Simple immune agar diffusion test was used to assay the contents of 12 plasma proteins in 70 cases of chronic pulmonary heart disease treated by Huang Qi Wu Wu Decoction (黄芪五物汤), with the other 70 cases who w... Simple immune agar diffusion test was used to assay the contents of 12 plasma proteins in 70 cases of chronic pulmonary heart disease treated by Huang Qi Wu Wu Decoction (黄芪五物汤), with the other 70 cases who were not given Huang Qi Wu Wu Decoction as the control group. The total clinical effective rate in the treatment group was 90.0%, while that in the control group was 75.7%, with a statistically significant difference between the two groups (P<0.05). In the treatment group, the levels of prealbumin, transferrin and fibronectin elevated obviously after treatment, and the contents of C-reactive protein, ceruloplasmin, haptoglobin, a 1-antitrypsin and a 1-acid glycoprotein decreased markedly (P<0.01). In the control group, only the levels of ceruloplasmin and C-reactive protein decreased significantly (P<0.05). It is shown that Huang Qi Wu Wu Decoction may enhance the therapeutic effects for pulmonary heart disease, regulate the metabolism of plasma proteins, and improve the life quality of the patients.展开更多
Background:Pulmonary artery hypertension associated withh congenital heart disease(PAH-CHD)occurs predominantly among patients with uncorrected CHD.Treatment of severe pediatric PAH-CHD remains a major intractability....Background:Pulmonary artery hypertension associated withh congenital heart disease(PAH-CHD)occurs predominantly among patients with uncorrected CHD.Treatment of severe pediatric PAH-CHD remains a major intractability.This study evaluated the predictors and prognoses of children with PAH-CHD who underwent surgical correction.Methods:The data for 59 children with severe PAH-CHD who underwent surgical correction,with or without postoperative medication,between May 2011 and June 2015 at the Guangdong Provincial People's Hospital were analyzed retrospectively.A regression analysis,receiver-operating characteristic(ROC)curves,and Kaplan-Meier curves were used for survival analysis.Results:Fifty-nine children with severe PAH-CHD underwent heart catheterization and correction,with or without specific anti-PAH drugs postoperatively,were included in this study.The pulmonary pressure,heart function,and ending events were observed and median observation period was 49±20 months.Twenty-eight patients(50%)received at least one additional anti-PAH drug after correction.The survival rate after 2 years was 91.5%(54/59);two patients were in a critical condition,and three were lost to follow-up.Twelve patients(29%)still received over one additional PAH-specific therapy at follow-up,whereas 42(75%)had successfully stopped drug treatment.Two patients(3.5%)died and one underwent a second thoracotomy to remove the ventricular septal defect patch.Acute vasoreactivity test(AVT)criteria had limited efficacy in predicting pediatric PAH-CHD,whereas pulmonary vascular resistance(PVR)<6.65 Wood units(WU)/m^2 or PVR/systemic vascular resistance(SVR)<0.39 during AVT indicated a good prognosis after surgical correction with an AUC of 98.3%(95%confidence interval[CI]:96.0-100%),98.4%(95%CI:96.0-100%)sensitivity of 100%,100%and specificity of 82.1%,92.9%,respectively.Conclusions:Although the criteria for positive AVT currently used are unsuitable for pediatric patients with PAH-CHD,PVR and PVR/SVR during AVT are excellent predictors of outcome in pediatric PAH-CHD.Surgery aided by anti-PAH drugs is an effective strategy and should be recommended for severe pediatric PAH-CHD with PVR<6.65 WU/m2 and PVR/SVR<0.39 after iloprost aerosol inhalation.展开更多
Objective： To observe the clinical effect of acupuncture on chronic obstructive pulmonary disease （COPD）, and the improvements of patients＇ pulmonary ventilation function and 6-minute walk test （6-MWT） distance....Objective： To observe the clinical effect of acupuncture on chronic obstructive pulmonary disease （COPD）, and the improvements of patients＇ pulmonary ventilation function and 6-minute walk test （6-MWT） distance. Methods： A total of 80 COPD patients [grade 3-4 in Global Initiative for Chronic Obstructive Lung Disease （GOLD）, qi deficiency of the lung and kidney in traditional Chinese medicine （TCM） pattern] were randomly allocated into a treatment group （n=40） and a control group （n=40）. Salmeterol Xinafoate and Fluticasone Propionate powder （Seretide, 50 μg/250 μg） for inhalation was used for basic treatment in both groups （once in the morning and once in the evening）. Patients in the treatment group received acupuncture at Feishu （BL 13）, Shenshu （BL 23）, O.ihai （CV 6）, Guanyuan （CV 4）, Dingchuan （EX-B 1）, Danzhong （CV 17） and Zusanli （ST 36] twice a week for 3 months. After 3 months of treatment, clinical effects, lung ventilation functions and 6-MWT distance were observed and compared in the two groups. Results： After 3 months of treatment, the total effective rate was 95.0% in the treatment group, versus 80.0% in the control group, showing a statistical difference （P〈O.05）; the phlegm expectoration, dyspnea and shortness of breath were more significantly improved in the treatment group than those in the control group （P〈0.01, P〈0.05）; and the 6-MWT distance and forced expiratory volume in 1 second percentage of predicted value （FEV1%） were more significantly improved in the treatment group than those in the control group （P〈0.05, P〈0.01）. Conclusion： Seretide inhaler combined with acupuncture can improve signs and symptoms in COPD patients, increase the 6-MWT distance, imorove FEV1% and obtain better results than Seretide alone.展开更多
文摘 Simple immune agar diffusion test was used to assay the contents of 12 plasma proteins in 70 cases of chronic pulmonary heart disease treated by Huang Qi Wu Wu Decoction (黄芪五物汤), with the other 70 cases who were not given Huang Qi Wu Wu Decoction as the control group. The total clinical effective rate in the treatment group was 90.0%, while that in the control group was 75.7%, with a statistically significant difference between the two groups (P<0.05). In the treatment group, the levels of prealbumin, transferrin and fibronectin elevated obviously after treatment, and the contents of C-reactive protein, ceruloplasmin, haptoglobin, a 1-antitrypsin and a 1-acid glycoprotein decreased markedly (P<0.01). In the control group, only the levels of ceruloplasmin and C-reactive protein decreased significantly (P<0.05). It is shown that Huang Qi Wu Wu Decoction may enhance the therapeutic effects for pulmonary heart disease, regulate the metabolism of plasma proteins, and improve the life quality of the patients.
