Pulsed Modulation in Electro-Hyperthermia

Modulated electro-hyperthermia (mEHT) is one of the novel oncological treatments with many preclinical and clinical results showing its advantages. The basis of the method is the synergy of thermal and nonthermal effects, similar to the thermal action of conventional hyperthermia combined with ionizing radiation (radiotherapy). The electric field and the radiofrequency current produced both the thermal and nonthermal processes. The thermal effects produce the elevated temperature as a thermal background to optimize the nonthermal impacts. The low frequency amplitude modulation ensures accurate targeting and promotes immunogenic cell death to develop the tumor specific memory T cells disrupting the malignant cells by immune surveillance. This process (abscopal effect) works like a vaccination. The low frequency amplitude modulation is combined in the new method with the high power pulses for short time, increasing the tumor distortion ability of the electric field. The new modulation combination has much deeper penetration triplicating the active thickness of the effective treatment. The short pulse absorption increases the safety and decreases the thermal toxicity of the treatment, making the treatment safer. The increased power allows for reduced treatment time with the prescribed dose.

Research of a fractional-turn ratio saturable pulse transformer and its application in a microsecond-range pulse modulator

As a combination device for a step-up pulse transformer and a magnetic switch,the saturable pulse transformer is widely used in pulsed-power and plasma technology.A fractional-turn ratio saturable pulse transformer is constructed and analyzed in this paper.Preliminary experimental results show that if the primary energy storage capacitors are charged to 300 V,an output voltage of about 19 kV can be obtained across the capacitor connected to the secondary windings of a fractional-tum ratio saturable pulse transformer.Theoretical and experimental results reveal that this kind of pulse transformer is not only able to integrate a step-up transformer and a magnetic switch into one device,but can also lower the saturable inductance of its secondary windings,thus leading to the relatively high step-up ratio of the pulse transformer.Meanwhile,the application of the fractional-turn ratio saturable pulse transformer in a μs range pulse modulator as a voltage step-up device and main switch is also included in this paper.The demonstrated experiments display that an output voltage with an amplitude of about 29 kV,and a 1.6 μs pulse width can be obtained across a 3500 Ω resistive load,based on a pulse modulator,if the primary energy storage capacitors are charged to 300 V.This compact fractional-turn ratio saturable pulse transformer can be applied in many other fields such as surface treatment,corona plasma generation and dielectric barrier discharge.

NUMERICAL SIMULATION OF THE TEMPERATURE FIELD IN A SOLDER BALL UNDER PULSED LASER AND ITS EFFECT ON THE VIBRATION OF THE SOLDER

The research presented here is focused on the vibration condition of a small volume solder solder ball,which is placed on the surface of a soldering pad and is exerted a pulse modulated continuous wave laser heat source. Finite element method is applied to analyzed the temperature field in the solder ball, and experi- ment is conducted to test the vibration. the results show that,that, the temperature field flucturates with the same frequency as that of the laser pulse, which in turn causes a forced vibration of the same frequency in the liquid solder ball.

Numerical simulation of atmospheric pulsemodulated radio-frequency glow discharge ignition characteristics assisted by a pulsed discharge

A one-dimensional self-consistent fluid numerical model was developed to study the ignition characteristics of a pulsc-tmxlulated(PM)radio-frequency(RF)glow discharge in atmospheric helium assisted by a sub-microsecond voltage excited pulsed discharge.The temporal evolution of discharge current density and electron density during PM RF discharge burst was investigated to demonstrate the discharge ignition characteristics with or without the pulsed discharge.Under the assistance of pulsed discharge,the electron density in RF discharge burst reaches the magnitude of 1.87 x 1017-3m within 10 RF cycles,accompanied by the formation of sheath structure.It proposes that the pulsed discharge plays an important role in the ignition of PM RF discharge burst.Furthermore,the dynamics of PM RF glow discharge arc demonstrated by the spatiotcmporal evolution of the election density with and without pulsed discharge.The spatial profiles of electron density,electron energy and electric field at specific time instants arc given to explain the assistive role of the pulsed discharge on PM RF discharge ignition.

