Carbon emissions reduction potentiality for railroad transportation based on life cycle assessment

This study addresses the comparative carbon emissions of different transportation modes within a unified evaluation framework,focusing on their carbon footprints from inception to disposal.Specifically,the entire life cycle carbon emissions of High-Speed Rail(HSR),battery electric vehicles,conventional internal combustion engine vehicles,battery electric buses,and conventional internal combustion engine buses are analyzed.The life cycle is segmented into vehicle manufacturing,fuel or electricity production,operational,and dismantlingrecycling stages.This analysis is applied to the Beijing-Tianjin intercity transportation system to explore emission reduction strategies.Results indicate that HSR demonstrates significant carbon emission reduction,with an intensity of only 24%-32% compared to private vehicles and 47%-89% compared to buses.Notably,HSR travel for Beijing-Tianjin intercity emits only 24% of private vehicle emissions,demonstrating the emission reduction benefits of transportation structure optimization.Additionally,predictive modeling reveals the potential for carbon emission reduction through energy structure optimization,providing a guideline for the development of effective transportation management systems.

Study on application potentiality of the first China's ocean satellite HY-1A

China has launched her first ocean color satellite HY-1A on May 15, 2002 since American ocean color satellite SeaSTAR was on the orbit in 1997. First, the properties and characteristics of HY-1A are briefly introduced; second, the quality and availability are evaluated by means of the complex signal noise ratio ( CSNR) which is simulated theoretically; third, the received HY-1A data are compared with SeaSTAR data to understand the accuracy of radiance measurement by the HY-1A; finally, the remote sensing products of ocean color and temperature are mapped to study the application potentiality of HY-1A. The results show that the HY-1A has its latent capability for the application of marine environment detection, the management and protection of marine resources, and the national rights and interests. Meanwhile some suggestions are proposed to modify the next ocean satellite.

TECTONIC EVOLUTION AND PETROLEUM POTENTIALITY OF THE JURASSIC IN NORTH QAIDAM BASIN,QINGHAI PROVINCE

The Jurassic in the northern Qaidam basin is an independent petroleum system.To find high－ quality source rock is the key problem in exploration.The result of plate tectonics research shows that the Jurassic basin had been formed in an extensional tectonic stress field after the Indo－ China movement along northwest and northeast directions.It belongs to a kind of compound fault subsidence.The area,where the different direction subsidences overlapped,is the oil－ generating center,and also is the favourable exploration target.

In vitro analysis on bactericidal screening and antioxidant potentiality of leaf and root extracts of Thottea siliquosa(Lam.)Ding Hou.An ethnobotanical plant

Objective:Natural products of plant origin are potential source of novel antimicrobial and antioxidative agents.Thottea siliquosa(Lam.)Ding Hou.(T.siliquosa).A medicinal herb used by local tribals for treating various ailments.The present study aims at the phytochemical screening,GC-MS analysis,in vitro antibacterial activity and antioxidant potentiality of root and leaf extracts of T.siliquosa.Methods:Hot continuous Soxhlct extraction,GC-MS analysis,antibacterial analysis by disc diffusion,microdilution assay and antioxidant potentialities by hydroxyl radical and nitric oxide radical scavenging.The data was statistically analyzed.Results:Phytochemical screening of the ethyl acetate and methanolic extract of leaf and root revealed the presence of phenols,alkaloids,tannins and saponin.The extract revealed a pool of phytochemicals by comparison with authentic standards from spectral library.Both the extracts has shown their broad spectrum of inhibition against the selected bacteria Staphylococcus aureus,Escherichia coli,Pseudomonas aeruginosa and Klebsiella pneumonia compared with standard antibiotic drug streptomycin.The extracts showed antioxidant activity by scavenging of free radicals such as hydroxyl and nitric oxide.The IC_(50)values of the ethyl acetate extracts leaf and root and standard in this assay were I67.5±0.67,99.4±1.2,192±2.5μg/mL respectively.Similarly those methanolic extracts of leaf and root were 269.5±0.89 and 289.1±2.66μg/mL respectively.Similarly,ethyl acetate and methanolic extracts also caused a moderate dose-dependent inhibition of nitric oxide with an IC_(50)range 65.5±1.55 to 148±3.09μg/mL.The inhibitory activities were found to be dose dependent.Conclusion:The present study provides evidence that ethyl acetate and methanol extract of leaf and root of T.siliquosa are potential source of natural antioxidants and bactericidal nature.It is essential that research should continue to isolate and purify the bio active components of this natural plant and use in drug discovery and development.

