Do changes in intracoronary pressure aid coronary spasm diagnosis using the spasm provocation test?

BACKGROUND Although the spasm provocation test(SPT)can diagnose coronary spasms,it would be helpful if it could also predict their occurrence.AIM To investigate whether coronary spasms can be predicted using changes in intracoronary artery pressure measured using a pressure wire during the SPT.METHODS Seventy patients underwent SPTs with pressure-wire measurement of intracoronary artery pressure.During each SPT,the pressure wire was advanced into the distal portion of the right coronary artery(RCA)and left anterior descending coronary artery,and the ratio of intracoronary pressure to aortic pressure(Pd/Pa)was monitored.Coronary spasm was defined as an arterial narrowing of>90%in response to the administration of acetylcholine(ACh),with chest symptoms and/or ischemic electrocardiographic changes.ACh was administered to the RCA at low,moderate,or high doses of 20,50,or 80μg,respectively,and to the left coronary artery(LCA)at low,moderate,or high doses of 50,100,or 200μg,respectively.Coronary arteries with coronary spasms at low doses of ACh were defined as group L,and those with coronary spasms at moderate or high doses were defined as group MH.Those who did not occur coronary spasms at any ACh dose were designated as group N.RESULTS Among the 132 coronary arteries assessed using a pressure wire,there were 49 in group N,25 in group L,and 58 in group MH.Baseline Pd/Pa was the lowest in group L(P=0.001).The decrease in the Pd/Pa between baseline to low doses of ACh was lower in group MH than in group N(P<0.001).A receiver-operating characteristics analysis showed that the cutoff baseline Pd/Pa value for predicting group L was 0.95,with a sensitivity of 0.600(15/25)and a specificity of 0.713(76/107)and that the cutoff value of Pd/Pa from baseline to low doses of ACh for predicting group MH was−0.04,with a sensitivity of 0.741(43/58)and a specificity of 0.694(34/49).CONCLUSION These findings suggest that indices of intracoronary pressure during SPT may be useful means for predicting the occurrence of coronary spasms.

Test and Study of the Rock Pressure Sensitivity for KeLa-2 Gas Reservoir in the Tarim Basin

KeLa-2 gas reservoir is the largest uncompartimentalized gas field so far discovered in China, with a reserve of hundreds of billions of cubic meters of dry gas. It has such features as extremely long interval (550m), high pressure (74.5MPa) and pressure coefficient (2.022). Gas reservoirs with a pressure coefficient of over 2.0 are not commonly found. The abnormal high-pressure reservoirs are quite different in characteristic and performance during the process of depletion exploitation. Therefore, it is necessary to know the property of pressure sensitivity for this abnormal high-pressure reservoir. The aim of this paper is to test the reservoir pressure sensitivity and to analyze its effect on the deliverability of gas. Through some experiments, the permeability change with the confining pressure of rock samples from KeLa-2 abnormal high-pressure gas reservoir is measured. A power function is used to match the measured data, and to derive an empirical equation to describe the change of permeability through the change of the reservoir pressure or effective overburden pressure. Considering the permeability change during the development of reservoirs, a conventional deliverability equation is modified, and the deliverability curve for KeLa-2 gas reservoir is predicted. The research indicates that the extent of the pressure sensitivity of rock samples from KeLa-2 is higher than that from the Daqing oilfield. KeLa-2 reservoir rock has the feature of an undercompaction state. The pressure sensitivity of a reservoir may decrease the well deliverability. It is concluded that for KeLa-2 reservoir the predicted absolute open flow (AOF), when the pressure sensitivity is taken into account, is approximately 70% of the AOF when permeability is constant and does not change with pressure.

Wireless distributed test system based on transient pressure signal detection and recognition

During the test on transient pressure signal in explosion field,false trigger caused by field interference can lead to test failure.To improve the stability of test system,a signal detection and recognition technology is proposed for transient pressure test system.In the process of signal acquisition,firstly,electrical levels are monitored in real time to find effective abrupt changes and mark them;then the effective data segments are detecdted totected;thus the effective signals can be acquired in turn finally.The experimental results show that the shock wave signal can be collected effectively and the reliability of the test system can be improved after removal of interferences.

