Integrated Statistical and Engineering Process Control Based on Smooth Transition Autoregressive Model

Traditional studies on integrated statistical process control and engineering process control (SPC-EPC) are based on linear autoregressive integrated moving average (ARIMA) time series models to describe the dynamic noise of the system.However,linear models sometimes are unable to model complex nonlinear autocorrelation.To solve this problem,this paper presents an integrated SPC-EPC method based on smooth transition autoregressive (STAR) time series model,and builds a minimum mean squared error (MMSE) controller as well as an integrated SPC-EPC control system.The performance of this method for checking the trend and sustained shift is analyzed.The simulation results indicate that this integrated SPC-EPC control method based on STAR model is effective in controlling complex nonlinear systems.

Process Control and Optimization for Heterologous Protein Production by Methylotrophic Pichia pastoris

The methylotrophic yeast Pichia pastoris is a highly successful system for production of a variety of heterologous proteins due to its unique features/abilities for effective protein expression, and tremendous efforts have been made to increase heterologous protein productivity by P. pastoris in recent years. When new engineered yeast strains are constructed and are ready to use tot industrial protein production, process control and optimization techniques should be applied to improve the fermentation performance in the following aspects： （1） increase recombinant cell concentrations in fermentor to high density during growth phase; （2） effectively induce heterologous proteins by enhancing/stabilizing titers or concentrations of the proteins during induction phase; （3） decrease operation costs by relieving the working loads of heat-exchange and oxygen supply. This article reviews and discusses the key and commonly used techniques in heterologous protein production by P. pastoris, with the focus on optimizations of fermentation media and basic operation conditions, development of optimal glycerol feeding strategies for achieving high density cultivation of P. pastoris and effective heterologous protein induction methods by regulating specific growth rate, methanol concentration, temperatures, mixture ratio of multi-carbon substrates, etc. Metabolic analysis for recombinant protein production by P. pastoris is also introduced to interpret the mechanism of sub-optimal heterologous protein production and to explore further optimal expression methods.

Hybrid Neural Network Model for RH Vacuum Refining Process Control

A hybrid neural network model,in which RH process(theoretical)model is combined organically with neural network(NN)and case-base reasoning(CBR),was established.The CBR method was used to select the operation mode and the RH operational guide parameters for different steel grades according to the initial conditions of molten steel,and a three-layer BP neural network was adopted to deal with nonlinear factors for improving and compensating the limitations of technological model for RH process control and end-point prediction.It was verified that the hybrid neural network is effective for improving the precision and calculation efficiency of the model.

Process control technology of low NO_x sintering based on coke pretreatment

Process control is an effective approach to reduce the NOx emission from sintering flue gas.The effects of different materials adhered on coke breeze on NOx emission characteristics and sintering performance were studied.Results showed that the coke breeze adhered with the mixture of CaO and Fe2O3 or calcium ferrite significantly lowers the NOx emission concentration and conversion ratio of fuel-N to NOx.Pretreating the coke with the mixture of lime slurry and iron ore fines helped to improve the granulation effect,and optimize the carbon distribution in granules.When the mass ratio of coke breeze,quick lime,water and iron ore fines was 2:1:1:1,the average NOx emission concentration was decreased from 220 mg/m3 to 166 mg/m3,and the conversion ratio of fuel-N was reduced from 54.2%to 40.9%.

A closed-loop particle swarm optimizer for multivariable process controller design

Design of general multivariable process controllers is an attractive and practical alternative to optimizing design by evolutionary algorithms (EAs) since it can be formulated as an optimization problem. A closed-loop particle swarm optimization (CLPSO) algorithm is proposed by mapping PSO elements into the closed-loop system based on control theories. At each time step, a proportional integral (PI) controller is used to calculate an updated inertia weight for each particle in swarms from its last fitness. With this modification, limitations caused by a uniform inertia weight for the whole population are avoided, and the particles have enough diversity. After the effectiveness, efficiency and robustness are tested by benchmark functions, CLPSO is applied to design a multivariable proportional-integral-derivative (PID) controller for a solvent dehydration tower in a chemical plant and has improved its performances.

Integrated Product and Process Control for Sustainable Semiconductor Manufacturing

Semiconductor fabrication is a manufacturing sequence with hundreds of sophisticated unit operations and it is always challenged by strategy development for ensuring the yield of defect-free products.In this paper,an advanced control strategy through integrating product and process control is established.The proposed multiscale scheme contains three layers for coordinated equipment control,process control and product quality control.In the upper layer,online control performance assessment is applied to reduce the quality variation and maximize the overall product performance （OPP）.It serves as supervisory control to update the recipe of the process controller in the middle layer.The process controller is designed as an exponentially weighted moving average （EWMA） run-to-run controller to reject disturbances,such as process shift,drift and tool worn out,that are exerted to the op-eration.The equipment in the process is individually controlled to maintain its optimal operational status and maximize the overall equipment effectiveness （OEE）,based on the set point given by the process controller.The ef-ficacy of the proposed integrated control scheme is demonstrated through case studies,where both the OPP （for product） and the OEE （for equipment） are enhanced.

