Multi-Objective Optimization of Multi-Product Parallel Disassembly Line Balancing Problem Considering Multi-Skilled Workers Using a Discrete Chemical Reaction Optimization Algorithm

This work investigates a multi-product parallel disassembly line balancing problem considering multi-skilled workers.A mathematical model for the parallel disassembly line is established to achieve maximized disassembly profit and minimized workstation cycle time.Based on a product’s AND/OR graph,matrices for task-skill,worker-skill,precedence relationships,and disassembly correlations are developed.A multi-objective discrete chemical reaction optimization algorithm is designed.To enhance solution diversity,improvements are made to four reactions:decomposition,synthesis,intermolecular ineffective collision,and wall invalid collision reaction,completing the evolution of molecular individuals.The established model and improved algorithm are applied to ball pen,flashlight,washing machine,and radio combinations,respectively.Introducing a Collaborative Resource Allocation(CRA)strategy based on a Decomposition-Based Multi-Objective Evolutionary Algorithm,the experimental results are compared with four classical algorithms:MOEA/D,MOEAD-CRA,Non-dominated Sorting Genetic Algorithm Ⅱ(NSGA-Ⅱ),and Non-dominated Sorting Genetic Algorithm Ⅲ(NSGA-Ⅲ).This validates the feasibility and superiority of the proposed algorithm in parallel disassembly production lines.

Crosstalk between degradation and bioenergetics: how autophagy and endolysosomal processes regulate energy production

Cells undergo metabolic reprogramming to adapt to changes in nutrient availability, cellular activity, and transitions in cell states. The balance between glycolysis and mitochondrial respiration is crucial for energy production, and metabolic reprogramming stipulates a shift in such balance to optimize both bioenergetic efficiency and anabolic requirements. Failure in switching bioenergetic dependence can lead to maladaptation and pathogenesis. While cellular degradation is known to recycle precursor molecules for anabolism, its potential role in regulating energy production remains less explored. The bioenergetic switch between glycolysis and mitochondrial respiration involves transcription factors and organelle homeostasis, which are both regulated by the cellular degradation pathways. A growing body of studies has demonstrated that both stem cells and differentiated cells exhibit bioenergetic switch upon perturbations of autophagic activity or endolysosomal processes. Here, we highlighted the current understanding of the interplay between degradation processes, specifically autophagy and endolysosomes, transcription factors, endolysosomal signaling, and mitochondrial homeostasis in shaping cellular bioenergetics. This review aims to summarize the relationship between degradation processes and bioenergetics, providing a foundation for future research to unveil deeper mechanistic insights into bioenergetic regulation.

Solutions to Insecurity Problems in Seed Production of Two-line Hybrid Rice

The insecure problems of seed production have seriously hampered the healthy and sustainable development of two-line hybrid rice.The safety issues on seed production of two-line hybrid rice and current research situation were pointed out in this paper.The three main reasons for unsafety in seed production of twoline hybrid rice were unsuitable site selection,high critical sterility-inducing temperature and the drift of critical temperature.In this paper,strategies and measures were put forward based on many years of practice.It could minimize the risk in seed production of two-line hybrid rice by selecting dual-purpose genic male sterile line with lower critical sterility-inducing temperature and long lower temperature resistant time.Based on the climate data and climatic demands of the ＂three safe-periods＂ in seed production,a new idea for determining appropriate bases and periods for seed production was proposed by using computer technology,which solved the aimless selection of sites and periods for the seed production of two-line hybrid rice.Besides,we established a system of single plant selection and identification method and original seed propagation with cyclic cold water,which could reduce the generation number of original seed propagation in seed production and avoid the drift of critical sterility-inducing temperature.This paper improved the seed production safety in the three aspects of seed nature,seed source and seed production site.