Design and implementation of configurable parameters test system for transient pressure measurement

For the shock wave overpressure signal measurement of explosion field, the type and equivalent of the ammunition as well as the distance from test nodes to ground zero have a great influence on the characteristics of shock wave signal. To ensure that shock wave signal with different characteristic parameters can be collected completely in the test of shooting range, a tran- sient pressure signal storage system with configurable parameters is presented. In order to meet the requirements of different test nodes, the system can set parameters of all test nodes by wireless communication in explosion field. The feasibility and re- liability of the system are fully verified through transient pressure measurement in explosion field.

Design and theoretical analysis of test system for propellants' gas pressure in warhead

Aiming at harsh environment of cluster bombs center tube explosion dispersion and difficulties in installation of traditional test systems,a storage test system based on 16-bit ultra-low power microcontroller MSP430 is designed in order to acquire gas pressure during cluster bombs dispersion.To meet the requirement of low power consumption,the working states of system＇s modules during data acquisition are elaborated and the equation to calculate the gas pressure change during cylindrical center tube opening the hatch is deduced.The field test is conducted and good test results are obtained.

Lateral earth pressure of granular backfills on retaining walls with expanded polystyrene geofoam inclusions under limited surcharge loading

Existing studies have focused on the behavior of the retaining wall equipped with expanded polystyrene(EPS)geofoam inclusions under semi-infinite surcharge loading rather than limited surcharge loading.In this paper,the failure mode and the earth pressure acting on the rigid retaining wall with EPS geofoam inclusions and granular backfills(henceforth referred to as EPS-wall),under limited surcharge loading are investigated through two-and three-dimensional model tests.The testing results show that different from the sliding of almost all the backfill in the EPS-wall under semi-infinite surcharge loading,only an approximately triangular backfill slides in the wall under limited surcharge loading.The distribution of the lateral earth pressure on the EPS-wall under limited surcharge loading is non-linear,and the distribution changes from the increase of the wall depth to the decrease with the increase of the limited surcharge loading.An approach based on the force equilibrium of a differential element is developed to predict the lateral earth pressure behind the EPS-wall subjected to limited surcharge loading,and its performance was fully validated by the three-dimensional model tests.

Impact pressure of waves generated by landslides on bank slopes

Impulse waves that are generated by landslides in narrow reservoir areas threaten the stability of buildings and bank slopes.To discuss the action process and evolution law of the wave pressure on bank slopes,a three-dimensional physical model test that considers impulse waves generated by landslides was performed,and factors including landslide width,thickness,slope angles of the sliding surface,and bank slope angle were considered.Based on wave forms on the bank slopes,wave pressure curve characteristics,and peak value,the action process of wave pressure could be divided into the following stages:maximum pulsating pressure stage,wave impact stage(when waves break),and stationary pulsation stage.It was found that wave breaking is dependent on the value of the surf similarity parameterξ.The distribution pattern of impact pressure decays linearly on both sides of the maximum impact pressure point,and the attenuation degree decreases when it attains 40%of the maximum value.Thus,it is proposed that the prediction formula for the maximum effective impact pressure of the bank slope be related to the reciprocal of wave steepness,relative water depth,and slope rate.The prediction formula provides strong theoretical support for early safety warning and for predicting the bank slope under impulse waves generated by landslides.

Surrounding rock pressure in the tunnel portal section through moraine under freeze-thaw action

