The new method proposed is based on the formation of hydralazine-Bromophenol blue ion pair simply and without further extraction or heating. The ion pair was prepared in the presence of pH 3 citrate buffer forming a y...The new method proposed is based on the formation of hydralazine-Bromophenol blue ion pair simply and without further extraction or heating. The ion pair was prepared in the presence of pH 3 citrate buffer forming a yellow-colored chromogen. A new maximum UV-visible band formed at 416 nm. The color was stable for more than 10 hours and obeyed Beer’s Law over the concentration range of 10 - 50 µg/mL. The calculated molar absorptivity and Sandell’s sensitivity were 1.01 × 104 L∙mol−1∙cm−1 and 0.0514 µg/mL, respectively. The elements of method validation stipulated by The International Conference on Harmonization [Q2 (R1)] were applied for hydralazine hydrochloride assay in pure and pharmaceutical tablet formulation. The average recoveries of the pure solution and the pharmaceutical formulation were 98.94% and 99.50%, respectively. The results were statistically compared by F-test, which indicates that the method can be precise and repeatable for both pure and pharmaceutical solutions. The method was found to be accurate, reproducible, and cost-effective, and validated for the assay of hydralazine in terms of the routine quality control.展开更多
通过金相组织分析、硬度试验、脉动拉伸疲劳试验及疲劳断口形貌分析,研究了1.5 mm 1.4003+3 mm Q345NQR2电阻点焊接头的组织和疲劳性能。结果表明:Q345NQR2钢母材组织为白色铁素体+层片状珠光体,1.4003铁素体不锈钢母材组织为多边形或...通过金相组织分析、硬度试验、脉动拉伸疲劳试验及疲劳断口形貌分析,研究了1.5 mm 1.4003+3 mm Q345NQR2电阻点焊接头的组织和疲劳性能。结果表明:Q345NQR2钢母材组织为白色铁素体+层片状珠光体,1.4003铁素体不锈钢母材组织为多边形或无规则型铁素体,Q345NQR2侧HAZ分为正火细晶区和过热粗晶区,正火细晶区珠光体较细小,过热粗晶区珠光体较粗大,1.4003铁素体不锈钢侧HAZ为单一块状的多边形铁素体,晶粒度4~5级,熔核区显微组织为少量珠光体、贝氏体、板条马氏体与极少量残余奥氏体混合组织。熔核区硬度值在425HV~505HV之间,明显高于母材及熔合线处硬度。疲劳断口位于熔核区,其接头指定寿命为1×10~7次循环下的中值疲劳强度,2.875 kN。展开更多
基金supported by the National Key Research and Development Program of China(No.2018YFA0707300)the National Natural Science Foundation of China(Nos.51901151,51905372,52275362,52171122)China Postdoctoral Science Foundation(Nos.2020M680918,2021T140503)。
文摘The new method proposed is based on the formation of hydralazine-Bromophenol blue ion pair simply and without further extraction or heating. The ion pair was prepared in the presence of pH 3 citrate buffer forming a yellow-colored chromogen. A new maximum UV-visible band formed at 416 nm. The color was stable for more than 10 hours and obeyed Beer’s Law over the concentration range of 10 - 50 µg/mL. The calculated molar absorptivity and Sandell’s sensitivity were 1.01 × 104 L∙mol−1∙cm−1 and 0.0514 µg/mL, respectively. The elements of method validation stipulated by The International Conference on Harmonization [Q2 (R1)] were applied for hydralazine hydrochloride assay in pure and pharmaceutical tablet formulation. The average recoveries of the pure solution and the pharmaceutical formulation were 98.94% and 99.50%, respectively. The results were statistically compared by F-test, which indicates that the method can be precise and repeatable for both pure and pharmaceutical solutions. The method was found to be accurate, reproducible, and cost-effective, and validated for the assay of hydralazine in terms of the routine quality control.
文摘通过金相组织分析、硬度试验、脉动拉伸疲劳试验及疲劳断口形貌分析,研究了1.5 mm 1.4003+3 mm Q345NQR2电阻点焊接头的组织和疲劳性能。结果表明:Q345NQR2钢母材组织为白色铁素体+层片状珠光体,1.4003铁素体不锈钢母材组织为多边形或无规则型铁素体,Q345NQR2侧HAZ分为正火细晶区和过热粗晶区,正火细晶区珠光体较细小,过热粗晶区珠光体较粗大,1.4003铁素体不锈钢侧HAZ为单一块状的多边形铁素体,晶粒度4~5级,熔核区显微组织为少量珠光体、贝氏体、板条马氏体与极少量残余奥氏体混合组织。熔核区硬度值在425HV~505HV之间,明显高于母材及熔合线处硬度。疲劳断口位于熔核区,其接头指定寿命为1×10~7次循环下的中值疲劳强度,2.875 kN。
