Meta-analysis of Therapeutic Efficacy of Purgation and Catharsis Method for Treating Severe Pneumonia

[Objectives]To make a systematic evaluation on the therapeutic efficacy of purgation and catharsis method combined with western medicine in treatment of severe pneumonia.[Methods]The literatures were retrieved from China Knowledge Infrastructure(CNKI),Chinese science and technology journal full-text database(VIP database,VIP),Wanfang Data,the Chinese biomedical database,PubMed,Embase,and the Cochrane Library.The retrieval time was set to the period from the creation of the database to June 2020.The randomized controlled trial(RCT)was conducted on the comparison between the purgation and catharsis method combined with western medicine and the western medicine alone in the treatment of severe pneumonia.The literature information was extracted and the methodological quality of the included literature was evaluated according to the bias risk assessment tool developed by the Cochrane Collaboration.Meta-analysis was performed with the aid of RevMan 5.3 software for the patient response rate,acute physiology and chronic health evaluations II(APACHE II),clinical pulmonary infection score(CPIS),oxygenation index(OI),procalcitonin(PCT),mechanical ventilation time,etc.[Results]A total of 20 articles were included,involving a total of 1661 patients,and the literature quality was low.Meta analysis results showed that compared with the treatment by western medicine alone,the purgation and catharsis method combined with western medicine can further improve the response rate[RR=1.21,95%CI(1.14,1.27),P<0.00001],and reduce the APACHE II score[WMD=-5.92,95%CI(-7.94,-3.89),P<0.00001],reduce CPIS score[WMD=-1.41,95%CI(-1.70,-1.12),P<0.00001],increase oxygenation index[WMD=39.52,95%CI(29.39,49.65),P<0.00001],reduce PCT level[WMD=-2.85,95%CI(-3.68,-2.01),P<0.00001],shorten the mechanical ventilation time[WMD=-13.00,95%CI(-16.51,-9.48),P<0.00001].[Conclusions]Within the scope of the study included,the purgation and catharsis method combined with western medicine in the treatment of severe pneumonia can further reduce the pulmonary infection,reduce PCT levels,increase oxygenation index,and improve vital organ functions,thereby improving clinical efficacy,shortening the mechanical ventilation time(MVT),and reducing the economic burden of patients.

Zhang Congzheng,physician and initiator of the'school of purgation'

Zhang Congzheng(courtesy name:Zhang Zihe,1156-1228)was a native of Sui Zhou(In present Henan Province).Once he served the emperor as an imperial physician.He was one of the great masters of the four famous medical schools in the Jin and Yuan dynasties(1115-1368).Many medical books were written by him and his masterpiece is Confucians'Duties to Their Parents(Ru Men Shi Qin).

Comparative Study on the Effect of Mongolian Medicine Euphorbia pekinensis and Pharbitidis Semen(Black)

[Objectives]To explore the difference of purgative effect of Mongolian medicine Euphorbia pekinensis and Pharbitidis Semen(black)by animal experiment,taking Euphorbia pekinensis and Pharbitidis Semen(black)as the research object.[Methods]Sixty Kunming mice were randomly divided into blank group(n=20),Euphorbia pekinensis group(n=20)and Pharbitidis Semen(black)group(n=20).After fasted but provided with free acess to drinking water for 3 d,the mice were intragastrically administered with drinking water,Euphorbia pekinensis test solution and Pharbitidis Semen(black)test solution,respectively.The mice were then placed separately in a mouse cage covered with filter paper for purgation test and intestinal propulsion test.[Results]The time of the first purgation in the Euphorbia pekinensis group and the Pharbitidis Semen(black)group was longer than that in the blank group(P<0.05).The total times of purgation and defecation within 5 h in the Euphorbia pekinensis group and the Pharbitidis Semen(black)group were higher than those in the blank group(P<0.05);the purgation index and intestinal propulsion rate in the Euphorbia pekinensis group and the Pharbitidis Semen(black)group were higher than those in the blank group(P<0.05).[Conclusions]The Mongolian medicine Euphorbia pekinensis was similar to Pharbitidis Semen(black)in purgation test and intestinal propulsion test,and could play a substitute role.

Discussion on the Theoretical Basis of Banxia Xiexin Decoction in the Treatment of Insulin Resistance Obesity

Through reading Chinese ancient book Huangdi Nejing,and summarizing and analyzing related literature,the basic pathogenesis of obesity have been found to be the stomach preponderance and spleen weakness,and the imbalance of ascending and descending.Banxia Xiexin Decoction not only has the functions of relieving heat to inhibit stomach intake,supplementing deficiency to assist spleen transport,regulate the ascending and descending,but also has the effects of improving insulin resistance and regulating glucolipid metabolism.Therefore,it is suggested that Banxia Xiexin Decoction can be used in the treatment of insulin resistant obesity,which provides ideas and methods for its treatment.

Effect of high-pressure detonation products on fuel injection and propagation characteristics of detonation wave

The effect of high-pressure detonation products on fuel injection and propagation characteristics of detonation wave has been investigated in the form of ion voltage by varying the equivalence ratio(ER),air mass flux,and operation duration with hydrogen-air mixtures.It has been shown experimentally that the ion voltage decays gradually during the initial stage of rotating detonation wave(RDW).The attenuation of ion voltage is a general phenomenon,and the decay rate of ion voltage and its peak value of the trough state are related to the equivalence ratio and air mass flux.The analysis of interaction between the combustor and hydrogen plenum indicates that the feedback of high-pressure detonation products leads to the attenuation of ion voltage.In addition,the long-duration tests show that the ion voltage will recover to a steady state with the extension of reaction time,when the purgation(products leaving plenums)of detonation products is greater than feedback(products entering plenums)of detonation products in the hydrogen plenum.The recovery of ion voltage starts earlier at the higher equivalence ratio and air mass flux,and the peak value of ion voltage in the steady state also increases with the increase of equivalence ratio and air mass flux.A low frequency oscillation about 10 e12 Hz occurs in the RDW at some operation conditions.This low frequency oscillation is related to the interaction between the combustor and hydrogen plenum,and can be eliminated by either increasing the equivalence ratio or decreasing the air mass flux.