The recursion relation of preventive maintenance (PM) cycle is built up concerning the concept of effective age and age setback factor proposed in this paper, which illustrates the dynamic relationship between failure...The recursion relation of preventive maintenance (PM) cycle is built up concerning the concept of effective age and age setback factor proposed in this paper, which illustrates the dynamic relationship between failure rate and preventive maintenance activity. And the nonlinear optimal PM policy model satisfying the reliability constraints in finite time horizon following Weibull distribution is proposed. The model built in this paper avoids the shortcoming of steady analytical PM model in infinite time horizon and can be used to aid scheduling the maintenance plan and providing decision supporting for job shop scheduling.展开更多
Due to the effective control of the local COVID-19 pandemic,and the previous related production capacity has been greatly improved,China has become the largest producer and exporter of anti-pandemic products such as m...Due to the effective control of the local COVID-19 pandemic,and the previous related production capacity has been greatly improved,China has become the largest producer and exporter of anti-pandemic products such as masks and protective clothing,helping many countries in the world to fight against pandemics.Except for China,reporters from the Global Times have reported that there are not many countries or regions that continue to export medical supplies.展开更多
As the most populous country in the world,China has made strides in health promotion in the past few decades.With the aging population,the burden of cancer in China continues to grow.Changes in risk factors for cancer...As the most populous country in the world,China has made strides in health promotion in the past few decades.With the aging population,the burden of cancer in China continues to grow.Changes in risk factors for cancer,especially diet,obesity,diabetes,and air pollution,continue to fuel the shift of cancer transition in China.The burden of upper gastrointestinal cancer in China is decreasing,but still heavy.The rising burden of colorectal,prostate,and breast cancers is also significant.Lung cancer became the top cause of cancer-related deaths,together with smoking as the most important contributor to cancer deaths.The Chinese government has taken several approaches to control cancer and cancer-related risk factors.Many achievements have been made,but some challenges remain.Health China 2030 is ambitious and depicts a bright vision of the future for cancer control in China.The decrease in the cancer burden in China will require cross-sector collaboration and coordinated efforts on primary and secondary preventions by governments,public health organizations,and individuals.In this review,we describe the trends of cancer burden and discuss cancer-related risk factors in China,identifying strategies to reduce the burden of cancer in China.展开更多
Over the past decade, seismically induced damage to bridges has been widely reported following major earthquakes such as the 1994 Northridge, 1995 Kobe and 1999 Chi-Chi events. Since these earthquakes, restrainers and...Over the past decade, seismically induced damage to bridges has been widely reported following major earthquakes such as the 1994 Northridge, 1995 Kobe and 1999 Chi-Chi events. Since these earthquakes, restrainers and stoppers have been installed on bridges to prevent unseating and excessive displacements, respectively. Alternatively, column jacketing has also been proven to be effective. However, the enhanced shear strength may result in extra retrofitting works on the footing. For bridges damaged in the Chi-Chi earthquake, investigations revealed that most bridge columns experienced none-to-minor damage in the longitudinal direction. The reason for this unexpected performance was the construction practice of using a rubber bearing, which is an unbolted design that may slide under large lateral forces. In this paper, parametric studies on simply-supported bridges retrofitted by a restrainer or concrete shear key along the longitudinal and transverse axes were carried out. The research focuses on finding suitable combinations of the design force and gap spacing so the restrainer and concrete shear key can be used as an unseating prevention device, with respect to the allowable column damage in terms of displacement ductility under near-fault type earthquakes. A two-lane PCI-girder bridge was selected as the benchmark model. In the longitudinal direction, a total of nine combinations considering yielding strength and gap spacing for the restrainer were analyzed; while parameters for the concrete shear key were divided into three shear force levels and three gap spacings. In the transverse direction, a similar approach was adapted, except smaller gap spacing was used. For each of the above mentioned earthquakes, seven input ground motions were selected and their PGAs were adjusted to 0.36g and 0.45g as the Design earthquake and Maximum Considerable Earthquake, respectively. Based on the results of nonlinear time history analyses, proper parameters to design the restrainers and concrete shear keys are obtained. Responses obtained from numerical simulations under the Chi-Chi earthquake leaded to new implications to design those devices. Restrainer should not exceed its breaking strain and sufficient unseating length will be needed always. Concrete Shear key was determined by considering both displacement demand of the superstructure and displacement ductility of the column at the same time. Further study is needed to provide optimal design parameters for use in performance based bridge design.展开更多