Installation and Debugging of Auto-control System in Fruit Wine Production Line

[Objective] The aim was to test the controlling effect of cleaning steriliza- tion system, material conveying system, and fermentation jar cooling system with equip- ments of fruit wine production line introduced in this study and its auto-control sys- tem field assembled and debugged. [Method] Based on controlling equipment and setting parameters on the configuration interface, the operation state of the control equipments could be real-time monitored and controlled with the help of configura- tion software. [Result] The result showed that the equipment system could reduce the temperature into 12 ℃ with the error of ＋0.5 ℃within 110 minutes when the fermentation temperature is set at 12 ℃ in real production. [Conclusion] The auto- control system of fruit wine production line was easy to be assembled and de- bugged to meet demands of different fruit wine productions.

Comparison of Efficiencies of Two Production Lines with Buffering Capacities at Common and Separative Allocation

In this paper, the efficiencies of two production lines, one is with commonly, the other is with separately buffer capacities are compared, the result is that the former one is better than the latter

Reproduction of the Three-line Genic Male Sterile Line Parent Mian 7MB-1 （Brasscia Napus L.） and Seed Production of F1 Based on Somatic Tissue Culture

[Objective] The aim was to study the reproduction of the three-line genic male sterile （GMS） lineparent Mian7MB-1 （B. NapusL.） and the seed production of F1 through somatic tissue culture. [Methed] Through hybridization, a new breeding material Mian 7MB-1 in three-line genic temporary maintainer line propagated by tissue culture was used to improve the sterile plant rate of rapeseed in dual-purpose recessive GMS line, such as Mian 7AB type, S45AB type, and etc. And then the variety comparative test was performed. [Result] In order to avoid some fertility restoration phenomena occurring during the process of self-reproduction, Mian 7AB was propagated in bulk with somatic tissue culture of temporary maintainer line plant stem. The propagated temporary maintainer line seedlings were applied to the breeding and seed production of net room male sterile line parent, promoting the sterile plant rate of the male sterile line parent to 91.7% -93.5%. The male sterile line parents per hectare were enough for the seed production of hybrid F1 in 7 500 -15 000 hm^2. [ Conclusion ] Compared with the original dual-purpose GMS line, the seed production ultilizing male sterile line with high sterile plant rate greatly reduced the labor, significantly improved the seed yield, ensuring the seed quality and forming a perfect breeding and seed production system.

Preliminary Discussion on Stigma Vitality of Sterile Line Rong 18A and Its Application in Seed Production

Rong 18A is an Indica three-line sterile line bred with M5B×D Xing B, and has the characteristics of stable sterility, high outcrossing rate, good combining ability and good quality. With Rong 18A as an experimental material and Ⅱ-32A, Jin 23A and Gang46 A as the CK materials, a seed setting rate estimation method by daily pollination was used for measuring its stigma vigor, to comparatively analyze the decreasing rates and lasting time of stigma vigor of various materials under natural condition. According to experimental results and combining with field breeding practice, the application of stigma vigor of sterile lines on hybrid rice seed production was discussed.

High-yielding Seed Production Techniques of Disease-resistant and High-quality Hybrid Rice Sterile Line Rong 18A

Rong 18A, bred by Crop Research Institute, Chengdu Academy of Agri- culture and Forestry Sciences is a new blast-highly resistant and high-combining ability hybrid rice sterile line. It is currently one of the male sterile lines in Sichuan Province which combine well high grain quality and rice blast resistance. More than 20 combinations of Rong 18A have passed the national and provincial variety iden- tification. Combined with the climate conditions in Chengdu, the key points of high- yielding seed production techniques for Rong18A are analyzed and summarized in this paper.

Effects of SPAD Decline Value of Mid-season Hybrid Rice Leaves after Full-heading Stage on Productivity of Rice Fertilized with Nitrogen

[Objective] The aim was to research relationship between SPAD decline index after full-heading stage （SDIFHS） and productivity of rice. fertilized with nitro- gen in order to provide theoretical and practical references for selection and breed- ing of rice varieties. [Method] From 2008 to 2010, 18 mid-season hybrid rice vari- eties were researched every year to explore relationship＇ between SDIFHS and pro- ductivity of rice fertilized with nitrogen. [Result] The productivity of rice fertilized with nitrogen was of extremely significant positive corretation with SDIFHS, because the higher SPAD decline index is, the higher LAI decline index and the transformation ratio of dry matter to spikes in overground plant would be. [Conclusion] The re- search established a new method to predict productivity of rice fertilized with nitro- gen based on SPAD decline index.