Studies on the Utilization Potentiality of the Nucleo-Cytoplasmic Hybrid in Wheat

A series of comparative studies was carried out on the genetic effects of 25 alien cytoplasms of wheat on the growth potential, heading stage, fertility, resistance against diseases, important agronomic traits and its heterosis of 125 nuclei-cytoplasmic hybrids of wheat. The results indicated that there were clearly effects of alien cytoplasms on some characteristics, but the nucleus still exerted main effect on other characteristics. The effect of interactions between nucleus and cytoplasm was comparative obvious in some combination. Consequently, when we utilize the effects of alien cytoplasms, we should pay full attention to the facts such as the characteristic to be improved, the effects of cytoplasm, nucleus, the nucleus-cytoplasm interactions on that characteristics. From the preliminary studies, we believed that the cytoplasmic types of M0, S1, Sv, D2, D and B, and the nucleo-cytoplasmic hybrids of (Ae. sharonensis)-B174, (Ae. squarrosa)-352-35 (Ae. cylindrica)-352-35, (Ae. cylindria)-E EN-1, (Ae. cylindrica)-NPFP, and (Ae. speltoides)-352-35 would have some utilization potentiality in cultivar improvement.

GIS-Mapping of Soil Available Plant Nutrients (Potentiality, Gradient, Anisotropy)

The research was elaborated in Kafr El-Dawar area (Egypt northern region) to study the availability of the soil plant nutrients. The research introduced three parameters to comprehensively and carefully describe the availability of the soil plant nutrients: potentiality, gradient and anisotropy. Potentiality defines the categories of soil ability to supply plant nutrients;meanwhile gradient expresses the increasing rate of the availability of the soil plant nutrients. The gradient anisotropy refers to the directions or orientation of the increasing rate of the availability of the soil plant nutrients. The introduced parameters enabled to spatially study the availability of the soil plant nutrients. Analytical data, of soil available phosphorus (P), indicated that P ranged from 0.2 ppm to 11.4 ppm to locate all studied soil samples into the low class of the soil nutritional P ability. This was not the case of available potassium (K), where the soil samples were distributed into three available K soil categories: medium, high, and very high. GIS map of soil P nutritional potentiality for plant (potato), displayed the soil studied area in one category, as low P soil nutritional potentiality to coincide with the analytical data classification. Contrary, the K map classified the soil studied area into three categories of soil K nutritional potentiality: medium, high and excessive. This obviously referred that the individual determination of soil K nutritional potentiality is misleading for interpretation of soil tests because it does care of the spatial distribution of soil available K. Nearly, all soil samples had high available micronutrients that they were located in the high category in both classification of analytical data and GIS maps. GIS gradient maps of the soil available plant nutrients referred that the soil plant nutrients, exception of K, had two gradients: non increasing-slight increasing and build up. Gradient of soil available potassium was classified into four classes: non increasing-slight increasing, build up, moderately increasing and hike. Regardless potassium case, the non increasing-slight increasing gradient class dominated the others. GIS maps of anisotropy soil availability of macronutrients (P and K) generally showed that their gradients mainly increased in two directions: north and south. The incasing directions of soil availability of micronutrients coincided with that of the macronutrients.

Primary study on evaluation index system for groundwater exploitation potentiality based on the niche theories

Based on the groundwater resources evaluation, the groundwater exploitation potentiality evaluation is aiming at providing references for management, planning and development of groundwater. Traditional evaluation methods mainly adopted individual indicator as a method which cannot fully reflect the affecting factors of the groundwater exploitation potential in a scientific way. The idea that the spatial distribution and dynamic change of groundwater is not only affected by socio-economic development and exploitation technology but also influenced by its regulation is coincided with the niche theory. This paper has preliminarily applied the niche theory to groundwater exploitation potential analysis, and proposed the concept of groundwater niche as well as its related definition, connotation and calculation formula. Meanwhile, by taking the Hebei Plain as an example, the article has made an evaluation of groundwater exploitation potentiality and a contrast with the results of the traditional evaluation methods on the construction of groundwater niche index system, and then verified the feasibility and rationality of this index system. It turns out that, it is truly comprehensive, scientific and rational to make groundwater niche calculation and exploitation potential analysis by using the evaluation index system. Niche theory has provided a new and fundamental attempt for the analysis and competition strategy for the groundwater exploitation potentiality evaluation.

