A multi-parameter-induced activation of gas therapeutic platform to remarkably amplify photodynamic therapy efficacy

Gas therapy(GT)combined with photodynamic therapy(PDT)is an effective strategy to compensate for the PDT limitation caused by the hypoxic tumor microenvironment,which can greatly improve PDT efficacy.The uncontrolled leakage of gas molecules during delivery seriously hinders its practical biological application.Herein,we report a multifunction nanomedicine that enables precise gas therapy(including carbon monoxide(CO)release and H_(2)S depletion)using a multi-parameter-induced activation gas release strategy,enlarging the PDT efficacy.This nanomedicine uses a disulfide bond to covalently link a photosensitizer with the CO donor 3-hydroxyflavone(3-HF).The disulfide bond can be specifically consumed in H_(2)S-rich tumor areas,releasing the CO donor(3-HF),and also depleting H_(2)S.More importantly,the photo-controlled production of^(1)O_(2)can induce 3-HF precise release of CO in the tumor location.Such H_(2)S,light,and^(1)O_(2)multi-parameter-induced activation of gas release strategy ensures the accuracy of GT to amplify PDT efficiency.As expected,in vitro and in vivo investigations show that GT makes up for the PDT limitation,exhibiting the highest tumor therapeutic effect.This multi-parameter-activated design strategy provides a new way to improve the precision and efficacy of multimodal synergistic therapy of tumors.

A new design of foam spray nozzle used for precise dust control in underground coal mines

In order to improve the utilization rate of foam,an arc jet nozzle was designed for precise dust control.Through theoretical analysis,the different demands of foam were compared amongst arc jets,flat jets and full cone jets when the dust source was covered identically by foam.It is proved that foam consumption was least when an arc jet was used.Foam production capability of an arc jet nozzle under different conditions was investigated through experiments.The results show that with the gas liquid ratio(GLR)increasing,the spray state of an arc jet nozzle presents successively water jet,foam jet and mist.Under a reasonable working condition range of foam production and a fixed GLR,foam production quantity increases at first,and then decreases with the increase of liquid supply quantity.When the inner diameter of the nozzle is 14 mm,the best GLR is 30 and the optimum liquid supply quantity is0.375 m^3/h.The results of field experiments show that the total dust and respirable dust suppression efficiency of arc jet nozzles is 85.8%and 82.6%respectively,which are 1.39 and 1.37 times higher than the full cone nozzles and 1.20 and 1.19 times higher than the fiat nozzles.