The Design of TZ-2 High Voltage Pulse Modulator

There are a few assistant heating objects included electron cyclotron resonate heating （ ECRH ）. Two 500 kW gyrotrons introduced from Russia were operated to launch 1 MW energy. So two set of TZ-2 high voltage pulse modulators are needed.

Three-stage Transformation of Chlorophyll Transient Fluorescence Pattern Under Sustained Dehydration and the Discovery of Critical Water Content in Seaweeds

The chlorophyll fluorescence kinetics of marine red alga Grateloupia turutunt Yamada, green alga Ulva pertusa Kjellm and brown alga Laminaria japonica Aresch during natural sustained dehydration were monitored and investigated. The pulse amplified modulation (PAM) system was used to analyze the distinct fluorescence parameters during thallus dehydration. Results proved that the fluorescence kinetics of different seaweed all showed three patterns of transformation with sustained water loss. These were: 1) peak kinetic pattern (at the early stage of dehydration fluorescence enhanced and quenched subsequently, representing a normal physiological state). 2) plateau kinetic pattern (with sustained water loss fluorescence enhanced continuously but quenching became slower, finally reaching its maximum). 3) Platform kinetic pattern (fluorescence fell and the shape of kinetic curve was similar to plateau kinetic pattern). A critical water content (CWC) could be found and defined as the percentage of water content just prior to the fluorescence drop and to be a significant physiological index for evaluation of plant drought tolerance. Once thallus water content became lower than this value the normal peak pattern can not be recovered even through rehydration, indicating an irreversible damage to the thylakoid membrane. The CWC value corresponding to different marine species were varied and negatively correlated with their desiccation tolerance, for example. Laminaria japonica had the highest CWC value (around 90%) and the lowest dehydration tolerance of the three. In addition, a fluorescence 'burst' was found only in red algae during rehydration. The different fluorescence parameters F-o, F-v and F-v, F-m were measured and compared during water loss. Both F-o and F-v increased in the first stage of dehydration but F-v/F-m. kept almost constant. So the immediate response of in vivo chlorophyll fluorescence to dehydration was an enhancement. Later with sustained dehydration F-o increased continuously while F-v decreased and tended to become smaller and smaller. The major changes in fluorescence (including fluorescence drop during dehydration and the burst during rehydration) were all attributed to the change in F-o instead of F-v This significance of F-o indicates that it is necessary to do more research on F-o as well as on its relationship with the state of thylakoid membrane.

A Kind of PWM Pneumatic Servo Control System——Modulation Methods and Dynamic Responses

Vibrations or dither's are features of the PWM servo control system in their steady outputs. On the grounds of analyses and experiments of a PWM pneumatic servo control system, the paper puts forward four varieties of PWM modulation methods, and concludes on the relationship between dithers and the different methods, and then discusses the influence of friction to the dithers. Results from experiments regarding the dynamic and static responses on the given system support the theories presented.

Property Analyses and Experiment Studies of a Kind of PWM System

The properties and the design of PWM systems are discussed. The relations among the orifice areas of the valves, initial times and the rate of piston areas are deduced. Also a PWM system is designed and some experiments are done. The experiment results agree with those of theory analyses. It can be shown that the relations are correct and the conclusion of theory analyses is reasonable.

ZERO-CURRENT AND ZERO-VOLTAGE SWITCHING PWM BOOST FULL-BRIDGE CON VERTER

This paper proposes a zer o current and zero voltage switching (ZCZVS) PWM Boost full bridge (FB) conve rter. With series inductors, the leading switches can realize zero current swit ching (ZCS) in a wide load range using the energy of the output capacitor. Ma king use of parasitic capacitors of the lagging switches and parallel auxiliary i nductance with the primary winding of the transformer, the lagging switches can realize zero voltage switching (ZVS) under any load. Compared with the ZCS PWM Boost FB converter, the new converter has no current duty cycle loss. Operat ional principle and parameter design are analyzed. Experimental results verify the effectiveness of the proposed converter.