Study on the developing potentiality of mouse morula produced in vitro or in vivo after vitrification

Objective: To assess the developing potentiality of mouse morula produced in vitro or in the after vitrification and to evaluate the effect of one-step and two-step vitrification methods. Method: Mouse morula produced in for and in the were vitrified in the solution containing ethylene glycol, Ficoll and sucrose (EFS solution) with one-step and two-step methods. The developing potential and status of the pellucid zona in vitified mouse morula were assessed. Results: The percentages of morula developed into blastocyst stage were 81. 8% and 82.4%, 97. 3% and 98.4%, respectively, after one-step and two-step exposure of in vitro morula or in vivo morula to EFS solution alone, which did not show significant difference compared to their controls (P > 0. 05). The percentage of in vitro morula developed into blastocyst vitrified by onestep method was significantly lower than that by two-step method and coned (P < 0.05, 70.6% vs 81 .3%; 70.6% vs 83 .6%, respectively). However, there was no significant difference between blastocyst rates of in vivo morula vitrified by one-step and two-step methods (P>0.05, 93. 1% us 95.7%). No rupture of pellucid zona was observed in all thawed morula after one-step and two-step vitrification, irrespective of in vitro morula or in vivo morula. Conclusion: Morula produced in vitro and in vivo after vitrification may maintain high survival rate and developing potential. Two-step vitrification method with EFS solution is suitable for in vitro morula, which can improve the developing potential of in vitro morula. Onestep and two-step vitrification method have no detrimennd effect on the developing potential of in vivo morula.

GIS-based assessment of land-agroforestry potentiality of Jharkhand State, India

Scaling-up agroforestry area in various forms is a scientific path towards achieving various sustainable development goals(SDGs),especially improving livelihood,reducing poverty,conserving environment and biodiversity,and transforming climate change.In this study,the effort was made to investigate the land potentiality for agroforestry at the district level in Jharkhand State,India by applying geographic information system(GIS)modeling technology using climate(temperature and precipitation),topography(slope and elevation),ecology(percent tree cover and normalized difference vegetation index(NDVI)),and social economics(poverty rate and tribal dominance)factors.The results revealed that six districts of Jharkhand State had agroforestry potential greater than 60.00%.The highest agroforestry suitability was found in Simdega District(78.20%),followed by Pakur(76.25%),West Singhbhum(72.70%),Dumka(68.84%),Sahibganj(64.63%),and Godda(63.43%)districts.Additionally,we identified 513 out of 32,620 villages of Jharkhand State potentially suitable(agroforestry suitability≥80.00%)for agroforestry with the objective of life improvement among marginalized society.Under the outside forest area,8.58%of the total geographical land of Jharkhand State was wasteland,much of which was found suitable for agroforestry practices.The agroforestry setups in those wastelands can absorb 637 t carbon annually in long run and can provide direct economic benefits to the locals besides additional income for carbon emission reduction.This study concluded that Jharkhand State has plenty of high potential land for agroforestry,and adoption of agroforestry at the village level must be given high priority.This study could guide the nodal authorities to prepare appropriate strategies for scaling the tree cover in agroforestry systems in village-level landscape planning which needs policy attention and investment for achieving 9 out of the 17 SDGs.