文摘Background:Pulmonary artery hypertension associated withh congenital heart disease(PAH-CHD)occurs predominantly among patients with uncorrected CHD.Treatment of severe pediatric PAH-CHD remains a major intractability.This study evaluated the predictors and prognoses of children with PAH-CHD who underwent surgical correction.Methods:The data for 59 children with severe PAH-CHD who underwent surgical correction,with or without postoperative medication,between May 2011 and June 2015 at the Guangdong Provincial People's Hospital were analyzed retrospectively.A regression analysis,receiver-operating characteristic(ROC)curves,and Kaplan-Meier curves were used for survival analysis.Results:Fifty-nine children with severe PAH-CHD underwent heart catheterization and correction,with or without specific anti-PAH drugs postoperatively,were included in this study.The pulmonary pressure,heart function,and ending events were observed and median observation period was 49±20 months.Twenty-eight patients(50%)received at least one additional anti-PAH drug after correction.The survival rate after 2 years was 91.5%(54/59);two patients were in a critical condition,and three were lost to follow-up.Twelve patients(29%)still received over one additional PAH-specific therapy at follow-up,whereas 42(75%)had successfully stopped drug treatment.Two patients(3.5%)died and one underwent a second thoracotomy to remove the ventricular septal defect patch.Acute vasoreactivity test(AVT)criteria had limited efficacy in predicting pediatric PAH-CHD,whereas pulmonary vascular resistance(PVR)<6.65 Wood units(WU)/m^2 or PVR/systemic vascular resistance(SVR)<0.39 during AVT indicated a good prognosis after surgical correction with an AUC of 98.3%(95%confidence interval[CI]:96.0-100%),98.4%(95%CI:96.0-100%)sensitivity of 100%,100%and specificity of 82.1%,92.9%,respectively.Conclusions:Although the criteria for positive AVT currently used are unsuitable for pediatric patients with PAH-CHD,PVR and PVR/SVR during AVT are excellent predictors of outcome in pediatric PAH-CHD.Surgery aided by anti-PAH drugs is an effective strategy and should be recommended for severe pediatric PAH-CHD with PVR<6.65 WU/m2 and PVR/SVR<0.39 after iloprost aerosol inhalation.
基金supported by Shanghai Key Laboratory for Clinical Chinese Medicine~~
文摘Objective： To observe the clinical effect of acupuncture on chronic obstructive pulmonary disease （COPD）, and the improvements of patients＇ pulmonary ventilation function and 6-minute walk test （6-MWT） distance. Methods： A total of 80 COPD patients [grade 3-4 in Global Initiative for Chronic Obstructive Lung Disease （GOLD）, qi deficiency of the lung and kidney in traditional Chinese medicine （TCM） pattern] were randomly allocated into a treatment group （n=40） and a control group （n=40）. Salmeterol Xinafoate and Fluticasone Propionate powder （Seretide, 50 μg/250 μg） for inhalation was used for basic treatment in both groups （once in the morning and once in the evening）. Patients in the treatment group received acupuncture at Feishu （BL 13）, Shenshu （BL 23）, O.ihai （CV 6）, Guanyuan （CV 4）, Dingchuan （EX-B 1）, Danzhong （CV 17） and Zusanli （ST 36] twice a week for 3 months. After 3 months of treatment, clinical effects, lung ventilation functions and 6-MWT distance were observed and compared in the two groups. Results： After 3 months of treatment, the total effective rate was 95.0% in the treatment group, versus 80.0% in the control group, showing a statistical difference （P〈O.05）; the phlegm expectoration, dyspnea and shortness of breath were more significantly improved in the treatment group than those in the control group （P〈0.01, P〈0.05）; and the 6-MWT distance and forced expiratory volume in 1 second percentage of predicted value （FEV1%） were more significantly improved in the treatment group than those in the control group （P〈0.05, P〈0.01）. Conclusion： Seretide inhaler combined with acupuncture can improve signs and symptoms in COPD patients, increase the 6-MWT distance, imorove FEV1% and obtain better results than Seretide alone.
