Objective To investigate the effect of dietary saturated fat (SFA) from animal sources on the urine excretion 11-dehydro thromboxane 62 (TXB2) and 6-keto prostaglandin F la (PGF la) in 27 healthy free-living male subj...Objective To investigate the effect of dietary saturated fat (SFA) from animal sources on the urine excretion 11-dehydro thromboxane 62 (TXB2) and 6-keto prostaglandin F la (PGF la) in 27 healthy free-living male subjects aged 30 to 55 years. Methods It was a randomized crossover design. Each volunteer was randomly assigned to one of the two diets (high fat and low fat) for a period of 4 weeks, after which each subject resumed his usual diet for 2 weeks as a 'wash-out period', before being assigned to the other diet for an additional 4 weeks. Results Serum proportion of 20:4n-6 was 5% lower in the high fat (6.2% of total fatty acid) than in the low fat diet (6.5% of total fatty acid), which was associated with a significantly decreased ratio of the urinary excretion 11-dehydro TXB2 to 6-keto PGF lα (P<0.05). However, there was no significant fall in the absolute urinary excretion of 11-dehydro TXB2. Conclusions Diet rich in SFA from animal sources may influence TXA2 formation via effect on tissue proportion of 20:4n-6.展开更多
目的：探讨清肾颗粒对慢性肾衰竭伴颈动脉斑块湿热证患者血栓调节蛋白（Tm）、前列环素（PGI2）水平的干预作用。方法：选择CKD 3～5期非透析伴颈动脉斑块湿热证患者70例,根据随机数据表分成实验组和对照组,每组35例,实际完成62例,实验...目的：探讨清肾颗粒对慢性肾衰竭伴颈动脉斑块湿热证患者血栓调节蛋白（Tm）、前列环素（PGI2）水平的干预作用。方法：选择CKD 3～5期非透析伴颈动脉斑块湿热证患者70例,根据随机数据表分成实验组和对照组,每组35例,实际完成62例,实验组33例,对照组29例,并选取健康人20例作为正常组。实验组和对照组均予常规治疗,实验组加用清肾颗粒,1次1袋,1 d 3次,疗程均为6个月。观察治疗前后血肌酐（Scr）、尿素氮（BUN）、甘油三酯（TG）、总胆固醇（TC）、高密度脂蛋白（HDL-C）、低密度脂蛋白（LDL-C）的水平及颈动脉中内膜厚度（IMT）,并应用ELISA法测定血清Tm、PGI2水平。结果：（1）对照组治疗前后IMT厚度无明显变化（P〉0.05）,实验组治疗后较治疗前IMT厚度明显缩小（P〈0.01）,且较对照组下降明显（P〈0.01）;（2）与本组治疗前比较,治疗后实验组SCr、BUN、TG、TC、LDL-C水平明显下降（P〈0.05）,HDL-C水平明显升高（P〈0.05）,对照组治疗前后以上指标无明显变化（P〉0.05）;（3）与正常组比较,治疗前实验组和对照组血清Tm水平升高（P〈0.01）、血清PGI2水平下降（P〈0.01）;与本组治疗前比较,治疗后实验组血清Tm水平下降（P〈0.01）、血清PGI2水平升高（P〈0.01）;而对照组治疗前后血清Tm、PGI2水平均无明显差异（P〉0.05）;（4）血清Tm水平与IMT呈正相关（r=0.268,P=0.035）,血清PGI2水平与IMT呈负相关（r=-0.397,P=0.001）。结论：清肾颗粒可以改善慢性肾衰竭患者颈动脉斑块程度,其机制可能与降低患者血清Tm,升高血清PGI2及调节血脂水平有关。展开更多
基金This project was supported by Department of Veterans Affairs, Australia
文摘Objective To investigate the effect of dietary saturated fat (SFA) from animal sources on the urine excretion 11-dehydro thromboxane 62 (TXB2) and 6-keto prostaglandin F la (PGF la) in 27 healthy free-living male subjects aged 30 to 55 years. Methods It was a randomized crossover design. Each volunteer was randomly assigned to one of the two diets (high fat and low fat) for a period of 4 weeks, after which each subject resumed his usual diet for 2 weeks as a 'wash-out period', before being assigned to the other diet for an additional 4 weeks. Results Serum proportion of 20:4n-6 was 5% lower in the high fat (6.2% of total fatty acid) than in the low fat diet (6.5% of total fatty acid), which was associated with a significantly decreased ratio of the urinary excretion 11-dehydro TXB2 to 6-keto PGF lα (P<0.05). However, there was no significant fall in the absolute urinary excretion of 11-dehydro TXB2. Conclusions Diet rich in SFA from animal sources may influence TXA2 formation via effect on tissue proportion of 20:4n-6.
文摘目的：探讨清肾颗粒对慢性肾衰竭伴颈动脉斑块湿热证患者血栓调节蛋白（Tm）、前列环素（PGI2）水平的干预作用。方法：选择CKD 3～5期非透析伴颈动脉斑块湿热证患者70例,根据随机数据表分成实验组和对照组,每组35例,实际完成62例,实验组33例,对照组29例,并选取健康人20例作为正常组。实验组和对照组均予常规治疗,实验组加用清肾颗粒,1次1袋,1 d 3次,疗程均为6个月。观察治疗前后血肌酐（Scr）、尿素氮（BUN）、甘油三酯（TG）、总胆固醇（TC）、高密度脂蛋白（HDL-C）、低密度脂蛋白（LDL-C）的水平及颈动脉中内膜厚度（IMT）,并应用ELISA法测定血清Tm、PGI2水平。结果：（1）对照组治疗前后IMT厚度无明显变化（P〉0.05）,实验组治疗后较治疗前IMT厚度明显缩小（P〈0.01）,且较对照组下降明显（P〈0.01）;（2）与本组治疗前比较,治疗后实验组SCr、BUN、TG、TC、LDL-C水平明显下降（P〈0.05）,HDL-C水平明显升高（P〈0.05）,对照组治疗前后以上指标无明显变化（P〉0.05）;（3）与正常组比较,治疗前实验组和对照组血清Tm水平升高（P〈0.01）、血清PGI2水平下降（P〈0.01）;与本组治疗前比较,治疗后实验组血清Tm水平下降（P〈0.01）、血清PGI2水平升高（P〈0.01）;而对照组治疗前后血清Tm、PGI2水平均无明显差异（P〉0.05）;（4）血清Tm水平与IMT呈正相关（r=0.268,P=0.035）,血清PGI2水平与IMT呈负相关（r=-0.397,P=0.001）。结论：清肾颗粒可以改善慢性肾衰竭患者颈动脉斑块程度,其机制可能与降低患者血清Tm,升高血清PGI2及调节血脂水平有关。
