Echinococcus granulosus in larval stage, is considered as one of the most dangerous parasitic zoonosis in the world. The obligate 2-host parasitic cycle of Echinococcus granulosus is predominantly synanthropic. Dogs are the usual definitive hosts, and lots of mammalian species can be intermediate hosts, including domestic livestock and human[I2]. In the Tibetan plateau, China, the population is mainly Tibetans primarily engaged in livestock husbandry and CE is therefore a health problem for both people and animal in Tibetan communities. The reported infection rate of Echinococcus gronulosus in slaughtered yak in slaughterhouses is usually very high, being about 50% or higher as reported, and the liver and lungs are the main affected organs[34].

Further Recognition of Petroleum Exploration Potential of Marine Carbonates in Western Tarim Basin

A series of significant discoveries in marine carbonate rocks show great petroleum exploration potential in the Tarim Basin. However, the oil and gas fields discovered in the carbonate rocks are mainly distributed around the Manjiaer Sag in the eastern Tarim Basin. Some explorations occurred and no oil or gas field was discovered around the Awati Sag in the western Tarim Basin. Information from wells and outcrops reveals that there are excellent oil and gas source rock conditions around the Awati Sag. Transformed reef-shoal reservoirs could be formed in the Ordovician carbonate rocks with paleo-geographic background and hydrothermal conditions. Therefore, it is necessary to make a systematical study and overall evaluation of the potential of the periphery of the Awati Sag in terms of source rock evolution, resource potential, high-grade reservoir formation and distribution, and main factors controlling hydrocarbon migration and accumulation.

The Dynamic Role of Breathing and Cellular Membrane Potentials in the Experience of Consciousness

Understanding the mechanics of consciousness remains one of the most important challenges in modern cognitive science. One key step toward understanding consciousness is to associate unconscious physiological processes with subjective experiences of sensory, motor, and emotional contents. This article explores the role of various cellular membrane potential differences and how they give rise to the dynamic infrastructure of conscious experience. This article explains that consciousness is a body-wide, biological process not limited to individual organs because the mind and body are unified as one entity;therefore, no single location of consciousness can be pinpointed. Consciousness exists throughout the entire body, and unified consciousness is experienced and maintained through dynamic repolarization during inhalation and expiration. Extant knowledge is reviewed to provide insight into how differences in cellular membrane potential play a vital role in the triggering of neural and non-neural oscillations. The role of dynamic cellular membrane potentials in the activity of the central nervous system, peripheral nervous system, cardiorespiratory system, and various other tissues (such as muscles and sensory organs) in the physiology of consciousness is also explored. Inspiration and expiration are accompanied by oscillating membrane potentials throughout all cells and play a vital role in subconscious human perception of feelings and states of mind. In addition, the role of the brainstem, hypothalamus, and complete nervous system (central, peripheral, and autonomic) within the mind-body space combine to allow consciousness to emerge and to come alive. This concept departs from the notion that the brain is the only organ that gives rise to consciousness.

Mineralogic Characterization and Petroleum Potential of Clays (Shales) of the N’Kappa Formation (Paléocene-Eocene) in the Douala Sedimentary Sub-basin (South-West Cameroon)

The aim of this research work was to report a facies analysis of the N’Kappa formation, identified the clay minerals present in those facies and evaluate their oil potential. For that to be done, Lithostratigraphic descriptions were performed on three natural outcrops chosen in three different localities of the northern border of Douala sedimentary basin. Ten shaly samples were then collected on those outcrops and submit to X ray diffraction and Rock-Eval pyrolysis. Lithologically, the N’Kappa formation is made up of dark to grey shales and fine to coarse sandtones. The mineralogic content of the shales is made up of Kaolinite, dickite, low quartz and vaterite. Those shaly facies present high amount of immature organic matter (average TOC content around 2%). The petroleum potential is fair to poor (average S2 for all the samples around 3.33 mg HC/g of rock) though some samples (M1 and M2) presenting a good petroleum potential up to 6.62 kg HC/t of rock and 6.44 kg HC/t of rock respectively. They have undergone a low degree of diagenesis (early to burying diagenesis). This is evidenced by the predominance of kaolinite and dickite, low quartz and vaterite which are minerals stable at low temperature.