ADVANCED QUALITY CONCEPTS AND COMPOSITE RELIABILITY THROUGH STATISTICALPROCESS CONTROL

The physical properties of thermosetting resins and resin based composites may be influenced by changes in any one of the mang formulating or process related variables involved in their manufacture. When resins and composite materials are required to perform in aggressive environments, reliable and predicable performance is essential and therefore these materials must be prepared and tested in accorkance with a strictquality plan. This paper outlines the elements of statistical process control (S.P.C.)as it may be applied to non-metallic materials and discusses the concept of Capability Index (Cp).

Compared Insights on Machine-Learning Anomaly Detection for Process Control Feature

Anomaly detection is becoming increasingly significant in industrial cyber security,and different machine-learning algorithms have been generally acknowledged as various effective intrusion detection engines to successfully identify cyber attacks.However,different machine-learning algorithms may exhibit their own detection effects even if they analyze the same feature samples.As a sequence,after developing one feature generation approach,the most effective and applicable detection engines should be desperately selected by comparing distinct properties of each machine-learning algorithm.Based on process control features generated by directed function transition diagrams,this paper introduces five different machine-learning algorithms as alternative detection engines to discuss their matching abilities.Furthermore,this paper not only describes some qualitative properties to compare their advantages and disadvantages,but also gives an in-depth and meticulous research on their detection accuracies and consuming time.In the verified experiments,two attack models and four different attack intensities are defined to facilitate all quantitative comparisons,and the impacts of detection accuracy caused by the feature parameter are also comparatively analyzed.All experimental results can clearly explain that SVM(Support Vector Machine)and WNN(Wavelet Neural Network)are suggested as two applicable detection engines under differing cases.

A novel Q-based online model updating strategy and its application in statistical process control for rubber mixing

To overcome the large time-delay in measuring the hardness of mixed rubber, rheological parameters were used to predict the hardness. A novel Q-based model updating strategy was proposed as a universal platform to track time-varying properties. Using a few selected support samples to update the model, the strategy could dramat- ically save the storage cost and overcome the adverse influence of low signal-to-noise ratio samples. Moreover, it could be applied to any statistical process monitoring system without drastic changes to them, which is practical for industrial practices. As examples, the Q-based strategy was integrated with three popular algorithms （partial least squares （PIE）, recursive PIE （RPLS）, and kernel PIE （KPIE）） to form novel regression ones, QPLS, QRPIE and QKPLS, respectively. The applications for predicting mixed rubber hardness on a large-scale tire plant in east China prove the theoretical considerations.

Risk Management of Clinical Reference Dosimetry of a Large Hospital Network Using Statistical Process Control

Managing TG-51 reference dosimetry in a large hospital network can be a challenging task. The objectives of this study are to investigate the effectiveness of using Statistical Process Control (SPC) to manage TG-51 workflow in such a network. All the sites in the network performed the annual reference dosimetry in water according to TG-51. These data were used to cross-calibrate the same ion chambers in plastic phantoms for monthly QA output measurements. An energy-specific dimensionless beam quality cross-calibration factor, , was derived to monitor the process across multiple sites. The SPC analysis was then performed to obtain the mean, , standard deviation, σk, the Upper Control Limit (UCL) and Lower Control Limit (LCL) in each beam. This process was first applied to 15 years of historical data at the main campus to assess the effectiveness of the process. A two-year prospective study including all 30 linear accelerators spread over the main campus and seven satellites in the network followed. The ranges of the control limits (±3σ) were found to be in the range of 1.7% - 2.6% and 3.3% - 4.2% for the main campus and the satellite sites respectively. The wider range in the satellite sites was attributed to variations in the workflow. Standardization of workflow was also found to be effective in narrowing the control limits. The SPC is effective in identifying variations in the workflow and was shown to be an effective tool in managing large network reference dosimetry.

Problems and Strategies in Applications of Advanced Process Control in China

Advanced Process Control （APC） is necessary for oil refining and chemical process in China, but some problems have emerged in the application of APC techniques in this field. This paper discusses the conditions of APC application concerning process design, distributed control system （DCS） choice and regular control. It analyzes the problems and strategies in APC application. Some suggestions are proposed for the enterprise to benefit from APC application.

Collaborative Simulation Method with Spatiotemporal Synchronization Process Control

When designing a complex mechatronics system, such as high speed trains, it is relatively difficult to effectively simulate the entire system＇s dynamic behaviors because it involves multi-disciplinary subsystems. Currently, a most practical approach for multi-disciplinary simulation is interface based coupling simulation method, but it faces a twofold challenge： spatial and time unsynchronizations among multi-directional coupling simulation of subsystems. A new collaborative simulation method with spatiotemporal synchronization process control is proposed for coupling simulating a given complex mechatronics system across multiple subsystems on different platforms. The method consists of 1） a coupler-based coupling mechanisms to define the interfacing and interaction mechanisms among subsystems, and 2） a simulation process control algorithm to realize the coupling simulation in a spatiotemporal synchronized manner. The test results from a case study show that the proposed method 1） can certainly be used to simulate the sub-systems interactions under different simulation conditions in an engineering system, and 2） effectively supports multi-directional coupling simulation among multi-disciplinary subsystems. This method has been successfully applied in China high speed train design and development processes, demonstrating that it can be applied in a wide range of engineering systems design and simulation with improved efficiency and effectiveness.

