<strong>Objective:</strong> The purpose of this work was to determine the epidemiological, clinical and evolutionary aspects of the pulmonary embolism of the young person in the cardiology department of th...<strong>Objective:</strong> The purpose of this work was to determine the epidemiological, clinical and evolutionary aspects of the pulmonary embolism of the young person in the cardiology department of the University Hospital Center (CHU) Point G in Bamako-Mali. <strong>Methodology:</strong> This was an analytical study from January 01, 2018 to December 31, 2018 in the CHU Point G cardiology department, including all patients hospitalized during this period. <strong>Results:</strong> Of 1379 hospitalized patients, 19 patients were concerned by pulmonary embolism of the young person. The prevalence of pulmonary embolism of the young person was 1.37%. The most affected age group was 21 - 30 (47.4%) of patients. The predominance was female (89.47%) with a gender ratio of 0.11 in favour of women. The average age in the series was 29.79 years with extremes of 16 years and 40 years. Factors predisposing to pulmonary embolism were dominated by peri partum, cardiomyopathy and obesity with 47.3%, 31.57% and 21.1%, respectively. The dominant signs were chest pain and dyspnea in 94.7% and 89.5% of cases respectively. Pulmonary embolism was unlikely in 60.52% according to the Geneva and Wells score simplified. At the thoracic angioscanner, the embolism was bilateral in 52.6% of cases and distal in 36.8% of patients;in 10 patients who performed cardiac ultrasound, pulmonary arterial hypertension (70%), dilation of the right ventricle (20%) and left ventricular dilation (40%). Hyper leucocytosis (47.4%), anemia and low prothrombin rate (TP) (22.2%) were the most found biological abnormalities. More than 2/3 (68.5%) our patients had an intermediate mortality risk according to the PESI (Pulmonary Embolism Severity Index) score. The average hospital stay was 10 days. Hospital mortality was 10.5%. <strong>Conclusion:</strong> The pulmonary embolism of the young person is a frequent, serious and multifactorial pathology and the female sex is most affected especially during peri partum periods, hence the need for preventive measures. Clinical signs are not specific and based on the assessment of clinical probability. Pulmonary angioscanner remains the confirmation review in our context.展开更多
目的通过网络药理学与分子对接法研究参七解郁方治疗双心疾病的潜在有效成分和作用通路。方法通过中药系统药理学数据库分析平台TCMSP和TCMID数据库查找该方所用药物的活性成分以及作用靶标,在Gene Cards数据库下载双心疾病靶点;以Strin...目的通过网络药理学与分子对接法研究参七解郁方治疗双心疾病的潜在有效成分和作用通路。方法通过中药系统药理学数据库分析平台TCMSP和TCMID数据库查找该方所用药物的活性成分以及作用靶标,在Gene Cards数据库下载双心疾病靶点;以String平台数据为基础,利用Cytoscape软件构建参七解郁方与双心疾病共同靶点的蛋白质-蛋白质相互作用网络(PPI);绘制“活性成分-靶点-通路”网络图;采用Auto Dock Tools工具进一步对接药物活性成分及可能作用的靶点。结果参七解郁方有89个主要活性成分,56个主要靶点,与30个信号通路有关。将度值大于5的前7个活性成分的分子配体与前5个靶点进行分子对接,结果显示活性成分与靶点分子对接能力均较好。结论参七解郁方通过多成分、多靶点、多通路参与双心疾病的治疗。展开更多
文摘<strong>Objective:</strong> The purpose of this work was to determine the epidemiological, clinical and evolutionary aspects of the pulmonary embolism of the young person in the cardiology department of the University Hospital Center (CHU) Point G in Bamako-Mali. <strong>Methodology:</strong> This was an analytical study from January 01, 2018 to December 31, 2018 in the CHU Point G cardiology department, including all patients hospitalized during this period. <strong>Results:</strong> Of 1379 hospitalized patients, 19 patients were concerned by pulmonary embolism of the young person. The prevalence of pulmonary embolism of the young person was 1.37%. The most affected age group was 21 - 30 (47.4%) of patients. The predominance was female (89.47%) with a gender ratio of 0.11 in favour of women. The average age in the series was 29.79 years with extremes of 16 years and 40 years. Factors predisposing to pulmonary embolism were dominated by peri partum, cardiomyopathy and obesity with 47.3%, 31.57% and 21.1%, respectively. The dominant signs were chest pain and dyspnea in 94.7% and 89.5% of cases respectively. Pulmonary embolism was unlikely in 60.52% according to the Geneva and Wells score simplified. At the thoracic angioscanner, the embolism was bilateral in 52.6% of cases and distal in 36.8% of patients;in 10 patients who performed cardiac ultrasound, pulmonary arterial hypertension (70%), dilation of the right ventricle (20%) and left ventricular dilation (40%). Hyper leucocytosis (47.4%), anemia and low prothrombin rate (TP) (22.2%) were the most found biological abnormalities. More than 2/3 (68.5%) our patients had an intermediate mortality risk according to the PESI (Pulmonary Embolism Severity Index) score. The average hospital stay was 10 days. Hospital mortality was 10.5%. <strong>Conclusion:</strong> The pulmonary embolism of the young person is a frequent, serious and multifactorial pathology and the female sex is most affected especially during peri partum periods, hence the need for preventive measures. Clinical signs are not specific and based on the assessment of clinical probability. Pulmonary angioscanner remains the confirmation review in our context.
文摘目的通过网络药理学与分子对接法研究参七解郁方治疗双心疾病的潜在有效成分和作用通路。方法通过中药系统药理学数据库分析平台TCMSP和TCMID数据库查找该方所用药物的活性成分以及作用靶标,在Gene Cards数据库下载双心疾病靶点;以String平台数据为基础,利用Cytoscape软件构建参七解郁方与双心疾病共同靶点的蛋白质-蛋白质相互作用网络(PPI);绘制“活性成分-靶点-通路”网络图;采用Auto Dock Tools工具进一步对接药物活性成分及可能作用的靶点。结果参七解郁方有89个主要活性成分,56个主要靶点,与30个信号通路有关。将度值大于5的前7个活性成分的分子配体与前5个靶点进行分子对接,结果显示活性成分与靶点分子对接能力均较好。结论参七解郁方通过多成分、多靶点、多通路参与双心疾病的治疗。