Hydrostratigraphy and Its Relation to Ground-Water Potentiality of an Area of the Ganges River Delta in Bangladesh

To identify the potential groundwater bearing zones for future groundwater resources development of the study area, an investigation has been made using lithology, groundwater monitoring and elevation data. The stratigraphic cross-sections of the area reveal six distinct hydrostratigraphic features viz. clay-silt-sand, fine sand, fine to medium sand, medium sand, medium to coarse sand and coarse sand. On the basis of lithological information, the groundwater bearing zone of the area has been divided into two main hydrostratigraphic units viz. aquitard and aquifer, which consist of clay-silt-sand and sands of different grain sizes respectively. The aquifer zone is further divided into two categories: “small scale aquifer” made dominantly of fine and “main aquifer” comprising of fine-medium to coarse sand. The annual fluctuation of water table in the study area is observed from 4.9 m to 5.6 m. The area is demarcated as three different groundwater bearing zones based on Catastrophe theory using GIS.

Using cemented paste backfill to tackle the phosphogypsum stockpile in China:A down-to-earth technology with new vitalities in pollutant retention and CO_(2) abatement

Phosphogypsum(PG),a hard-to-dissipate by-product of the phosphorus fertilizer production industry,places strain on the biogeochemical cycles and ecosystem functions of storage sites.This pervasive problem is already widespread worldwide and requires careful stewardship.In this study,we review the presence of potentially toxic elements(PTEs)in PG and describe their associations with soil properties,anthropogenic activities,and surrounding organisms.Then,we review different ex-/in-situ solutions for promoting the sustainable management of PG,with an emphasis on in-situ cemented paste backfill,which offers a cost-effective and highly scalable opportunity to advance the value-added recovery of PG.However,concerns related to the PTEs'retention capacity and long-term effectiveness limit the implementation of this strategy.Furthermore,given that the large-scale demand for ordinary Portland cement from this conventional option has resulted in significant CO_(2) emissions,the technology has recently undergone additional scrutiny to meet the climate mitigation ambition of the Paris Agreement and China's Carbon Neutrality Economy.Therefore,we discuss the ways by which we can integrate innovative strategies,including supplementary cementitious materials,alternative binder solutions,CO_(2) mineralization,CO_(2) curing,and optimization of the supply chain for the profitability and sustainability of PG remediation.However,to maximize the co-benefits in environmental,social,and economic,future research must bridge the gap between the feasibility of expanding these advanced pathways and the multidisciplinary needs.

Treadmill exercise improves hippocampal neural plasticity and relieves cognitive deficits in a mouse model of epilepsy

Epilepsy frequently leads to cognitive dysfunction and approaches to treatment remain limited.Although regular exercise effectively improves learning and memory functions across multiple neurological diseases,its application in patients with epilepsy remains controversial.Here,we adopted a 14-day treadmill-exercise paradigm in a pilocarpine injection-induced mouse model of epilepsy.Cognitive assays confirmed the improvement of object and spatial memory after endurance training,and electrophysiological studies revealed the maintenance of hippocampal plasticity as a result of physical exercise.Investigations of the mechanisms underlying this effect revealed that exercise protected parvalbumin interneurons,probably via the suppression of neuroinflammation and improved integrity of blood-brain barrier.In summary,this work identified a previously unknown mechanism through which exercise improves cognitive rehabilitation in epilepsy.

Geochemical fingerprints and hydrocarbon potential of Paleocene mudrocks in the Tano Basin, Ghana: insights from biomarkers and stable carbon isotopes

