Promethazine modified carbon paste ion selective electrode has been prepared, based on the ion pair of promethazine hydrochloride Pm.Cl with sodium tetraphenyl boron(III) Pm-TPB dissolved in dioctyl phthalate DOP as a...Promethazine modified carbon paste ion selective electrode has been prepared, based on the ion pair of promethazine hydrochloride Pm.Cl with sodium tetraphenyl boron(III) Pm-TPB dissolved in dioctyl phthalate DOP as a pasting liquid. The electrode showed the linear response with mean calibration graph slope of 58 mV/decade at 25℃;at a concentration range and a lower detection limit of 1 × 10-5 -6 × 10-2 M and 8 × 10-6 M promethazine hydrochloride, respectively. The change of pH of the tested solution within the range 4.2 -6.8 did not affect the electrode performance. The electrode showed a very good selectivity toward Pm+ cations with respect to a large number of organic and inorganic cations and compounds. The standard addition and potentiometric titration methods were applied for the determination of promethazine hydrochloride in pure solution and in pharmaceutical preparations with an?average recovery range of 97.3% -101.4% and a mean relative standard deviation (RSD) of 0.35% -1.83 % which were of comparable accuracy and precision to the previously reported works.展开更多
Objective:To explore the effect of cinepazide maleate combined with promethazine hydrochloride in the treatment of emergency vertigo.Methods:48 cases of emergency vertigo patients in our hospital from November 2017 to...Objective:To explore the effect of cinepazide maleate combined with promethazine hydrochloride in the treatment of emergency vertigo.Methods:48 cases of emergency vertigo patients in our hospital from November 2017 to November 2019 were divided into experimental group(24 cases,treated with cinepazide maleate combined with promethazine hydrochloride)and control group (24 cases,treated with cinepazide maleate).The clinical efficacy,symptom relief time,adverse reactions and quality of life were compared.Results:The total effective rate of the experimental group(95.83%,23/24)was higher than that of the control group(75.00%),The remission time of nausea and vomiting(1.75±0.22)d,vertigo(3.54±0.63)d,deafiiess and tinnitus(3.47±0.58)d,night sweats(3.05±0.33)d in the experimental group were shorter than those in the control group,P<0.05;the incidence of adverse reactions in the experimental group(8.33%,2/24)was lower than that in the control group(33.33%),The scores of social function,material life attitude,physical health and psychological function in the experimental group were 59.14±7.23,54.05±8.04,53.58±0.86 and 60.11±8.44 respectively,P<0.05.Conclusion:In the process of clinical treatment of emergency vertigo patients,the combined application of cinepazide maleate and promethazine hydrochloride has definite curative effect,can relieve clinical symptoms in a short time,has less adverse reactions,and improves the quality of life of patients to a certain extent,which is worthy of promotion.展开更多
目的建立测定盐酸异丙嗪咖啡因片的含量及溶出度的高效液相色谱法。方法色谱柱：Agilent TC C18柱（250 mm×4.6 mm,5μm）;流动相：甲醇-三乙胺水溶液（浓度为3‰,磷酸调至p H2.3）=（50∶50）;流速：1.0 ml/min;检测波长分别为250...目的建立测定盐酸异丙嗪咖啡因片的含量及溶出度的高效液相色谱法。方法色谱柱：Agilent TC C18柱（250 mm×4.6 mm,5μm）;流动相：甲醇-三乙胺水溶液（浓度为3‰,磷酸调至p H2.3）=（50∶50）;流速：1.0 ml/min;检测波长分别为250和272 nm;柱温：30℃;进样量20μl（溶出度测定时进样量为10μl）。溶出条件采用桨法,温度为37℃,分别以900 ml p H1.2盐酸、p H 4.5醋酸缓冲液、p H 6.8磷酸缓冲液及水为溶出介质,以50、75 r/min作为转速进行溶出条件的筛选。结果该HPLC检测方法专属性良好;盐酸异丙嗪、咖啡因分别在0.5~100μg/ml和4.0~400μg/ml范围内线性关系良好,线性回归方程分别为Y=96.21X-7.303（r=1）、Y=51.33X＋68.88（r=0.9999）;盐酸异丙嗪检测限为15 ng/ml,定量限为40 ng/ml;咖啡因检测限为2 ng/ml,定量限为10 ng/ml。平均回收率分别为盐酸异丙嗪（100.04±1.39）%（n=9）,咖啡因（99.42±1.07）%（n=9）;供试溶液在12 h保持稳定。确立了以900 ml p H 1.2盐酸为溶出介质,桨法转速为50 r/min的溶出方法,溶出时间30 min。制剂在4种溶出介质中溶出度均在15 min内达85%以上,其溶出不受体液p H影响。结论所选溶出条件适用于盐酸异丙嗪咖啡因片的溶出测定。所建含量及溶出度检测方法简便、快速、灵敏,精密度高,重现性好,结果准确,适合同时对盐酸异丙嗪及咖啡因进行含量及溶出度分析。展开更多
