Fas ligand expression in colon cancer:A possible mechanism of tumor immune privilege

AIM: To detect the expression of Fas ligand (FasL) in colon cancer tissues and cell lines and analyze the function of FasL-expressing colon cancer cells in inducing Fas-sensitive T lymphocyte apoptosis. METHODS: Ninety surgically resected colon cancer tissues and 15 hepatic metastasis specimens were investigatedby immunohistochemical method with normal colon mucosa and colon adenoma as control. The relationship between FasL expression and pathologic features was also analyzed.FasL expression of 4 colon cancer cell lines, SW620, Lovo, LS-174T and SW1116, were detected by Western blotting assay. The function of FasL expressed on colon cancer cells was determined by coculture assay with Jurkat T lymphocytes, the apoptotic rate of which was detectedby flow cytometry assay.RESULTS: Fifty-six (62.22%) cases of all the 90 colon cancer tissues and all (100%) the liver metastasis specimens expressed FasL, significantly higher than normal colon mucosa and colonic adenoma. Higher expression of FasL was found in more advanced stage of colon cancer and in cancer tissues with lymphatic or hepatic metastasis.All the colon cancer cell lines were found to express FasL.After coculture with the SW1116 cells for 24 h with an effector: target ratio 10:1, the rate of apoptosis of Jurkat cells rose from 1.9% to 21.0%.CONCLUSION: The expression of FasL is upregulated in colon cancer and the functionally expressed FasL can induce apoptosis of Fas-expressing T lymphocytes.

Least Privileges and Role’s Inheritance of RBAC

The main advantages of role-based access control （RBAC） are able to support the well-known security principles and roles＇inheritance. But for there remains a lack of specific definition and the necessary formalization for RBAC, it is hard to realize RBAC in practical work. Our contribution here is to formalize the main relations of RBAC and take first step to propose concepts of action closure and deta closure of a role, based on which we got the specification and algorithm for the least privileges of a role. We propose that roles＇ inheritance should consist of inheritance of actions and inheritance of data, and then we got the inheritance of privileges among roles, which can also be supported by existing exploit tools.

Privilege Flow Oriented Intrusion Detection Based on Hidden Semi-MarkovModel

A privilege flow oriented intrusion detection method based on HSMM (Hidden semi-Markov Model) is discussed. The privilege flow model and HSMM are incorporated in the implementation of an anomaly detection IDS (Intrusion Detection System). Using the dataset of DARPA 1998, our experiment results reveal good detection performance and acceptable computation cost.

A Privilege Separation Method for Security Commercial Transactions

Privilege user is needed to manage the commercial transactions, but a super-administrator may have monopolize power and cause serious security problem. Relied on trusted computing technology, a privilege separation method is proposed to satisfy the security management requirement for information systems. It authorizes the system privilege to three different managers, and none of it can be interfered by others. Process algebra Communication Sequential Processes is used to model the three powers mechanism, and safety effect is analyzed and compared.

Effect of Vasocation Intestinal Peptide on Immune Privilege of the Rat Testis

Objective To study the effect of vasocation intestinal peptide （VIP） on immune privilege of the rat testis. Methods The UU infected SD rats and Leydig cells were intervened by VIP, the secretion of TGF-β and the expression of FasL in rat Leydig cells were compared between VIP-intervened group and control group to test the effect of VIP on immune privilege of the rat testis in vitro and in vivo. Results In vitro, the secretion of TGF-β in Leydig cells could be increased by low dosage of VIP while inhibitited by high dosage of VIP; expression of FasL mRNA in Leydig cells could be decreased by VIP In vivo, increased expression of TGF-β mRNA and decreased FasL mRNA were observed in VIP group in 2-3 weeks after infected by UU. In addition, the apoptosis of Jurkat cells mediated by Leydig cells could be prevented by VIP Conclusion When Leydig cells or testis infected by UU, VIP could regulate the immune function of rat Leydig cells and participate in the regulation of immune privilege of testis through the regulation of TGF-β secretion and FasL expression pattern of Leydig cells.

A Cache Considering Role-Based Access Control and Trust in Privilege Management Infrastructure

PMI （privilege management infrastructure） is used to perform access control to resource in an E-commerce or E-government system. With the ever-increasing need for secure transaction, the need for systems that offer a wide variety of QoS （quality-of-service） features is also growing. In order to improve the QoS of PMI system, a cache based on RBAC （Role-based Access control） and trust is proposed. Our system is realized based on Web service. How to design the cache based on RBAC and trust in the access control model is deseribed in detail. The algorithm to query role permission in cache and to add records in cache is dealt with. The policy to update cache is introduced also.