Seed Production Techniques of Two-line Indica Hybrid Rice Yanliangyou 2208

Yanliangyou 2208, bred by the Jiangsu Institute of Agricultural Sciences in Coastal Areas, is a two-line indica hybrid rice combination characterized with strong heterosis, moderate maturity, wide adaptability, good stability and disease resistance. It was identified as a new variety by the National Crop Variety Approval Committee in 2013. According to the characteristics of parents of Yanliangyou 2208 and com- bined with many years of seed production experience, high-yielding seed production techniques of Yanliangyou 2208 are summed up in this paper.

Genetic Parameters Evaluation of Main Reproductive Traits for the New Yorkshire Dam Line with High Prolificacy

The genetic parameters of main reproductive traits for the new Yorkshire line with high prolificacy were evaluated by multiple animal model DFREML The re- suits showed that the heritability evaluates of the total number of born （TNB）, alive number of born （ANB）, litter weigh at birth （LWB） and litter weight at age of 21 days were 0.10, 0.15, 0.09 and 0.14, respectively. The genetic correlations between these traits, for example, the correlations between TNB/ANB, NB/LWB, TNB/LW21, ANB/LWB, ANB/LW21 and LWB/LW21 were 0.87, 0.74, 0.43, 0.69, 0.59 and 0.51, respectively.

Multi-objective reconfigurable production line scheduling for smart home appliances

In a typical discrete manufacturing process,a new type of reconfigurable production line is introduced,which aims to help small-and mid-size enterprises to improve machine utilization and reduce production cost.In order to effectively handle the production scheduling problem for the manufacturing system,an improved multi-objective particle swarm optimization algorithm based on Brownian motion(MOPSO-BM)is proposed.Since the existing MOPSO algorithms are easily stuck in the local optimum,the global search ability of the proposed method is enhanced based on the random motion mechanism of the BM.To further strengthen the global search capacity,a strategy of fitting the inertia weight with the piecewise Gaussian cumulative distribution function(GCDF)is included,which helps to maintain an excellent convergence rate of the algorithm.Based on the commonly used indicators generational distance(GD)and hypervolume(HV),we compare the MOPSO-BM with several other latest algorithms on the benchmark functions,and it shows a better overall performance.Furthermore,for a real reconfigurable production line of smart home appliances,three algorithms,namely non-dominated sorting genetic algorithm-II(NSGA-II),decomposition-based MOPSO(dMOPSO)and MOPSO-BM,are applied to tackle the scheduling problem.It is demonstrated that MOPSO-BM outperforms the others in terms of convergence rate and quality of solutions.

RECONFIGURABLE PRODUCTION LINE MODELING AND SCHEDULING USING PETRI NETS AND GENETIC ALGORITHM

In response to the production capacity and functionality variations, a genetic algorithm （GA） embedded with deterministic timed Petri nets（DTPN） for reconfigurable production line（RPL） is proposed to solve its scheduling problem. The basic DTPN modules are presented to model the corresponding variable structures in RPL, and then the scheduling model of the whole RPL is constructed. And in the scheduling algorithm, firing sequences of the Petri nets model are used as chromosomes, thus the selection, crossover, and mutation operator do not deal with the elements in the problem space, but the elements of Petri nets model. Accordingly, all the algorithms for GA operations embedded with Petri nets model are proposed. Moreover, the new weighted single-objective optimization based on reconfiguration cost and E/T is used. The results of a DC motor RPL scheduling suggest that the presented DTPN-GA scheduling algorithm has a significant impact on RPL scheduling, and provide obvious improvements over the conventional scheduling method in practice that meets duedate, minimizes reconfiguration cost, and enhances cost effectivity.

