利托君防治早产的临床疗效

目的:观察利托君防治早产的效果。方法:将50例先兆早产的孕妇分为2组,A组(n=28)用利托君50μg·min^(-1),iv gtt,并逐渐加量至宫缩消失后改为口服;B组(n=22)用硫酸镁10g+5％ GS 500mL,iv gtt,3～6h滴完,至宫缩消失再维持12h。结果:A组和B组8h内抑制宫缩百分率分别为85.72％和68.18％;平均延长孕周为(4.33+2.63)wk和(3.74+2.02)wk;妊娠至足月为78.57％和63.64％。以上2组比较,P均>0.05。结论:利托君可以作为一种有效的宫缩抑制剂,用于防治早产的发生。

西沙必利和小剂量红霉素治疗早产儿喂养困难疗效和不良反应观察

目的:观察小剂量红霉素、西沙必利治疗早产儿喂养困难的疗效和不良反应。方法:将75例喂养困难早产儿随机分为3组,对照组(C组)常规治疗,西沙必利组(A组)及红霉素组(B组)在常规治疗基础上分别加用西沙必利和小剂量红霉素。结果:西沙必利组总有效率为88%、红霉素组总有效率为84%、对照组为52%。平均症状消失时间红霉素组及西沙必利组均较对照组缩短,两组疗效无显著性差异。结论:西沙必利、小剂量红霉素均能改善早产儿喂养困难,两者疗效对比无显著性差异。

Study of the Relationship between Anti-Peroxidase Antibody and Miscarriage, Preterm Labor and IUGR in Egyptian Pregnant Women

Background: This research studied the relationship between anti-peroxidase anti-body in euthyroid pregnant female and miscarriage, preterm labor and IUGR in Egyptian patients. Patients and Methods: This prospective study was carried on patients who attended to the Obstetrics and Gynecology department of Tanta University Hospital for routine antenatal care from January 2016 to November 2016. 80 women enrolled in the study and were divided into four groups, 20 cases for each group, a control group, recurrent unexplained abortion group, preterm labor group and IUGR group. A Thyroperoxidase (TPO) antibody was measured in all cases. Results & Discussion: The eighty patients were randomly enrolled into 4 groups, 20 patients in each group. Their age ranged from 20 to 35 years and BMI ranged from 18 to 35. The percentage of +ve TPO Ab of the control group was 5% and of the recurrent abortion group was 20% and of the preterm labor group was 15% and of the IUGR group it was 5%. (P value 0.026) indicating statistically significant correlation between TPO Ab and recurrent unexplained abortion and preterm labor. Conclusion: The presence of (TPO) antibodies could be correlated to recurrent unexplained abortion and preterm labor. More studies are required to determine whether an intervention is needed to treat thyroid autoantibody positivity during pregnancy.

β-溶血性链球菌与未足月胎膜早破的关系及母儿预后

目的探讨未足月胎膜早破与孕妇生殖道溶血性链球菌感染的关系。方法收集我院2006～2009年因未足月胎膜早破于我院住院治疗的孕妇230例,同期门诊检查的同孕周正常妊娠孕妇140例作为对照,取宫颈-阴道分泌物进行GBS的培养,并将GBS阴性的未足月胎膜早破患者与阳性患者的新生儿作比较,了解GBS感染对母儿预后的影响。结果发生未足月胎膜早破的患者GBS的感染率(18.57%),明显高于未破膜的正常妊娠者(5.71%)(P<0.05)。GBS感染阳性者比阴性者胎儿窘迫、低体重儿发生率高(P<0.05),新生儿感染、产褥感染的发生率高,但差异无统计学意义。结论 GBS感染可导致未足月胎膜早破、早产。增加了胎儿窘迫、新生儿感染、产褥感染的发生率。