The role of local field potential coupling in epileptic synchronization

This review hopes to clearly explain the following viewpoints： （1） Neuronal synchronization underlies brain functioning, and it seems possible that blocking excessive synchronization in an epileptic neural network could reduce or even control seizures. （2） Local field potential coupling is a very common phenomenon during synchronization in networks. Removal of neurons or neuronal networks that are coupled can significantly alter the extracellular field potential. Interventions of coupling mediated by local field potentials could result in desynchronization of epileptic seizures. （3） The synchronized electrical activity generated by neurons is sensitive to changes in the size of the extracellular space, which affects the efficiency of field potential transmission and the threshold of cell excitability. （4） Manipulations of the field potential fluctuations could help block synchronization at seizure onset.

Petroleum Hydrocarbon Degradation Potential of Soil Bacteria Native to the Yellow River Delta

The bioremediation potential of bacteria indigenous to soils of the Yellow River Delta in China was evaluated as a treatment option for soil remediation. Petroleum hydrocarbon degraders were isolated from contaminated soil samples from the Yellow River Delta. Four microbial communities and eight isolates were obtained. The optimal temperature, salinity, pH, and the ratios of C, N, and P (C:N:P) for the maximum biodegradation of diesel oil, crude oil, n-alkanes, and polyaromatic hydrocarbons by indigenous bacteria were determined, and the kinetics changes in microbial communities were monitored. In general, the mixed microbial consortia demonstrated wider catabolic versatility and faster overall rate of hydrocarbon degradation than individual isolates. Our experimental results demonstrated the feasibility of biodegradation of petroleum hydrocarbon by indigenous bacteria for soil remediation in the Yellow River Delta.

Petroleum geological framework and hydrocarbon potential in the Yellow Sea

Sedimentary basins in the Yellow Sea can be grouped tectonically into the North Yellow Sea Basin (NYSB), the northern basin of the South Yellow Sea (SYSNB) and the southern basin of the South Yellow Sea (SYSSB). The NYSB is connected to Anju Basin to the east. The SYSSB extends to Subei Basin to the west. The acoustic basement of basins in the North Yellow Sea and South Yellow Sea is disparate, having different stratigraphic evolution and oil accumulation features, even though they have been under the same stress regime since the Late Triassic. The acoustic basement of the NYSB features China-Korea Platform crystalline rocks, whereas those in the SYSNB and SYSSB are of the Paleozoic Yangtze Platform sedimentary layers or metamorphic rocks. Since the Late Mesozoic terrestrial strata in the eastern of the NYSB (West Korea Bay Basin) were discovered having industrial hydrocarbon accumulation, the oil potential in the Mesozoic strata in the west depression of the basin could be promising, although the petroleum exploration in the South Yellow Sea has made no break-through yet. New deep reflection data and several drilling wells have indicated the source rock of the Mesozoic in the basins of South Yellow Sea, and the Paleozoic platform marine facies in the SYSSB and Central Rise could be the other hosts of oil or natural gas. The Mesozoic hydrocarbon could be found in the Mesozoic of the foredeep basin in the SYSNB that bears potential hydrocarbon in thick Cretaceous strata, and so does the SYSSB where the same petroleum system exists to that of oil-bearing Subei Basin.

The role of potential soil cavity on ground subsidence and collapse in coal mining area

Based on five basic assumptions, of the ground subsidence and collapse was using theoretical analysis method, the nature revealed from the mechanics point. Divided into four phases as groundwater level descent, soil cavity formation, soil cavity expansion, and ground collapse emersion, the whole process of ground subsidence and collapse was analyzed in detail. The study shows that ground subsidence and collapse is the macro- scopic performance and inevitable result of the soil cavity expansion and development, and the dynamic mechanics is the spalling force induced by the groundwater falling. The activities of underground water play a very important role in the process from the formation of soil cavity to the production of ground subsidence.

Role of methylation in vernalization and photoperiod pathway:a potential flowering regulator?