Background: Although evidence on the health effects of sedentary behavior(SB) has grown systematically in recent years, few developing countries have reported population levels of SB, especially in South America. Our ...Background: Although evidence on the health effects of sedentary behavior(SB) has grown systematically in recent years, few developing countries have reported population levels of SB, especially in South America. Our objective was to describe time spent sitting in a representative sample from Chile categorized by age, gender, educational level, and body mass index(BMI).Methods: A national health survey was conducted in Chile in a nationally representative sample(n = 5411) in 2009-2010. Sitting time(ST) was measured with the Global Physical Activity Questionnaire Version 2.Results: Data were from 5031 participants(43.26±0.41 years, mean±SE; 40.3% male). Overall, there were no gender differences in mean ST(men: 158.10±5.80 min/day, women 143.45±4.77 min/day; p = 0.05). ST was lower in those who lived in rural areas compared with urban areas(99.4 min/day vs. 160.0 min/day; p = 0.001). ST increased significantly with increasing BMI, but only in men(p = 0.009), and was positively related to years of education in both men and women(p < 0.0001).Conclusion: The findings were different from those reported in other countries and contexts, reinforcing the need for international surveillance and monitoring over time to inform policy makers. Differences in ST across different groups emphasize the need to develop tailored messages and interventions for reducing ST in different population subgroups.展开更多
Effective landscape-scale fuel management strategies are essential for reducing wildfire risk in Mediterranean fire-prone areas.In this study,the minimum travel time(MTT)fire-spread algorithm as implemented in FlamMap...Effective landscape-scale fuel management strategies are essential for reducing wildfire risk in Mediterranean fire-prone areas.In this study,the minimum travel time(MTT)fire-spread algorithm as implemented in FlamMap was applied to assess the potential of alternative fuel treatments for lowering wildfire losses in a 5,740-ha study area in eastern Sardinia,Italy.Twenty-seven wildfires at 10-m resolution were simulated considering three wind speeds(15,18,and 21 km h-1)to compare fuel treatments:no treatment(NT),irrigated agroforestry areas with shrub clearing(T1),prescribed fire in eucalyptus stands(T2),and irrigated grasslands(T3).The simulations replicated a recent large wildfire that occurred in the study area(Orrìwildfire,2019)and considered the weather and fuel moisture conditions associated with this event.The average wildfire exposure outputs(burned area,probability of burning,conditional flame length,potential crown fire occurrence,and surfaces withflame lengths above 2.5 m)decreased after fuel treatments,compared to no treatment.T1 was the most effective strategy in mitigating wildfire hazards and provided the most significant performance for several wildfire exposure indicators.Treating only 0.5%of the study area(~30 ha)resulted in a decrease in all wildfire exposure metrics to~10%within the study area.In addition,the total surface characterized by high flame length(average>2.5 m)was the lowest in the T1 treatment.This study can help land and fire managers optimize fuel treatment opportunities and wildfire risk mitigation strategies in Mediterranean areas.展开更多
Functional inspection is a type of preventive maintenance of Reliability Centered Maintenance ( RCM). We, in this paper, establish a functional inspection model( FIM) the cost model and the availability model for ...Functional inspection is a type of preventive maintenance of Reliability Centered Maintenance ( RCM). We, in this paper, establish a functional inspection model( FIM) the cost model and the availability model for the immeasurable potential failure state based on the delay time concept. This model can be used to determine the appropriate Functional Inspection Interval(FII) to achieve the goal of specific cost and availability and to assist in maintenance decision making.展开更多
Periodical inspections and an age-based preventive replacement( APR) model were proposed based on a two-stage failure process for a single component system. Inspection activities were performed at regular intervals. O...Periodical inspections and an age-based preventive replacement( APR) model were proposed based on a two-stage failure process for a single component system. Inspection activities were performed at regular intervals. Once the system was identified to be at defective state by inspection,a maintenance decision needed to be made that whether to replace the defective system immediately or wait till the preset APR time. So a threshold was introduced into the model and called as inspection-based preventive replacement( IPR) threshold. If the distance from the defect identification point to the APR time was longer than the threshold, a preventive replacement( PR) action was made; otherwise PR action was to wait till the APR time. Two models were proposed and compared,and a numerical example was conducted to illustrate the applicability of the model.展开更多
