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Alterations of organ histopathology and metallolhionein mRNA expression in silver barb,Puntius gonionotus during subchronic cadmium exposure 被引量:1
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作者 Alisa Wangsongsak Suwimol Utampongsa +3 位作者 Maleeya Kruatrachue Mathurose Ponglikitmongkol Prayad Pokethitiyook Thitinun Sumranwanich 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2007年第11期1341-1348,共8页
Common silver barb, Puntius gonionotus, exposed to the nominal concentration of 0.06 mg/L Cd for 60 d, were assessed for histopathological alterations (gills, liver and kidney), metal accumulation, and metallothione... Common silver barb, Puntius gonionotus, exposed to the nominal concentration of 0.06 mg/L Cd for 60 d, were assessed for histopathological alterations (gills, liver and kidney), metal accumulation, and metallothionein (MT) mRNA expression. Fish exhibited pathological symptoms such as hypertrophy and hyperplasia of primary and secondary gill lamellae, vacuolization in hepatocytes, and prominent tubular and glomerular damage in the kidney. In addition, kidney accumulated the highest content of cadmium, more than gills and liver. Expression of MT mRNA was increased in both liver and kidney of treated fish. Hepatic MT levels remained high after fish were removed to Cd-free water. In contrast, MT expression in kidney was peaked after 28 d of treatment and drastically dropped when fish were removed to Cd-free water. The high concentrations of Cd in hepatic tissues indicated an accumulation site or permanent damage on this tissue. 展开更多
关键词 CADMIUM puntius gonionotus HISTOPATHOLOGY metallothionein mRNA
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