Recognized as a pivotal developmental transition,flowering marks the continuation of a plant’s life cycle.Vernalization and pho-toperiod are two major flowering pathways orchestrating numerous florigenic signals.Methylation,including histone,DNA and RNA methylation,is one of the recent foci in plant development.Considerable studies reveal that methylation seems to show an increasing potential regulatory role in plant flowering via altering relevant gene expression without altering the genetic basis.However,little has been reviewed about whether and how methylation acts on vernalization-and photoperiod-induced flowering before and after FLOWERING LOCUS C(FLC)reactivation,what role RNA methylation plays in vernalization-and photoperiod-induced flowering,how methylation participates simultaneously in both vernalization-and photoperiod-induced flowering,the heritability of methylation memory under the vernalization/photoperiod pathway,and whether and how methylation replaces vernalization/photoinduction to regulate flowering.Our review provides insight about the crosstalk among the genetic control of the flowering gene network,methylation(methyltransferases/demethylases)and external signals(cold,light,sRNA and phytohormones)in vernalization and photoperiod pathways.The existing evidence that RNA methylation may play a potential regulatory role in vernalization-and photoperiod-induced flowering has been gathered and represented for the first time.This review speculates about and discusses the possibility of substituting methylation for vernalization and photoinduction to promote flowering.Current evidence is utilized to discuss the possibility of future methylation reagents becoming flowering regulators at the molecular level.

Petroleum Potentials of the Nigerian Benue Trough and Anambra Basin: A Regional Synthesis

A review on the geology and petroleum potentials of the Nigerian Benue Trough and Anambra Basin is done to identify potential petroleum systems in the basins. The tectonic, stratigraphic and organic geochemical evaluations of these basins suggest the similarity with the contiguous basins of Chad and Niger Republics and Sudan, where commercial oil discovery have been made. At least two potential petroleum systems may be presented in the basins: the Lower Cretaceous petroleum system likely capable of both oil and gas generation and the Upper Cretaceous petroleum system that could be mainly gas-generating. These systems are closely correlative in temporal disposition, structures, source and reservoir rocks and perhaps generation mechanism to what obtains in the Muglad Basin of Sudan and Termit Basin of Niger and Chad Republics. They are very effective in planning future exploration campaigns in the basins.

TECTONIC EVOLUTION AND PETROLEUM POTENTIALITY OF THE JURASSIC IN NORTH QAIDAM BASIN,QINGHAI PROVINCE

The Jurassic in the northern Qaidam basin is an independent petroleum system.To find high－ quality source rock is the key problem in exploration.The result of plate tectonics research shows that the Jurassic basin had been formed in an extensional tectonic stress field after the Indo－ China movement along northwest and northeast directions.It belongs to a kind of compound fault subsidence.The area,where the different direction subsidences overlapped,is the oil－ generating center,and also is the favourable exploration target.

Petroleum geological conditions and exploration potential of Lower Paleozoic carbonate rocks in Gucheng Area, Tarim Basin, China

Lower Paleozoic carbonate rocks are an important exploration area in craton area of the Tarim Basin,with the proven oil and gas reserves of more than 2.2×10^8 t,but no large-scale discovery has been made in the Gucheng area so far.The key issues restricting exploration are that the source rock,reservoir scale and law of oil and gas enrichment are unclear.By systematically examining the petroleum geological conditions of Lower Paleozoic carbonate rocks,the following findings are reached:(1)Source rocks of slope-basin facies developed in Cambrian-Lower Ordovician in the Gucheng area.(2)The dolomitized beach in the lower part of Ordovician Yingshan Formation has large-scale reservoirs,good reservoir-cap assemblage and developed gas source faults,and is an important field for increasing reserves and production in the near future;hydrocarbon enrichment is controlled by reservoir and gas source faults,and the central dolomitized beach zone is the main exploration area.(3)The Cambrian platform margin reef beach,large in scale,good in physical properties and close to source rocks,has the possibility to form monolithic gas field;the caprock and preservation conditions are the key factors for hydrocarbon enrichment;the northern part of the phasesⅠandⅡplatform margin reefs has better sealing conditions,and is the main direction of next exploration.(4)Limestone fault solution reservoirs in the upper part of Ordovician Yingshan Formation,controlled by faults and small in scale,but good in reservoir-cap combination,worth exploring.(5)The granular limestone beach of Ordovician Yijianfang Formation is well developed and gas-bearing,but short in exposure dissolution time,and the reservoirs are strongly heterogeneous,and are a potential exploration field.