Influence of process control agents on the performance of Ni_3Al by mechanical alloying

The influence of process control agents （PCAs） on the mechanical properties of Ni3AI intermetallic compounds by mechanical alloying was investigated in order to develop oxide deposition reinforced intermetallics. The PCAs in mechanical alloying were pure ligroin, 75 vol.% ligroin ＋ 25 vol.% alcohol, 50 vol.% ligroin ＋ 50 vol.% alcohol, 25 vol.% ligroin ＋ 75 vol.% alcohol, and pure alcohol. The normal composition is Ni-22.9at.%Al-0.5at.%B, the ball-to-powder weight ratio is 10：1, and the milling time is 30 min. Then, the powders were sintered by spark plasma sintering under 40 MPa for 5 min at 1000℃. The results show that a higher bending strength and a higher hardness were obtained when the PCAs were 75% ligroin ＋ 25% alcohol in mechanical alloying. The bending strength is about 2700 MPa and the hardness （HV） is more than 6 GPa.

Reduction Process of Blue Tungsten Oxide and its Microcomputer Process Control

Grain size control of tungsten powder is essential for high quality tungsten products. Based on studies on the hydrogen reduction process of tungsten oxide, a microcomputer system is described for reduction process control. The system, now running in Zhuzhou Tungsten and Molybdenum Materials Plant, controls the temperature of the reduction furnace and hydrogen pressure. It also controls a mechanical pusher which pushs the boats charged with blue tungsten oxide into the furnace tubes. Some of the technical problems in the process are analysed.

Formal Reduction of Interfaces to Large-scale Process Control Systems

A formal methodology is proposed to reduce the amount of information displayed to remote human operators at interfaces to large-scale process control plants of a certain type. The reduction proceeds in two stages. In the first stage, minimal reduced subsets of components, which give full information about the state of the whole system, are generated by determining functional dependencies between components. This is achieved by using a temporal logic proof obligation to check whether the state of all components can be inferred from the state of components in a subset in specified situations that the human operator needs to detect, with respect to a finite state machine model of the system and other human operator behavior. Generation of reduced subsets is automated with the help of a temporal logic model checker. The second stage determines the interconnections between components to be displayed in the reduced system so that the natural overall graphical structure of the system is maintained. A formal definition of an aesthetic for the required subgraph of a graph representation of the full system, containing the reduced subset of components, is given for this purpose. The methodology is demonstrated by a case study.

Advances in Process Control for Refractory Production

This paper reviews main problems of domestic refractories, in terms of the structure, principle, performance and new theory of automatic control, such as modern control, fuzzy control, artificial neural network, and expert system. Advanced equipment used in Rill Dalian Plant is introduced, as well as quality control and guarantee in Europe. Some topics to upgrade Chinese refractory industry are discussed.

基于Statistical Process Control风险等级判定及神经网络模型构建珠海市传染病指数

目的建立珠海市传染病指数预报模型,为传染病风险预测预报提供思路。方法利用统计过程控制(SPC)的控制下限、中线和控制上限划分全市2014—2017年以周次为时间计量单位的流感样病例比例、手足口病及其他感染性腹泻发病率的风险等级(布雷图指数采用5、10、20判定)。运用长短时记忆神经网络模型(LSTM)和自回归移动平均模型(ARIMA)对2018年15~19周数据进行预测。计算传染病指数并将预测值与实际值对比进而评估预测一致性。结果珠海市手足口病发病率LSTM模型中,测试集MSE为9.0441,RMSE为3.0073,训练集MSE为1.1812,RMSE为1.0868。其余模型在训练集和测试集均表现良好,没有出现过拟合现象。风险指数等级预测与实际值对比,预测一致率为96.0%。结论利用SPC划分风险等级,运用LSTM等构建传染病指数预测模型可行。

Process Control for Nanoimprint Lithography

To tackle the demoulding and conglutinating problem with the resist and hard mold in the nanoimprint lithography process, a soft mould can be used to demould and reduce the macro or mi- cro mismatch between mould bottom surface and wafer top surface. In nanoimprint lithography process, a mathematical equation is formulated to demonstrate the relation between the residual re- sist thickness and the pressing force during pressing the mould toward the resist-coated wafer. Based on these analytical studies, a new imprint process, which includes a pre-cure release of the pressing force, was proposed for the high-conformity transfer of nano-patterns from the mould to the wafer. The results of a series of imprint experiments showed that the proposed loading process could meet the requirements for the imprint of different patterns and feature sizes while maintaining a uniform residual resist and non-distorted transfer of nano-patterns from the mould to the resist- coated wafer.

A Pole Assignment Design Method of Process Control System for Tubular Heat Exchanger

This Paper has first studied the simplified model of tubular heat exchanger which is widely used in the industry and other field.On the basis of reference 2,a new pole assignment design method of pro-cess control system with derivative control action is found.For the above system,the method and the for-mation which calculate the feedback matrix K and gain matrix L is given,and the simulation of the system is made.