Use and Abuse of Privileged Information in Italian Listed Companies

Privileged information has significant importance to listed companies, given both the extent of the markets in which it is used and the relevant effects that it can produce on the prices of financial instruments. The term “privileged information” means information that has not yet been made known to the public, which, if disclosed, is able to affect significantly the prices of the securities of listed issuers. This article aims to prove that in many cases, the effects of privileged information can be adequately represented in financial statements, despite their “confidential” nature. For this purpose, this research proposes the existence of a relationship—which can be virtuous or vicious—between financial statements and privileged information. In order to demonstate this thesis, the author carried out an empirical survey concerning both the economic and the legal sector. For the first one, the research considered the price-sensitive information published by companies listed on the Italian Stock Exchange during the first half of 2018, and the result shows that a lot of privileged information is able to generate accounting effects;for the second one, the empirical survey analyzed some significant judgments passed by the Italian Court of Cassation in the 2000s which confirm the companies’ violation of the duty to present privileged information in financial statements.

Identity Governance Framework for Privileged Users

Information technology companies have grown in size and recognized the need to protect their valuable assets.As a result,each IT application has its authentication mechanism,and an employee needs a username and password.As the number of applications increased,as a result,it became increasingly complex to manage all identities like the number of usernames and passwords of an employee.All identities had to be retrieved by users.Both the identities and the access rights associated with those identities had to be protected by an administrator.Management couldn’t even capture such access rights because they couldn’t verify things like privacy and security.Identity management can help solve this problem.The concept behind identity management is to centralize identity management and manage access identity centrally rather than multiple applications with their authentication and authorization mechanisms.In this research work,we develop governance and an identity management framework for information and technology infrastructures with privileged access management,consisting of cybersecurity policies and strategies.The results show the efficiency of the framework compared to the existing information security components.The integrated identity and access management and privileged access management enable organizations to respond to incidents and facilitate compliance.It can automate use cases that manage privileged accounts in the real world.

Discussion on the privilege system in the laws of the Ming Dynasty

An important guiding thought that ran through the laws of the Ming Dynasty was ＂governing the country according to the corpus juries＂. The founding emperor of Ming Dynasty Zhu Yuanzhang found that the laws of the former Yuan Dynasty could not suit the demands of the development of the new situations, so he developed the new statutes. The laws of the Ming Dynasty absorbed the lessons that the Yuan government law and discipline ceased to be binding or become lax, and put forward that the laws must be strict, and abolished the system of the prime minister, showing a high degree of centralization. The laws of the Ming Dynasty had the important influence on the political thoughts in the late feudal society, so the researches on the legal systems in the Ming dynasty have practical significance. This paper briefly expounds the legal privileges of the Ming Dynasty for reference.

Chinese-Language Software-A Privilege for Chinese

Since China has had more than 10 years of experience in the tech-nology for Chinese-language com-puter systems,one American firm,Microsoft,has started cooperation with Chinese software manufachur-ers to develop a Chinese edition of Windows 4.0.Microsoft will also support the Legend Group in devel-oping the Chinese edition of DOS 6.0,a new system that will hopeful-ly be on computer store shelves be-fore very long.

Genius Is Not a Privilege of the Few

ＧｅｎｉｕｓＩｓＮｏｔａＰｒｉｖｉｌｅｇｅｏｆｔｈｅＦｅｗＲａｄｉｃａｌｗａｙｓｔｏｂｏｏｓｔｏｎｅ＇ｓｂｒａｉｎｐｏｗｅｒ．ＢｙｓｔａｆｆｒｅｐｏｒｔｅｒｓＬＩＣＨＡＯＣＨＥＮａｎｄＨＯＵＲＵＩＬＩＨＯＷＭＡＮＹｗｏｒｄｓｏｕｔｏｆ３５ｇｉｖｅｎｔ...

Farmers' Privilege under the Protection of New Plant Varieties

This paper studies farmers'privilege under the protection of new plant varieties,and points out that farmers'privilege is given to balance interests of plant breeders and relevant public.Based on this,it analyzes shortcomings of farmers'privilege regulations,and puts forward that it is required to improve farmers'privilege regulations in subjects,objects and contents of rights on the basis of learning from advanced legislation experience of foreign countries,and build the interest sharing mechanism between breeders and farmers.

Immune privilege induced by cotransplantation of islet and allogeneic testicular cells

Objective To induce islet allograft long-term survival through cotransplantation of islet cells with sertoli cells.Methods Testicular sertoli cells were prepared by digestion with collagenase, trypsin and DNase, and were cultured for 48 hours. Collagenase digested and Ficoll purified donor (Wistar rat) islets were cotransplanted with allogeneic sertoli cells in the absence of systemic immunosuppression. Terminal leoxynucleotidyl transferase-mediated X-dUTP nick-end labeling (TUNEL) was used to label apoptosis of lymphocytes surrounding the islet graft.Results Cotransplantation of islets and 1 × 107 sertoli cells reversed the diabetic state for more than 60days in 100% (6/6) of the chemically diabetic Sprague Dawley rats. Grafts consisting of islets alone or islets plus 1 × 105 sertoli cells survived only for 5 - 6 days. Apoptosis of lymphocytes surrounding the islets was quite clear.Conclusion Cotransplantation of islets with FasL+ sertoli cells induces local immune privilege and allows long-term graft survival without systemic immunosuppression.

