Diabetes mellitus is a metabolic disease possible to treat via pancreas/islet transplantation but most immunosuppressive drugs are diabetogenic. In this letter, we review current up to date methods to assess insulin a...Diabetes mellitus is a metabolic disease possible to treat via pancreas/islet transplantation but most immunosuppressive drugs are diabetogenic. In this letter, we review current up to date methods to assess insulin action and secretion (using the surrogate indexes) suggesting their use in large studies in populations of pancreas/ islets transplanted patients.展开更多
Purpose： Determine if three weeks of HIT （high-intensity interval training） improves fasting insulin sensitivity in healthy males. Methods： Participants were recreationally active （ ≥ l0 hours per week） men bet...Purpose： Determine if three weeks of HIT （high-intensity interval training） improves fasting insulin sensitivity in healthy males. Methods： Participants were recreationally active （ ≥ l0 hours per week） men between 18 and 35 years of age （Ht： 180 ± 1.44 cm; Wt： 85 ± 2.95 kg; BMh 26.1 ± 0.59 kg/m^2; body fat： 19.7 ± 1.76%）. HIT training occurred 3 days weekly for 3 weeks, at intensities equivalent to 7.5% of body mass. Training volume increased weekly as follows： three sprints per session （week 1）, four sprints per session （week 2）, and five sprints per session （week 3）. Fasting blood samples were collected at baseline and after each week and tested for glucose and insulin. A repeated measures ANOVA was used to measure changes in both fasting glucose and insulin concentrations as well as HOMA（IR） （homeostatic model assessment） and QUICKI （quantitative insulin sensitivity check index）. Results： Values were in the normal range throughout the study and there were no significant improvements in glucose （P = 0.346）, insulin （P = 0.680）, HOMA （P = 0.567）, or QUICKI （P = 0.186）, as a result of HIT. Conclusion： While HIT may be useful in maintaining insulin sensitivity in healthy males, 3-weeks of HIT did not further improve insulin sensitivity in this group.展开更多
Clinically, determination of insulin resistance is important for diabetic patients. We evaluated the relationship among 20/(fasting C-peptide × fasting plasma glucose), HOMA-IR and QUICKI indices in type 2 diabet...Clinically, determination of insulin resistance is important for diabetic patients. We evaluated the relationship among 20/(fasting C-peptide × fasting plasma glucose), HOMA-IR and QUICKI indices in type 2 diabetic patients. The study included 40 patients with type 2 diabetes. Patients divided into three groups based on their medication: metformin, metformin + glibenclamide and metformin + glitazone. Fasting blood sugar, and lipid profile were measured by enzymatic method, serum insulin, and C-peptide were measured by ELISA method. Insulin resistance was calculated by using of 20/(fasting C-peptide × fasting plasma glucose), HOMA-IR and QUICKI indices. There was no significant relationship between 20/(fasting C-peptide × fasting plasma glucose) index and other parameters in all studied groups except QUICKI in metformin group showed a significant correlation with 20/(fasting C-peptide × fasting plasma glucose) index (r = 0.56 and p = 0.03). There was a significant correlation between HOMA-IR and QUICKI indices in all studied groups. There was no significant relationship between 20/(fasting C-peptide × fasting plasma glucose) index with other clinical parameters. On the other hand, our data strongly suggested a significant correlation between HOMA-IR and QUICKI indices in studied subjects with type 2 diabetes.展开更多
文摘Diabetes mellitus is a metabolic disease possible to treat via pancreas/islet transplantation but most immunosuppressive drugs are diabetogenic. In this letter, we review current up to date methods to assess insulin action and secretion (using the surrogate indexes) suggesting their use in large studies in populations of pancreas/ islets transplanted patients.
文摘Purpose： Determine if three weeks of HIT （high-intensity interval training） improves fasting insulin sensitivity in healthy males. Methods： Participants were recreationally active （ ≥ l0 hours per week） men between 18 and 35 years of age （Ht： 180 ± 1.44 cm; Wt： 85 ± 2.95 kg; BMh 26.1 ± 0.59 kg/m^2; body fat： 19.7 ± 1.76%）. HIT training occurred 3 days weekly for 3 weeks, at intensities equivalent to 7.5% of body mass. Training volume increased weekly as follows： three sprints per session （week 1）, four sprints per session （week 2）, and five sprints per session （week 3）. Fasting blood samples were collected at baseline and after each week and tested for glucose and insulin. A repeated measures ANOVA was used to measure changes in both fasting glucose and insulin concentrations as well as HOMA（IR） （homeostatic model assessment） and QUICKI （quantitative insulin sensitivity check index）. Results： Values were in the normal range throughout the study and there were no significant improvements in glucose （P = 0.346）, insulin （P = 0.680）, HOMA （P = 0.567）, or QUICKI （P = 0.186）, as a result of HIT. Conclusion： While HIT may be useful in maintaining insulin sensitivity in healthy males, 3-weeks of HIT did not further improve insulin sensitivity in this group.
文摘Clinically, determination of insulin resistance is important for diabetic patients. We evaluated the relationship among 20/(fasting C-peptide × fasting plasma glucose), HOMA-IR and QUICKI indices in type 2 diabetic patients. The study included 40 patients with type 2 diabetes. Patients divided into three groups based on their medication: metformin, metformin + glibenclamide and metformin + glitazone. Fasting blood sugar, and lipid profile were measured by enzymatic method, serum insulin, and C-peptide were measured by ELISA method. Insulin resistance was calculated by using of 20/(fasting C-peptide × fasting plasma glucose), HOMA-IR and QUICKI indices. There was no significant relationship between 20/(fasting C-peptide × fasting plasma glucose) index and other parameters in all studied groups except QUICKI in metformin group showed a significant correlation with 20/(fasting C-peptide × fasting plasma glucose) index (r = 0.56 and p = 0.03). There was a significant correlation between HOMA-IR and QUICKI indices in all studied groups. There was no significant relationship between 20/(fasting C-peptide × fasting plasma glucose) index with other clinical parameters. On the other hand, our data strongly suggested a significant correlation between HOMA-IR and QUICKI indices in studied subjects with type 2 diabetes.