Role and maintenance of redox potential on chalcopyrite biohydrometallurgy:An overview

Chalcopyrite is one of the most important copper minerals;however,the extracted efficiency of chalcopyrite is still not satisfactory in hydrometallurgy owing to its high lattice energy which leads to its low dissolution kinetics.To overcome the difficulties,many advanced technologies have been developed,including the selection of high effectively bacteria,the inhibition of the passivation film adhered onto the minerals surface,and the maintenance of solution redox potential under an optimum range.Up to date,considerable researches on the first two terms have been summarized,while the overview of the last term has been rarely reported.Based on corresponding works in recent years,key trends and roles of solution redox potential in copper hydrometallurgy,including its definition,effect and maintenance,have been introduced in this review.

A NEW INTERPRETATION OF THE EVOLUTION OF THE TETHYS CRUSTOBODY AND THE PETROLEUM POTENTIAL OF THE QINGHAI-XIZANG (TIBET) PLATEAU

Although large amounts of data have been collected during the past 30 yesrs in the study of the formation, evolution and dynamics of the Tethys Sea by the use of the theory of plate tectonics, a large volume of geological and geophysical information has also been accumulated which cannot be explained by the plate tectonic hypothesis. For example, the Qinghai-Xizang Plateau is underlain by many thousands of meters of Ordovician through Eocene, gently-dipping, essentially undeformed, stable platform sequences. Stratigraphic and tectonic investigations reveal that the plateau-wide east-west fracture zones, interpreted as "sutures" in a plate-tectonic model, are not sutures at all. On the other hand, from the Late Carboniferous to the beginning of the Early Permian, it was impossible for the Tethys ocean with a width of several thousand kilometers to."open" and "close" (the speed could not be so great). The east-west fracture zones, with very sharp angles, exerted no control over deposition. Stress analysis of magmatic activity indicates that the Himalayan zone is presently under compression, the Gangdise zone under interwoven comprepsion and tension, and the Qinghai and Deccan Plateaus under weak tension. Lateral compression caused by weak tension at the northern and southern terminations was not enough for Xizang and its surroundings between India and Qinghai Province of China with an area of 2,400,000 km2 to rise to a height of 4,000 m above mean sea level. The authors believe that surge tectonics is the force driving the evolution of the Tethys Sea and the rising of the Qinghai-Xizang Plateau. G. G. T. demonstrates that two surge channels, an upper and a lower, exist in the Yadong-Anduo litho sphere, and the upper mantle in the southern part is uplifted. During the Eocene, as a result of tectogenesis, molten magma poured out from the channel along the Yarlung Zangbo River,forming ophiolites and melanges, and earthquakes and terrestrial heat are also distributed along the fracture zone. Likewise, at an earlier time the Banggong Co-Nujiang and Longmu Co-Yushu Jinshajiang surge channels and their fracture zones formed. During the Miocene, the three surge channels merged laterally, and then the unified rise of the Qinghai-Xizang Plateau took place. The formation and evolution of the surge channels resulted in a variety of worthy Paleozoic, Mesozoic and Cenozoic exploration targets and a series of sedimentary basins with the largest Qamdo Basin occupying 120, 000 km2 with sediments attaining a thickness of 15, 000 m. These basins contain multiple source-beds, reservoirs, traps and seals of different ages, showing oil and gas every-where. In the northern part lithology and facies are more stable than in the southern, and subsequent tectonic overprinting and volcanic activity are relatively weak. At present commercial oil flow has been penetrated by drilling in the Tertiary Lunpola Basin.

Potential therapeutic interventions based on the role of the endoplasmic reticulum stress response in progressive neurodegenerative diseases

In 1945,Porter et al.published an electon microscopy study of cultured chick fibroblasts in which they observed：＇a granular background and details of a darker lacelike reticulum which in places appears to be made up of chains of＂vesicles＂＇（Porter et al.,1945）.This constituted the first published observation of the endoplasmic reticulum（ER）and,while it was not evident at that time,this cytoplasmic system of interconnecting membrane-lined channels, comprising vesicles, tubules and cisternae, has numerous important functions.