Moraines,characterized by the accumulation of rock and soil debris transported by glacial activity,present unique challenges for tunnel construction,particularly in portal sections,due to prevailing geographical and climatic conditions that facilitate freeze-thaw action.Despite these challenges,there is a dearth of studies investigating the influence of freeze-thaw action and water content on the mechanical properties of moraines,and no research on calculating surrounding rock pressure in moraine tunnels subjected to freeze-thaw conditions.In this study,direct shear tests under freeze-thaw cycles were conducted to examine the effects of freeze-thaw cycles and water content on the mechanical properties of frozen moraine.A comprehensive parameter K,integrating the number of freeze-thaws and water content,was introduced to model cohesion c.Drawing on Terzaghi Theory,we propose an improved algorithm for calculating surrounding rock pressure at the portal section of moraine tunnels.Using a tunnel as a case study,surrounding rock pressure was calculated under various conditions to validate the Improved Algorithm's efficacy.The results show that:(1)Strength loss exhibits a linear trend with the number of freeze-thaw cycles at water content levels of 4%and 8%,while at 12%water content,previous freeze-thaw cycles induce more significant damage to the soil.(2)Moraine saturation peaks between 8%and 12%water content.Following repeated freeze-thaw cycles,moraine shear strength initially increases before decreasing with varying water content.(3)The internal friction angle of moraine experiences slight reductions with prolonged freeze-thaw cycles,but both freeze-thaw cycles and water content significantly influence cohesion.(4)Vertical surrounding rock pressure increases after the initial freeze-thaw cycle,particularly with higher water content,although freeze-thaw cycles have minimal effect on it.(5)Freeze-thaw cycles lead to a substantial increase in lateral surrounding rock pressure,necessitating reinforced support structures at the arch wall,arch waist,and arch foot in engineering projects to mitigate freeze-thaw effects.This study provides a foundation for designing and selecting tunnel support structures in similar geological conditions.

Air pressure law of a reservoir constructed in karst sinkholes

Karst sinkholes with natural negative landform provide favorable conditions for the pumped storage reservoir construction for less excavation work.However,the construction of the reservoir would plug the natural karst channels for water and air,which would cause remarkable air pressure in karst channels when the groundwater level fluctuates.A large laboratory simulation test was carried out to study the air pressure variation of a reservoir built on the karst sinkhole.The air pressure in the karst channel and inside the model was monitored during the groundwater rising and falling process.Result showed that the variation of air pressure in the karst channel and the surrounding rock exhibited a high degree of similarity.The air pressure increased rapidly at the initial stage of water level rising,followed by a slight decrease,then the air pressure increased sharply when the water level approached the top of the karst cave.The initial peak of air pressure and the final peak of air pressure were defined,and both air pressure peaks were linearly increasing with the water level rising rate.The negative air pressure was also analyzed during the drainage process,which was linearly correlated with the water level falling rate.The causes of air pressure variation in karst channels of a pumped storage reservoir built on the karst sinkhole were discussed.The initial rapid increase,then slight decrease and final sudden increase of air pressure were controlled by the combined effects of air compression in karst channel and air seepage into the surrounding rock.For the drainage process,the instant negative air pressure and gradual recovering of air pressure were controlled by the combined effects of negative air pressure induced by water level falling and air supply from surrounding rock.This work could provide valuable reference for the reservoir construction in karst area.

A Numerical Investigation of the Effect of Boundary Conditions on Acoustic Pressure Distribution in a Sonochemical Reactor Chamber

The intensification of physicochemical processes in the sonochemical reactor chamber is widely used in problems of synthesis,extraction and separation.One of the most important mechanisms at play in such processes is the acoustic cavitation due to the non-uniform distribution of acoustic pressure in the chamber.Cavitation has a strong impact on the surface degradation mechanisms.In this work,a numerical calculation of the acoustic pressure distribution inside the reactor chamber was performed using COMSOL Multiphysics.The numerical results have revealed the dependence of the structure of the acoustic pressure field on the boundary conditions for various thicknesses of the piezoelectric transducer.In particular,the amplitude of the acoustic pressure is minimal in the case of absorbing boundaries,and the attenuation becomes more significant as the thickness of the piezoelectric transducer increases.In addition,reflective boundaries play a significant role in the formation and distribution of zones of maximum cavitation activity.

A Transient-Pressure-Based Numerical Approach for Interlayer Identification in Sand Reservoirs

Almost all sandstone reservoirs contain interlayers. The identification and characterization of these interlayers iscritical for minimizing the uncertainty associated with oilfield development and improving oil and gas recovery.Identifying interlayers outside wells using identification methods based on logging data and machine learning isdifficult and seismic-based identification techniques are expensive. Herein, a numerical model based on seepageand well-testing theories is introduced to identify interlayers using transient pressure data. The proposed modelrelies on the open-source MATLAB Reservoir Simulation Toolbox. The effects of the interlayer thickness, position,and width on the pressure response are thoroughly investigated. A procedure for inverting interlayer parametersin the reservoir using the bottom-hole pressure is also proposed. This method uses only transient pressuredata during well testing and can effectively identify the interlayer distribution near the wellbore at an extremelylow cost. The reliability of the model is verified using effective oilfield examples.

