Side effects of different doses of ephedrine in rats with cerebral ischemia/reperfusion injury

Ephedrine has a protective effect against cerebral ischemia,but its side effects limit its clinical application.Results from a previous study showed that 1.5 mg/kg per day ephedrine can promote motion recovery in rats following cerebral ischemia/reperfusion without significant side effects.In the present study,ephedrine at doses of 3.0,2.5 and 2.0 mg/kg was used to treat rats with cerebral ischemia/reperfusion and the effects of ephedrine on the heart,liver,kidney and cerebrum were observed.Results showed that the blood pressure of rats with cerebral ischemia/reperfusion injury following ephedrine treatment was lower than in rats that recovered naturally from cerebral ischemia/reperfusion,but the pressure decreased with increasing doses of ephedrine.In addition,serum aspartate transaminase,alkaline phosphatase and creatinine concentration in rats with cerebral ischemia/reperfusion injury following ephedrine treatment were greater than in rats that recovered naturally from cerebral ischemia/reperfusion.The concentrations of these enzymes were decreased with increasing doses of ephedrine.Ephedrine-treated rats displayed hyperemia,degeneration and edema in the cerebrum,liver,heart and kidney.Results demonstrated that ephedrine exhibited side effects on the cerebrum,heart,liver and kidney in rats following cerebral ischemia/reperfusion in a dose-dependent manner.

功能磁共振在大脑皮质发育障碍患者的初步应用研究

目的:应用功能磁共振(fMRI)探讨6名正常受试者及2例皮质发育障碍(DCDs)患者在进行汉语词汇加工过程中脑激活模式,探讨DCDs患者与正常受试者之间脑激活区域的差异与临床意义。方法:本实验采用听觉刺激,以汉语单词理解为语言作业任务。结果:①正常受试者均出现显著的脑区激活,传统语言脑区Wernicke和Broca区激活在双侧大脑半球基本是对称的。除传统语言脑区激活外,还出现其它脑区激活现象。②两例DCDs患者表现为基本语言功能区的激活,诸如Wernicke区和Broca区激活。但脑激活表现为显著的不对称性,甚至完全偏侧性。结论:fMRI能够对大脑DCDs患者功能重塑皮质进行定位,为DCDs伴难治性癫痫患者手术治疗,避免损伤重要功能区提供了有益的保障。

胰岛素样生长因子1对局灶性脑缺血再灌注损伤保护作用的研究

摘 要：目的 探讨胰岛素样生长因子1（IGF-1）对局灶性脑缺血再灌注损伤的保护作用。方法 利用TTC染色测定脑梗死体积，同时用酸性品红／硫堇染色进行病理学观察和死亡神经细胞计数。结果 与缺血再灌注组相比，给药组大鼠脑梗死体积显著缩小（P＜0．01）；死亡神经细胞数／总的神经细胞数也明显减小（P＜0．01）。结论IGF-1对缺血再灌注引发的脑损伤起保护作用，IGF-1可能通过抑制凋亡、营养支持等机制而起作用。