The Paleocene mudrocks in Ghana’s Tano Basin have received limited attention despite ongoing efforts to explore hydrocarbon resources.A thorough geochemical analysis is imperative to assess these mudrocks’petroleum generation potential and formulate effective exploration strategies.In this study,a comprehensive geochemical analysis was carried out on ten Paleocene rock cuttings extracted from TP-1,a discovery well within the Tano Basin.Various analytical techniques,including total organic carbon(TOC)analysis,Rock–Eval pyrolysis,gas chromatography-mass spectrometry,and isotope ratio-mass spectrometry,were employed to elucidate their hydrocar-bon potential and organic facies.Thefindings in this study were subsequently compared to existing geochemical data on Paleocene source rocks in the South Atlantic marginal basins.The results indicated that the Paleocene samples have TOC content ranging from 0.68 to 2.93 wt%.The prevalent kerogen types identified in these samples were Type Ⅱ and Type Ⅲ.Molecular and isotope data suggest that the organic matter found in the Paleocene mudrocks can be traced back to land plants and lower aquatic organisms.These mudrocks were deposited in a transi-tional environment withfluctuating water salinity,charac-terized by sub-oxic redox conditions.Maturity indices,both bulk and molecular,indicated a spectrum of maturity levels within the Paleocene mudrocks,spanning from immature to marginally mature,with increasing maturity observed with greater depth.In comparison,the organic composition and depositional environments of Paleocene source rocks in the Tano Basin closely resemble those found in the Niger Delta Basin,Douala,and Kribi-Campo Basins,the Kwanza Formation in Angola,and certain Brazilian marginal basins.However,it is worth noting that Paleocene source rocks in some of the basins,such as the Niger Delta and Brazilian marginal basins,exhibit rela-tively higher thermal maturity levels compared to those observed in the current Paleocene samples from the Tano Basin.In conclusion,the comprehensive geochemical analysis of Paleocene mudrocks within Ghana’s Tano Basin has unveiled their marginal hydrocarbon generation potential.The shared geochemical characteristics between the Paleocene mudrocks in the Tano Basin and those in the nearby South Atlantic marginal basins offer valuable insights into source rock quality,which is crucial for shaping future strategies in petroleum exploration in this region.

Quantitative effect of kerogen type on the hydrocarbon generation potential of Paleogene lacustrine source rocks,Liaohe Western Depression,China

Kerogen types exert a decisive effect on the onset and capacity of hydrocarbon generation of source rocks.Lacustrine source rocks in the Liaohe Western Depression are characterized by thick deposition,high total organic carbon(TOC)content,various kerogen types,and a wide range of thermal maturity.Consequently,their hydrocarbon generation potential and resource estimation can be misinterpreted.In this study,geochemical tests,numerical analysis,hydrocarbon generation kinetics,and basin modeling were integrated to investigate the differential effects of kerogen types on the hydrocarbon generation potential of lacustrine source rocks.Optimized hydrocarbon generation and expulsion(HGE)models of different kerogen types were established quantitatively upon abundant Rock-Eval/TOC/vitrinite reflectance(R_(o))datasets.Three sets of good-excellent source rocks deposited in the fourth(Es4),third(Es3),and first(Es1)members of Paleogene Shahejie Formation,are predominantly types I-II_(1),II_(1)-II_(2),and II-III,respectively.The activation energy of types I-II_(2)kerogen is concentrated(180-230 kcal/mol),whereas that of type III kerogen is widely distributed(150-280 kcal/mol).The original hydrocarbon generation potentials of types I,II_(1),II_(2),and III kerogens are 790,510,270,and 85 mg/g TOC,respectively.The Ro values of the hydrocarbon generation threshold for type I-III source rocks gradually increase from 0.42%to 0.74%,and Ro values of the hydrocarbon expulsion threshold increase from 0.49%to 0.87%.Types I and II_(1)source rocks are characterized by earlier hydrocarbon generation,more rapid hydrocarbon expulsion,and narrower hydrocarbon generation windows than types II_(2)and III source rocks.The kerogen types also affect the HGE history and resource potential.Three types(conventional,tight,and shale oil/gas)and three levels(realistic,expected,and prospective)of hydrocarbon resources of different members in the Liaohe Western Depression are evaluated.Findings suggest that the Es3 member has considerable conventional and unconventional hydrocarbon resources.This study can quantitatively characterize the hydrocarbon generation potential of source rocks with different kerogen types,and facilitate a quick and accurate assessment of hydrocarbon resources,providing strategies for future oil and gas exploration.

Transient receptor potential channels as predictive marker and potential indicator of chemoresistance in colon cancer