文摘Promethazine modified carbon paste ion selective electrode has been prepared, based on the ion pair of promethazine hydrochloride Pm.Cl with sodium tetraphenyl boron(III) Pm-TPB dissolved in dioctyl phthalate DOP as a pasting liquid. The electrode showed the linear response with mean calibration graph slope of 58 mV/decade at 25℃;at a concentration range and a lower detection limit of 1 × 10-5 -6 × 10-2 M and 8 × 10-6 M promethazine hydrochloride, respectively. The change of pH of the tested solution within the range 4.2 -6.8 did not affect the electrode performance. The electrode showed a very good selectivity toward Pm+ cations with respect to a large number of organic and inorganic cations and compounds. The standard addition and potentiometric titration methods were applied for the determination of promethazine hydrochloride in pure solution and in pharmaceutical preparations with an?average recovery range of 97.3% -101.4% and a mean relative standard deviation (RSD) of 0.35% -1.83 % which were of comparable accuracy and precision to the previously reported works.
文摘Objective:To explore the effect of cinepazide maleate combined with promethazine hydrochloride in the treatment of emergency vertigo.Methods:48 cases of emergency vertigo patients in our hospital from November 2017 to November 2019 were divided into experimental group(24 cases,treated with cinepazide maleate combined with promethazine hydrochloride)and control group (24 cases,treated with cinepazide maleate).The clinical efficacy,symptom relief time,adverse reactions and quality of life were compared.Results:The total effective rate of the experimental group(95.83%,23/24)was higher than that of the control group(75.00%),The remission time of nausea and vomiting(1.75±0.22)d,vertigo(3.54±0.63)d,deafiiess and tinnitus(3.47±0.58)d,night sweats(3.05±0.33)d in the experimental group were shorter than those in the control group,P<0.05;the incidence of adverse reactions in the experimental group(8.33%,2/24)was lower than that in the control group(33.33%),The scores of social function,material life attitude,physical health and psychological function in the experimental group were 59.14±7.23,54.05±8.04,53.58±0.86 and 60.11±8.44 respectively,P<0.05.Conclusion:In the process of clinical treatment of emergency vertigo patients,the combined application of cinepazide maleate and promethazine hydrochloride has definite curative effect,can relieve clinical symptoms in a short time,has less adverse reactions,and improves the quality of life of patients to a certain extent,which is worthy of promotion.
文摘目的建立测定盐酸异丙嗪咖啡因片的含量及溶出度的高效液相色谱法。方法色谱柱：Agilent TC C18柱（250 mm×4.6 mm,5μm）;流动相：甲醇-三乙胺水溶液（浓度为3‰,磷酸调至p H2.3）=（50∶50）;流速：1.0 ml/min;检测波长分别为250和272 nm;柱温：30℃;进样量20μl（溶出度测定时进样量为10μl）。溶出条件采用桨法,温度为37℃,分别以900 ml p H1.2盐酸、p H 4.5醋酸缓冲液、p H 6.8磷酸缓冲液及水为溶出介质,以50、75 r/min作为转速进行溶出条件的筛选。结果该HPLC检测方法专属性良好;盐酸异丙嗪、咖啡因分别在0.5~100μg/ml和4.0~400μg/ml范围内线性关系良好,线性回归方程分别为Y=96.21X-7.303（r=1）、Y=51.33X＋68.88（r=0.9999）;盐酸异丙嗪检测限为15 ng/ml,定量限为40 ng/ml;咖啡因检测限为2 ng/ml,定量限为10 ng/ml。平均回收率分别为盐酸异丙嗪（100.04±1.39）%（n=9）,咖啡因（99.42±1.07）%（n=9）;供试溶液在12 h保持稳定。确立了以900 ml p H 1.2盐酸为溶出介质,桨法转速为50 r/min的溶出方法,溶出时间30 min。制剂在4种溶出介质中溶出度均在15 min内达85%以上,其溶出不受体液p H影响。结论所选溶出条件适用于盐酸异丙嗪咖啡因片的溶出测定。所建含量及溶出度检测方法简便、快速、灵敏,精密度高,重现性好,结果准确,适合同时对盐酸异丙嗪及咖啡因进行含量及溶出度分析。