A NOVEL AERONAUTICAL STATIC INVERTER WITH HIGH FREQUENCY PULSE DC LINK

A new combined soft switching technique and a novel topology of aeronautical static inverter with high frequency pulse dc link are proposed in this paper, namely an electrical isolated converter can realize soft switching of two stage cascade converters. It lays technical foundation for high power density, high efficiency and low cost aeronautical static inverter. The operation and design approach of this topology are carefully analyzed and studied. The validity of this topology is verified by simulation and test.

An Optoelectronic Pulse Frequency Modulation Circuit for Retinal Prosthesis

A pulse frequency modulation（PFM） circuit for retinal prosthesis,which generates electrical pulses with frequency proportional to the intensity of incident light, is presented. The fundamental characteristic of the circuit is described and analyzed. The circuit is realized in 0.6μm CMOS process,and the simulation results testify to the possibility of sub-retinal implantation.

A generic PWM strategy for multi-leg VSI-fed machine drives

A generic pulse width modulation（PWM） strategy is proposed for the multi-leg voltage source inverter（VSI）.First, the multi-leg VSI is modeled, which is independent from the load structure. Secondly, the proposed PWM strategy is deduced by inverting the mathematical model of the multileg VSI. According to the relationship between the leg number of VSIs and the phase number of electrical machines, the multi-leg VSI-fed machine drives are classified into two types：matched and unmatched applications. The leg numbers of VSIs and the phase number of electrical machines are equal in matched applications while they are different in unmatched applications. The existing PWM strategies cannot be directly used for both matched and unmatched applications. However,the proposed PWM strategy can be general for both matched and unmatched applications, and no modifications are required. The effectiveness of the proposed PWM strategy is verified by experimental results.

IMPROVEMENT IN WAVEFORM OF SWITCHING POINT-PRESET SPWM INVERTERS

Total harmonic distortion (THD) is one of the key technical indexes of inverter output voltage. Optimization o f switching points and filter parameters could ensure the switching-point-preset sinusoidal pulse width modulation (SPWM) inverters with low harmonyic content in theory.The THD value would be increased by switching time delay of power devices and control circuit. A new control coecuit with delay time compensation is presented in this paper. With this control scheme, the output of the inverter could be basically identified with the theory given.Test results of experimental circuit verify that the control circuit presented in this paper is feasible. The THD of the inverter output voltage could be reduced to a certain extent by this method.

On the Describing Functions of PWM Pneumatic High-Speed On-Off Valves

High-speed on-off valves are widey used in PWM electropneumatic servo sys- tems and their characteristics are generally described by their on and off delay time. This paper focuses on establishing the relationships between their on-off switching behaviors and their frequency response characteristics. A method is proposed by which the frequency response characteristics of an analog PWM high-speed on-off valve can be calculated for inputs whose periods are certain multiples of the carrier period, based on its switching be- haviors. Thus, a simple and direct describing function for a PWM high-speed on-off valve is established.

ANALYSIS OF A NEW SOFT SWITCHING PWM INVERTER

Resonant dc link inverter is a zero voltage switching inverter.This paper proposes a new cascade resonant dc link inverter that consists of two power converter units,a rugged resonant dc link and an inverter bridge.A detailed analysis of the soft switching process in the rugged resonant dc link and the realization of pulse width modulation (PWM) control strategy in the inverter bridge are presented in the paper. The operation modes, the input and output features and the interface between the rugged resonant dc link and the inverter bridge are also discussed. The relationship between the circuit features and the parameters is deduced, which provides a theoretical base for the circuit design. The analysis results show that the rugged resonant dc link can be regulated by open-loop control and the control of the rugged resonant dc link is independent of that of the inverter bridge, which makes the inverter control easy and realizable.The circuit of the inverter is simulated with a standard circuit simulation program PSPICE. The simulation results are corresponding to the predicted ones of the circuit analysis.

A Study on the Static Characteristics of Typical Composite High Speed On-Off Valves

Natural properties of high speed on-off valves can be described through their on-off behavior and spool movement (static and oscillating) characteristics. High speed on-off valves can be combined with actuators in systems into four typical types of composite valves whose static characteristics are related not only to the structures of the single valves and the composite ones, but also to the PWM control modes. It is proved that the composite valves have similar features as those of servo valves. The nonlinear specific properties of single valves composited can be completely compensated by the suitable PWM control modes.

