Massive efforts are currently being invested to improve the performance,versatility,and scope of applications of nucleic acid catalysts.G-quadruplex(G4)/hemin DNAzymes are of particular interest owing to their structu...Massive efforts are currently being invested to improve the performance,versatility,and scope of applications of nucleic acid catalysts.G-quadruplex(G4)/hemin DNAzymes are of particular interest owing to their structural programmability and chemical robustness.However,optimized catalytic efficiency is still bottleneck and the activation mechanism is unclear.Herein,we have designed a series of parallel G4s with different proximal cytosine(dC)derivatives to fine-tune the hemin-binding pocket for G4-DNAzymes.展开更多
基金support of the National Natural Science Foundation of China(nos.21977045 and 21635005)the Fundamental Research Funds for the Central Universities(no.02051430210)+5 种基金the Technology Innovation Fund Project of Nanjing University(no.020514913415)the Excellent Research Program of Nanjing University(no.ZYJH004)the funds of Nanjing University(no.020514912216)the Netherlands Organization for Scientific Research(NWO/CW)the CNRS,Agence Nationale de la Recherche(no.ANR-17-CE170010-01)Universitéde Bourgogne and Conseil Régional de Bourgogne(PARI),and the European Union(PO FEDER-FSE Bourgogne 2014/2020 programs).
文摘Massive efforts are currently being invested to improve the performance,versatility,and scope of applications of nucleic acid catalysts.G-quadruplex(G4)/hemin DNAzymes are of particular interest owing to their structural programmability and chemical robustness.However,optimized catalytic efficiency is still bottleneck and the activation mechanism is unclear.Herein,we have designed a series of parallel G4s with different proximal cytosine(dC)derivatives to fine-tune the hemin-binding pocket for G4-DNAzymes.
