The sliding-rolling mixed motion behavior degrades the ball screw’s precision at different levels.Based on the sliding-rolling mixed motion between ball and screw/nut raceway,the ball screw’s precision loss consider...The sliding-rolling mixed motion behavior degrades the ball screw’s precision at different levels.Based on the sliding-rolling mixed motion between ball and screw/nut raceway,the ball screw’s precision loss considering different given axial loading and rotational speed working conditions was investigated.Since creep and lubrication relate to sliding and rolling motion wear,the creep and lubrication characteristics are analyzed under different working conditions.Besides,the precision loss was calculated considering the sole influence of sliding behavior between ball and screw and compared with the results from other current models.Finally,research on precision loss owing to the sliding-rolling mixed motion behavior was realized under given working conditions,and suitable wear tests were carried out.The analytical results of precision loss are in good agreement with the experimental test conclusions,which is conducive to better predicting the law of precision loss in stable wear period.展开更多
Precision medicine（PM） proposes customized medical care based on a patient＇s unique genome, biomarkers, environment and behaviors. Hearing loss（HL） is the most common sensorineural disorder worldwide and is frequ...Precision medicine（PM） proposes customized medical care based on a patient＇s unique genome, biomarkers, environment and behaviors. Hearing loss（HL） is the most common sensorineural disorder worldwide and is frequently caused by a single genetic mutation. With recent advances in PM tools such as genetic sequencing and data analysis, the field of HL is ideally positioned to adopt the strategies of PM.Here, we review current and future applications of PM in HL as they relate to the four core qualities of PM（P4）： predictive, personalized, patient-centered, and participatory. We then introduce a strategy for effective incorporation of HL PM into the design of future research studies, electronic medical records,and clinical practice to improve diagnostics, prognostics, and, ultimately, individualized patient treatment. Finally, specific anticipated ethical and economic concerns in this growing era of genomics-based HL treatment are discussed. By integrating PM principles into translational HL research and clinical practice, hearing specialists are uniquely positioned to effectively treat the heterogeneous causes and manifestations of HL on an individualized basis.展开更多
基金Project(51975012)supported by the National Natural Science Foundation of ChinaProject(Z1511000003150138)supported by the Beijing Nova Program,China+1 种基金Project(Z191100001119010)supported by the Shanghai Sailing Program,ChinaProject(2018ZX04033001-003)supported by the National Science and Technology Major Project,China。
文摘The sliding-rolling mixed motion behavior degrades the ball screw’s precision at different levels.Based on the sliding-rolling mixed motion between ball and screw/nut raceway,the ball screw’s precision loss considering different given axial loading and rotational speed working conditions was investigated.Since creep and lubrication relate to sliding and rolling motion wear,the creep and lubrication characteristics are analyzed under different working conditions.Besides,the precision loss was calculated considering the sole influence of sliding behavior between ball and screw and compared with the results from other current models.Finally,research on precision loss owing to the sliding-rolling mixed motion behavior was realized under given working conditions,and suitable wear tests were carried out.The analytical results of precision loss are in good agreement with the experimental test conclusions,which is conducive to better predicting the law of precision loss in stable wear period.
基金supported by grants from the National Institutes of Health/National Institute on Deafness and Other Communication Disorders(R01 DC05575, R01 DC01246 and R01 DC012115)
文摘Precision medicine（PM） proposes customized medical care based on a patient＇s unique genome, biomarkers, environment and behaviors. Hearing loss（HL） is the most common sensorineural disorder worldwide and is frequently caused by a single genetic mutation. With recent advances in PM tools such as genetic sequencing and data analysis, the field of HL is ideally positioned to adopt the strategies of PM.Here, we review current and future applications of PM in HL as they relate to the four core qualities of PM（P4）： predictive, personalized, patient-centered, and participatory. We then introduce a strategy for effective incorporation of HL PM into the design of future research studies, electronic medical records,and clinical practice to improve diagnostics, prognostics, and, ultimately, individualized patient treatment. Finally, specific anticipated ethical and economic concerns in this growing era of genomics-based HL treatment are discussed. By integrating PM principles into translational HL research and clinical practice, hearing specialists are uniquely positioned to effectively treat the heterogeneous causes and manifestations of HL on an individualized basis.