小型全电艇动力总成系统

为了提高小型船艇的操作性能和环保性能,采用数字舵机和直流无刷电机设计一种小型吊舱式推进器,并在此基础上以锂电池组作为动力能源,结合DSP(digital signal processing)技术,开发相应的推进控制系统。样船测试结果表明:该小型全电艇动力总成系统能够满足船速、转向、续航能力等方面的性能要求,运行稳定。

Regenerative Braking Strategy for Motor Hoist by Ultracapacitor

Rising concern in environmental issues on global scale has made energy saving in powered equipment a very important subject.In order to improve the energy efficiency and driving range of a motor hoist,a regenerative braking system is designed and discussed.The system takes a unique ultracapacitor-only approach to energy storage system.The bi-directional bride DC？DC converter which regulates current flow to and from the ultracapacitor operates in two modes：boost and buck,depending on the direction of the flow.In order to provide constant input and output current at the ultracapacitor,this system uses a double proportional-integral（PI） control strategy in regulating the duty cycle of PWM to the DC？DC converter.The permanent magnet synchronous motor（PWSM） drive system is also studied.The space vector pulse width modulation（SVPWM） technique,along with a two-closed-loop vector control model,is adopted after detailed analysis of PMSM characteristics.The overall model and control strategy for this regenerative braking system is ultimately built and simulated under the MATLAB and Simulink environment.A test platform is built to obtain experimental results.Analysis of the results reveals that more than half of the gravitational potential energy can be recovered by this system.Simulation and experimentation results testify the validity of the double PI control strategy for interface circuit of ultracapacitor and SVPWM strategy for PMSM.

Temperature and light tolerance of representative brown,green and red algae in tumble culture revealed by chlorophyll fluorescence measurements

Laminaria japonica, Undaria pinnatifida, Ulva lactuca, Grateloupia turuturu and Palmaria palmata are suitable species that fit the requirements of a seaweed-animal integrated aquaculture system in terms of their viable biomass, rapid growth and promising nutrient uptake rates. In this investigation, the responses of the optimal chlorophyll fluorescence yield of the five algal species in tumble culture were assessed at a temperature range of 10 - 30℃. The results revealed that Ulva lactuca was the most resistant species to high temperature, withstanding 30℃ for 4 h without apparent decline in the optimal chlorophyll fluorescence yield . While the arctic alga Palmaria palmata was the most vulnerable one, showing significant decline in the optimal chlorophyll fluorescence yield at 25℃ for 2 h. The cold-water species Laminaria japonica, however, demonstrated strong ability to cope with higher temperature （24 -26℃ ） for shorter time （within 24 h） without significant decline in the optimal chlorophyll fluorescence yield . Grateloupia turuturu showed a general decrease in the optimal chlorophyll fluorescence yield with the rising temperature from 23 to 30℃ , similar to the temperate kelp Undaria pinnatifida. Changes of chlorophyll fluorescence yields of these algae were characterized differently indicating the existence of species-unique strategy to cope with high light. Measurements of the optimal chlorophyll fluorescence yield after short exposure to direct solar irradiance revealed how long these exposures could be without significant photoinhibition or with promising recovery in photosynthetic activities. Seasonal pattern of alternation of algal species in tank culture in the Northern Hemisphere at the latitude of 36°N was proposed according to these basic measurements.

FPGA-based high resolution DPWM control circuit

Two improved structures of high resolution digital pulse width modulator(DPWM) control circuit are proposed. Embedded digital clock manager(DCM) blocks and digital programmable delay circuits are employed as the basic resources to construct the field-programmable gate array(FPGA)-based DPWM implementations. Detailed schemes are illustrated and the circuits have been successfully implemented on the Artix-7 FPGA device developed by Xilinx. Experimental results show that when the basic clock operates at the frequency of 200 MHz, the resolutions of the two approaches can reach 625 ps and 500 ps, respectively. Besides,the presented schemes possess other merits including flexible resolution, strong versatility and relatively good stability.