Estrogen produces several beneficial effects in healthy neurological tissues and exhibits cardioprotective effects.Hormone therapy has been widely used to treat menopausal estrogen deficiency for more than 80 years.De...Estrogen produces several beneficial effects in healthy neurological tissues and exhibits cardioprotective effects.Hormone therapy has been widely used to treat menopausal estrogen deficiency for more than 80 years.Despite high initial expectations of cardioprotective effects,there has been substantial distrust following important randomized clinical trials,such as the Women’s Health Initiative.Subsequently,the timing of treatment in relation to the onset of menopause came under consideration and led to the proposal of the timing hypothesis,that early initial treatment is important,and benefits are lost as the timing since menopause becomes prolonged.Subsequent analyses of the Women’s Health Initiative data,together with more recent data from randomized and observational trials,consistently show reductions in coronary heart disease and mortality in younger menopausal women.Regarding cognitive function,the timing hypothesis is consistent with observations from basic and animal studies.There is some clinical evidence to support the benefits of hormonal therapy in this context,though skepticism remains due to the paucity of clinical trials of substantial length in younger menopausal women.It is likely that the effects of estrogens on cognitive performance are due to rapid mechanisms,including mechanisms that influence Ca2+homeostasis dynamics,provide protection in a hostile environment and reduce inflammatory signals from neural tissues.In the future,inflammatory profiles accounting for early signs of pathological inflammation might help identify the‘window of opportunity’to use estrogen therapy for successful cognitive protection.展开更多
Recent developments in technology have helped to reduce the physical size and weight of devices and opened up new opportunities for their application in delivering unobtrusive healthcare services. In particular, kinet...Recent developments in technology have helped to reduce the physical size and weight of devices and opened up new opportunities for their application in delivering unobtrusive healthcare services. In particular, kinetic and kinematic systems, that use sensors attached to the body, are currently being used to measure and understand many different aspects of human gait and behaviour. This has been particularly useful in treating stroke patients, rehabilitation, and understanding sedentary behaviour. Nonetheless, many of these systems are only capable of providing information about rudimentary movement rather than data on the mechanics of motion itself (tendons, ligaments and so on). Therefore, the information required by healthcare professionals to treat diseases like progressive deterioration of the musculoskeletal system, i.e. arthritis, cannot be determined. This paper discusses some of the technologies currently used to assess movement and posits a novel approach based on strain gauge technology to measure the constituent parts of a joint and its movement. In this way, the mechanics of motion can be studied and used to help detect and treat musculoskeletal diseases. A case study is presented to demonstrate the applicability of our approach.展开更多
基金Natural Science Foundation of China (No. 59889505)
文摘The recursion relation of preventive maintenance (PM) cycle is built up concerning the concept of effective age and age setback factor proposed in this paper, which illustrates the dynamic relationship between failure rate and preventive maintenance activity. And the nonlinear optimal PM policy model satisfying the reliability constraints in finite time horizon following Weibull distribution is proposed. The model built in this paper avoids the shortcoming of steady analytical PM model in infinite time horizon and can be used to aid scheduling the maintenance plan and providing decision supporting for job shop scheduling.
文摘Due to the effective control of the local COVID-19 pandemic,and the previous related production capacity has been greatly improved,China has become the largest producer and exporter of anti-pandemic products such as masks and protective clothing,helping many countries in the world to fight against pandemics.Except for China,reporters from the Global Times have reported that there are not many countries or regions that continue to export medical supplies.
基金supported by the National Key Research and Development Program of China(Grant No.2018YFC1313100)the National Natural Science Foundation of China(Grant No.81602931)+1 种基金the CAMS Innovation Fund for Medical Sciences(Grant No.2016-I2M-2-004)the Sanming Project of Medicine in Shenzhen(Grant No.SZSM201911015)。
文摘As the most populous country in the world,China has made strides in health promotion in the past few decades.With the aging population,the burden of cancer in China continues to grow.Changes in risk factors for cancer,especially diet,obesity,diabetes,and air pollution,continue to fuel the shift of cancer transition in China.The burden of upper gastrointestinal cancer in China is decreasing,but still heavy.The rising burden of colorectal,prostate,and breast cancers is also significant.Lung cancer became the top cause of cancer-related deaths,together with smoking as the most important contributor to cancer deaths.The Chinese government has taken several approaches to control cancer and cancer-related risk factors.Many achievements have been made,but some challenges remain.Health China 2030 is ambitious and depicts a bright vision of the future for cancer control in China.The decrease in the cancer burden in China will require cross-sector collaboration and coordinated efforts on primary and secondary preventions by governments,public health organizations,and individuals.In this review,we describe the trends of cancer burden and discuss cancer-related risk factors in China,identifying strategies to reduce the burden of cancer in China.