In-Situ Test and Numerical Analysis of Bore Pressure on Sheet-Pile Groin

An in-situ test of bore pressure on a sheet-pile groin is carried out to investigate the characteristics of the bore pressure of fide in the Qian-tang River. The histories of bore pressure and the rule of the distribution of bore pressure on the sheet-pile groin are obtained through the test, which shows that the bore pressure on the sheet-pile groin are varies with time and space. The peak value of bore pressure on sheet-pile groin at different heights occurs almost at the same time. vertical distribution of bore pressure on the sheet-pile groin is linear above the still water level. The maximum bore pressure on the sheet-pile groin occurs at the still water level. Then a numerical method is also used to further study the characteristics of bore pressure. The standard k - ε turbulence model and VOF （volume of fluid） method for surface tracking are used to simulate the bore against the sheet-pile groin. The numerical results show flow fields, the position of free surface and time history and spatial distribution of bore pressure on the sheet-pile groin. The numerical and test resuits show good agreement.

Centrifugal model test and numerical simulation of vertical earth pressure on soft foundation box culvert

To obtain the vertical earth pressure on a soft foundation box culvert and investigate the interaction of the soil-culvert-foundation system, both a centrifugal model test and a numerical simulation were conducted and the comparisons with the current methods to determine the load on a culvert were completed. The results of the model test and numerical analysis are in satisfactory agreement, which shows that the direction of the shear stress between the culvert and the adjacent embankment depends on the differential settlement between them. A vertical earth pressure concentration appears on the culvert with a rigid piles foundation because of a downward shear stress. The ratio of the load on a soft foundation culvert and the overburden pressure above the culvert raises first and then decreases as the backfill height increases. In order to reduce the load on a culvert, it is suggested to limit the stiffness difference of the foundations under the culvert and embankment and to use a light backfill over the culvert.

Orthogonal Test About Biogas Upgrading by Pressured Water Scrubbing

Biogas is a kind of regenerable energy which is inexpensive and friendly to the environment, but the potential ofbiogas is difficult to develop fully in China, for most biogas have badly qualities and the utilization of it is monotonous. The suitable operation term about biogas upgrading by pressurized water scrubbing was researched through the orthogonal test in this study. Two sorts of scrubber packing included the random multidimensional hollow sphere packing and the structured screen packing were also used, and the effects of experiment factors included packing, water temperature, gas flow speed, water flow speed and washing pressure were studied. The results showed that better effect was got when the screen structured packing was used; all the five test factors affected the processing significantly in the arrange as before and had better and better significant effects.

Effect of aeration on fast gas pressure tests

Given the problem of the long time required for testing gas pressure, we propose a fast-test method in which we used a technique of fast borehole sealing and air replenishing. Based on the characteristics of gas emission from boreholes to be tested, we built a theoretical model for calculating parameters during the process of increasing natural pressure and aeration. Using this model, we investigated the effect of different aeration conditions on velocity of pressure tests. The result shows that: 1) aerating air into boreholes can speed up gas pressure tests and 2) the more similar the pressure of the aerated air to the original gas pressure, the smaller the gas volume absorbed by coal and the shorter the time needed in pressure test. A case study in the Lu’an mining area shows that the time needed for gas pressure test is only 4 h using our method of aeration and 29 h under conditions of increasing natural pressure, saving time by 86.2%. This case study also indicates that, by using the aeration method, only one hour is needed for gas pressure to reach a stable state, which breaks the record of the shortest time needed for gas pressure tests in China.