Equivalence of crossed product of linear categories and generalized Maschke theorem

Some sufficient and necessary conditions are given for the equivalence between two crossed product actions of Hopf algebra H on the same linear category, and the Maschke theorem is generalized. Based on the result of the crossed product in the classic Hopf algebra theory, first, let A be a k-linear category and H be a Hopf algebra, and the two crossed products A#_σH and A#＇_σH are isomorphic under some conditions. Then, let A#_σH be a crossed product category for a finite dimensional and semisimple Hopf algebra H. If V is a left A#σH-module and WC V is a submodule such that W has a complement as a left A-module, then W has a complement as a A#_σH-module.

Identifying Counterexamples Without Variability in Software Product Line Model Checking

Product detection based on state abstraction technologies in the software product line(SPL)is more complex when compared to a single system.This variability constitutes a new complexity,and the counterexample may be valid for some products but spurious for others.In this paper,we found that spurious products are primarily due to the failure states,which correspond to the spurious counterexamples.The violated products correspond to the real counterexamples.Hence,identifying counterexamples is a critical problem in detecting violated products.In our approach,we obtain the violated products through the genuine counterexamples,which have no failure state,to avoid the tedious computation of identifying spurious products dealt with by the existing algorithm.This can be executed in parallel to improve the efficiency further.Experimental results showthat our approach performswell,varying with the growth of the system scale.By analyzing counterexamples in the abstract model,we observed that spurious products occur in the failure state.The approach helps in identifying whether a counterexample is spurious or genuine.The approach also helps to check whether a failure state exists in the counterexample.The performance evaluation shows that the proposed approach helps significantly in improving the efficiency of abstraction-based SPL model checking.

Research on Theories and Techniques of Irrigation for Safeguarding Seed Production of Two-Line Hybrid Rice

By inducing frequency, intensity and duration of lower temperature in the middle and last ten-day periods in August in the rice-growing areas of southern China, increasing temperature for safe seed production was defined as 2℃. During the sensitive period of fertility, characters of panicle height and canopy structure of TGMS rice, Pei＇ai64S, were measured. Results showed that temperature changes caused by irrigation in fields were below 40 cm of rice plant, and heating effect was significant at 20 cm when the temperature was increased by 3.1 ℃. For the present study, the following irrigation techniques were put forth： the water depth of 15-20 cm, current water used, irrigating after 17：00 and bailing at 10：00 in sunny or cloudy weather, irrigating on whole day, in shady or rainy weather, increasing inflows and outflows in large fields. In the present experiment, pollen fertility and self-fertilized seed setting rate accepted that the techniques were feasible and effective for against lower temperature and safeguarding seed production of two-line hybrid rice.

Simultaneous Determination of Melamine, Ammelide, Ammeline, and Cyanuric Acid in Milk and Milk Products by Gas Chromatography-tandem Mass Spectrometry

Objective To develop an analytical method for simultaneously qualitative and quantitative determination of melamine and triazine-related by-products including ammelide, ammeline, and cyanuric acid in milk and milk products by gas chromatography- tandem mass spectrometry （GC-MS/MS）. Methods Melamine and triazine-related by-products namely ammelide, ammeline and cyanuric acid in the samples were extracted in a solvent mixture of diethylamine, water, and acetonitrile （10：40：50, V/V/V）. After centrifugation, an aliquot of the supernatant was evaporated to dryness under a gentle stream of nitrogen gas, and then melamine and triazine-related by-products were derivatized using BSTFA with 1% TMCS. The derivatives of melamine and its analogues were determined by gas chromatography/tandem mass spectrometry using multiple reactional monitoring （MRM） with 2, 6-Diamino-4-chloropyrimidine （DACP） being used as an internal standard. Results The linear detectable ranges were from 0.004 mg/kg to 1.6 mg/kg for melamine, ammelide, ammeline, and cyanuric acid with a correlation coefficient no less than 0.999. The recovery rates of the tour compounds in spiked blank milk powder at concentrations 0.5, 1, 2 mg/kg were between 61.4%-117.2%, and the relative standard deviation was no more than 11.5% （n=6）. The detection limits of melamine, ammelide, ammeline and cyanuric acid in milk powder were 0.002 mg/kg with a ratio of signal to noise of 3. Conclusion This GC-MS/MS method for simultaneous determination of melamine, ammelide, ammeline, and cyanuric acid in milk and milk products is sensitive and specific.