文摘Over the past decade, seismically induced damage to bridges has been widely reported following major earthquakes such as the 1994 Northridge, 1995 Kobe and 1999 Chi-Chi events. Since these earthquakes, restrainers and stoppers have been installed on bridges to prevent unseating and excessive displacements, respectively. Alternatively, column jacketing has also been proven to be effective. However, the enhanced shear strength may result in extra retrofitting works on the footing. For bridges damaged in the Chi-Chi earthquake, investigations revealed that most bridge columns experienced none-to-minor damage in the longitudinal direction. The reason for this unexpected performance was the construction practice of using a rubber bearing, which is an unbolted design that may slide under large lateral forces. In this paper, parametric studies on simply-supported bridges retrofitted by a restrainer or concrete shear key along the longitudinal and transverse axes were carried out. The research focuses on finding suitable combinations of the design force and gap spacing so the restrainer and concrete shear key can be used as an unseating prevention device, with respect to the allowable column damage in terms of displacement ductility under near-fault type earthquakes. A two-lane PCI-girder bridge was selected as the benchmark model. In the longitudinal direction, a total of nine combinations considering yielding strength and gap spacing for the restrainer were analyzed; while parameters for the concrete shear key were divided into three shear force levels and three gap spacings. In the transverse direction, a similar approach was adapted, except smaller gap spacing was used. For each of the above mentioned earthquakes, seven input ground motions were selected and their PGAs were adjusted to 0.36g and 0.45g as the Design earthquake and Maximum Considerable Earthquake, respectively. Based on the results of nonlinear time history analyses, proper parameters to design the restrainers and concrete shear keys are obtained. Responses obtained from numerical simulations under the Chi-Chi earthquake leaded to new implications to design those devices. Restrainer should not exceed its breaking strain and sufficient unseating length will be needed always. Concrete Shear key was determined by considering both displacement demand of the superstructure and displacement ductility of the column at the same time. Further study is needed to provide optimal design parameters for use in performance based bridge design.
基金funded by the Ministry of Health, ChileNAF was supported by the Direccion de Cooperacion Internacional (26/2016), Universidad de La FronteraPMF was supported by the Direccion de Investigacion, Universidad de La Frontera (DIUFRO16-0110)
文摘Background: Although evidence on the health effects of sedentary behavior(SB) has grown systematically in recent years, few developing countries have reported population levels of SB, especially in South America. Our objective was to describe time spent sitting in a representative sample from Chile categorized by age, gender, educational level, and body mass index(BMI).Methods: A national health survey was conducted in Chile in a nationally representative sample(n = 5411) in 2009-2010. Sitting time(ST) was measured with the Global Physical Activity Questionnaire Version 2.Results: Data were from 5031 participants(43.26±0.41 years, mean±SE; 40.3% male). Overall, there were no gender differences in mean ST(men: 158.10±5.80 min/day, women 143.45±4.77 min/day; p = 0.05). ST was lower in those who lived in rural areas compared with urban areas(99.4 min/day vs. 160.0 min/day; p = 0.001). ST increased significantly with increasing BMI, but only in men(p = 0.009), and was positively related to years of education in both men and women(p < 0.0001).Conclusion: The findings were different from those reported in other countries and contexts, reinforcing the need for international surveillance and monitoring over time to inform policy makers. Differences in ST across different groups emphasize the need to develop tailored messages and interventions for reducing ST in different population subgroups.
基金funded by"MED-Star"(Grant No.E88H19000120007)“Med-Foreste”(grant no.B85I1900010007)+5 种基金“Med-Coopfi re”(Grant No.B81I1900010007)projectssupported by the European Union under the cross-border Programma Italia-Francia Marittimo 2014–2020the“FOE2019-Climate Change:risk mitigation for sustainable development”(Ministerial Decree no.856/19)projectfunded by the Italian Ministry of EducationUniversity and Research(MIUR)co-financed by the University of Sassari,Fondo di Ateneo per la Ricerca Scientifica(FAR)2020。
文摘Effective landscape-scale fuel management strategies are essential for reducing wildfire risk in Mediterranean fire-prone areas.In this study,the minimum travel time(MTT)fire-spread algorithm as implemented in FlamMap was applied to assess the potential of alternative fuel treatments for lowering wildfire losses in a 5,740-ha study area in eastern Sardinia,Italy.Twenty-seven wildfires at 10-m resolution were simulated considering three wind speeds(15,18,and 21 km h-1)to compare fuel treatments:no treatment(NT),irrigated agroforestry areas with shrub clearing(T1),prescribed fire in eucalyptus stands(T2),and irrigated grasslands(T3).The simulations replicated a recent large wildfire that occurred in the study area(Orrìwildfire,2019)and considered the weather and fuel moisture conditions associated with this event.The average wildfire exposure outputs(burned area,probability of burning,conditional flame length,potential crown fire occurrence,and surfaces withflame lengths above 2.5 m)decreased after fuel treatments,compared to no treatment.T1 was the most effective strategy in mitigating wildfire hazards and provided the most significant performance for several wildfire exposure indicators.Treating only 0.5%of the study area(~30 ha)resulted in a decrease in all wildfire exposure metrics to~10%within the study area.In addition,the total surface characterized by high flame length(average>2.5 m)was the lowest in the T1 treatment.This study can help land and fire managers optimize fuel treatment opportunities and wildfire risk mitigation strategies in Mediterranean areas.
