Epigallocatechin-3-gallate treatment to promote neuroprotection and functional recovery after nervous system injury

Traumatic spinal cord injury （SCI） causes motor paralysis, sensory anesthesia and autonomic dysfunction below the le- sion site and additionally some SCI patients refer neuropathic pain together with these signs and symptoms. Clinical and experimental studies have revealed the main pathological changes of injured spinal cord implicated in all these signs and symptoms, including neuropathic pain. After few hours of traumatic SCI, it is usual to observe broken blood brain barrier with plasma and blood cells extravasation, cell necrosis, disruption of ascending and descending spinal cord pathways and increased potassium and glutamate. Glutamate contributes to excitotoxicity of neurons whereas potassium facilitates ectopic depolarization of survival neurons and activation of resident microglia.

Combined treatment promotes the long-range axon regeneration to right brain targets

Axons in the peripheral nervous system(PNS)can regenerate after injury.However,the adult mammalian central nervous system(CNS)loses the intrinsic regrowth ability.No robust axon regeneration occurs spontaneously after nerve injury,which was clearly observed by Ramon y Cajal in the early 20^(th) century(1,2).Due to lack

Treatment Based on Narcolepsy Promote Sleep in Insomniacs

瑞士Actelion制药公司的研究人员在新一期《自然医学》杂志上报告说,他们新发现一种可以阻止大脑激素神经肤活动的化学物质,可以帮助白天昏昏欲睡但夜间无法入睡的人摆脱痛苦。神经肽与睡眠有关,这种激素在有嗜睡症的人体内含量较低,使他们习惯性地昏昏欲睡,甚至会在工作时或驾车时入睡。研究人员称,现有的大多数治疗失眠药物都有一些副作用,会导致服用者第二天出现记忆损失和头昏等症状,但新发现的化学物质基本没有这类副作用。