Logical Image Acquisition and Analysis of Android Smartphones

Android smartphones largely dominate the smartphone market. For this reason, it is very important to examine these smartphones in terms of digital forensics since they are often used as evidence in trials. It is possible to acquire a physical or logical image of these devices. Acquiring physical and logical images has advantages and disadvantages compared to each other. Creating the logical image is done at the file system level. Analysis can be made on this logical image. Both logical image acquisition and analysis of the image can be done by software tools. In this study, the differences between logical image and physical image acquisition in Android smartphones, their advantages and disadvantages compared to each other, the difficulties that may be encountered in obtaining physical images, which type of image contributes to obtaining more useful and effective data, which one should be preferred for different conditions, and the benefits of having root authority are discussed. The practice of getting the logical image of the Android smartphones and making an analysis on the image is also included. Although root privileges are not required for logical image acquisition, it has been observed that very limited data will be obtained with the logical image created without root privileges. Nevertheless, logical image acquisition has advantages too against physical image acquisition.

IAM Excellence: Exploring Saviynt’s Role in Modern Information Technology

Organizations may increase data security and operational efficiency by connecting Salesforce with Identity and Access Management (IAM) systems like Saviynt. This study delves deeply into the details of this revolution that is being encouraged to shift towards IAM software and potential drawbacks such as excessive provisioning and implementation issues. The study illuminated excellent practices and emphasized the importance of constant monitoring by using secondary theme analysis and qualitative research as proof. The findings indicate Saviynt as a viable solution and provide detailed information for firms seeking a smooth and secure integration path.

Saviynt Meets GCP: A Deep Dive into Integrated IAM for Modern Cloud Security

The Google Cloud Platform (GCP) is a popular choice for companies seeking a comprehensive cloud computing solution because it provides everything from essential computing resources to powerful data analytics and machine learning capabilities. Saviynt is a cloud-based Identity and Access Management (IAM) system that integrates with Google Cloud Platform (GCP) and other services for additional functionality. However, other problems are associated with the transition, such as the requirement to correctly integrate IAM Saviynt into current IT infrastructures and provide comprehensive training to users on the new system. The paper will give a detailed review of the advantages, disadvantages, and best practices related to this transition.

Testicular defense systems： immune privilege and innate immunity

The mammalian testis possesses a special immunological environment because of its properties of remarkable immune privilege and effective local innate immunity. Testicular immune privilege protects immunogenic germ cells from systemic immune attack, and local innate immunity is important in preventing testicular microbial infections. The breakdown of local testicular immune homeostasis may lead to orchitis, an etiological factor of male infertility. The mechanisms underlying testicular immune privilege have been investigated for a long time. Increasing evidence shows that both a local immunosuppressive milieu and systemic immune tolerance are involved in maintaining testicular immune privilege status. The mechanisms underlying testicular innate immunity are emerging based on the investigation of the pattern recognition receptor-mediated innate immune response in testicular cells. This review summarizes our current understanding of testicular defense mechanisms and identifies topics that merit further investigation.

A new formal model for privilege control with supporting POSIX capability mechanism

In order to enforce the least privilege principle in the operating system, it is necessary for the process privilege to be effectively controlled; but this is very difficult because a process always changes as time changes. In this paper, based on the analysis on how the process privilege is generated and how it works, a hierarchy implementing the least privilege principle with three layers, i.e. administration layer, functionality control layer and performance layer, is posed. It is clearly demonstrated that to bound privilege's working scope is a critical part for controlling privilege, but this is only mentioned implicitly while not supported in POSIX capability mechanism. Based on analysis of existing control mechanism for privilege, not only an improved capability inheritance formula but also a new complete formal model for controlling process based on integrating RBAC, DTE, and POSIX capability mechanism is introduced. The new invariants in the model show that this novel privilege control mechanism is different from RBAC's, DTE's, and POSIX's, and it generalizes subdomain control mechanism and makes this mechanism dynamic.

Learning with privileged information using Bayesian networks

For many supervised learning applications, addi- tional information, besides the labels, is often available dur- ing training, but not available during testing. Such additional information, referred to the privileged information, can be exploited during training to construct a better classifier. In this paper, we propose a Bayesian network （BN） approach for learning with privileged information. We propose to in- corporate the privileged information through a three-node BN. We further mathematically evaluate different topologies of the three-node BN and identify those structures, through which the privileged information can benefit the classifica- tion. Experimental results on handwritten digit recognition, spontaneous versus posed expression recognition, and gender recognition demonstrate the effectiveness of our approach.