基金the National Equipment Advanced Research Foundation under Grant No.9140A04050707JW0507
文摘Functional inspection is a type of preventive maintenance of Reliability Centered Maintenance ( RCM). We, in this paper, establish a functional inspection model( FIM) the cost model and the availability model for the immeasurable potential failure state based on the delay time concept. This model can be used to determine the appropriate Functional Inspection Interval(FII) to achieve the goal of specific cost and availability and to assist in maintenance decision making.
基金National Natural Science Foundation of China(NSFC)(No.71231001)China Postdoctoral Science Foundation Funded Project(No.2013M530531)+1 种基金the Fundamental Research Funds for the Central Universities of China(Nos.FRF-M P-13-009A,FRF-TP-13-026A)the MOE PhD Supervisor Fund,China(No.20120006110025)
文摘Periodical inspections and an age-based preventive replacement( APR) model were proposed based on a two-stage failure process for a single component system. Inspection activities were performed at regular intervals. Once the system was identified to be at defective state by inspection,a maintenance decision needed to be made that whether to replace the defective system immediately or wait till the preset APR time. So a threshold was introduced into the model and called as inspection-based preventive replacement( IPR) threshold. If the distance from the defect identification point to the APR time was longer than the threshold, a preventive replacement( PR) action was made; otherwise PR action was to wait till the APR time. Two models were proposed and compared,and a numerical example was conducted to illustrate the applicability of the model.
文摘Estrogen produces several beneficial effects in healthy neurological tissues and exhibits cardioprotective effects.Hormone therapy has been widely used to treat menopausal estrogen deficiency for more than 80 years.Despite high initial expectations of cardioprotective effects,there has been substantial distrust following important randomized clinical trials,such as the Women’s Health Initiative.Subsequently,the timing of treatment in relation to the onset of menopause came under consideration and led to the proposal of the timing hypothesis,that early initial treatment is important,and benefits are lost as the timing since menopause becomes prolonged.Subsequent analyses of the Women’s Health Initiative data,together with more recent data from randomized and observational trials,consistently show reductions in coronary heart disease and mortality in younger menopausal women.Regarding cognitive function,the timing hypothesis is consistent with observations from basic and animal studies.There is some clinical evidence to support the benefits of hormonal therapy in this context,though skepticism remains due to the paucity of clinical trials of substantial length in younger menopausal women.It is likely that the effects of estrogens on cognitive performance are due to rapid mechanisms,including mechanisms that influence Ca2+homeostasis dynamics,provide protection in a hostile environment and reduce inflammatory signals from neural tissues.In the future,inflammatory profiles accounting for early signs of pathological inflammation might help identify the‘window of opportunity’to use estrogen therapy for successful cognitive protection.
文摘Recent developments in technology have helped to reduce the physical size and weight of devices and opened up new opportunities for their application in delivering unobtrusive healthcare services. In particular, kinetic and kinematic systems, that use sensors attached to the body, are currently being used to measure and understand many different aspects of human gait and behaviour. This has been particularly useful in treating stroke patients, rehabilitation, and understanding sedentary behaviour. Nonetheless, many of these systems are only capable of providing information about rudimentary movement rather than data on the mechanics of motion itself (tendons, ligaments and so on). Therefore, the information required by healthcare professionals to treat diseases like progressive deterioration of the musculoskeletal system, i.e. arthritis, cannot be determined. This paper discusses some of the technologies currently used to assess movement and posits a novel approach based on strain gauge technology to measure the constituent parts of a joint and its movement. In this way, the mechanics of motion can be studied and used to help detect and treat musculoskeletal diseases. A case study is presented to demonstrate the applicability of our approach.