Transient receptor potential(TRP)channels are strongly associated with colon cancer development and progression.This study leveraged a multivariate Cox regression model on publicly available datasets to construct a TRP channels-associated gene signature,with further validation of signature in real world samples from our hospital treated patient samples.Kaplan-Meier(K-M)survival analysis and receiver operating characteristic(ROC)curves were employed to evaluate this gene signature’s predictive accuracy and robustness in both training and testing cohorts,respectively.Additionally,the study utilized the CIBERSORT algorithm and single-sample gene set enrichment analysis to explore the signature’s immune infiltration landscape and underlying functional implications.The support vector machine algorithm was applied to evaluate the signature’s potential in predicting chemotherapy outcomes.The findings unveiled a novel three TRP channels-related gene signature(MCOLN1,TRPM5,and TRPV4)in colon adenocarcinoma(COAD).The ROC and K-M survival curves in the training dataset(AUC=0.761;p=1.58e-05)and testing dataset(AUC=0.699;p=0.004)showed the signature’s robust predictive capability for the overall survival of COAD patients.Analysis of the immune infiltration landscape associated with the signature revealed higher immune infiltration,especially an increased presence of M2 macrophages,in high-risk group patients compared to their low-risk counterparts.High-risk score patients also exhibited potential responsiveness to immune checkpoint inhibitor therapy,evident through increased CD86 and PD-1 expression profiles.Moreover,the TRPM5 gene within the signature was highly expressed in the chemoresistance group(p=0.00095)and associated with poor prognosis(p=0.036)in COAD patients,highlighting its role as a hub gene of chemoresistance.Ultimately,this signature emerged as an independent prognosis factor for COAD patients(p=6.48e-06)and expression of model gene are validated by public data and real-world patients.Overall,this bioinformatics study provides valuable insights into the prognostic implications and potential chemotherapy resistance mechanisms associated with TRPs-related genes in colon cancer.

Path-Following Control With Obstacle Avoidance of Autonomous Surface Vehicles Subject to Actuator Faults

This paper investigates the path-following control problem with obstacle avoidance of autonomous surface vehicles in the presence of actuator faults,uncertainty and external disturbances.Autonomous surface vehicles inevitably suffer from actuator faults in complex sea environments,which may cause existing obstacle avoidance strategies to fail.To reduce the influence of actuator faults,an improved artificial potential function is constructed by introducing the lower bound of actuator efficiency factors.The nonlinear state observer,which only depends on measurable position information of the autonomous surface vehicle,is used to address uncertainties and external disturbances.By using a backstepping technique and adaptive mechanism,a path-following control strategy with obstacle avoidance and fault tolerance is designed which can ensure that the tracking errors converge to a small neighborhood of zero.Compared with existing results,the proposed control strategy has the capability of obstacle avoidance and fault tolerance simultaneously.Finally,the comparison results through simulations are given to verify the effectiveness of the proposed method.

3'-Deoxyadenosin alleviates methamphetamine-induced aberrant synaptic plasticity and seeking behavior by inhibiting the NLRP3 inflammasome

Methamphetamine addiction is a brain disorder characterized by persistent drug-seeking behavior, which has been linked with aberrant synaptic plasticity. An increasing body of evidence suggests that aberrant synaptic plasticity is associated with the activation of the NOD-like receptor family pyrin domain containing-3(NLRP3) inflammasome. 3′-Deoxyadenosin, an active component of the Chinese fungus Cordyceps militaris, has strong anti-inflammatory effects. However, whether 3′-deoxyadenosin attenuates methamphetamine-induced aberrant synaptic plasticity via an NLRP3-mediated inflammatory mechanism remains unclear. We first observed that 3′-deoxyadenosin attenuated conditioned place preference scores in methamphetamine-treated mice and decreased the expression of c-fos in hippocampal neurons. Furthermore, we found that 3′-deoxyadenosin reduced the aberrant potentiation of glutamatergic transmission and restored the methamphetamine-induced impairment of synaptic plasticity. We also found that 3′-deoxyadenosin decreased the expression of NLRP3 and neuronal injury. Importantly, a direct NLRP3 deficiency reduced methamphetamine-induced seeking behavior, attenuated the impaired synaptic plasticity, and prevented neuronal damage. Finally, NLRP3 activation reversed the effect of 3′-deoxyadenosin on behavior and synaptic plasticity, suggesting that the anti-neuroinflammatory mechanism of 3′-deoxyadenosin on aberrant synaptic plasticity reduces methamphetamine-induced seeking behavior. Taken together, 3′-deoxyadenosin alleviates methamphetamine-induced aberrant synaptic plasticity and seeking behavior by inhibiting the NLRP3 inflammasome.

