Objective: To compare the effect between nebulized and intravenous administration of Shenmai Injection (参麦注射液) on pulmonary gas exchange function of patients following tourniquet-induced lower limb ischemia-re...Objective: To compare the effect between nebulized and intravenous administration of Shenmai Injection (参麦注射液) on pulmonary gas exchange function of patients following tourniquet-induced lower limb ischemia-repeffusion. Methods: Thirty-eight patients scheduled for lower extremity surgery were randomized into three groups using the closed envelop method: Shenmai Injection was administered 30 min before tourniquet inflation by nebulization [0.6 mL/kg in 10 mL normal saline (NS)] in the nebulization group or by intravenous drip (0.6 mL/kg dissolved in 250 mL of 10% glucose) in the intravenous drip group, and equal volume of NS was given intravenously in the NS group; 15 in each group. Arterial blood gases were analyzed, serum levels of malonaldehyde (MDA) and interleukine-6 (IL-6) and interleukine-8 (IL-8) were determined using the method of thiobarbituric acid reaction and enzyme-linked immuno sorbent assay respectively just before tourniquet inflation (TO), and at 0.5 h (T1), 2 h (TZ), 6 h (T3) after tourniquet deflation. Results: Compared with baselines at TO, MDA levels significantly increased at TZ, T3 in the NS group and at T3 in the nebulization group, and IL-6 and IL-8 levels were significantly increased at TZ, T3 in NS, the intravenous drip and the nebulization groups (P〈0.05). Arterial pressure of oxygen (PaO2) at T3 was decreased, while alveolar- arterial oxygen tension showed difference (PA-aDO2) at T3 in the NS group; RI at T3 in both intravenous drip and the nebulization groups were enhanced (P〈0.05). Compared with the NS group, MDA and IL-8 levels at TZ, T3, 11-6 at T3 in the intravenous drip group, and IL-8 at T3 in the nebulization group were all remarkably increased (P〈0.05). Additionally, MDA level at T3 in the nebulization group was higher than that in the intravenous drip group (P〈0.05). Conclusions: Intravenous administration of Shenmai Injection provided a better protective effect than nebulization in mitigating pulmonary gas exchange dysfunction in patients following tourniquet-induced limb ischemia-repertusion.展开更多
基金Supported by the Administration of Traditional Chinese Medicine Scientific Research of Zhejiang Province(No.2010ZA087)
文摘Objective: To compare the effect between nebulized and intravenous administration of Shenmai Injection (参麦注射液) on pulmonary gas exchange function of patients following tourniquet-induced lower limb ischemia-repeffusion. Methods: Thirty-eight patients scheduled for lower extremity surgery were randomized into three groups using the closed envelop method: Shenmai Injection was administered 30 min before tourniquet inflation by nebulization [0.6 mL/kg in 10 mL normal saline (NS)] in the nebulization group or by intravenous drip (0.6 mL/kg dissolved in 250 mL of 10% glucose) in the intravenous drip group, and equal volume of NS was given intravenously in the NS group; 15 in each group. Arterial blood gases were analyzed, serum levels of malonaldehyde (MDA) and interleukine-6 (IL-6) and interleukine-8 (IL-8) were determined using the method of thiobarbituric acid reaction and enzyme-linked immuno sorbent assay respectively just before tourniquet inflation (TO), and at 0.5 h (T1), 2 h (TZ), 6 h (T3) after tourniquet deflation. Results: Compared with baselines at TO, MDA levels significantly increased at TZ, T3 in the NS group and at T3 in the nebulization group, and IL-6 and IL-8 levels were significantly increased at TZ, T3 in NS, the intravenous drip and the nebulization groups (P〈0.05). Arterial pressure of oxygen (PaO2) at T3 was decreased, while alveolar- arterial oxygen tension showed difference (PA-aDO2) at T3 in the NS group; RI at T3 in both intravenous drip and the nebulization groups were enhanced (P〈0.05). Compared with the NS group, MDA and IL-8 levels at TZ, T3, 11-6 at T3 in the intravenous drip group, and IL-8 at T3 in the nebulization group were all remarkably increased (P〈0.05). Additionally, MDA level at T3 in the nebulization group was higher than that in the intravenous drip group (P〈0.05). Conclusions: Intravenous administration of Shenmai Injection provided a better protective effect than nebulization in mitigating pulmonary gas exchange dysfunction in patients following tourniquet-induced limb ischemia-repertusion.