In vitro cytotoxicity of Indonesian stingless bee products against human cancer cell lines

Objective:To screen crude extracts of propolis,bee pollen and honey from four stingless bee species[Trigona incisa(T.incisa)],Timia apicalis,Trigona fuso-baltata and Trigona filscibasis)native to East Kalimantan.Indonesia for cytotoxic activity against five human cancer cell lines(HepG2,SW620,ChaGo-1,KATO-Ⅲand BT474).Methods:All samples were extracted with methanol,and then subpartitioned with n-hexane and ethyl acetate.Each crude extract was screened at 20μg/mL for in vitro cytotoxicity against the cell lines using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay.Tn addition,four previously shown bioactive components from propolis(apigenin,cafieic acid phenyl ester,kaempferol and naringenin)and two chemotherapeutic drugs(doxorubicin and 5-fluorouracil)were used to evaluate the sensitivity of the cell lines.Results:Overall,crude extracts from propolis and honey had higher cytotoxic activities than bee pollen,but the activity was dependent upon the extraction solvent,bee species and cell line.Propolis extracts from T.incisa and Tarda apicalis showed the highest and lowest cytotoxic activity,respectively.Only the HepG2 cell line was broadly sensitive to the honey extracts.For pure compounds,doxorubicin was the most cytotoxic,the four propolis compounds the least,but the ChaGo-I cell line was sensitive to kaempferol at 10μg/mL and KATO-Ⅲwas sensitive to kaempferol and apigenin at 10μg/mL,.All pure compounds were effective against the BT474 cell line.Conclusions:Propolis from f,incisa and Trigona fusco-balteata contain an in vitro cytotoxic activity against human cancer cell lines.Further study is required,including the isolation and characterization of the active antiproliferative agent(s).

Establishment of Embryonic Stem Cell Lines Derived from Outbred Mouse Embryos and Production of Chimeras

The aim of the present investigation was to determine if embryonic stem (ES) cells could be isolated from outbred mouse embryos (KM) and if chimeras could be producedly using outbred ES cells. Three ES cell lines,designated KE1, KE2, and KE5,were isolated from 5 Kunming albino blastocysts. Normal diploid composition of these cell lines was above 70%. By using C57BL/6J and 615 blastocysts as host embryos, one chimera was obtained in living pups. It was shown for the first time that chimeras can be produced by using outhred ES cells. This work implies that to establish ES cell lines from other animal embryos is possible. More interestingly, white color dots from ES cells on the coat of this chimeric mouse enlarged a lot after half a year, indicated that ES cells were inhibited by cells from outbred mouse or the cells of outbred mouse grew vigiously.

Dynamic Analysis of Semi-Submersible Production Platform Under the Failure of Mooring Lines

This paper quantitatively studies the transient dynamic response of a semi-submersible production platform with the loss of one or several positioning mooring lines.A semi-submersible platform,production risers,and positioning mooring lines are all included in the numerical simulation.Increased motion of the semi-submersible platform,tension variation of the remaining mooring lines/risers and the risk of mooring line or riser clashing are all investigated through fully coupled time-domain analysis.Combined environmental loads are selected from irregular waves and the steady current varying from very rough to extreme sea conditions.Three dimension radiation/diffraction theories and Morison’s equation are applied to calculate first-order wave force and second-order mean drift force of floating semi-submersible platform.Nonlinear time-domain finite element methods are employed to analyze the behavior of mooring lines and risers.Results show that the failure of mooring lines seriously reduce the platform’s stability performance.The tension of the rest lines is also increased accordingly.Remaining lines which are closer to the failed lines will have larger tension increase to compensate.Line-Line distance provides practical information for the risk of clashing investigation.