Probing the electric double layer structure at nitrogen-doped graphite electrodes by constant-potential molecular dynamics simulations

Electric double layer(EDL)is a critical topic in electrochemistry and largely determines the working performance of lithium batteries.However,atomic insights into the EDL structures on heteroatom-modified graphite anodes and EDL evolution with electrode potential are very lacking.Herein,a constant-potential molecular dynamics(CPMD)method is proposed to probe the EDL structure under working conditions,taking N-doped graphite electrodes and carbonate electrolytes as an example.An interface model was developed,incorporating the electrode potential and atom electronegativities.As a result,an insightful atomic scenario for the EDL structure under varied electrode potentials has been established,which unveils the important role of doping sites in regulating both the EDL structures and the following electrochemical reactions at the atomic level.Specifically,the negatively charged N atoms repel the anions and adsorb Li~+at high and low potentials,respectively.Such preferential adsorption suggests that Ndoped graphite can promote Li~+desolvation and regulate the location of Li~+deposition.This CPMD method not only unveils the mysterious function of N-doping from the viewpoint of EDL at the atomic level but also applies to probe the interfacial structure on other complicated electrodes.

Petrogenesis, oxidation state and volatile content of Dongga tonalite in the Gangdese belt, Xizang: Implication for porphyry Cu mineralization

The Gangdese belt in Xizang has experienced both Jurassic subduction and Cenozoic continental collision processes, making it a globally renowned region for magmatic rocks and porphyry copper deposits. Numerous Jurassic intrusions have been identified in the belt. Apart from the quartz diorite porphyry in the large Xietongmen deposit, the Cu mineralization potential of other Jurassic intrusions in this belt remains unclear. This study presents zircon U–Pb dating and trace elements, apatite major and trace elements as well as published whole-rock geochemical and isotopic data of the Dongga tonalite in the central part of the Gangdese belt, aiming to reveal the petrogenesis, oxidation state, volatile content, and Cu mineralization potential of this intrusion. The Dongga tonalite has a zircon U–Pb age of 179.4 ± 0.9 Ma. It exhibits high whole-rock V/Sc values(8.76–14.6), relatively low apatite CeN/CeN*ratios(1.04–1.28), elevated zircon(Eu/Eu*)Nvalues(an average of 0.44), high Ce4+/Ce3+values(205–1896), and high ?FMQ values(1.3–3.7), collectively suggesting a high magmatic oxygen fugacity. The Dongga tonalite features amphibole phenocrysts, relatively high whole-rock Sr/Y ratios(20.3–58.9), and lower zircon Ti temperatures (502–740 ℃), reflecting a high magmatic water content. Estimation of magmatic sulfur content(0.002–0.024 wt%) based on apatite SO3contents indicates an enriched magma sulfur content. Combined with previous studies and the collected Sr–Nd–Hf isotopes, the Dongga tonalite is derived from juvenile lower crust related with subduction of the Neo-Tethys oceanic slab. When compared with Xietongmen orebearing porphyries, the Dongga tonalite exhibits remarkable similarities with the Xietongmen ore-bearing porphyries in terms of magma source, tectonic background, magmatic redox state, and volatile components, which indicates that the Dongga tonalite has a high porphyry Cu mineralization potential, and therefore, provides important guidance for the future mineralization exploration.

Physical exercise and synaptic protection in human and pre-clinical models of multiple sclerosis

In multiple sclerosis,only immunomodulato ry and immunosuppressive drugs are recognized as disease-modifying therapies.Howeve r,in recent years,several data from pre-clinical and clinical studies suggested a possible role of physical exe rcise as disease-modifying therapy in multiple sclerosis.Current evidence is sparse and often conflicting,and the mechanisms underlying the neuroprotective and antinflammatory role of exercise in multiple sclerosis have not been fully elucidated.Data,mainly derived from pre-clinical studies,suggest that exe rcise could enhance longterm potentiation and thus neuroplasticity,could reduce neuroinflammation and synaptopathy,and dampen astrogliosis and microgliosis.In humans,most trials focused on direct clinical and MRI outcomes,as investigating synaptic,neuroinflammato ry,and pathological changes is not straightfo rward compared to animal models.The present review analyzed current evidence and limitations in research concerning the potential disease-modifying therapy effects of exercise in multiple sclerosis in animal models and human studies.