BACKGROUND Dissociation,which is defined as the failure to associate consciousness,memory,identity,emotion,perception,body representation,motor control,and behavior into an integrated whole,has long been assumed to be...BACKGROUND Dissociation,which is defined as the failure to associate consciousness,memory,identity,emotion,perception,body representation,motor control,and behavior into an integrated whole,has long been assumed to be generated by trauma.If dissociation is a product of trauma exposure,then dissociation would be a major mental health outcome observed in studies of disaster survivors.Although some studies have examined dissociation in disasters,no systematic literature reviews have been conducted to date on the topic.AIM To systematically evaluate the literature on the association between disaster and dissociation to determine the prevalence and incidence of dissociation after exposure to disaster and further examine their relationship.METHODS EMBASE,Medline,and PsychINFO were searched from inception to January 1,2019 to identify studies examining dissociative disorders or symptoms related to a disaster in adult or child disaster survivors and disaster responders.Studies of military conflicts and war,articles not in English,and those with samples of 30 or more participants were excluded.Search terms used were“disaster*”and dissociation(“dissociat*,”“multiple personality,”“fugue,”“psychogenic amnesia,”“derealization,”and“depersonalization”).Reference lists of identified articles were scrutinized to identify studies for additional articles.RESULTS The final number of articles in the review was 53,including 36 articles with samples of adults aged 18 and above,5 of children/adolescents under age 18,and 12 of disaster workers.Included articles studied several types of disasters that occurred between 1989 and 2017,more than one-third(38%)from the United States.Only two studies had a primary aim to investigate dissociation in relation to disaster and none reported data on dissociative disorders.All of the studies used self-report symptom scales;none used structured interviews providing full diagnostic assessment of dissociative disorders or other psychopathology.Several studies mixed exposed and unexposed samples or did not differentiate outcomes between exposure groups.Studies examining associations between dissociation and disaster exposure have been inconclusive.The majority(75%)of the studies compared dissociation with posttraumatic stress,with inconsistent findings.Dissociation was found to be associated with a wide range of other psychiatric disorders,symptoms,and negative emotional,cognitive,and functional states.CONCLUSION The studies reviewed had serious methodological limitations including problems with measurement of psychopathology,sampling,and generation of unwarranted conclusions,precluding conclusions that dissociation is an established outcome of disaster.展开更多
Rapid and dynamic change in hydrogen peroxide （H2O2） levels can serve as an important signal to regulate various biological processes in plants. The change is realized by tilting the balance between its production a...Rapid and dynamic change in hydrogen peroxide （H2O2） levels can serve as an important signal to regulate various biological processes in plants. The change is realized by tilting the balance between its production and scavenging rates, in which membrane-associated NADPH oxidases are known to play a crucial role. Functioning independently from NADPH oxidases, glycolate oxidase （GLO） was recently demonstrated as an aitemative source for H2O2 production during both germ-for-germ and non-host resistance in plants. In this study, we show that GLO physically interacts with catalase （CAT） in rice leaves, and that the interaction can be deregulated by salicylic acid （SA）. Furthermore, the GLO-mediated H2O2 accumulation is synergistically enhanced by SA. Based on the well-known mechanism of substrate channeling in enzyme complexes, SA-induced H2O2 accumulation likely results from SA-induced GLO-CAT dissociation. In the GLO-CAT complex, GLO-mediated H2O2 production during photorespiration is very high, whereas the affinity of CAT for H2O2 （measured Km ≈ 43 raM） is extraordinarily low. This unique combination can further potentiate the increase in H2O2 when GLO is dissociated from CAT. Taken together, we propose that the physical association-dissociation of GLO and CAT, in response to environmental stress or stimuli, seems to serve as a specific mechanism to modulate H2O2 levels in rice.展开更多
文摘BACKGROUND Dissociation,which is defined as the failure to associate consciousness,memory,identity,emotion,perception,body representation,motor control,and behavior into an integrated whole,has long been assumed to be generated by trauma.If dissociation is a product of trauma exposure,then dissociation would be a major mental health outcome observed in studies of disaster survivors.Although some studies have examined dissociation in disasters,no systematic literature reviews have been conducted to date on the topic.AIM To systematically evaluate the literature on the association between disaster and dissociation to determine the prevalence and incidence of dissociation after exposure to disaster and further examine their relationship.METHODS EMBASE,Medline,and PsychINFO were searched from inception to January 1,2019 to identify studies examining dissociative disorders or symptoms related to a disaster in adult or child disaster survivors and disaster responders.Studies of military conflicts and war,articles not in English,and those with samples of 30 or more participants were excluded.Search terms used were“disaster*”and dissociation(“dissociat*,”“multiple personality,”“fugue,”“psychogenic amnesia,”“derealization,”and“depersonalization”).Reference lists of identified articles were scrutinized to identify studies for additional articles.RESULTS The final number of articles in the review was 53,including 36 articles with samples of adults aged 18 and above,5 of children/adolescents under age 18,and 12 of disaster workers.Included articles studied several types of disasters that occurred between 1989 and 2017,more than one-third(38%)from the United States.Only two studies had a primary aim to investigate dissociation in relation to disaster and none reported data on dissociative disorders.All of the studies used self-report symptom scales;none used structured interviews providing full diagnostic assessment of dissociative disorders or other psychopathology.Several studies mixed exposed and unexposed samples or did not differentiate outcomes between exposure groups.Studies examining associations between dissociation and disaster exposure have been inconclusive.The majority(75%)of the studies compared dissociation with posttraumatic stress,with inconsistent findings.Dissociation was found to be associated with a wide range of other psychiatric disorders,symptoms,and negative emotional,cognitive,and functional states.CONCLUSION The studies reviewed had serious methodological limitations including problems with measurement of psychopathology,sampling,and generation of unwarranted conclusions,precluding conclusions that dissociation is an established outcome of disaster.
基金This work was supported by the National Natural Science Foundation of China （31170222, 31470343, U 1201212）.
文摘Rapid and dynamic change in hydrogen peroxide （H2O2） levels can serve as an important signal to regulate various biological processes in plants. The change is realized by tilting the balance between its production and scavenging rates, in which membrane-associated NADPH oxidases are known to play a crucial role. Functioning independently from NADPH oxidases, glycolate oxidase （GLO） was recently demonstrated as an aitemative source for H2O2 production during both germ-for-germ and non-host resistance in plants. In this study, we show that GLO physically interacts with catalase （CAT） in rice leaves, and that the interaction can be deregulated by salicylic acid （SA）. Furthermore, the GLO-mediated H2O2 accumulation is synergistically enhanced by SA. Based on the well-known mechanism of substrate channeling in enzyme complexes, SA-induced H2O2 accumulation likely results from SA-induced GLO-CAT dissociation. In the GLO-CAT complex, GLO-mediated H2O2 production during photorespiration is very high, whereas the affinity of CAT for H2O2 （measured Km ≈ 43 raM） is extraordinarily low. This unique combination can further potentiate the increase in H2O2 when GLO is dissociated from CAT. Taken together, we propose that the physical association-dissociation of GLO and CAT, in response to environmental stress or stimuli, seems to serve as a specific mechanism to modulate H2O2 levels in rice.