Model test study of frost heaving pressures in tunnels excavated in fractured rock mass in cold regions

Based on the similarity theory, taking the horseshoe, city-gate and round linings as examples, the value and distribution regularities of normal frost heaving pressures （hereinafter as frost heaving pressures） in tunnels excavated in fractured rock mass in cold regions under different constraints and freezing depths were studied by a test model. It was found that the larger the frozen depth, the larger the frost heaving pressure, and the stronger the top constraint, the larger the frost heaving pressure. For the horseshoe lining and city-gate lining, the top constraint has a greater effect on the frost heaving pressures on the arch and the inverted arch. For the round lining, the influences of the top constraint on the frost heaving pressure in all linings are almost the same. The frost heaving pressure is maximum on the city-gate lining and minimal on the round lining. The largest frost heaving pressure all occur near the foot of the inverted arch for the three kinds of lining. Thus, the test data basically coincide with the observed in situ data.

Approach to minish scattering of results for split Hopkinson pressure bar test

Split Hopkinson pressure bar（SHPB） apparatus, usually used for testing behavior of material in median and high strain-rate, is now widely used in the study of rock dynamic constitutive relation, damage evolvement mechanism and energy consumption. However, the possible reasons of sampling disturbance, machining error and so on often lead to the scattering of test results, and bring ultimate difficulty for forming general test conclusion. Based on the stochastic finite element method, the uncertain parameters of specimen density ps, specimen radius Rs, specimen elastic modulus Es and specimen length Ls in the data processing of SHPB test were considered, and the correlation between the parameters and the test results was analyzed. The results show that the specimen radius Rs has direct correlation with the test result, improving the accuracy in preparing and measuring of specimen is an effective way to improve the accuracy of test and minish the scattering of results for SHPB test.

A Test Model of Water Pressures within a Fault in Rock Slope

This paper introduces model test results of water pressure in a fault, which is located in a slope and 16 different conditions. The results show that the water pressures in fault can be expressed by a linear function, which is similar to the theoretical model suggested by Hoek. Factors affecting water pressures are water level in tension crack, dip angle of fault, the height of filling materials and thickness of fault zone in sequence.

Comparison of intraocular pressure peak and fluctuations among Filipino patients with non-glaucomatous eyes and glaucoma suspects using water drinking test and diurnal intraocular pressure

AIM:To compare the intraocular pressure(IOP)peaks and fluctuations using water drinking tests(WDTs)and mean diurnal IOP among Filipino patients with normal eyes and glaucoma suspectsMETHODS:This prospective study included normal and glaucoma suspect patients.Each patient underwent both WDT and mean diurnal examination on separate visits.For mean diurnal examination,IOP was recorded every 2 h for 8 h while in WDT,IOP was recorded prior to WDT,and postWDT at 5,15,30,45,and 60 min.IOP peak was recorded as the highest IOP for both methods,and IOP fluctuation was recorded as highest IOP minus lowest IOP.RESULTS:With the comparison of diagnostic tests,both normal eyes and glaucoma suspect groups,the peak IOP was caught at 15 min.Comparative analysis of both groups also showed that the peak IOP measurements were statistically higher for the WDT compared to mean diurnal IOP(P=0.039,P=0.048 under normal group and P=0.032 and P=0.031 under glaucoma suspect group).Similarly,the WDT had a statistically higher mean IOP fluctuation score than the mean diurnal IOP method in both groups(P=0.003,P=0.011 under normal group;P=0.002 and P=0.005 under glaucoma suspect group).CONCLUSION:This study shows that WDT is a comparable diagnostic exam in predicting IOP fluctuations than mean diurnal measurement.WDT is a promising diagnostic procedure for risk assessment in glaucoma.

Wind tunnel testing of wind pressures on a large gymnasium roof

A wind tunnel test was conducted for a large steel gymnasium structure. Simultaneous pressure measurements were made on its entire ellipsoidal roof in a simulated suburban boundary layer flow field. Special attention is paid to the charaeteristics of fluctuating wind pressures in different zones on the roof. Some selected results are presented： 1） correlations between fluctuating wind pressures on both roof surfaces, 2） eigenvalues and eigenvectors of covariance matrices of the fluctuating wind pressures, 3） probability distributions of the fluctuating wind pressures, and 4） statistical characteristics of peak factor. Furthermore, the applicability of the quasi-steady approach is discussed in detail. Based on the results, an empirical formula for estimating the minimum pressure coefficients, using a peak factor approach, is presented. Comparison of the minimum pressure coefficients determined by the proposed formula and those obtained from the wind tunnel tests is made to examine the applicability and accuracy of the proposed formula.