Curcumin has been shown to significantly improve spatial memory impairment induced by HIV-1 gp 120 V3 in rats, but the electrophysiological mechanism remains unknown. Using extracellular microelectrode recording techn...Curcumin has been shown to significantly improve spatial memory impairment induced by HIV-1 gp 120 V3 in rats, but the electrophysiological mechanism remains unknown. Using extracellular microelectrode recording techniques, this study confirmed that the gp120 V3 loop could suppress long-term potentiation in the rat hippocampal CA1 region and synaptic plasticity, and that curcumin could antagonize these inhibitory effects. Using a Fura-2/AM calcium ion probe, we found that curcumin resisted the effects of the gp120 V3 loop on hippocampal synaptosomes and decreased Ca2＋ concentration in synaptosomes. This effect of curcumin was identical to nimodipine, suggesting that curcumin improved the inhibitory effects of gpl20 on synaptic plasticity, ameliorated damage caused to the central nervous system, and might be a potential neuroprotective drug.展开更多
The infinite set of cycloids is created. Each cycloid of this set is defined as a movement trajectory of a point when this point circulates on the convex closed contour of arbitrary form when this contour moves rectil...The infinite set of cycloids is created. Each cycloid of this set is defined as a movement trajectory of a point when this point circulates on the convex closed contour of arbitrary form when this contour moves rectilinearly without rotation on the plane with a velocity equal to the tangential velocity of a point on circulation contour. The classical cycloid is elements of this set. The differential equation of a cycloid set is derived and its solution in quadratures is received. The inverse problem when for the given cycloid it is necessary to fine the form of a circulation contour is solved. The problem of differential equation of the second order with boundary conditions about a bend of big curvature of an elastic rod of infinite length is solved in quadratures. Geometry of the loop which is formed at such bend is investigated. It is discovered that at movement of an elastic loop on a rod when the form and the size of a loop don’t change, each point of a loop moves on a trajectory which named by us the cycloid and which represents a circumference arch.展开更多
基金supported by the National Natural Science Foundation of China,No.81171134 and 81471235a grant from the Introducing Talents of Discipline to Universities,No.B14036+4 种基金a grant from the College Students’Extracurricular Scientific Innovation and Entrepreneurial Activity Research Topic of Jinan University Challenge Cup,No.(2013)27 and (2014)16a grant from the College Students’Extracurricular Scientific Innovation and Entrepreneurial Activity Research Topic of Jinan University in China,No.201410559079,1055914162 and CX14261a grant from the National Basic Research Program of China(973 Program),No.2011CB707501the Science and Technology Foundation of Guangdong Province in China,No.2010B030700016the Natural Science Foundation of Guangdong Province in China,No.2014A030313360
文摘Curcumin has been shown to significantly improve spatial memory impairment induced by HIV-1 gp 120 V3 in rats, but the electrophysiological mechanism remains unknown. Using extracellular microelectrode recording techniques, this study confirmed that the gp120 V3 loop could suppress long-term potentiation in the rat hippocampal CA1 region and synaptic plasticity, and that curcumin could antagonize these inhibitory effects. Using a Fura-2/AM calcium ion probe, we found that curcumin resisted the effects of the gp120 V3 loop on hippocampal synaptosomes and decreased Ca2＋ concentration in synaptosomes. This effect of curcumin was identical to nimodipine, suggesting that curcumin improved the inhibitory effects of gpl20 on synaptic plasticity, ameliorated damage caused to the central nervous system, and might be a potential neuroprotective drug.
文摘The infinite set of cycloids is created. Each cycloid of this set is defined as a movement trajectory of a point when this point circulates on the convex closed contour of arbitrary form when this contour moves rectilinearly without rotation on the plane with a velocity equal to the tangential velocity of a point on circulation contour. The classical cycloid is elements of this set. The differential equation of a cycloid set is derived and its solution in quadratures is received. The inverse problem when for the given cycloid it is necessary to fine the form of a circulation contour is solved. The problem of differential equation of the second order with boundary conditions about a bend of big curvature of an elastic rod of infinite length is solved in quadratures. Geometry of the loop which is formed at such bend is investigated. It is discovered that at movement of an elastic loop on a rod when the form and the size of a loop don’t change, each point of a loop moves on a trajectory which named by us the cycloid and which represents a circumference arch.
